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P14965

- PYRF_SCHPO

UniProt

P14965 - PYRF_SCHPO

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Protein

Orotidine 5'-phosphate decarboxylase

Gene
ura4, SPCC330.05c
Organism
Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Status
Reviewed - Annotation score: 4 out of 5 - Protein inferred from homologyi

Functioni

Catalytic activityi

Orotidine 5'-phosphate = UMP + CO2.

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei40 – 401Substrate By similarity
Active sitei95 – 951Proton donor By similarity
Binding sitei214 – 2141Substrate By similarity
Binding sitei233 – 2331Substrate By similarity

GO - Molecular functioni

  1. orotidine-5'-phosphate decarboxylase activity Source: PomBase

GO - Biological processi

  1. 'de novo' pyrimidine nucleobase biosynthetic process Source: PomBase
  2. 'de novo' UMP biosynthetic process Source: UniProtKB-UniPathway
  3. UMP biosynthetic process Source: PomBase
Complete GO annotation...

Keywords - Molecular functioni

Decarboxylase, Lyase

Keywords - Biological processi

Pyrimidine biosynthesis

Enzyme and pathway databases

ReactomeiREACT_227862. Pyrimidine biosynthesis.
UniPathwayiUPA00070; UER00120.

Names & Taxonomyi

Protein namesi
Recommended name:
Orotidine 5'-phosphate decarboxylase (EC:4.1.1.23)
Alternative name(s):
OMP decarboxylase
Short name:
OMPDCase
Short name:
OMPdecase
Uridine 5'-monophosphate synthase
Short name:
UMP synthase
Gene namesi
Name:ura4
ORF Names:SPCC330.05c
OrganismiSchizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Taxonomic identifieri284812 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaTaphrinomycotinaSchizosaccharomycetesSchizosaccharomycetalesSchizosaccharomycetaceaeSchizosaccharomyces
ProteomesiUP000002485: Chromosome III

Organism-specific databases

PomBaseiSPCC330.05c.

Subcellular locationi

GO - Cellular componenti

  1. cytosol Source: PomBase
  2. nucleus Source: PomBase
Complete GO annotation...

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 264264Orotidine 5'-phosphate decarboxylasePRO_0000134683Add
BLAST

Interactioni

Protein-protein interaction databases

BioGridi275351. 6 interactions.
MINTiMINT-4687324.
STRINGi4896.SPCC330.05c-1.

Structurei

3D structure databases

ProteinModelPortaliP14965.
SMRiP14965. Positions 7-262.

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni62 – 643Substrate binding By similarity
Regioni93 – 10210Substrate binding By similarity

Sequence similaritiesi

Belongs to the OMP decarboxylase family.

Phylogenomic databases

eggNOGiCOG0284.
HOGENOMiHOG000213905.
KOiK01591.
OMAiMGQQYRT.
OrthoDBiEOG7CVQ76.
PhylomeDBiP14965.

Family and domain databases

Gene3Di3.20.20.70. 1 hit.
InterProiIPR013785. Aldolase_TIM.
IPR014732. OMPdecase.
IPR018089. OMPdecase_AS.
IPR001754. OMPdeCOase_dom.
IPR011060. RibuloseP-bd_barrel.
[Graphical view]
PfamiPF00215. OMPdecase. 1 hit.
[Graphical view]
SMARTiSM00934. OMPdecase. 1 hit.
[Graphical view]
SUPFAMiSSF51366. SSF51366. 1 hit.
TIGRFAMsiTIGR01740. pyrF. 1 hit.
PROSITEiPS00156. OMPDECASE. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P14965-1 [UniParc]FASTAAdd to Basket

« Hide

MDARVFQSYS ARAEGMKNPI AKELLALMEE KQSNLSVAVD LTKKSEILEL    50
VDKIGPYVCV IKTHIDVVED FDQDMVEKLV ALGKKHRFLI FEDRKFADIG 100
NTVKLQYASG VYKIASWAHI TNCHTVPGEG IIQGLKEVGL PLGRGLLLLA 150
EMSSKGSLAT GSYTEKTLEW FEKHTDFCFG FIAGRRFPNL QSDYITMSPG 200
IGLDVKGDGL GQQYRTPEEV IVNCGSDIII VGRGVYGAGR NPVVEAKRYR 250
EAGWKAYQQR LSQH 264
Length:264
Mass (Da):29,362
Last modified:April 1, 1990 - v1
Checksum:iC9B78224E1EE1299
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
X13976 Genomic DNA. Translation: CAA32157.1.
CU329672 Genomic DNA. Translation: CAA20910.1.
PIRiS08503.
RefSeqiNP_587705.1. NM_001022700.2.

Genome annotation databases

EnsemblFungiiSPCC330.05c.1; SPCC330.05c.1:pep; SPCC330.05c.
GeneIDi2538768.
KEGGispo:SPCC330.05c.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
X13976 Genomic DNA. Translation: CAA32157.1 .
CU329672 Genomic DNA. Translation: CAA20910.1 .
PIRi S08503.
RefSeqi NP_587705.1. NM_001022700.2.

3D structure databases

ProteinModelPortali P14965.
SMRi P14965. Positions 7-262.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 275351. 6 interactions.
MINTi MINT-4687324.
STRINGi 4896.SPCC330.05c-1.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblFungii SPCC330.05c.1 ; SPCC330.05c.1:pep ; SPCC330.05c .
GeneIDi 2538768.
KEGGi spo:SPCC330.05c.

Organism-specific databases

PomBasei SPCC330.05c.

Phylogenomic databases

eggNOGi COG0284.
HOGENOMi HOG000213905.
KOi K01591.
OMAi MGQQYRT.
OrthoDBi EOG7CVQ76.
PhylomeDBi P14965.

Enzyme and pathway databases

UniPathwayi UPA00070 ; UER00120 .
Reactomei REACT_227862. Pyrimidine biosynthesis.

Miscellaneous databases

NextBioi 20799952.

Family and domain databases

Gene3Di 3.20.20.70. 1 hit.
InterProi IPR013785. Aldolase_TIM.
IPR014732. OMPdecase.
IPR018089. OMPdecase_AS.
IPR001754. OMPdeCOase_dom.
IPR011060. RibuloseP-bd_barrel.
[Graphical view ]
Pfami PF00215. OMPdecase. 1 hit.
[Graphical view ]
SMARTi SM00934. OMPdecase. 1 hit.
[Graphical view ]
SUPFAMi SSF51366. SSF51366. 1 hit.
TIGRFAMsi TIGR01740. pyrF. 1 hit.
PROSITEi PS00156. OMPDECASE. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Genetic engineering of Schizosaccharomyces pombe: a system for gene disruption and replacement using the ura4 gene as a selectable marker."
    Grimm C., Kohli J., Murray J., Maundrell K.
    Mol. Gen. Genet. 215:81-86(1988) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
  2. "The genome sequence of Schizosaccharomyces pombe."
    Wood V., Gwilliam R., Rajandream M.A., Lyne M.H., Lyne R., Stewart A., Sgouros J.G., Peat N., Hayles J., Baker S.G., Basham D., Bowman S., Brooks K., Brown D., Brown S., Chillingworth T., Churcher C.M., Collins M.
    , Connor R., Cronin A., Davis P., Feltwell T., Fraser A., Gentles S., Goble A., Hamlin N., Harris D.E., Hidalgo J., Hodgson G., Holroyd S., Hornsby T., Howarth S., Huckle E.J., Hunt S., Jagels K., James K.D., Jones L., Jones M., Leather S., McDonald S., McLean J., Mooney P., Moule S., Mungall K.L., Murphy L.D., Niblett D., Odell C., Oliver K., O'Neil S., Pearson D., Quail M.A., Rabbinowitsch E., Rutherford K.M., Rutter S., Saunders D., Seeger K., Sharp S., Skelton J., Simmonds M.N., Squares R., Squares S., Stevens K., Taylor K., Taylor R.G., Tivey A., Walsh S.V., Warren T., Whitehead S., Woodward J.R., Volckaert G., Aert R., Robben J., Grymonprez B., Weltjens I., Vanstreels E., Rieger M., Schaefer M., Mueller-Auer S., Gabel C., Fuchs M., Duesterhoeft A., Fritzc C., Holzer E., Moestl D., Hilbert H., Borzym K., Langer I., Beck A., Lehrach H., Reinhardt R., Pohl T.M., Eger P., Zimmermann W., Wedler H., Wambutt R., Purnelle B., Goffeau A., Cadieu E., Dreano S., Gloux S., Lelaure V., Mottier S., Galibert F., Aves S.J., Xiang Z., Hunt C., Moore K., Hurst S.M., Lucas M., Rochet M., Gaillardin C., Tallada V.A., Garzon A., Thode G., Daga R.R., Cruzado L., Jimenez J., Sanchez M., del Rey F., Benito J., Dominguez A., Revuelta J.L., Moreno S., Armstrong J., Forsburg S.L., Cerutti L., Lowe T., McCombie W.R., Paulsen I., Potashkin J., Shpakovski G.V., Ussery D., Barrell B.G., Nurse P.
    Nature 415:871-880(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: 972 / ATCC 24843.

Entry informationi

Entry nameiPYRF_SCHPO
AccessioniPrimary (citable) accession number: P14965
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 1, 1990
Last sequence update: April 1, 1990
Last modified: September 3, 2014
This is version 111 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. Schizosaccharomyces pombe
    Schizosaccharomyces pombe: entries and gene names
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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