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P14923

- PLAK_HUMAN

UniProt

P14923 - PLAK_HUMAN

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Protein

Junction plakoglobin

Gene

JUP

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli

Functioni

Common junctional plaque protein. The membrane-associated plaques are architectural elements in an important strategic position to influence the arrangement and function of both the cytoskeleton and the cells within the tissue. The presence of plakoglobin in both the desmosomes and in the intermediate junctions suggests that it plays a central role in the structure and function of submembranous plaques. Acts as a substrate for VE-PTP and is required by it to stimulate VE-cadherin function in endothelial cells. Can replace beta-catenin in E-cadherin/catenin adhesion complexes which are proposed to couple cadherins to the actin cytoskeleton By similarity.By similarity

GO - Molecular functioni

  1. alpha-catenin binding Source: BHF-UCL
  2. cadherin binding Source: BHF-UCL
  3. protein homodimerization activity Source: BHF-UCL
  4. protein kinase binding Source: RefGenome
  5. protein phosphatase binding Source: UniProtKB
  6. structural constituent of cell wall Source: BHF-UCL
  7. structural molecule activity Source: BHF-UCL
  8. transcription coactivator activity Source: BHF-UCL

GO - Biological processi

  1. adherens junction organization Source: Reactome
  2. atrioventricular valve morphogenesis Source: RefGenome
  3. bundle of His cell to Purkinje myocyte communication Source: BHF-UCL
  4. cell-cell junction organization Source: Reactome
  5. cell junction assembly Source: Reactome
  6. cell migration Source: BHF-UCL
  7. cell morphogenesis Source: RefGenome
  8. cellular response to indole-3-methanol Source: UniProtKB
  9. cytoskeletal anchoring at plasma membrane Source: BHF-UCL
  10. desmosome assembly Source: BHF-UCL
  11. detection of mechanical stimulus Source: BHF-UCL
  12. ectoderm development Source: RefGenome
  13. endothelial cell-cell adhesion Source: BHF-UCL
  14. establishment of protein localization to plasma membrane Source: UniProt
  15. gastrulation Source: RefGenome
  16. morphogenesis of embryonic epithelium Source: RefGenome
  17. negative regulation of heart induction by canonical Wnt signaling pathway Source: RefGenome
  18. negative regulation of Wnt signaling pathway involved in heart development Source: RefGenome
  19. nervous system development Source: RefGenome
  20. oocyte development Source: RefGenome
  21. positive regulation of canonical Wnt signaling pathway Source: BHF-UCL
  22. positive regulation of protein import into nucleus Source: BHF-UCL
  23. positive regulation of sequence-specific DNA binding transcription factor activity Source: BHF-UCL
  24. protein heterooligomerization Source: Ensembl
  25. regulation of cell proliferation Source: BHF-UCL
  26. regulation of heart rate by cardiac conduction Source: BHF-UCL
  27. single organismal cell-cell adhesion Source: BHF-UCL
  28. skin development Source: RefGenome
  29. ventricular cardiac muscle cell action potential Source: BHF-UCL
Complete GO annotation...

Keywords - Biological processi

Cell adhesion

Enzyme and pathway databases

ReactomeiREACT_19195. Adherens junctions interactions.
SignaLinkiP14923.

Names & Taxonomyi

Protein namesi
Recommended name:
Junction plakoglobin
Alternative name(s):
Catenin gamma
Desmoplakin III
Desmoplakin-3
Gene namesi
Name:JUP
Synonyms:CTNNG, DP3
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 17

Organism-specific databases

HGNCiHGNC:6207. JUP.

Subcellular locationi

Cell junctionadherens junction 1 Publication. Cell junctiondesmosome 1 Publication. Cytoplasmcytoskeleton 1 Publication. Membrane 1 Publication; Peripheral membrane protein 1 Publication
Note: Cytoplasmic in a soluble and membrane-associated form.

GO - Cellular componenti

  1. actin cytoskeleton Source: RefGenome
  2. apicolateral plasma membrane Source: Ensembl
  3. basolateral plasma membrane Source: RefGenome
  4. catenin complex Source: BHF-UCL
  5. cell-cell adherens junction Source: UniProtKB
  6. cell-cell junction Source: UniProtKB
  7. cytoplasm Source: BHF-UCL
  8. cytoplasmic side of plasma membrane Source: BHF-UCL
  9. cytoskeleton Source: BHF-UCL
  10. cytosol Source: BHF-UCL
  11. desmosome Source: BHF-UCL
  12. extracellular vesicular exosome Source: UniProt
  13. fascia adherens Source: RefGenome
  14. focal adhesion Source: UniProtKB
  15. gamma-catenin-TCF7L2 complex Source: BHF-UCL
  16. intercalated disc Source: BHF-UCL
  17. intermediate filament Source: Ensembl
  18. lateral plasma membrane Source: Ensembl
  19. nucleus Source: BHF-UCL
  20. plasma membrane Source: BHF-UCL
  21. protein-DNA complex Source: BHF-UCL
  22. Z disc Source: RefGenome
  23. zonula adherens Source: BHF-UCL
Complete GO annotation...

Keywords - Cellular componenti

Cell junction, Cytoplasm, Cytoskeleton, Membrane

Pathology & Biotechi

Involvement in diseasei

Naxos disease (NXD) [MIM:601214]: An autosomal recessive disorder characterized by the association of diffuse non-epidermolytic palmoplantar keratoderma with woolly hair and cardiac abnormalities such as dilated cardiomyopathy and arrhythmogenic right ventricular dysplasia.1 Publication
Note: The disease is caused by mutations affecting the gene represented in this entry.
Arrhythmogenic right ventricular dysplasia, familial, 12 (ARVD12) [MIM:611528]: A congenital heart disease characterized by infiltration of adipose and fibrous tissue into the right ventricle and loss of myocardial cells, resulting in ventricular and supraventricular arrhythmias.2 Publications
Note: The disease is caused by mutations affecting the gene represented in this entry.
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti19 – 191T → I in ARVD12. 1 Publication
VAR_065698
Natural varianti39 – 391S → SS in ARVD12; affects the structure and distribution of mechanical and electrical cell junctions. 1 Publication
VAR_037803

Mutagenesis

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Mutagenesisi14 – 141T → A: Abolishes glycosylation. Does not affect binding to CDH1, DSC1 or DSG1. 1 Publication
Mutagenesisi19 – 191T → A: Reduces glycosylation. 1 Publication
Mutagenesisi21 – 211T → A: Does not affect glycosylation. 1 Publication
Mutagenesisi24 – 241S → A: Does not affect glycosylation. 1 Publication
Mutagenesisi28 – 281S → A: Does not affect glycosylation. 1 Publication
Mutagenesisi32 – 321T → A: Does not affect glycosylation. 1 Publication

Keywords - Diseasei

Cardiomyopathy, Disease mutation, Palmoplantar keratoderma

Organism-specific databases

MIMi601214. phenotype.
611528. phenotype.
Orphaneti293899. Familial isolated arrhythmogenic ventricular dysplasia, biventricular form.
293888. Familial isolated arrhythmogenic ventricular dysplasia, left dominant form.
293910. Familial isolated arrhythmogenic ventricular dysplasia, right dominant form.
158687. Lethal acantholytic epidermolysis bullosa.
34217. Naxos disease.
PharmGKBiPA30009.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 745745Junction plakoglobinPRO_0000064278Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei1 – 11N-acetylmethionine2 Publications
Glycosylationi14 – 141O-linked (GlcNAc)1 Publication
Modified residuei182 – 1821Phosphoserine1 Publication
Modified residuei665 – 6651Phosphoserine2 Publications

Post-translational modificationi

May be phosphorylated by FER.3 Publications

Keywords - PTMi

Acetylation, Glycoprotein, Phosphoprotein

Proteomic databases

MaxQBiP14923.
PaxDbiP14923.
PRIDEiP14923.

PTM databases

PhosphoSiteiP14923.

Miscellaneous databases

PMAP-CutDBP14923.

Expressioni

Gene expression databases

BgeeiP14923.
CleanExiHS_JUP.
ExpressionAtlasiP14923. baseline and differential.
GenevestigatoriP14923.

Organism-specific databases

HPAiCAB002139.
HPA032047.

Interactioni

Subunit structurei

Homodimer. Component of an E-cadherin/catenin adhesion complex composed of at least E-cadherin/CDH1 and gamma-catenin/JUP, and possibly alpha-catenin/CTNNA1; the complex is located to adherens junctions. The stable association of CTNNA1 is controversial as CTNNA1 was shown not to bind to F-actin when assembled in the complex. Interacts with MUC1. Interacts with CAV1 By similarity. Interacts with PTPRJ. Interacts with DSG1. Interacts with DSC1 and DSC2. Interacts with PKP2.By similarity8 Publications

Binary interactionsi

WithEntry#Exp.IntActNotes
APCP250542EBI-702484,EBI-727707
CTNNA1P352212EBI-702484,EBI-701918
PECAM1P162847EBI-702484,EBI-716404
PSEN1P497684EBI-702484,EBI-297277
TCF7L2Q9NQB013EBI-702484,EBI-924724
WDYHV1Q96HA83EBI-702484,EBI-741158

Protein-protein interaction databases

BioGridi109931. 97 interactions.
IntActiP14923. 38 interactions.
MINTiMINT-105053.
STRINGi9606.ENSP00000311113.

Structurei

Secondary structure

1
745
Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Helixi127 – 1315
Helixi133 – 14210
Helixi144 – 1518
Helixi156 – 16914
Helixi173 – 1808
Helixi183 – 19311
Helixi199 – 21214
Helixi216 – 2249
Helixi227 – 2337
Helixi234 – 2363
Helixi240 – 25617
Helixi260 – 2667
Helixi269 – 2724
Helixi274 – 2785
Helixi282 – 29615
Helixi300 – 3089
Helixi311 – 32111
Helixi325 – 33814
Helixi344 – 3507
Helixi353 – 3586
Helixi359 – 3624
Helixi366 – 38015
Helixi390 – 3978
Turni398 – 4014
Helixi405 – 41814
Turni419 – 4213
Helixi423 – 4297
Turni430 – 4334
Helixi434 – 44512
Helixi449 – 46214
Beta strandi464 – 4663
Helixi469 – 4779
Turni478 – 4803
Helixi481 – 4877
Helixi488 – 4903
Helixi495 – 50814
Helixi512 – 5143
Helixi515 – 5206
Helixi523 – 54321
Helixi556 – 57015
Helixi574 – 5829
Helixi586 – 5927
Helixi598 – 61114
Helixi615 – 6239
Turni624 – 6263
Helixi627 – 6337
Helixi639 – 65113
Helixi662 – 6676

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
3IFQX-ray2.80A/B124-676[»]
ProteinModelPortaliP14923.
SMRiP14923. Positions 111-673.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP14923.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Repeati132 – 17140ARM 1Add
BLAST
Repeati172 – 21544ARM 2Add
BLAST
Repeati216 – 25540ARM 3Add
BLAST
Repeati258 – 29740ARM 4Add
BLAST
Repeati298 – 34144ARM 5Add
BLAST
Repeati342 – 38140ARM 6Add
BLAST
Repeati383 – 42038ARM 7Add
BLAST
Repeati423 – 46442ARM 8Add
BLAST
Repeati470 – 51041ARM 9Add
BLAST
Repeati512 – 55140ARM 10Add
BLAST
Repeati574 – 61340ARM 11Add
BLAST
Repeati615 – 66147ARM 12Add
BLAST

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni132 – 297166Interaction with DSC1 and DSG1Add
BLAST
Regioni574 – 66188Interaction with DSC1Add
BLAST

Domaini

The entire ARM repeats region mediates binding to CDH1/E-cadherin. The N-terminus and first three ARM repeats are sufficient for binding to DSG1. The N-terminus and first ARM repeat are sufficient for association with CTNNA1. DSC1 association requires both ends of the ARM repeat region.2 Publications

Sequence similaritiesi

Belongs to the beta-catenin family.Curated
Contains 12 ARM repeats.PROSITE-ProRule annotation

Keywords - Domaini

Repeat

Phylogenomic databases

eggNOGiNOG297695.
GeneTreeiENSGT00730000110821.
HOVERGENiHBG000919.
InParanoidiP14923.
KOiK10056.
OMAiMNLIEQP.
PhylomeDBiP14923.
TreeFamiTF317997.

Family and domain databases

Gene3Di1.25.10.10. 1 hit.
InterProiIPR011989. ARM-like.
IPR016024. ARM-type_fold.
IPR000225. Armadillo.
IPR013284. Beta-catenin.
[Graphical view]
PfamiPF00514. Arm. 3 hits.
[Graphical view]
PRINTSiPR01869. BCATNINFAMLY.
SMARTiSM00185. ARM. 12 hits.
[Graphical view]
SUPFAMiSSF48371. SSF48371. 1 hit.
PROSITEiPS50176. ARM_REPEAT. 9 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P14923-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MEVMNLMEQP IKVTEWQQTY TYDSGIHSGA NTCVPSVSSK GIMEEDEACG
60 70 80 90 100
RQYTLKKTTT YTQGVPPSQG DLEYQMSTTA RAKRVREAMC PGVSGEDSSL
110 120 130 140 150
LLATQVEGQA TNLQRLAEPS QLLKSAIVHL INYQDDAELA TRALPELTKL
160 170 180 190 200
LNDEDPVVVT KAAMIVNQLS KKEASRRALM GSPQLVAAVV RTMQNTSDLD
210 220 230 240 250
TARCTTSILH NLSHHREGLL AIFKSGGIPA LVRMLSSPVE SVLFYAITTL
260 270 280 290 300
HNLLLYQEGA KMAVRLADGL QKMVPLLNKN NPKFLAITTD CLQLLAYGNQ
310 320 330 340 350
ESKLIILANG GPQALVQIMR NYSYEKLLWT TSRVLKVLSV CPSNKPAIVE
360 370 380 390 400
AGGMQALGKH LTSNSPRLVQ NCLWTLRNLS DVATKQEGLE SVLKILVNQL
410 420 430 440 450
SVDDVNVLTC ATGTLSNLTC NNSKNKTLVT QNSGVEALIH AILRAGDKDD
460 470 480 490 500
ITEPAVCALR HLTSRHPEAE MAQNSVRLNY GIPAIVKLLN QPNQWPLVKA
510 520 530 540 550
TIGLIRNLAL CPANHAPLQE AAVIPRLVQL LVKAHQDAQR HVAAGTQQPY
560 570 580 590 600
TDGVRMEEIV EGCTGALHIL ARDPMNRMEI FRLNTIPLFV QLLYSSVENI
610 620 630 640 650
QRVAAGVLCE LAQDKEAADA IDAEGASAPL MELLHSRNEG TATYAAAVLF
660 670 680 690 700
RISEDKNPDY RKRVSVELTN SLFKHDPAAW EAAQSMIPIN EPYGDDMDAT
710 720 730 740
YRPMYSSDVP LDPLEMHMDM DGDYPIDTYS DGLRPPYPTA DHMLA
Length:745
Mass (Da):81,745
Last modified:September 2, 2008 - v3
Checksum:i3519A0973748BCF4
GO

Sequence cautioni

The sequence AAH00441.2 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened.

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti91 – 911P → S in AAO85780. 1 PublicationCurated
Sequence conflicti264 – 2707VRLADGL → CAGRRA in AAA64895. (PubMed:2726765)Curated

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti19 – 191T → I in ARVD12. 1 Publication
VAR_065698
Natural varianti39 – 391S → SS in ARVD12; affects the structure and distribution of mechanical and electrical cell junctions. 1 Publication
VAR_037803
Natural varianti142 – 1421R → H.2 Publications
Corresponds to variant rs41283425 [ dbSNP | Ensembl ].
VAR_065699
Natural varianti648 – 6481V → I.1 Publication
Corresponds to variant rs143043662 [ dbSNP | Ensembl ].
VAR_065700
Natural varianti697 – 6971M → L.6 Publications
Corresponds to variant rs1126821 [ dbSNP | Ensembl ].
VAR_037804

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
M23410 mRNA. Translation: AAA64895.1.
Z68228 mRNA. Translation: CAA92522.1.
AF306723, AF233882 Genomic DNA. Translation: AAG16727.1.
AY243535 mRNA. Translation: AAO85780.1.
AC109319 Genomic DNA. No translation available.
CH471152 Genomic DNA. Translation: EAW60762.1.
BC000441 mRNA. Translation: AAH00441.2. Different initiation.
BC011865 mRNA. Translation: AAH11865.1.
AJ249711 Genomic DNA. Translation: CAC04246.1.
CCDSiCCDS11407.1.
PIRiA32905.
RefSeqiNP_002221.1. NM_002230.2.
NP_068831.1. NM_021991.2.
XP_006721936.1. XM_006721873.1.
XP_006721937.1. XM_006721874.1.
XP_006721938.1. XM_006721875.1.
XP_006721939.1. XM_006721876.1.
XP_006721940.1. XM_006721877.1.
XP_006721941.1. XM_006721878.1.
UniGeneiHs.514174.

Genome annotation databases

EnsembliENST00000310706; ENSP00000311113; ENSG00000173801.
ENST00000393930; ENSP00000377507; ENSG00000173801.
ENST00000393931; ENSP00000377508; ENSG00000173801.
GeneIDi3728.
KEGGihsa:3728.
UCSCiuc002hxq.2. human.

Polymorphism databases

DMDMi205371866.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
M23410 mRNA. Translation: AAA64895.1 .
Z68228 mRNA. Translation: CAA92522.1 .
AF306723 , AF233882 Genomic DNA. Translation: AAG16727.1 .
AY243535 mRNA. Translation: AAO85780.1 .
AC109319 Genomic DNA. No translation available.
CH471152 Genomic DNA. Translation: EAW60762.1 .
BC000441 mRNA. Translation: AAH00441.2 . Different initiation.
BC011865 mRNA. Translation: AAH11865.1 .
AJ249711 Genomic DNA. Translation: CAC04246.1 .
CCDSi CCDS11407.1.
PIRi A32905.
RefSeqi NP_002221.1. NM_002230.2.
NP_068831.1. NM_021991.2.
XP_006721936.1. XM_006721873.1.
XP_006721937.1. XM_006721874.1.
XP_006721938.1. XM_006721875.1.
XP_006721939.1. XM_006721876.1.
XP_006721940.1. XM_006721877.1.
XP_006721941.1. XM_006721878.1.
UniGenei Hs.514174.

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
Entry Method Resolution (Å) Chain Positions PDBsum
3IFQ X-ray 2.80 A/B 124-676 [» ]
ProteinModelPortali P14923.
SMRi P14923. Positions 111-673.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 109931. 97 interactions.
IntActi P14923. 38 interactions.
MINTi MINT-105053.
STRINGi 9606.ENSP00000311113.

PTM databases

PhosphoSitei P14923.

Polymorphism databases

DMDMi 205371866.

Proteomic databases

MaxQBi P14923.
PaxDbi P14923.
PRIDEi P14923.

Protocols and materials databases

DNASUi 3728.
Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000310706 ; ENSP00000311113 ; ENSG00000173801 .
ENST00000393930 ; ENSP00000377507 ; ENSG00000173801 .
ENST00000393931 ; ENSP00000377508 ; ENSG00000173801 .
GeneIDi 3728.
KEGGi hsa:3728.
UCSCi uc002hxq.2. human.

Organism-specific databases

CTDi 3728.
GeneCardsi GC17M039776.
GeneReviewsi JUP.
HGNCi HGNC:6207. JUP.
HPAi CAB002139.
HPA032047.
MIMi 173325. gene.
601214. phenotype.
611528. phenotype.
neXtProti NX_P14923.
Orphaneti 293899. Familial isolated arrhythmogenic ventricular dysplasia, biventricular form.
293888. Familial isolated arrhythmogenic ventricular dysplasia, left dominant form.
293910. Familial isolated arrhythmogenic ventricular dysplasia, right dominant form.
158687. Lethal acantholytic epidermolysis bullosa.
34217. Naxos disease.
PharmGKBi PA30009.
GenAtlasi Search...

Phylogenomic databases

eggNOGi NOG297695.
GeneTreei ENSGT00730000110821.
HOVERGENi HBG000919.
InParanoidi P14923.
KOi K10056.
OMAi MNLIEQP.
PhylomeDBi P14923.
TreeFami TF317997.

Enzyme and pathway databases

Reactomei REACT_19195. Adherens junctions interactions.
SignaLinki P14923.

Miscellaneous databases

ChiTaRSi JUP. human.
EvolutionaryTracei P14923.
GeneWikii Plakoglobin.
GenomeRNAii 3728.
NextBioi 14595.
PMAP-CutDB P14923.
PROi P14923.
SOURCEi Search...

Gene expression databases

Bgeei P14923.
CleanExi HS_JUP.
ExpressionAtlasi P14923. baseline and differential.
Genevestigatori P14923.

Family and domain databases

Gene3Di 1.25.10.10. 1 hit.
InterProi IPR011989. ARM-like.
IPR016024. ARM-type_fold.
IPR000225. Armadillo.
IPR013284. Beta-catenin.
[Graphical view ]
Pfami PF00514. Arm. 3 hits.
[Graphical view ]
PRINTSi PR01869. BCATNINFAMLY.
SMARTi SM00185. ARM. 12 hits.
[Graphical view ]
SUPFAMi SSF48371. SSF48371. 1 hit.
PROSITEi PS50176. ARM_REPEAT. 9 hits.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Molecular cloning and amino acid sequence of human plakoglobin, the common junctional plaque protein."
    Franke W.W., Goldschmidt M.D., Zimbelmann R., Mueller H.M., Schiller D.L., Cowin P.
    Proc. Natl. Acad. Sci. U.S.A. 86:4027-4031(1989) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
  2. Zimbelmann R.
    Submitted (DEC-1995) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
  3. "Genomic organization and amplification of the human plakoglobin gene (JUP)."
    Whittock N.V., Eady R.A.J., McGrath J.A.
    Exp. Dermatol. 9:323-326(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
  4. "Homo sapiens gamma-catenin mRNA from human KB epidermoid adenocarcinoma cells."
    Liang X.-J., Gottesman M.M.
    Submitted (FEB-2003) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA], VARIANT LEU-697.
    Tissue: Epidermal carcinoma.
  5. "DNA sequence of human chromosome 17 and analysis of rearrangement in the human lineage."
    Zody M.C., Garber M., Adams D.J., Sharpe T., Harrow J., Lupski J.R., Nicholson C., Searle S.M., Wilming L., Young S.K., Abouelleil A., Allen N.R., Bi W., Bloom T., Borowsky M.L., Bugalter B.E., Butler J., Chang J.L.
    , Chen C.-K., Cook A., Corum B., Cuomo C.A., de Jong P.J., DeCaprio D., Dewar K., FitzGerald M., Gilbert J., Gibson R., Gnerre S., Goldstein S., Grafham D.V., Grocock R., Hafez N., Hagopian D.S., Hart E., Norman C.H., Humphray S., Jaffe D.B., Jones M., Kamal M., Khodiyar V.K., LaButti K., Laird G., Lehoczky J., Liu X., Lokyitsang T., Loveland J., Lui A., Macdonald P., Major J.E., Matthews L., Mauceli E., McCarroll S.A., Mihalev A.H., Mudge J., Nguyen C., Nicol R., O'Leary S.B., Osoegawa K., Schwartz D.C., Shaw-Smith C., Stankiewicz P., Steward C., Swarbreck D., Venkataraman V., Whittaker C.A., Yang X., Zimmer A.R., Bradley A., Hubbard T., Birren B.W., Rogers J., Lander E.S., Nusbaum C.
    Nature 440:1045-1049(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  6. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA], VARIANT LEU-697.
  7. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], VARIANT LEU-697.
    Tissue: Lung and Placenta.
  8. Bienvenut W.V., Vousden K.H., Lukashchuk N., Calvo F., Kolch W.
    Submitted (MAR-2008) to UniProtKB
    Cited for: PROTEIN SEQUENCE OF 1-12; 116-142; 150-172; 177-203; 217-233; 273-279; 304-320; 327-333; 368-394; 427-460; 466-533; 583-602; 638-661 AND 664-674, ACETYLATION AT MET-1, IDENTIFICATION BY MASS SPECTROMETRY.
    Tissue: Cervix carcinoma and Lung carcinoma.
  9. "Identification of a deletion in plakoglobin in arrhythmogenic right ventricular cardiomyopathy with palmoplantar keratoderma and woolly hair (Naxos disease)."
    McKoy G., Protonotarios N., Crosby A., Tsatsopoulou A., Anastasakis A., Coonar A., Norman M., Baboonian C., Jeffery S., McKenna W.J.
    Lancet 355:2119-2124(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 634-745, VARIANT LEU-697, INVOLVEMENT IN NAXOS DISEASE.
    Tissue: Leukocyte.
  10. "Distinct cadherin-catenin complexes in Ca(2+)-dependent cell-cell adhesion."
    Butz S., Kemler R.
    FEBS Lett. 355:195-200(1994) [PubMed] [Europe PMC] [Abstract]
    Cited for: IDENTIFICATION IN AN E-CADHERIN/CATENIN ADHESION COMPLEX.
  11. Cited for: DOMAIN, INTERACTION WITH CTNNA1; DSC1 AND DSG1.
  12. "Interaction of the DF3/MUC1 breast carcinoma-associated antigen and beta-catenin in cell adhesion."
    Yamamoto M., Bharti A., Li Y., Kufe D.
    J. Biol. Chem. 272:12492-12494(1997) [PubMed] [Europe PMC] [Abstract]
    Cited for: INTERACTION WITH MUC1.
  13. "Characterization of the interactions of alpha-catenin with alpha-actinin and beta-catenin/plakoglobin."
    Nieset J.E., Redfield A.R., Jin F., Knudsen K.A., Johnson K.R., Wheelock M.J.
    J. Cell Sci. 110:1013-1022(1997) [PubMed] [Europe PMC] [Abstract]
    Cited for: INTERACTION WITH CTNNA1.
  14. "The transmembrane receptor protein tyrosine phosphatase DEP1 interacts with p120(ctn)."
    Holsinger L.J., Ward K., Duffield B., Zachwieja J., Jallal B.
    Oncogene 21:7067-7076(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: INTERACTION WITH PTPRJ.
  15. "Plakoglobin is O-glycosylated close to the N-terminal destruction box."
    Hatsell S., Medina L., Merola J., Haltiwanger R., Cowin P.
    J. Biol. Chem. 278:37745-37752(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: GLYCOSYLATION AT THR-14, MUTAGENESIS OF THR-14; THR-19; THR-21; SER-24; SER-28 AND THR-32.
  16. "Tyrosine phosphorylation of plakoglobin causes contrary effects on its association with desmosomes and adherens junction components and modulates beta-catenin-mediated transcription."
    Miravet S., Piedra J., Castano J., Raurell I., Franci C., Dunach M., Garcia de Herreros A.
    Mol. Cell. Biol. 23:7391-7402(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION BY FER.
  17. "Global, in vivo, and site-specific phosphorylation dynamics in signaling networks."
    Olsen J.V., Blagoev B., Gnad F., Macek B., Kumar C., Mortensen P., Mann M.
    Cell 127:635-648(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-182 AND SER-665, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Cervix carcinoma.
  18. "Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis."
    Olsen J.V., Vermeulen M., Santamaria A., Kumar C., Miller M.L., Jensen L.J., Gnad F., Cox J., Jensen T.S., Nigg E.A., Brunak S., Mann M.
    Sci. Signal. 3:RA3-RA3(2010) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-665, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Cervix carcinoma.
  19. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
  20. "Mechanistic insights into arrhythmogenic right ventricular cardiomyopathy caused by desmocollin-2 mutations."
    Gehmlich K., Syrris P., Peskett E., Evans A., Ehler E., Asimaki A., Anastasakis A., Tsatsopoulou A., Vouliotis A.I., Stefanadis C., Saffitz J.E., Protonotarios N., McKenna W.J.
    Cardiovasc. Res. 90:77-87(2011) [PubMed] [Europe PMC] [Abstract]
    Cited for: INTERACTION WITH DSC2.
  21. "Molecular insights into arrhythmogenic right ventricular cardiomyopathy caused by plakophilin-2 missense mutations."
    Kirchner F., Schuetz A., Boldt L.H., Martens K., Dittmar G., Haverkamp W., Thierfelder L., Heinemann U., Gerull B.
    Circ. Cardiovasc. Genet. 5:400-411(2012) [PubMed] [Europe PMC] [Abstract]
    Cited for: INTERACTION WITH PKP2, SUBCELLULAR LOCATION.
  22. "Comparative large-scale characterisation of plant vs. mammal proteins reveals similar and idiosyncratic N-alpha acetylation features."
    Bienvenut W.V., Sumpton D., Martinez A., Lilla S., Espagne C., Meinnel T., Giglione C.
    Mol. Cell. Proteomics 11:M111.015131-M111.015131(2012) [PubMed] [Europe PMC] [Abstract]
    Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT MET-1, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
  23. "Interactions of plakoglobin and beta-catenin with desmosomal cadherins: basis of selective exclusion of alpha- and beta-catenin from desmosomes."
    Choi H.J., Gross J.C., Pokutta S., Weis W.I.
    J. Biol. Chem. 284:31776-31788(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: X-RAY CRYSTALLOGRAPHY (2.8 ANGSTROMS) OF 124-676 IN COMPLEX WITH PHOSPHORYLATED MOUSE E-CADHERIN, DOMAIN ARM REPEATS, INTERACTION WITH DSC1 AND DSG1.
  24. "A novel dominant mutation in plakoglobin causes arrhythmogenic right ventricular cardiomyopathy."
    Asimaki A., Syrris P., Wichter T., Matthias P., Saffitz J.E., McKenna W.J.
    Am. J. Hum. Genet. 81:964-973(2007) [PubMed] [Europe PMC] [Abstract]
    Cited for: VARIANT ARVD12 SER-39 INS, CHARACTERIZATION OF VARIANT ARVD12 SER-39 INS.
  25. "Comprehensive desmosome mutation analysis in North Americans with arrhythmogenic right ventricular dysplasia/cardiomyopathy."
    den Haan A.D., Tan B.Y., Zikusoka M.N., Llado L.I., Jain R., Daly A., Tichnell C., James C., Amat-Alarcon N., Abraham T., Russell S.D., Bluemke D.A., Calkins H., Dalal D., Judge D.P.
    Circ. Cardiovasc. Genet. 2:428-435(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: VARIANT ARVD12 ILE-19, VARIANTS HIS-142; ILE-648 AND LEU-697.
  26. "Role of genetic testing in arrhythmogenic right ventricular cardiomyopathy/dysplasia."
    Barahona-Dussault C., Benito B., Campuzano O., Iglesias A., Leung T.L., Robb L., Talajic M., Brugada R.
    Clin. Genet. 77:37-48(2010) [PubMed] [Europe PMC] [Abstract]
    Cited for: VARIANTS HIS-142 AND LEU-697.

Entry informationi

Entry nameiPLAK_HUMAN
AccessioniPrimary (citable) accession number: P14923
Secondary accession number(s): Q15093
, Q15151, Q7L3S5, Q86W21, Q9BWC4, Q9HCX9
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 1, 1990
Last sequence update: September 2, 2008
Last modified: October 29, 2014
This is version 156 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. Human chromosome 17
    Human chromosome 17: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  6. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3