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Protein

Pollen allergen Lol p 1

Gene
N/A
Organism
Lolium perenne (Perennial ryegrass)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

GO - Biological processi

Complete GO annotation...

Names & Taxonomyi

Protein namesi
Recommended name:
Pollen allergen Lol p 1
Alternative name(s):
Allergen Lol p I
Allergen R7
Allergen: Lol p 1
OrganismiLolium perenne (Perennial ryegrass)
Taxonomic identifieri4522 [NCBI]
Taxonomic lineageiEukaryotaViridiplantaeStreptophytaEmbryophytaTracheophytaSpermatophytaMagnoliophytaLiliopsidaPoalesPoaceaeBOP cladePooideaePoodaePoeaePoeae Chloroplast Group 2 (Poeae type)LoliinaeLolium

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Secreted

Pathology & Biotechi

Allergenic propertiesi

Causes an allergic reaction in human. Causes grass pollen allergy. Binds to IgE.

Keywords - Diseasei

Allergen

Protein family/group databases

Allergomei450. Lol p 1.
451. Lol p 1.0101.
452. Lol p 1.0102.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 23232 PublicationsAdd
BLAST
Chaini24 – 263240Pollen allergen Lol p 1PRO_0000008720Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi32 – 321N-linked (GlcNAc...)Sequence analysis

Keywords - PTMi

Glycoprotein

Structurei

3D structure databases

ProteinModelPortaliP14946.
SMRiP14946. Positions 26-262.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini61 – 167107Expansin-like EG45PROSITE-ProRule annotationAdd
BLAST
Domaini181 – 26282Expansin-like CBDPROSITE-ProRule annotationAdd
BLAST

Sequence similaritiesi

Belongs to the expansin family. Expansin B subfamily.Curated
Contains 1 expansin-like CBD domain.PROSITE-ProRule annotation
Contains 1 expansin-like EG45 domain.PROSITE-ProRule annotation

Keywords - Domaini

Signal

Family and domain databases

Gene3Di2.40.40.10. 1 hit.
2.60.40.760. 1 hit.
InterProiIPR007118. Expan_Lol_pI.
IPR007112. Expansin/allergen_DPBB_dom.
IPR007117. Expansin_CBD.
IPR005795. LolPI.
IPR009009. RlpA-like_DPBB.
[Graphical view]
PfamiPF03330. DPBB_1. 1 hit.
PF01357. Pollen_allerg_1. 1 hit.
[Graphical view]
PRINTSiPR01225. EXPANSNFAMLY.
PR00829. LOLP1ALLERGN.
SMARTiSM00837. DPBB_1. 1 hit.
[Graphical view]
SUPFAMiSSF49590. SSF49590. 1 hit.
SSF50685. SSF50685. 1 hit.
PROSITEiPS50843. EXPANSIN_CBD. 1 hit.
PS50842. EXPANSIN_EG45. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P14946-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MASSSSVLLV VALFAVFLGS AHGIAKVPPG PNITAEYGDK WLDAKSTWYG
60 70 80 90 100
KPTGAGPKDN GGACGYKNVD KAPFNGMTGC GNTPIFKDGR GCGSCFEIKC
110 120 130 140 150
TKPESCSGEA VTVTITDDNE EPIAPYHFDL SGHAFGSMAK KGEEQNVRSA
160 170 180 190 200
GELELQFRRV KCKYPDDTKP TFHVEKASNP NYLAILVKYV DGDGDVVAVD
210 220 230 240 250
IKEKGKDKWI ELKESWGAVW RIDTPDKLTG PFTVRYTTEG GTKSEFEDVI
260
PEGWKADTSY SAK
Length:263
Mass (Da):28,438
Last modified:August 1, 1991 - v2
Checksum:i7675896F279C88C9
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti28 – 281P → C AA sequence (PubMed:3718469).Curated
Sequence conflicti31 – 311P → C AA sequence (PubMed:3718469).Curated
Sequence conflicti48 – 481W → WW AA sequence (PubMed:3718469).Curated

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti68 – 681N → D.
Natural varianti177 – 1771A → G.
Natural varianti210 – 2101I → T.
Natural varianti246 – 2461F → V.

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M57474 mRNA. Translation: AAA63279.1.
M57476 mRNA. Translation: AAA63278.1.
PIRiA23341.
B37881.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M57474 mRNA. Translation: AAA63279.1.
M57476 mRNA. Translation: AAA63278.1.
PIRiA23341.
B37881.

3D structure databases

ProteinModelPortaliP14946.
SMRiP14946. Positions 26-262.
ModBaseiSearch...
MobiDBiSearch...

Protein family/group databases

Allergomei450. Lol p 1.
451. Lol p 1.0101.
452. Lol p 1.0102.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Family and domain databases

Gene3Di2.40.40.10. 1 hit.
2.60.40.760. 1 hit.
InterProiIPR007118. Expan_Lol_pI.
IPR007112. Expansin/allergen_DPBB_dom.
IPR007117. Expansin_CBD.
IPR005795. LolPI.
IPR009009. RlpA-like_DPBB.
[Graphical view]
PfamiPF03330. DPBB_1. 1 hit.
PF01357. Pollen_allerg_1. 1 hit.
[Graphical view]
PRINTSiPR01225. EXPANSNFAMLY.
PR00829. LOLP1ALLERGN.
SMARTiSM00837. DPBB_1. 1 hit.
[Graphical view]
SUPFAMiSSF49590. SSF49590. 1 hit.
SSF50685. SSF50685. 1 hit.
PROSITEiPS50843. EXPANSIN_CBD. 1 hit.
PS50842. EXPANSIN_EG45. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "cDNA cloning and immunological characterization of the rye grass allergen Lol p I."
    Perez M., Ishioka G.Y., Walker L.E., Chesnut R.W.
    J. Biol. Chem. 265:16210-16215(1990) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
  2. "Cloning and sequencing of Lol pI, the major allergenic protein of rye-grass pollen."
    Griffith I.J., Smith P.M., Pollock J., Theerakulpisut P., Avjoglu A., Davies S., Hough T., Singh M.B., Simpson R.J., Ward L.D., Knox R.B.
    FEBS Lett. 279:210-215(1991) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA], PROTEIN SEQUENCE OF 24-48.
    Tissue: Pollen.
  3. "Physicochemical and immunochemical characterization of allergenic proteins from rye-grass (Lolium perenne) pollen prepared by a rapid and efficient purification method."
    Cottam G.P., Moran D.M., Standring R.
    Biochem. J. 234:305-310(1986) [PubMed] [Europe PMC] [Abstract]
    Cited for: PROTEIN SEQUENCE OF 24-53.
    Tissue: Pollen.
  4. "Isolation and characterization of a major cross-reactive grass group I allergenic determinant."
    Esch R.E., Klapper D.G.
    Mol. Immunol. 26:557-561(1989) [PubMed] [Europe PMC] [Abstract]
    Cited for: PROTEIN SEQUENCE OF 236-263.

Entry informationi

Entry nameiMPAL1_LOLPR
AccessioniPrimary (citable) accession number: P14946
Secondary accession number(s): P19964
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 1, 1990
Last sequence update: August 1, 1991
Last modified: February 17, 2016
This is version 95 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programPlant Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Direct protein sequencing

Documents

  1. Allergens
    Nomenclature of allergens and list of entries
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.