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Protein

Cecropin-A1/A2

Gene

CecA1

more
Organism
Drosophila melanogaster (Fruit fly)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at transcript leveli

Functioni

Cecropins have lytic and antibacterial activity against several Gram-positive and Gram-negative bacteria.

GO - Biological processi

  • antibacterial humoral response Source: FlyBase
  • autophagic cell death Source: FlyBase
  • cytolysis Source: UniProtKB
  • defense response to bacterium Source: FlyBase
  • defense response to fungus Source: FlyBase
  • defense response to Gram-negative bacterium Source: UniProtKB
  • defense response to Gram-positive bacterium Source: UniProtKB
  • humoral immune response Source: FlyBase
  • innate immune response Source: UniProtKB-KW
  • response to bacterium Source: FlyBase
  • salivary gland cell autophagic cell death Source: FlyBase
Complete GO annotation...

Keywords - Molecular functioni

Antibiotic, Antimicrobial

Keywords - Biological processi

Immunity, Innate immunity

Names & Taxonomyi

Protein namesi
Recommended name:
Cecropin-A1/A2
Gene namesi
Name:CecA1
ORF Names:CG1365
AND
Name:CecA2
ORF Names:CG1367
OrganismiDrosophila melanogaster (Fruit fly)
Taxonomic identifieri7227 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaArthropodaHexapodaInsectaPterygotaNeopteraEndopterygotaDipteraBrachyceraMuscomorphaEphydroideaDrosophilidaeDrosophilaSophophora
Proteomesi
  • UP000000803 Componenti: Chromosome 3R

Organism-specific databases

FlyBaseiFBgn0000276. CecA1.
FBgn0000277. CecA2.

Subcellular locationi

GO - Cellular componenti

  • extracellular region Source: UniProtKB
  • extracellular space Source: FlyBase
Complete GO annotation...

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2323Add
BLAST
Chaini24 – 6239Cecropin-A1/A2PRO_0000004839Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei62 – 621Arginine amideBy similarity

Keywords - PTMi

Amidation

Proteomic databases

PaxDbiP14954.

Expressioni

Tissue specificityi

Strongly expressed in larval, pupal and adult fat body and hemocytes after injection of bacteria. Maximal expression in the adult involves fat body cells of the head, thorax and abdomen.1 Publication

Inductioni

Induced as part of the humoral response to a bacterial invasion. Transcripts appear within one hour after injection of bacteria into the hemocoel, reach a maximum after 2-6 hours and have almost disappeared after 24 hours. Similar response is seen when flies ingest bacteria present in their food.2 Publications

Gene expression databases

BgeeiP14954.

Interactioni

Protein-protein interaction databases

DIPiDIP-20122N.
IntActiP14954. 1 interaction.
MINTiMINT-933523.
STRINGi7227.FBpp0084978.

Structurei

3D structure databases

ProteinModelPortaliP14954.
SMRiP14954. Positions 24-52.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the cecropin family.Curated

Keywords - Domaini

Signal

Phylogenomic databases

GeneTreeiENSGT00540000073806.
InParanoidiP14954.
OrthoDBiEOG7K9K6B.
PhylomeDBiP14954.

Family and domain databases

InterProiIPR000875. Cecropin.
IPR020400. Cecropin_diptera.
[Graphical view]
PfamiPF00272. Cecropin. 1 hit.
[Graphical view]
ProDomiPD001670. Cecropin_diptera. 1 hit.
[Graphical view] [Entries sharing at least one domain]
PROSITEiPS00268. CECROPIN. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P14954-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MNFYNIFVFV ALILAITIGQ SEAGWLKKIG KKIERVGQHT RDATIQGLGI
60
AQQAANVAAT ARG
Length:63
Mass (Da):6,771
Last modified:April 1, 1990 - v1
Checksum:iF709070C5BEC7D74
GO

Sequence cautioni

The sequence ACD81810.1 differs from that shown. Reason: Frameshift at position 32. Curated

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti31 – 311K → R in ACD81810 (Ref. 7) Curated

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti2 – 21N → D in CecA2; strain: Z5.
Natural varianti2 – 21N → K in CecA2; strain: Z24. 1 Publication
Natural varianti3 – 31F → L in CecA2; strain: M2, MJ1 and MJ3. 2 Publications
Natural varianti7 – 71F → L in CecA2; strain: B226. 1 Publication
Natural varianti8 – 81V → A in CecA1; strain: M26.
Natural varianti8 – 81V → G in CecA2; strain: Z5. 2 Publications
Natural varianti11 – 111A → P in CecA1; strain: B226 and B316.
Natural varianti11 – 111A → T in CecA2; strain: B115, M11 and M47. 2 Publications
Natural varianti14 – 141L → V in CecA1; strain: MJ3. 1 Publication
Natural varianti20 – 201Q → E in CecA1; strain: B316. 1 Publication
Natural varianti36 – 361V → A in CecA2; strain: MJ2. 1 Publication
Natural varianti45 – 451I → IFT in CecA1; strain: M40.
Natural varianti45 – 451I → V in CecA1; strain: MJ1. 2 Publications
Natural varianti56 – 561N → D in CecA1; strain: MJ1. 1 Publication
Natural varianti61 – 611A → G in CecA1; strain: Z24. 1 Publication

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X16972 Genomic DNA. Translation: CAA34843.1.
X16972 Genomic DNA. Translation: CAA34844.1.
AF018964 Genomic DNA. Translation: AAB82461.1.
AF018965 Genomic DNA. Translation: AAB82462.1.
AF018966 Genomic DNA. Translation: AAB82463.1.
AF018967 Genomic DNA. Translation: AAB82464.1.
AF018968 Genomic DNA. Translation: AAB82465.1.
AF018969 Genomic DNA. Translation: AAB82466.1.
AF018970 Genomic DNA. Translation: AAB82467.1.
AF018971 Genomic DNA. Translation: AAB82468.1.
AF018972 Genomic DNA. Translation: AAB82469.1.
AF018973 Genomic DNA. Translation: AAB82470.1.
AF018974 Genomic DNA. Translation: AAB82471.1.
AF018976 Genomic DNA. Translation: AAB82473.1.
AF018977 Genomic DNA. Translation: AAB82474.1.
AF018978 Genomic DNA. Translation: AAB82475.1.
AF018979 Genomic DNA. Translation: AAB82476.1.
AF018980 Genomic DNA. Translation: AAB82477.1.
AF018981 Genomic DNA. Translation: AAB82478.1.
AF018982 Genomic DNA. Translation: AAB82479.1.
AF018983 Genomic DNA. Translation: AAB82480.1.
AF018984 Genomic DNA. Translation: AAB82481.1.
AB010791 Genomic DNA. Translation: BAA28719.1.
AB010791 Genomic DNA. Translation: BAA28721.1.
AB010792 Genomic DNA. Translation: BAA28723.1.
AB010792 Genomic DNA. Translation: BAA28725.1.
AB010793 Genomic DNA. Translation: BAA28727.1.
AB010793 Genomic DNA. Translation: BAA28728.1.
AB010794 Genomic DNA. Translation: BAA28730.1.
AB010794 Genomic DNA. Translation: BAA28732.1.
AB010795 Genomic DNA. Translation: BAA28734.1.
AB010796 Genomic DNA. Translation: BAA28736.1.
AB010796 Genomic DNA. Translation: BAA28738.1.
AB010797 Genomic DNA. Translation: BAA28740.1.
AB010797 Genomic DNA. Translation: BAA28742.1.
Y16852 Genomic DNA. Translation: CAA76425.1.
Y16852 Genomic DNA. Translation: CAA76427.1.
Y16853 Genomic DNA. Translation: CAA76431.1.
Y16853 Genomic DNA. Translation: CAA76433.1.
Y16854 Genomic DNA. Translation: CAA76437.1.
Y16854 Genomic DNA. Translation: CAA76439.1.
Y16855 Genomic DNA. Translation: CAA76443.1.
Y16855 Genomic DNA. Translation: CAA76445.1.
Y16856 Genomic DNA. Translation: CAA76449.1.
Y16856 Genomic DNA. Translation: CAA76451.1.
Y16857 Genomic DNA. Translation: CAA76455.1.
Y16857 Genomic DNA. Translation: CAA76457.1.
Y16858 Genomic DNA. Translation: CAA76461.1.
Y16858 Genomic DNA. Translation: CAA76463.1.
Y16859 Genomic DNA. Translation: CAA76467.1.
Y16859 Genomic DNA. Translation: CAA76469.1.
Y16861 Genomic DNA. Translation: CAA76477.1.
Y16861 Genomic DNA. Translation: CAA76479.1.
AE014297 Genomic DNA. Translation: AAF57025.1.
AE014297 Genomic DNA. Translation: AAF57026.1.
BT032790 mRNA. Translation: ACD81804.1.
BT032796 mRNA. Translation: ACD81810.1. Frameshift.
PIRiS07664.
RefSeqiNP_524588.1. NM_079849.4.
NP_524589.1. NM_079850.4.
UniGeneiDm.24116.

Genome annotation databases

EnsemblMetazoaiFBtr0085612; FBpp0084977; FBgn0000276.
FBtr0085614; FBpp0084978; FBgn0000277.
GeneIDi43596.
43597.
KEGGidme:Dmel_CG1365.
dme:Dmel_CG1367.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X16972 Genomic DNA. Translation: CAA34843.1.
X16972 Genomic DNA. Translation: CAA34844.1.
AF018964 Genomic DNA. Translation: AAB82461.1.
AF018965 Genomic DNA. Translation: AAB82462.1.
AF018966 Genomic DNA. Translation: AAB82463.1.
AF018967 Genomic DNA. Translation: AAB82464.1.
AF018968 Genomic DNA. Translation: AAB82465.1.
AF018969 Genomic DNA. Translation: AAB82466.1.
AF018970 Genomic DNA. Translation: AAB82467.1.
AF018971 Genomic DNA. Translation: AAB82468.1.
AF018972 Genomic DNA. Translation: AAB82469.1.
AF018973 Genomic DNA. Translation: AAB82470.1.
AF018974 Genomic DNA. Translation: AAB82471.1.
AF018976 Genomic DNA. Translation: AAB82473.1.
AF018977 Genomic DNA. Translation: AAB82474.1.
AF018978 Genomic DNA. Translation: AAB82475.1.
AF018979 Genomic DNA. Translation: AAB82476.1.
AF018980 Genomic DNA. Translation: AAB82477.1.
AF018981 Genomic DNA. Translation: AAB82478.1.
AF018982 Genomic DNA. Translation: AAB82479.1.
AF018983 Genomic DNA. Translation: AAB82480.1.
AF018984 Genomic DNA. Translation: AAB82481.1.
AB010791 Genomic DNA. Translation: BAA28719.1.
AB010791 Genomic DNA. Translation: BAA28721.1.
AB010792 Genomic DNA. Translation: BAA28723.1.
AB010792 Genomic DNA. Translation: BAA28725.1.
AB010793 Genomic DNA. Translation: BAA28727.1.
AB010793 Genomic DNA. Translation: BAA28728.1.
AB010794 Genomic DNA. Translation: BAA28730.1.
AB010794 Genomic DNA. Translation: BAA28732.1.
AB010795 Genomic DNA. Translation: BAA28734.1.
AB010796 Genomic DNA. Translation: BAA28736.1.
AB010796 Genomic DNA. Translation: BAA28738.1.
AB010797 Genomic DNA. Translation: BAA28740.1.
AB010797 Genomic DNA. Translation: BAA28742.1.
Y16852 Genomic DNA. Translation: CAA76425.1.
Y16852 Genomic DNA. Translation: CAA76427.1.
Y16853 Genomic DNA. Translation: CAA76431.1.
Y16853 Genomic DNA. Translation: CAA76433.1.
Y16854 Genomic DNA. Translation: CAA76437.1.
Y16854 Genomic DNA. Translation: CAA76439.1.
Y16855 Genomic DNA. Translation: CAA76443.1.
Y16855 Genomic DNA. Translation: CAA76445.1.
Y16856 Genomic DNA. Translation: CAA76449.1.
Y16856 Genomic DNA. Translation: CAA76451.1.
Y16857 Genomic DNA. Translation: CAA76455.1.
Y16857 Genomic DNA. Translation: CAA76457.1.
Y16858 Genomic DNA. Translation: CAA76461.1.
Y16858 Genomic DNA. Translation: CAA76463.1.
Y16859 Genomic DNA. Translation: CAA76467.1.
Y16859 Genomic DNA. Translation: CAA76469.1.
Y16861 Genomic DNA. Translation: CAA76477.1.
Y16861 Genomic DNA. Translation: CAA76479.1.
AE014297 Genomic DNA. Translation: AAF57025.1.
AE014297 Genomic DNA. Translation: AAF57026.1.
BT032790 mRNA. Translation: ACD81804.1.
BT032796 mRNA. Translation: ACD81810.1. Frameshift.
PIRiS07664.
RefSeqiNP_524588.1. NM_079849.4.
NP_524589.1. NM_079850.4.
UniGeneiDm.24116.

3D structure databases

ProteinModelPortaliP14954.
SMRiP14954. Positions 24-52.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

DIPiDIP-20122N.
IntActiP14954. 1 interaction.
MINTiMINT-933523.
STRINGi7227.FBpp0084978.

Proteomic databases

PaxDbiP14954.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblMetazoaiFBtr0085612; FBpp0084977; FBgn0000276.
FBtr0085614; FBpp0084978; FBgn0000277.
GeneIDi43596.
43597.
KEGGidme:Dmel_CG1365.
dme:Dmel_CG1367.

Organism-specific databases

CTDi43596.
43597.
FlyBaseiFBgn0000276. CecA1.
FBgn0000277. CecA2.

Phylogenomic databases

GeneTreeiENSGT00540000073806.
InParanoidiP14954.
OrthoDBiEOG7K9K6B.
PhylomeDBiP14954.

Miscellaneous databases

NextBioi834770.
PROiP14954.

Gene expression databases

BgeeiP14954.

Family and domain databases

InterProiIPR000875. Cecropin.
IPR020400. Cecropin_diptera.
[Graphical view]
PfamiPF00272. Cecropin. 1 hit.
[Graphical view]
ProDomiPD001670. Cecropin_diptera. 1 hit.
[Graphical view] [Entries sharing at least one domain]
PROSITEiPS00268. CECROPIN. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "The cecropin locus in Drosophila; a compact gene cluster involved in the response to infection."
    Kylsten P., Samakovlis C., Hultmark D.
    EMBO J. 9:217-224(1990) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] (CECA1 AND CECA2), INDUCTION.
    Strain: Canton-S.
  2. "Molecular population genetics of Drosophila immune system genes."
    Clark A.G., Wang L.
    Genetics 147:713-724(1997) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] (CECA1 AND CECA2), VARIANTS LYS-2; LEU-7; GLY-8; THR-11; GLU-20 AND GLY-61.
    Strain: B115, B137, B141, B205, B208, B222, B225, B226, B316, M13, Z10, Z18, Z22, Z24 and Z5.
  3. "Evolutionary history and mechanism of the Drosophila cecropin gene family."
    Date A., Satta Y., Takahata N., Chigusa S.I.
    Immunogenetics 47:417-429(1998) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] (CECA1 AND CECA2), VARIANTS LEU-3; VAL-14; ALA-36; VAL-45 AND ASP-56.
    Strain: 3RC, MA1, MA2, MA3, MJ1, MJ2 and MJ3.
  4. "Molecular evolution of the Cecropin multigene family in Drosophila: functional genes vs pseudogenes."
    Ramos-Onsins S., Aguade M.
    Genetics 150:157-171(1998) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] (CECA1 AND CECA2), VARIANTS LEU-3; GLY-8; THR-11 AND VAL-45.
    Strain: M11, M2, M26, M36, M40, M47, M54, M55 and M66.
  5. "The genome sequence of Drosophila melanogaster."
    Adams M.D., Celniker S.E., Holt R.A., Evans C.A., Gocayne J.D., Amanatides P.G., Scherer S.E., Li P.W., Hoskins R.A., Galle R.F., George R.A., Lewis S.E., Richards S., Ashburner M., Henderson S.N., Sutton G.G., Wortman J.R., Yandell M.D.
    , Zhang Q., Chen L.X., Brandon R.C., Rogers Y.-H.C., Blazej R.G., Champe M., Pfeiffer B.D., Wan K.H., Doyle C., Baxter E.G., Helt G., Nelson C.R., Miklos G.L.G., Abril J.F., Agbayani A., An H.-J., Andrews-Pfannkoch C., Baldwin D., Ballew R.M., Basu A., Baxendale J., Bayraktaroglu L., Beasley E.M., Beeson K.Y., Benos P.V., Berman B.P., Bhandari D., Bolshakov S., Borkova D., Botchan M.R., Bouck J., Brokstein P., Brottier P., Burtis K.C., Busam D.A., Butler H., Cadieu E., Center A., Chandra I., Cherry J.M., Cawley S., Dahlke C., Davenport L.B., Davies P., de Pablos B., Delcher A., Deng Z., Mays A.D., Dew I., Dietz S.M., Dodson K., Doup L.E., Downes M., Dugan-Rocha S., Dunkov B.C., Dunn P., Durbin K.J., Evangelista C.C., Ferraz C., Ferriera S., Fleischmann W., Fosler C., Gabrielian A.E., Garg N.S., Gelbart W.M., Glasser K., Glodek A., Gong F., Gorrell J.H., Gu Z., Guan P., Harris M., Harris N.L., Harvey D.A., Heiman T.J., Hernandez J.R., Houck J., Hostin D., Houston K.A., Howland T.J., Wei M.-H., Ibegwam C., Jalali M., Kalush F., Karpen G.H., Ke Z., Kennison J.A., Ketchum K.A., Kimmel B.E., Kodira C.D., Kraft C.L., Kravitz S., Kulp D., Lai Z., Lasko P., Lei Y., Levitsky A.A., Li J.H., Li Z., Liang Y., Lin X., Liu X., Mattei B., McIntosh T.C., McLeod M.P., McPherson D., Merkulov G., Milshina N.V., Mobarry C., Morris J., Moshrefi A., Mount S.M., Moy M., Murphy B., Murphy L., Muzny D.M., Nelson D.L., Nelson D.R., Nelson K.A., Nixon K., Nusskern D.R., Pacleb J.M., Palazzolo M., Pittman G.S., Pan S., Pollard J., Puri V., Reese M.G., Reinert K., Remington K., Saunders R.D.C., Scheeler F., Shen H., Shue B.C., Siden-Kiamos I., Simpson M., Skupski M.P., Smith T.J., Spier E., Spradling A.C., Stapleton M., Strong R., Sun E., Svirskas R., Tector C., Turner R., Venter E., Wang A.H., Wang X., Wang Z.-Y., Wassarman D.A., Weinstock G.M., Weissenbach J., Williams S.M., Woodage T., Worley K.C., Wu D., Yang S., Yao Q.A., Ye J., Yeh R.-F., Zaveri J.S., Zhan M., Zhang G., Zhao Q., Zheng L., Zheng X.H., Zhong F.N., Zhong W., Zhou X., Zhu S.C., Zhu X., Smith H.O., Gibbs R.A., Myers E.W., Rubin G.M., Venter J.C.
    Science 287:2185-2195(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA] (CECA1 AND CECA2).
    Strain: Berkeley.
  6. Cited for: GENOME REANNOTATION.
    Strain: Berkeley.
  7. Carlson J.W., Booth B., Frise E., Park S., Wan K.H., Yu C., Celniker S.E.
    Submitted (MAY-2008) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (CECA2).
    Strain: Berkeley.
  8. "The immune response in Drosophila: pattern of cecropin expression and biological activity."
    Samakovlis C., Kimbrell D.A., Kylsten P., Engstrom A., Hultmark D.
    EMBO J. 9:2969-2976(1990) [PubMed] [Europe PMC] [Abstract]
    Cited for: INDUCTION, TISSUE SPECIFICITY.
    Strain: Canton-S.

Entry informationi

Entry nameiCECA_DROME
AccessioniPrimary (citable) accession number: P14954
Secondary accession number(s): B3DN02
, B3DN08, O16815, O16816, O16817, O16818, O16819, O16820, O16821, O61275, O61276, O61277, O61279, O62590, P82449
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 1, 1990
Last sequence update: April 1, 1990
Last modified: May 11, 2016
This is version 132 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programDrosophila annotation project

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Drosophila
    Drosophila: entries, gene names and cross-references to FlyBase
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.