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P14964

- PYRF_SCHCO

UniProt

P14964 - PYRF_SCHCO

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Protein

Orotidine 5'-phosphate decarboxylase

Gene

URA1

Organism
Schizophyllum commune (Split gill fungus)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi

Functioni

Catalytic activityi

Orotidine 5'-phosphate = UMP + CO2.PROSITE-ProRule annotation

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei40 – 401SubstrateBy similarity
Active sitei95 – 951Proton donorPROSITE-ProRule annotation
Binding sitei223 – 2231SubstrateBy similarity
Binding sitei242 – 2421SubstrateBy similarity

GO - Molecular functioni

  1. orotidine-5'-phosphate decarboxylase activity Source: UniProtKB-EC

GO - Biological processi

  1. 'de novo' pyrimidine nucleobase biosynthetic process Source: InterPro
  2. 'de novo' UMP biosynthetic process Source: UniProtKB-UniPathway
Complete GO annotation...

Keywords - Molecular functioni

Decarboxylase, Lyase

Keywords - Biological processi

Pyrimidine biosynthesis

Enzyme and pathway databases

UniPathwayiUPA00070; UER00120.

Names & Taxonomyi

Protein namesi
Recommended name:
Orotidine 5'-phosphate decarboxylase (EC:4.1.1.23)
Alternative name(s):
OMP decarboxylase
Short name:
OMPDCase
Short name:
OMPdecase
Uridine 5'-monophosphate synthase
Short name:
UMP synthase
Gene namesi
Name:URA1
OrganismiSchizophyllum commune (Split gill fungus)
Taxonomic identifieri5334 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaBasidiomycotaAgaricomycotinaAgaricomycetesAgaricomycetidaeAgaricalesSchizophyllaceaeSchizophyllum

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 278278Orotidine 5'-phosphate decarboxylasePRO_0000134682Add
BLAST

Structurei

3D structure databases

ProteinModelPortaliP14964.
SMRiP14964. Positions 5-276.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni62 – 643Substrate bindingBy similarity
Regioni93 – 10210Substrate bindingBy similarity

Sequence similaritiesi

Belongs to the OMP decarboxylase family.Curated

Phylogenomic databases

OMAiMGQQYRT.

Family and domain databases

Gene3Di3.20.20.70. 1 hit.
InterProiIPR013785. Aldolase_TIM.
IPR014732. OMPdecase.
IPR018089. OMPdecase_AS.
IPR001754. OMPdeCOase_dom.
IPR011060. RibuloseP-bd_barrel.
[Graphical view]
PfamiPF00215. OMPdecase. 1 hit.
[Graphical view]
SMARTiSM00934. OMPdecase. 1 hit.
[Graphical view]
SUPFAMiSSF51366. SSF51366. 1 hit.
TIGRFAMsiTIGR01740. pyrF. 1 hit.
PROSITEiPS00156. OMPDECASE. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P14964-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MTAAHKLTYG QRAARFTNPA AKALLETMER KKSNLSVSVD VVKSADLLAI
60 70 80 90 100
VDTVGPYICL IKTHVDVVED FDSSLVTKLQ ALAEKHDFLI FEDRKFADIG
110 120 130 140 150
NTVALQYSSG VHKIASWSHI TNAHPVPGPS IISGLASVGQ PLGRGLLLLA
160 170 180 190 200
EMSTKGSLAT GAYTEAAVQM ARENRGFVIG FIAQRRMDGI GAPPGVNVED
210 220 230 240 250
EDFLVLTPGV GLDVKGDGMG QQYRTPKQVV QEDGCDVIIV GRGIYGKDPS
260 270
KVEEIRRQAE RYQAAGWAAY IERVNALV
Length:278
Mass (Da):29,979
Last modified:April 1, 1990 - v1
Checksum:i847543EF68288C12
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M26019 Genomic DNA. Translation: AAA33928.1.
PIRiJQ0122. DCSJOS.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M26019 Genomic DNA. Translation: AAA33928.1 .
PIRi JQ0122. DCSJOS.

3D structure databases

ProteinModelPortali P14964.
SMRi P14964. Positions 5-276.
ModBasei Search...
MobiDBi Search...

Protocols and materials databases

Structural Biology Knowledgebase Search...

Phylogenomic databases

OMAi MGQQYRT.

Enzyme and pathway databases

UniPathwayi UPA00070 ; UER00120 .

Family and domain databases

Gene3Di 3.20.20.70. 1 hit.
InterProi IPR013785. Aldolase_TIM.
IPR014732. OMPdecase.
IPR018089. OMPdecase_AS.
IPR001754. OMPdeCOase_dom.
IPR011060. RibuloseP-bd_barrel.
[Graphical view ]
Pfami PF00215. OMPdecase. 1 hit.
[Graphical view ]
SMARTi SM00934. OMPdecase. 1 hit.
[Graphical view ]
SUPFAMi SSF51366. SSF51366. 1 hit.
TIGRFAMsi TIGR01740. pyrF. 1 hit.
PROSITEi PS00156. OMPDECASE. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Sequence analysis of the URA1 gene encoding orotidine-5'-monophosphate decarboxylase of Schizophyllum commune."
    Froeliger E.H., Ullrich R.C., Novotny C.P.
    Gene 83:387-393(1989) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].

Entry informationi

Entry nameiPYRF_SCHCO
AccessioniPrimary (citable) accession number: P14964
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 1, 1990
Last sequence update: April 1, 1990
Last modified: October 1, 2014
This is version 78 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3