P14953 (TRPE_CLOTM) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Anthranilate synthase component 1
EC=4.1.3.27

Alternative name(s):
Anthranilate synthase component I

Gene names

Name:

trpE

Organism

Clostridium thermocellum

Taxonomic identifier

1515 [NCBI]

Taxonomic lineage

Bacteria › Firmicutes › Clostridia › Clostridiales › Clostridiaceae › Clostridium

Protein attributes

Sequence length	494 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Catalytic activity	Chorismate + L-glutamine = anthranilate + pyruvate + L-glutamate.
Pathway	Amino-acid biosynthesis; L-tryptophan biosynthesis; L-tryptophan from chorismate: step 1/5.
Subunit structure	Tetramer of two components I and two components II By similarity.
Miscellaneous	Component I catalyzes the formation of anthranilate using ammonia rather than glutamine, whereas component II provides glutamine amidotransferase activity.
Sequence similarities	Belongs to the anthranilate synthase component I family.

Ontologies

Keywords
Biological process	Amino-acid biosynthesis Aromatic amino acid biosynthesis Tryptophan biosynthesis
Molecular function	Lyase
Gene Ontology (GO)
Biological process	tryptophan biosynthetic process Inferred from electronic annotation. Source: UniProtKB-KW
Molecular function	anthranilate synthase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 494	494	Anthranilate synthase component 1		PRO_0000154090

Sequences

	Sequence		Length	Mass (Da)
	P14953 [UniParc]. Last modified April 1, 1990. Version 1. Checksum: 32DF1EF22344447D	FASTA	494	56,020
	10 20 30 40 50 60 MFYPTLDEVK IMAKDYNIIP VTMEVYADME TPISLFKRFE ESSCCFLLES VEGGEKWARY 70 80 90 100 110 120 SIIGKNPFLV VESYKNKTII RERNGSQREV EGNPVEIIKG IMGKFKGANL PNLPRFNGGA 130 140 150 160 170 180 VGYFGYDLIR HYENLPNVPE DDMGLPECHF MFTDEVLVYD HLKQKIHIIV NLHVNGNIER 190 200 210 220 230 240 AYISAVDRIK TIHREILDTR WKTADNSVLS YNKKKNELAV TSNISKEDFC RNVLKAKQYI 250 260 270 280 290 300 RDGDIFQVVL SQRLCVETNE NPFNIYRALR VINPSPYMYY LKFGGYRIIG SSPEMLVRVE 310 320 330 340 350 360 NGIVETCPIA GTRKRGRTKE EDEALEKELL SDEKEIAEHV MLVDLGRNDI GRVSKFGTVA 370 380 390 400 410 420 VKNLMHIERY SHVMHVVTNV QGEIREDKTP FDALMSILPA GTLSGAPKVR AMEIIDELET 430 440 450 460 470 480 VKRGPYGGAI GYLSFNGNLD SCITIRTIIL KDGKAYVQAG AGIVADSVPE REYEECYNKA 490 MALLKAIEEA GEIR

References

[1]	"Molecular cloning and the nucleotide sequence of the Clostridium thermocellum trpE gene." Sato S., Nakada Y., Hon-Nami K., Yasui K., Shiratsuchi A. J. Biochem. 105:362-366(1989) [PubMed: 2732211] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	D00399 Genomic DNA. Translation: BAA00300.1.
PIR	JX0065.
3D structure databases
ProteinModelPortal	P14953.
ModBase	Search...
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Phylogenomic databases
PhylomeDB	P14953.
Family and domain databases
InterPro	IPR005801. ADC_synthase. IPR019999. Anth_synth_I. IPR006805. Anth_synth_I_N. IPR005256. Anth_synth_I_PabB. IPR015890. Chorismate-bd_C. [Graphical view]
Gene3D	G3DSA:3.60.120.10. TRPE_1_chor_bd. 1 hit.
Pfam	PF04715. Anth_synt_I_N. 1 hit. PF00425. Chorismate_bind. 1 hit. [Graphical view]
PRINTS	PR00095. ANTSNTHASEI.
SUPFAM	SSF56322. TRPE_1_chor_bd. 1 hit.
TIGRFAMs	TIGR00564. TrpE_most. 1 hit.
ProtoNet	Search...

Entry information

Entry name

TRPE_CLOTM

Accession

Primary (citable) accession number: P14953

Entry history

Integrated into UniProtKB/Swiss-Prot:	April 1, 1990
Last sequence update:	April 1, 1990
Last modified:	September 21, 2011
This is version 65 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program