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Protein

Cecropin-A1/A2

Gene

CecA1

more
Organism
Drosophila melanogaster (Fruit fly)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at transcript leveli

Functioni

Cecropins have lytic and antibacterial activity against several Gram-positive and Gram-negative bacteria.

GO - Biological processi

  • antibacterial humoral response Source: FlyBase
  • autophagic cell death Source: FlyBase
  • cytolysis Source: UniProtKB
  • defense response to bacterium Source: FlyBase
  • defense response to Gram-negative bacterium Source: UniProtKB
  • defense response to Gram-positive bacterium Source: UniProtKB
  • humoral immune response Source: FlyBase
  • innate immune response Source: UniProtKB-KW
  • response to bacterium Source: FlyBase
  • salivary gland cell autophagic cell death Source: FlyBase
Complete GO annotation...

Keywords - Molecular functioni

Antibiotic, Antimicrobial

Keywords - Biological processi

Immunity, Innate immunity

Names & Taxonomyi

Protein namesi
Recommended name:
Cecropin-A1/A2
Gene namesi
Name:CecA1
ORF Names:CG1365
AND
Name:CecA2
ORF Names:CG1367
OrganismiDrosophila melanogaster (Fruit fly)
Taxonomic identifieri7227 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaArthropodaHexapodaInsectaPterygotaNeopteraEndopterygotaDipteraBrachyceraMuscomorphaEphydroideaDrosophilidaeDrosophilaSophophora
Proteomesi
  • UP000000803 Componenti: Chromosome 3R

Organism-specific databases

FlyBaseiFBgn0000276. CecA1.
FBgn0000277. CecA2.

Subcellular locationi

GO - Cellular componenti

  • extracellular region Source: UniProtKB
  • extracellular space Source: FlyBase
Complete GO annotation...

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 23Add BLAST23
ChainiPRO_000000483924 – 62Cecropin-A1/A2Add BLAST39

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei62Arginine amideBy similarity1

Keywords - PTMi

Amidation

Proteomic databases

PaxDbiP14954.
PRIDEiP14954.

Expressioni

Tissue specificityi

Strongly expressed in larval, pupal and adult fat body and hemocytes after injection of bacteria. Maximal expression in the adult involves fat body cells of the head, thorax and abdomen.1 Publication

Inductioni

Induced as part of the humoral response to a bacterial invasion. Transcripts appear within one hour after injection of bacteria into the hemocoel, reach a maximum after 2-6 hours and have almost disappeared after 24 hours. Similar response is seen when flies ingest bacteria present in their food.2 Publications

Gene expression databases

BgeeiFBgn0000276.

Interactioni

Protein-protein interaction databases

DIPiDIP-20122N.
IntActiP14954. 1 interactor.
MINTiMINT-933523.
STRINGi7227.FBpp0084978.

Structurei

3D structure databases

ProteinModelPortaliP14954.
SMRiP14954.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the cecropin family.Curated

Keywords - Domaini

Signal

Phylogenomic databases

GeneTreeiENSGT00540000073806.
InParanoidiP14954.
KOiK20696.
OMAiSRCNINI.
OrthoDBiEOG091G1A7G.
PhylomeDBiP14954.

Family and domain databases

InterProiIPR000875. Cecropin.
IPR020400. Cecropin_diptera.
[Graphical view]
PfamiPF00272. Cecropin. 1 hit.
[Graphical view]
ProDomiPD001670. Cecropin_diptera. 1 hit.
[Graphical view] [Entries sharing at least one domain]
PROSITEiPS00268. CECROPIN. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P14954-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MNFYNIFVFV ALILAITIGQ SEAGWLKKIG KKIERVGQHT RDATIQGLGI
60
AQQAANVAAT ARG
Length:63
Mass (Da):6,771
Last modified:April 1, 1990 - v1
Checksum:iF709070C5BEC7D74
GO

Sequence cautioni

The sequence ACD81810 differs from that shown. Reason: Frameshift at position 32.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti31K → R in ACD81810 (Ref. 7) Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural varianti2N → D in CecA2; strain: Z5. 1
Natural varianti2N → K in CecA2; strain: Z24. 1 Publication1
Natural varianti3F → L in CecA2; strain: M2, MJ1 and MJ3. 2 Publications1
Natural varianti7F → L in CecA2; strain: B226. 1 Publication1
Natural varianti8V → A in CecA1; strain: M26. 1
Natural varianti8V → G in CecA2; strain: Z5. 2 Publications1
Natural varianti11A → P in CecA1; strain: B226 and B316. 1
Natural varianti11A → T in CecA2; strain: B115, M11 and M47. 2 Publications1
Natural varianti14L → V in CecA1; strain: MJ3. 1 Publication1
Natural varianti20Q → E in CecA1; strain: B316. 1 Publication1
Natural varianti36V → A in CecA2; strain: MJ2. 1 Publication1
Natural varianti45I → IFT in CecA1; strain: M40. 1
Natural varianti45I → V in CecA1; strain: MJ1. 2 Publications1
Natural varianti56N → D in CecA1; strain: MJ1. 1 Publication1
Natural varianti61A → G in CecA1; strain: Z24. 1 Publication1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X16972 Genomic DNA. Translation: CAA34843.1.
X16972 Genomic DNA. Translation: CAA34844.1.
AF018964 Genomic DNA. Translation: AAB82461.1.
AF018965 Genomic DNA. Translation: AAB82462.1.
AF018966 Genomic DNA. Translation: AAB82463.1.
AF018967 Genomic DNA. Translation: AAB82464.1.
AF018968 Genomic DNA. Translation: AAB82465.1.
AF018969 Genomic DNA. Translation: AAB82466.1.
AF018970 Genomic DNA. Translation: AAB82467.1.
AF018971 Genomic DNA. Translation: AAB82468.1.
AF018972 Genomic DNA. Translation: AAB82469.1.
AF018973 Genomic DNA. Translation: AAB82470.1.
AF018974 Genomic DNA. Translation: AAB82471.1.
AF018976 Genomic DNA. Translation: AAB82473.1.
AF018977 Genomic DNA. Translation: AAB82474.1.
AF018978 Genomic DNA. Translation: AAB82475.1.
AF018979 Genomic DNA. Translation: AAB82476.1.
AF018980 Genomic DNA. Translation: AAB82477.1.
AF018981 Genomic DNA. Translation: AAB82478.1.
AF018982 Genomic DNA. Translation: AAB82479.1.
AF018983 Genomic DNA. Translation: AAB82480.1.
AF018984 Genomic DNA. Translation: AAB82481.1.
AB010791 Genomic DNA. Translation: BAA28719.1.
AB010791 Genomic DNA. Translation: BAA28721.1.
AB010792 Genomic DNA. Translation: BAA28723.1.
AB010792 Genomic DNA. Translation: BAA28725.1.
AB010793 Genomic DNA. Translation: BAA28727.1.
AB010793 Genomic DNA. Translation: BAA28728.1.
AB010794 Genomic DNA. Translation: BAA28730.1.
AB010794 Genomic DNA. Translation: BAA28732.1.
AB010795 Genomic DNA. Translation: BAA28734.1.
AB010796 Genomic DNA. Translation: BAA28736.1.
AB010796 Genomic DNA. Translation: BAA28738.1.
AB010797 Genomic DNA. Translation: BAA28740.1.
AB010797 Genomic DNA. Translation: BAA28742.1.
Y16852 Genomic DNA. Translation: CAA76425.1.
Y16852 Genomic DNA. Translation: CAA76427.1.
Y16853 Genomic DNA. Translation: CAA76431.1.
Y16853 Genomic DNA. Translation: CAA76433.1.
Y16854 Genomic DNA. Translation: CAA76437.1.
Y16854 Genomic DNA. Translation: CAA76439.1.
Y16855 Genomic DNA. Translation: CAA76443.1.
Y16855 Genomic DNA. Translation: CAA76445.1.
Y16856 Genomic DNA. Translation: CAA76449.1.
Y16856 Genomic DNA. Translation: CAA76451.1.
Y16857 Genomic DNA. Translation: CAA76455.1.
Y16857 Genomic DNA. Translation: CAA76457.1.
Y16858 Genomic DNA. Translation: CAA76461.1.
Y16858 Genomic DNA. Translation: CAA76463.1.
Y16859 Genomic DNA. Translation: CAA76467.1.
Y16859 Genomic DNA. Translation: CAA76469.1.
Y16861 Genomic DNA. Translation: CAA76477.1.
Y16861 Genomic DNA. Translation: CAA76479.1.
AE014297 Genomic DNA. Translation: AAF57025.1.
AE014297 Genomic DNA. Translation: AAF57026.1.
BT032790 mRNA. Translation: ACD81804.1.
BT032796 mRNA. Translation: ACD81810.1. Frameshift.
PIRiS07664.
RefSeqiNP_524588.1. NM_079849.4.
NP_524589.1. NM_079850.4.
UniGeneiDm.24116.

Genome annotation databases

EnsemblMetazoaiFBtr0085612; FBpp0084977; FBgn0000276.
FBtr0085614; FBpp0084978; FBgn0000277.
GeneIDi43596.
43597.
KEGGidme:Dmel_CG1365.
dme:Dmel_CG1367.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X16972 Genomic DNA. Translation: CAA34843.1.
X16972 Genomic DNA. Translation: CAA34844.1.
AF018964 Genomic DNA. Translation: AAB82461.1.
AF018965 Genomic DNA. Translation: AAB82462.1.
AF018966 Genomic DNA. Translation: AAB82463.1.
AF018967 Genomic DNA. Translation: AAB82464.1.
AF018968 Genomic DNA. Translation: AAB82465.1.
AF018969 Genomic DNA. Translation: AAB82466.1.
AF018970 Genomic DNA. Translation: AAB82467.1.
AF018971 Genomic DNA. Translation: AAB82468.1.
AF018972 Genomic DNA. Translation: AAB82469.1.
AF018973 Genomic DNA. Translation: AAB82470.1.
AF018974 Genomic DNA. Translation: AAB82471.1.
AF018976 Genomic DNA. Translation: AAB82473.1.
AF018977 Genomic DNA. Translation: AAB82474.1.
AF018978 Genomic DNA. Translation: AAB82475.1.
AF018979 Genomic DNA. Translation: AAB82476.1.
AF018980 Genomic DNA. Translation: AAB82477.1.
AF018981 Genomic DNA. Translation: AAB82478.1.
AF018982 Genomic DNA. Translation: AAB82479.1.
AF018983 Genomic DNA. Translation: AAB82480.1.
AF018984 Genomic DNA. Translation: AAB82481.1.
AB010791 Genomic DNA. Translation: BAA28719.1.
AB010791 Genomic DNA. Translation: BAA28721.1.
AB010792 Genomic DNA. Translation: BAA28723.1.
AB010792 Genomic DNA. Translation: BAA28725.1.
AB010793 Genomic DNA. Translation: BAA28727.1.
AB010793 Genomic DNA. Translation: BAA28728.1.
AB010794 Genomic DNA. Translation: BAA28730.1.
AB010794 Genomic DNA. Translation: BAA28732.1.
AB010795 Genomic DNA. Translation: BAA28734.1.
AB010796 Genomic DNA. Translation: BAA28736.1.
AB010796 Genomic DNA. Translation: BAA28738.1.
AB010797 Genomic DNA. Translation: BAA28740.1.
AB010797 Genomic DNA. Translation: BAA28742.1.
Y16852 Genomic DNA. Translation: CAA76425.1.
Y16852 Genomic DNA. Translation: CAA76427.1.
Y16853 Genomic DNA. Translation: CAA76431.1.
Y16853 Genomic DNA. Translation: CAA76433.1.
Y16854 Genomic DNA. Translation: CAA76437.1.
Y16854 Genomic DNA. Translation: CAA76439.1.
Y16855 Genomic DNA. Translation: CAA76443.1.
Y16855 Genomic DNA. Translation: CAA76445.1.
Y16856 Genomic DNA. Translation: CAA76449.1.
Y16856 Genomic DNA. Translation: CAA76451.1.
Y16857 Genomic DNA. Translation: CAA76455.1.
Y16857 Genomic DNA. Translation: CAA76457.1.
Y16858 Genomic DNA. Translation: CAA76461.1.
Y16858 Genomic DNA. Translation: CAA76463.1.
Y16859 Genomic DNA. Translation: CAA76467.1.
Y16859 Genomic DNA. Translation: CAA76469.1.
Y16861 Genomic DNA. Translation: CAA76477.1.
Y16861 Genomic DNA. Translation: CAA76479.1.
AE014297 Genomic DNA. Translation: AAF57025.1.
AE014297 Genomic DNA. Translation: AAF57026.1.
BT032790 mRNA. Translation: ACD81804.1.
BT032796 mRNA. Translation: ACD81810.1. Frameshift.
PIRiS07664.
RefSeqiNP_524588.1. NM_079849.4.
NP_524589.1. NM_079850.4.
UniGeneiDm.24116.

3D structure databases

ProteinModelPortaliP14954.
SMRiP14954.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

DIPiDIP-20122N.
IntActiP14954. 1 interactor.
MINTiMINT-933523.
STRINGi7227.FBpp0084978.

Proteomic databases

PaxDbiP14954.
PRIDEiP14954.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblMetazoaiFBtr0085612; FBpp0084977; FBgn0000276.
FBtr0085614; FBpp0084978; FBgn0000277.
GeneIDi43596.
43597.
KEGGidme:Dmel_CG1365.
dme:Dmel_CG1367.

Organism-specific databases

CTDi43596.
43597.
FlyBaseiFBgn0000276. CecA1.
FBgn0000277. CecA2.

Phylogenomic databases

GeneTreeiENSGT00540000073806.
InParanoidiP14954.
KOiK20696.
OMAiSRCNINI.
OrthoDBiEOG091G1A7G.
PhylomeDBiP14954.

Miscellaneous databases

PROiP14954.

Gene expression databases

BgeeiFBgn0000276.

Family and domain databases

InterProiIPR000875. Cecropin.
IPR020400. Cecropin_diptera.
[Graphical view]
PfamiPF00272. Cecropin. 1 hit.
[Graphical view]
ProDomiPD001670. Cecropin_diptera. 1 hit.
[Graphical view] [Entries sharing at least one domain]
PROSITEiPS00268. CECROPIN. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiCECA_DROME
AccessioniPrimary (citable) accession number: P14954
Secondary accession number(s): B3DN02
, B3DN08, O16815, O16816, O16817, O16818, O16819, O16820, O16821, O61275, O61276, O61277, O61279, O62590, P82449
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 1, 1990
Last sequence update: April 1, 1990
Last modified: November 2, 2016
This is version 136 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programDrosophila annotation project

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Drosophila
    Drosophila: entries, gene names and cross-references to FlyBase
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.