Reviewed,
UniProtKB/Swiss-Prot P14901 (HMOX1_MOUSE)
Last modified
June 16, 2009.
Version 77.
History...
Clusters with 100%,
90%,
50% identity |
Documents (2) |
Third-party data |
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Names and origin
| Protein names | Recommended name: Heme oxygenase 1 Short name=HO-1 EC=1.14.99.3 Alternative name(s): P32 protein | ||
| Gene names |
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| Organism | Mus musculus (Mouse) | ||
| Taxonomic identifier | 10090 [NCBI] | ||
| Taxonomic lineage | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Sciurognathi › Muroidea › Muridae › Murinae › Mus |
Protein attributes
| Sequence length | 289 AA. |
| Sequence status | Complete. |
| Sequence processing | The displayed sequence is not processed. |
| Protein existence | Evidence at transcript level. |
General annotation (Comments)
| Function | Heme oxygenase cleaves the heme ring at the alpha methene bridge to form biliverdin. Biliverdin is subsequently converted to bilirubin by biliverdin reductase. Under physiological conditions, the activity of heme oxygenase is highest in the spleen, where senescent erythrocytes are sequestrated and destroyed. |
| Catalytic activity | Heme + 3 AH2 + 3 O2 = biliverdin + Fe2+ + CO + 3 A + 3 H2O. |
| Subcellular location | |
| Induction | Heme oxygenase 1 activity is highly inducible by its substrate heme and by various non-heme substances such as heavy metals, bromobenzene, and endotoxin. |
| Sequence similarities | Belongs to the heme oxygenase family. |
Ontologies
| Keywords | |
|---|---|
| Cellular component | Endoplasmic reticulum Microsome |
| Ligand | Heme Iron Metal-binding |
| Molecular function | Oxidoreductase |
| PTM | Phosphoprotein |
| Gene Ontology (GO) | |
| Biological process | heme oxidation Inferred from electronic annotation. Source: InterPro oxidation reductionInferred from electronic annotation. Source: UniProtKB-KW response to stimulusInferred from direct assay. Source: MGI |
| Cellular component | endoplasmic reticulum Inferred from electronic annotation. Source: UniProtKB-SubCell microsomeInferred from electronic annotation. Source: UniProtKB-SubCell nucleusInferred from direct assay. Source: UniProtKB |
| Molecular function | heme oxygenase (decyclizing) activity Inferred from electronic annotation. Source: EC iron ion bindingInferred from electronic annotation. Source: UniProtKB-KW |
| Complete GO annotation... | |
Sequence annotation (Features)
Sequences
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References
| « Hide 'large scale' references | |
| [1] | "Isolation and characterization of a complementary DNA clone for a Mr 32,000 protein which is induced with tumor promoters in BALB/c 3T3 cells." Kageyama H., Hiwasa T., Tokunaga K., Sakiyama S. Cancer Res. 48:4795-4798(1988) [PubMed: 3409220] [Abstract] Cited for: NUCLEOTIDE SEQUENCE. Strain: BALB/c. Tissue: Fibroblast. |
| [2] | "Isolation and characterization of the mouse heme oxygenase-1 gene. Distal 5' sequences are required for induction by heme or heavy metals." Alam J., Cai J., Smith A. J. Biol. Chem. 269:1001-1009(1994) [PubMed: 8288554] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA]. |
| [3] | "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed: 15489334] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Strain: FVB/N. Tissue: Kidney. |
| + | Additional computationally mapped references. |
Cross-references
Sequence databases | |
|---|---|
| M33203 mRNA. Translation: AAA39872.1. X13356 mRNA. Translation: CAA31732.1. X56824 X56827 Genomic DNA. Translation: CAA40159.1. BC010757 mRNA. Translation: AAH10757.1. | |
| IPI | IPI00131577. |
| PIR | I48409. |
| RefSeq | NP_034572.1. |
| UniGene | Mm.276389 |
3D structure databases | |
| HSSP | HSSP built from PDB template 1IRM based on UniProtKB P06762. |
| SMR | P14901. Positions 11-232. |
| ModBase | Search... |
PTM databases | |
| PhosphoSite | P14901. |
Genome annotation databases | |
| Ensembl | ENSMUSG00000005413. Mus musculus. [Contig view] |
| GeneID | 15368. |
| KEGG | mmu:15368. |
Organism-specific databases | |
| MGI | MGI:96163. Hmox1. |
Phylogenomic databases | |
| HOGENOM | P14901. |
| HOVERGEN | P14901. |
| OMA | P14901. LEQDMAF. |
Enzyme and pathway databases | |
| BRENDA | 1.14.99.3. 244. |
Gene expression databases | |
| ArrayExpress | P14901. |
| Bgee | P14901. |
| CleanEx | MM_HMOX1. |
| GermOnline | ENSMUSG00000005413. Mus musculus. |
Family and domain databases | |
| InterPro | IPR002051. Haem_Oase. IPR016053. Haem_Oase-like. IPR016084. Haem_Oase-like_multi-hlx. IPR018207. Haem_oxygenase_CS. [Graphical view] |
| Gene3D | G3DSA:1.20.910.10. Haem_Oase-like_multi-hlx. 1 hit. |
| PANTHER | PTHR10720. Haem_Oase. 1 hit. |
| Pfam | PF01126. Heme_oxygenase. 1 hit. [Graphical view] |
| PIRSF | PIRSF000343. Haem_Oase. 1 hit. |
| PRINTS | PR00088. HAEMOXYGNASE. |
| PROSITE | PS00593. HEME_OXYGENASE. 1 hit. [Graphical view] |
| ProtoNet | Search... |
Other Resources | |
| NextBio | 287998. |
| SOURCE | Search... |
Entry information
| Entry name | HMOX1_MOUSE | ||||||||
| Accession | Primary (citable) accession number: P14901 | ||||||||
| Entry history |
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| Entry status | Reviewed (UniProtKB/Swiss-Prot) | ||||||||
| Annotation project | HPI (Human Proteome Initiative) | ||||||||
Relevant documents
| MGD cross-references Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot |
| SIMILARITY comments Index of protein domains and families |

Clusters with


