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Protein

Thioredoxin

Gene

trxA

Organism
Bacillus subtilis (strain 168)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

Participates in various redox reactions through the reversible oxidation of its active center dithiol to a disulfide and catalyzes dithiol-disulfide exchange reactions.

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Electron transport, Transport

Enzyme and pathway databases

BioCyciBSUB:BSU28500-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Thioredoxin
Short name:
Trx
Gene namesi
Name:trxA
Synonyms:trx
Ordered Locus Names:BSU28500
OrganismiBacillus subtilis (strain 168)
Taxonomic identifieri224308 [NCBI]
Taxonomic lineageiBacteriaFirmicutesBacilliBacillalesBacillaceaeBacillus
Proteomesi
  • UP000001570 Componenti: Chromosome

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Initiator methionineiRemoved1 Publication
ChainiPRO_00001200762 – 104ThioredoxinAdd BLAST103

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi29 ↔ 32Redox-activePROSITE-ProRule annotation

Keywords - PTMi

Disulfide bond

Proteomic databases

PaxDbiP14949.
PRIDEiP14949.

Interactioni

Protein-protein interaction databases

IntActiP14949. 1 interactor.
MINTiMINT-8366866.
STRINGi224308.Bsubs1_010100015561.

Structurei

Secondary structure

1104
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Beta strandi3 – 6Combined sources4
Turni8 – 10Combined sources3
Helixi11 – 15Combined sources5
Beta strandi16 – 25Combined sources10
Helixi30 – 34Combined sources5
Helixi35 – 46Combined sources12
Turni47 – 49Combined sources3
Beta strandi51 – 56Combined sources6
Turni57 – 59Combined sources3
Helixi63 – 66Combined sources4
Beta strandi71 – 79Combined sources9
Beta strandi82 – 89Combined sources8
Helixi93 – 101Combined sources9

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2GZYNMR-A1-104[»]
2GZZNMR-A1-104[»]
2IPANMR-A1-104[»]
2VOCX-ray1.50A/B1-104[»]
ProteinModelPortaliP14949.
SMRiP14949.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP14949.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini2 – 104ThioredoxinPROSITE-ProRule annotationAdd BLAST103

Sequence similaritiesi

Belongs to the thioredoxin family.Curated
Contains 1 thioredoxin domain.PROSITE-ProRule annotation

Keywords - Domaini

Redox-active center

Phylogenomic databases

eggNOGiENOG4105K63. Bacteria.
COG0526. LUCA.
HOGENOMiHOG000292977.
InParanoidiP14949.
KOiK03671.
OMAiMSEHIHY.
PhylomeDBiP14949.

Family and domain databases

Gene3Di3.40.30.10. 1 hit.
InterProiIPR005746. Thioredoxin.
IPR012336. Thioredoxin-like_fold.
IPR017937. Thioredoxin_CS.
IPR013766. Thioredoxin_domain.
[Graphical view]
PANTHERiPTHR10438. PTHR10438. 1 hit.
PfamiPF00085. Thioredoxin. 1 hit.
[Graphical view]
PIRSFiPIRSF000077. Thioredoxin. 1 hit.
SUPFAMiSSF52833. SSF52833. 1 hit.
TIGRFAMsiTIGR01068. thioredoxin. 1 hit.
PROSITEiPS00194. THIOREDOXIN_1. 1 hit.
PS51352. THIOREDOXIN_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P14949-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAIVKATDQS FSAETSEGVV LADFWAPWCG PCKMIAPVLE ELDQEMGDKL
60 70 80 90 100
KIVKIDVDEN QETAGKYGVM SIPTLLVLKD GEVVETSVGF KPKEALQELV

NKHL
Length:104
Mass (Da):11,393
Last modified:January 23, 2007 - v3
Checksum:iB2989161062C264D
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
J03294 Genomic DNA. Translation: AAA87315.1.
Z75208 Genomic DNA. Translation: CAA99577.1.
AL009126 Genomic DNA. Translation: CAB14810.1.
X79976 Genomic DNA. Translation: CAA56300.1.
X99275 Genomic DNA. Translation: CAA67667.1.
PIRiB37192.
RefSeqiNP_390728.1. NC_000964.3.
WP_003222500.1. NZ_JNCM01000036.1.

Genome annotation databases

EnsemblBacteriaiCAB14810; CAB14810; BSU28500.
GeneIDi11240460.
938187.
KEGGibsu:BSU28500.
PATRICi18977582. VBIBacSub10457_2979.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
J03294 Genomic DNA. Translation: AAA87315.1.
Z75208 Genomic DNA. Translation: CAA99577.1.
AL009126 Genomic DNA. Translation: CAB14810.1.
X79976 Genomic DNA. Translation: CAA56300.1.
X99275 Genomic DNA. Translation: CAA67667.1.
PIRiB37192.
RefSeqiNP_390728.1. NC_000964.3.
WP_003222500.1. NZ_JNCM01000036.1.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2GZYNMR-A1-104[»]
2GZZNMR-A1-104[»]
2IPANMR-A1-104[»]
2VOCX-ray1.50A/B1-104[»]
ProteinModelPortaliP14949.
SMRiP14949.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

IntActiP14949. 1 interactor.
MINTiMINT-8366866.
STRINGi224308.Bsubs1_010100015561.

Proteomic databases

PaxDbiP14949.
PRIDEiP14949.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiCAB14810; CAB14810; BSU28500.
GeneIDi11240460.
938187.
KEGGibsu:BSU28500.
PATRICi18977582. VBIBacSub10457_2979.

Phylogenomic databases

eggNOGiENOG4105K63. Bacteria.
COG0526. LUCA.
HOGENOMiHOG000292977.
InParanoidiP14949.
KOiK03671.
OMAiMSEHIHY.
PhylomeDBiP14949.

Enzyme and pathway databases

BioCyciBSUB:BSU28500-MONOMER.

Miscellaneous databases

EvolutionaryTraceiP14949.

Family and domain databases

Gene3Di3.40.30.10. 1 hit.
InterProiIPR005746. Thioredoxin.
IPR012336. Thioredoxin-like_fold.
IPR017937. Thioredoxin_CS.
IPR013766. Thioredoxin_domain.
[Graphical view]
PANTHERiPTHR10438. PTHR10438. 1 hit.
PfamiPF00085. Thioredoxin. 1 hit.
[Graphical view]
PIRSFiPIRSF000077. Thioredoxin. 1 hit.
SUPFAMiSSF52833. SSF52833. 1 hit.
TIGRFAMsiTIGR01068. thioredoxin. 1 hit.
PROSITEiPS00194. THIOREDOXIN_1. 1 hit.
PS51352. THIOREDOXIN_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiTHIO_BACSU
AccessioniPrimary (citable) accession number: P14949
Secondary accession number(s): O07960, Q45687
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 1, 1990
Last sequence update: January 23, 2007
Last modified: November 2, 2016
This is version 132 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. Bacillus subtilis
    Bacillus subtilis (strain 168): entries, gene names and cross-references to SubtiList
  2. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  3. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.