P14859 (PO2F1_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
POU domain, class 2, transcription factor 1

Alternative name(s):
Octamer-binding transcription factor 1
Short name=OTF-1
Octamer-binding protein 1
Short name=Oct-1
NF-A1

Gene names

Name:	POU2F1
Synonyms:	OCT1, OTF1

Organism

Homo sapiens (Human) [Complete proteome]

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo

Protein attributes

Sequence length	743 AA.
Sequence status	Complete.
Protein existence	Evidence at protein level.

General annotation (Comments)

Function	Transcription factor that binds to the octamer motif (5'-ATTTGCAT-3') and activates the promoters of the genes for some small nuclear RNAs (snRNA) and of genes such as those for histone H2B and immunoglobulins. Modulates transcription transactivation by NR3C1, AR and PGR By similarity. In case of human herpes simplex virus (HSV) infection, POU2F1 forms a multiprotein-DNA complex with the viral transactivator protein VP16 and HCFC1 thereby enabling the transcription of the viral immediate early genes.
Subunit structure	Interacts with NR3C1, AR, PGR and HCFC1. Associates with the herpes simplex virus VP16-induced complex; binding to HCFC1 activates the viral transcriptional activator VP16 for association with POU2F1, to form a multiprotein-DNA complex responsible for activating transcription of the viral immediate early genes. Ref.6 Ref.7
Subcellular location	Nucleus.
Tissue specificity	Ubiquitous. Isoform 2 is lymphocyte-specific.
Post-translational modification	Phosphorylated by PRKDC. Ref.8 Ref.10 Ref.11 Ref.12 Ref.13 Ref.14
Sequence similarities	Belongs to the POU transcription factor family. Class-2 subfamily. Contains 1 homeobox DNA-binding domain. Contains 1 POU-specific domain.

Ontologies

Keywords
Biological process	Transcription Transcription regulation
Cellular component	Nucleus
Coding sequence diversity	Alternative splicing Polymorphism
Domain	Homeobox
Ligand	DNA-binding
Molecular function	Activator
PTM	Phosphoprotein
Technical term	3D-structure Complete proteome
Gene Ontology (GO)
Biological process	negative regulation of transcription, DNA-dependent Inferred from direct assay. Source: UniProtKB transcription Inferred from electronic annotation. Source: UniProtKB-KW
Molecular function	protein binding Ref.7 Inferred from physical interaction. Source: UniProtKB sequence-specific DNA binding Inferred from direct assay. Source: UniProtKB transcription factor activity Traceable author statement. Source: ProtInc transcription repressor activity Inferred from direct assay. Source: UniProtKB
Complete GO annotation...

Binary interactions

With	Entry	#Exp.	IntAct	Notes
HCFC1	P51610	1	EBI-624770,EBI-396176
SP1	P08047	1	EBI-624770,EBI-298336

Alternative products

This entry describes 4 isoforms produced by alternative splicing. [Align] [Select]

Isoform 1 (identifier: P14859-1)

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

Isoform 2 (identifier: P14859-2)

Also known as: Oct-1L; lymphocyte-specific;

The sequence of this isoform differs from the canonical sequence as follows:
     1-1: M → MLDCSDYVLDSRM

Isoform 3 (identifier: P14859-3)

The sequence of this isoform differs from the canonical sequence as follows:
     1-20: MNNPSETSKPSMESGDGNTG → MKTRMKIFVMIHFHLMNS

Note: No experimental confirmation available.

Isoform 4 (identifier: P14859-4)

The sequence of this isoform differs from the canonical sequence as follows:
     641-653: ALASGGSLPITSL → GLLHGLENFLTKN
     654-743: Missing.

Note: No experimental confirmation available.

Sequence annotation (Features)

Feature key

Position(s)

Length

Description

Graphical view

Feature identifier

Molecule processing

Chain

1 – 743

743

POU domain, class 2, transcription factor 1

PRO_0000100707

Regions

Domain

280 – 354

75

POU-specific

DNA binding

379 – 438

60

Homeobox

Amino acid modifications

Modified residue

270

1

Phosphothreonine Ref.13 Ref.14

Modified residue

283

1

Phosphoserine Ref.13

Modified residue

335

1

Phosphoserine Ref.12

Modified residue

385

1

Phosphoserine Ref.12

Modified residue

447

1

Phosphoserine Ref.14

Modified residue

448

1

Phosphoserine Ref.10 Ref.11 Ref.13 Ref.14

Natural variations

Alternative sequence

1 – 20

20

MNNPS…DGNTG → MKTRMKIFVMIHFHLMNS in isoform 3.

VSP_013421

Alternative sequence

1

1

M → MLDCSDYVLDSRM in isoform 2.

VSP_002320

Alternative sequence

641 – 653

13

ALASG…PITSL → GLLHGLENFLTKN in isoform 4.

VSP_013422

Alternative sequence

654 – 743

90

Missing in isoform 4.

VSP_013423

Natural variant

88

1

S → F in a breast cancer sample; somatic mutation. Ref.19

VAR_035816

Experimental info

Sequence conflict

225

1

L → Q in CAA31767. Ref.1

Sequence conflict

546

1

T → I in AAM77920. Ref.2

Secondary structure

1

.

.

.

.

.

.

.

.

.

.

.

.

.

.

.

743

Helix Strand Turn

Details...

Helix

285 – 301

17

Helix

306 – 317

12

Helix

323 – 331

9

Helix

336 – 353

18

Helix

388 – 400

13

Helix

406 – 416

11

Helix

420 – 434

15

Sequences

	Sequence		Length	Mass (Da)
	Isoform 1 [UniParc]. Last modified February 1, 2003. Version 2. Checksum: FAB27FFC79CF2276	FASTA	743	76,472
	10 20 30 40 50 60 MNNPSETSKP SMESGDGNTG TQTNGLDFQK QPVPVGGAIS TAQAQAFLGH LHQVQLAGTS 70 80 90 100 110 120 LQAAAQSLNV QSKSNEESGD SQQPSQPSQQ PSVQAAIPQT QLMLAGGQIT GLTLTPAQQQ 130 140 150 160 170 180 LLLQQAQAQA QLLAAAVQQH SASQQHSAAG ATISASAATP MTQIPLSQPI QIAQDLQQLQ 190 200 210 220 230 240 QLQQQNLNLQ QFVLVHPTTN LQPAQFIISQ TPQGQQGLLQ AQNLLTQLPQ QSQANLLQSQ 250 260 270 280 290 300 PSITLTSQPA TPTRTIAATP IQTLPQSQST PKRIDTPSLE EPSDLEELEQ FAKTFKQRRI 310 320 330 340 350 360 KLGFTQGDVG LAMGKLYGND FSQTTISRFE ALNLSFKNMC KLKPLLEKWL NDAENLSSDS 370 380 390 400 410 420 SLSSPSALNS PGIEGLSRRR KKRTSIETNI RVALEKSFLE NQKPTSEEIT MIADQLNMEK 430 440 450 460 470 480 EVIRVWFCNR RQKEKRINPP SSGGTSSSPI KAIFPSPTSL VATTPSLVTS SAATTLTVSP 490 500 510 520 530 540 VLPLTSAAVT NLSVTGTSDT TSNNTATVIS TAPPASSAVT SPSLSPSPSA SASTSEASSA 550 560 570 580 590 600 SETSTTQTTS TPLSSPLGTS QVMVTASGLQ TAAAAALQGA AQLPANASLA AMAAAAGLNP 610 620 630 640 650 660 SLMAPSQFAA GGALLSLNPG TLSGALSPAL MSNSTLATIQ ALASGGSLPI TSLDATGNLV 670 680 690 700 710 720 FANAGGAPNI VTAPLFLNPQ NLSLLTSNPV SLVSAAAASA GNSAPVASLH ATSTSAESIQ 730 740 NSLFTVASAS GAASTTTTAS KAQ
	Isoform 2 (Oct-1L) (lymphocyte-specific). Checksum: 084E222919B616AA	FASTA	755	77,870
	10 20 30 40 50 60 MLDCSDYVLD SRMNNPSETS KPSMESGDGN TGTQTNGLDF QKQPVPVGGA ISTAQAQAFL 70 80 90 100 110 120 GHLHQVQLAG TSLQAAAQSL NVQSKSNEES GDSQQPSQPS QQPSVQAAIP QTQLMLAGGQ 130 140 150 160 170 180 ITGLTLTPAQ QQLLLQQAQA QAQLLAAAVQ QHSASQQHSA AGATISASAA TPMTQIPLSQ 190 200 210 220 230 240 PIQIAQDLQQ LQQLQQQNLN LQQFVLVHPT TNLQPAQFII SQTPQGQQGL LQAQNLLTQL 250 260 270 280 290 300 PQQSQANLLQ SQPSITLTSQ PATPTRTIAA TPIQTLPQSQ STPKRIDTPS LEEPSDLEEL 310 320 330 340 350 360 EQFAKTFKQR RIKLGFTQGD VGLAMGKLYG NDFSQTTISR FEALNLSFKN MCKLKPLLEK 370 380 390 400 410 420 WLNDAENLSS DSSLSSPSAL NSPGIEGLSR RRKKRTSIET NIRVALEKSF LENQKPTSEE 430 440 450 460 470 480 ITMIADQLNM EKEVIRVWFC NRRQKEKRIN PPSSGGTSSS PIKAIFPSPT SLVATTPSLV 490 500 510 520 530 540 TSSAATTLTV SPVLPLTSAA VTNLSVTGTS DTTSNNTATV ISTAPPASSA VTSPSLSPSP 550 560 570 580 590 600 SASASTSEAS SASETSTTQT TSTPLSSPLG TSQVMVTASG LQTAAAAALQ GAAQLPANAS 610 620 630 640 650 660 LAAMAAAAGL NPSLMAPSQF AAGGALLSLN PGTLSGALSP ALMSNSTLAT IQALASGGSL 670 680 690 700 710 720 PITSLDATGN LVFANAGGAP NIVTAPLFLN PQNLSLLTSN PVSLVSAAAA SAGNSAPVAS 730 740 750 LHATSTSAES IQNSLFTVAS ASGAASTTTT ASKAQ
	Isoform 3. Checksum: 28E72DF211628CE3	FASTA	741	76,696
	10 20 30 40 50 60 MKTRMKIFVM IHFHLMNSTQ TNGLDFQKQP VPVGGAISTA QAQAFLGHLH QVQLAGTSLQ 70 80 90 100 110 120 AAAQSLNVQS KSNEESGDSQ QPSQPSQQPS VQAAIPQTQL MLAGGQITGL TLTPAQQQLL 130 140 150 160 170 180 LQQAQAQAQL LAAAVQQHSA SQQHSAAGAT ISASAATPMT QIPLSQPIQI AQDLQQLQQL 190 200 210 220 230 240 QQQNLNLQQF VLVHPTTNLQ PAQFIISQTP QGQQGLLQAQ NLLTQLPQQS QANLLQSQPS 250 260 270 280 290 300 ITLTSQPATP TRTIAATPIQ TLPQSQSTPK RIDTPSLEEP SDLEELEQFA KTFKQRRIKL 310 320 330 340 350 360 GFTQGDVGLA MGKLYGNDFS QTTISRFEAL NLSFKNMCKL KPLLEKWLND AENLSSDSSL 370 380 390 400 410 420 SSPSALNSPG IEGLSRRRKK RTSIETNIRV ALEKSFLENQ KPTSEEITMI ADQLNMEKEV 430 440 450 460 470 480 IRVWFCNRRQ KEKRINPPSS GGTSSSPIKA IFPSPTSLVA TTPSLVTSSA ATTLTVSPVL 490 500 510 520 530 540 PLTSAAVTNL SVTGTSDTTS NNTATVISTA PPASSAVTSP SLSPSPSASA STSEASSASE 550 560 570 580 590 600 TSTTQTTSTP LSSPLGTSQV MVTASGLQTA AAAALQGAAQ LPANASLAAM AAAAGLNPSL 610 620 630 640 650 660 MAPSQFAAGG ALLSLNPGTL SGALSPALMS NSTLATIQAL ASGGSLPITS LDATGNLVFA 670 680 690 700 710 720 NAGGAPNIVT APLFLNPQNL SLLTSNPVSL VSAAAASAGN SAPVASLHAT STSAESIQNS 730 740 LFTVASASGA ASTTTTASKA Q
	Isoform 4. Checksum: 1C82E7818D70A368	FASTA	653	68,143
	10 20 30 40 50 60 MNNPSETSKP SMESGDGNTG TQTNGLDFQK QPVPVGGAIS TAQAQAFLGH LHQVQLAGTS 70 80 90 100 110 120 LQAAAQSLNV QSKSNEESGD SQQPSQPSQQ PSVQAAIPQT QLMLAGGQIT GLTLTPAQQQ 130 140 150 160 170 180 LLLQQAQAQA QLLAAAVQQH SASQQHSAAG ATISASAATP MTQIPLSQPI QIAQDLQQLQ 190 200 210 220 230 240 QLQQQNLNLQ QFVLVHPTTN LQPAQFIISQ TPQGQQGLLQ AQNLLTQLPQ QSQANLLQSQ 250 260 270 280 290 300 PSITLTSQPA TPTRTIAATP IQTLPQSQST PKRIDTPSLE EPSDLEELEQ FAKTFKQRRI 310 320 330 340 350 360 KLGFTQGDVG LAMGKLYGND FSQTTISRFE ALNLSFKNMC KLKPLLEKWL NDAENLSSDS 370 380 390 400 410 420 SLSSPSALNS PGIEGLSRRR KKRTSIETNI RVALEKSFLE NQKPTSEEIT MIADQLNMEK 430 440 450 460 470 480 EVIRVWFCNR RQKEKRINPP SSGGTSSSPI KAIFPSPTSL VATTPSLVTS SAATTLTVSP 490 500 510 520 530 540 VLPLTSAAVT NLSVTGTSDT TSNNTATVIS TAPPASSAVT SPSLSPSPSA SASTSEASSA 550 560 570 580 590 600 SETSTTQTTS TPLSSPLGTS QVMVTASGLQ TAAAAALQGA AQLPANASLA AMAAAAGLNP 610 620 630 640 650 SLMAPSQFAA GGALLSLNPG TLSGALSPAL MSNSTLATIQ GLLHGLENFL TKN

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"The ubiquitous octamer-binding protein Oct-1 contains a POU domain with a homeo box subdomain." Sturm R.A., Das G., Herr W. Genes Dev. 2:1582-1599(1988) [PubMed: 2905684] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1). Tissue: Teratocarcinoma.
[2]	"Human Oct-1L isoform has tissue-specific expression pattern similar to Oct-2." Luchina N.N., Krivega I.V., Pankratova E.V. Immunol. Lett. 85:237-241(2003) [PubMed: 12663137] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 2). Tissue: B-cell lymphoma.
[3]	"The DNA sequence and biological annotation of human chromosome 1." Gregory S.G., Barlow K.F., McLay K.E., Kaul R., Swarbreck D., Dunham A., Scott C.E., Howe K.L., Woodfine K., Spencer C.C.A., Jones M.C., Gillson C., Searle S., Zhou Y., Kokocinski F., McDonald L., Evans R., Phillips K. , Atkinson A., Cooper R., Jones C., Hall R.E., Andrews T.D., Lloyd C., Ainscough R., Almeida J.P., Ambrose K.D., Anderson F., Andrew R.W., Ashwell R.I.S., Aubin K., Babbage A.K., Bagguley C.L., Bailey J., Beasley H., Bethel G., Bird C.P., Bray-Allen S., Brown J.Y., Brown A.J., Buckley D., Burton J., Bye J., Carder C., Chapman J.C., Clark S.Y., Clarke G., Clee C., Cobley V., Collier R.E., Corby N., Coville G.J., Davies J., Deadman R., Dunn M., Earthrowl M., Ellington A.G., Errington H., Frankish A., Frankland J., French L., Garner P., Garnett J., Gay L., Ghori M.R.J., Gibson R., Gilby L.M., Gillett W., Glithero R.J., Grafham D.V., Griffiths C., Griffiths-Jones S., Grocock R., Hammond S., Harrison E.S.I., Hart E., Haugen E., Heath P.D., Holmes S., Holt K., Howden P.J., Hunt A.R., Hunt S.E., Hunter G., Isherwood J., James R., Johnson C., Johnson D., Joy A., Kay M., Kershaw J.K., Kibukawa M., Kimberley A.M., King A., Knights A.J., Lad H., Laird G., Lawlor S., Leongamornlert D.A., Lloyd D.M., Loveland J., Lovell J., Lush M.J., Lyne R., Martin S., Mashreghi-Mohammadi M., Matthews L., Matthews N.S.W., McLaren S., Milne S., Mistry S., Moore M.J.F., Nickerson T., O'Dell C.N., Oliver K., Palmeiri A., Palmer S.A., Parker A., Patel D., Pearce A.V., Peck A.I., Pelan S., Phelps K., Phillimore B.J., Plumb R., Rajan J., Raymond C., Rouse G., Saenphimmachak C., Sehra H.K., Sheridan E., Shownkeen R., Sims S., Skuce C.D., Smith M., Steward C., Subramanian S., Sycamore N., Tracey A., Tromans A., Van Helmond Z., Wall M., Wallis J.M., White S., Whitehead S.L., Wilkinson J.E., Willey D.L., Williams H., Wilming L., Wray P.W., Wu Z., Coulson A., Vaudin M., Sulston J.E., Durbin R.M., Hubbard T., Wooster R., Dunham I., Carter N.P., McVean G., Ross M.T., Harrow J., Olson M.V., Beck S., Rogers J., Bentley D.R. Nature 441:315-321(2006) [PubMed: 16710414] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA], NUCLEOTIDE SEQUENCE OF 93-653.
[4]	Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M., Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J., Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S., Turner R. , Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H., Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K., Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D., Hunkapiller M.W., Myers E.W., Venter J.C. Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[5]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed: 15489334] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1), NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 93-653 (ISOFORM 4). Tissue: Lung, Lymph and Skin.
[6]	"Selective binding of steroid hormone receptors to octamer transcription factors determines transcriptional synergism at the mouse mammary tumor virus promoter." Prefontaine G.G., Walther R., Giffin W., Lemieux M.E., Pope L., Hache R.J.G. J. Biol. Chem. 274:26713-26719(1999) [PubMed: 10480874] [Abstract] Cited for: INTERACTION WITH NR3C1; AR AND PGR.
[7]	"Mutations in host cell factor 1 separate its role in cell proliferation from recruitment of VP16 and LZIP." Mahajan S.S., Wilson A.C. Mol. Cell. Biol. 20:919-928(2000) [PubMed: 10629049] [Abstract] Cited for: INTERACTION WITH HCFC1.
[8]	"Down-regulation of histone H2B by DNA-dependent protein kinase in response to DNA damage through modulation of octamer transcription factor 1." Schild-Poulter C., Shih A., Yarymowich N.C., Hache R.J.G. Cancer Res. 63:7197-7205(2003) [PubMed: 14612514] [Abstract] Cited for: PHOSPHORYLATION.
[9]	"The herpes simplex virus VP16-induced complex: the makings of a regulatory switch." Wysocka J., Herr W. Trends Biochem. Sci. 28:294-304(2003) [PubMed: 12826401] [Abstract] Cited for: REVIEW ON HERPES INFECTION.
[10]	"Large-scale characterization of HeLa cell nuclear phosphoproteins." Beausoleil S.A., Jedrychowski M., Schwartz D., Elias J.E., Villen J., Li J., Cohn M.A., Cantley L.C., Gygi S.P. Proc. Natl. Acad. Sci. U.S.A. 101:12130-12135(2004) [PubMed: 15302935] [Abstract] Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-448, MASS SPECTROMETRY. Tissue: Cervix carcinoma.
[11]	"Global proteomic profiling of phosphopeptides using electron transfer dissociation tandem mass spectrometry." Molina H., Horn D.M., Tang N., Mathivanan S., Pandey A. Proc. Natl. Acad. Sci. U.S.A. 104:2199-2204(2007) [PubMed: 17287340] [Abstract] Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-448, MASS SPECTROMETRY. Tissue: Embryonic kidney.
[12]	"Kinase-selective enrichment enables quantitative phosphoproteomics of the kinome across the cell cycle." Daub H., Olsen J.V., Bairlein M., Gnad F., Oppermann F.S., Korner R., Greff Z., Keri G., Stemmann O., Mann M. Mol. Cell 31:438-448(2008) [PubMed: 18691976] [Abstract] Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-335 AND SER-385, MASS SPECTROMETRY. Tissue: Cervix carcinoma.
[13]	"A quantitative atlas of mitotic phosphorylation." Dephoure N., Zhou C., Villen J., Beausoleil S.A., Bakalarski C.E., Elledge S.J., Gygi S.P. Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008) [PubMed: 18669648] [Abstract] Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT THR-270; SER-283 AND SER-448, MASS SPECTROMETRY. Tissue: Cervix carcinoma.
[14]	"Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach." Gauci S., Helbig A.O., Slijper M., Krijgsveld J., Heck A.J., Mohammed S. Anal. Chem. 81:4493-4501(2009) [PubMed: 19413330] [Abstract] Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT THR-270; SER-447 AND SER-448, MASS SPECTROMETRY. Tissue: Embryonic kidney.
[15]	"Solution structure of the POU-specific DNA-binding domain of Oct-1." Dekker N., Cox M., Boelens R., Verrijzer C.P., van der Vliet P.C., Kaptein R. Nature 362:852-855(1993) [PubMed: 8479524] [Abstract] Cited for: STRUCTURE BY NMR OF 284-359.
[16]	"The solution structure of the Oct-1 POU-specific domain reveals a striking similarity to the bacteriophage lambda repressor DNA-binding domain." Assa-Munt N., Mortishire-Smith R.J., Aurora R., Herr W., Wright P.E. Cell 73:193-205(1993) [PubMed: 8462099] [Abstract] Cited for: STRUCTURE BY NMR OF 284-354.
[17]	"Solution structure of the Oct-1 POU homeodomain determined by NMR and restrained molecular dynamics." Cox M., van Tilborg P.J.A., de Laat W., Boelens R., van Leeuwen H.C., van der Vliet P.C., Kaptein R. J. Biomol. NMR 6:23-32(1995) [PubMed: 7663141] [Abstract] Cited for: STRUCTURE BY NMR OF 378-437.
[18]	"Crystal structure of the Oct-1 POU domain bound to an octamer site: DNA recognition with tethered DNA-binding modules." Klemm J.D., Rould M.A., Aurora R., Herr W., Pabo C.O. Cell 77:21-32(1994) [PubMed: 8156594] [Abstract] Cited for: X-RAY CRYSTALLOGRAPHY (3.0 ANGSTROMS) OF 284-439.
[19]	"The consensus coding sequences of human breast and colorectal cancers." Sjoeblom T., Jones S., Wood L.D., Parsons D.W., Lin J., Barber T.D., Mandelker D., Leary R.J., Ptak J., Silliman N., Szabo S., Buckhaults P., Farrell C., Meeh P., Markowitz S.D., Willis J., Dawson D., Willson J.K.V. , Gazdar A.F., Hartigan J., Wu L., Liu C., Parmigiani G., Park B.H., Bachman K.E., Papadopoulos N., Vogelstein B., Kinzler K.W., Velculescu V.E. Science 314:268-274(2006) [PubMed: 16959974] [Abstract] Cited for: VARIANT [LARGE SCALE ANALYSIS] PHE-88.
+	Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ

X13403 mRNA. Translation: CAA31767.1.
AY113189 mRNA. Translation: AAM77920.1.
CH471067 Genomic DNA. Translation: EAW90786.1.
BC001664 mRNA. Translation: AAH01664.1.
BC003571 mRNA. Translation: AAH03571.1.
BC007388 mRNA. Translation: AAH07388.1.
BC052274 mRNA. Translation: AAH52274.1.
AL136984 Genomic DNA. Translation: CAI15167.1.
AL136984 Genomic DNA. Translation: CAI15169.1.
AL136984 Genomic DNA. Translation: CAI15170.1.
AL136984 Genomic DNA. Translation: CAI15171.1.

IPI

IPI00027828.
IPI00219171.
IPI00555623.
IPI00555806.

PIR

A47001.

RefSeq

NP_002688.2.

UniGene

Hs.493649.

3D structure databases

PDBe
RCSB PDB
PDBj

Entry	Method	Resolution (Å)	Chain	Positions	PDBsum
1CQT	X-ray	3.20	A/B	280-438	[»]
1E3O	X-ray	1.90	C	280-438	[»]
1GT0	X-ray	2.60	C	280-438	[»]
1HF0	X-ray	2.70	A/B	280-438	[»]
1O4X	NMR	-	A	280-442	[»]
1OCT	X-ray	3.00	C	284-439	[»]
1POG	NMR	-	A	378-437	[»]
1POU	NMR	-	A	284-354	[»]

ProteinModelPortal

P14859.

DisProt

DP00231.

ModBase

Search...

Protein-protein interaction databases

DIP

DIP-226N.

IntAct

P14859. 3 interactions.

MINT

MINT-149153.

STRING

P14859.

PTM databases

PhosphoSite

P14859.

Proteomic databases

PRIDE

P14859.

Genome annotation databases

Ensembl

ENST00000271411; ENSP00000271411; ENSG00000143190; Homo sapiens. [Genome view]
ENST00000367862; ENSP00000356836; ENSG00000143190; Homo sapiens. [Genome view]
ENST00000367866; ENSP00000356840; ENSG00000143190; Homo sapiens. [Genome view]

GeneID

5451.

KEGG

hsa:5451.

UCSC

uc001gec.1. human.
uc001ged.1. human.
uc001geg.2. human.

Organism-specific databases

CTD

5451.

GeneCards

GC01P167190.

H-InvDB

HIX0018279.

HGNC

HGNC:9212. POU2F1.

HPA

CAB002608.

MIM

164175. gene.

PharmGKB

PA33536.

GenAtlas

Search...

Phylogenomic databases

eggNOG

prNOG05307.

HOGENOM

HBG447127.

HOVERGEN

HBG057016.

InParanoid

P14859.

OMA

CAMESGD.

OrthoDB

EOG954CK0.

PhylomeDB

P14859.

Enzyme and pathway databases

Pathway_Interaction_DB

nfat_tfpathway. Calcineurin-regulated NFAT-dependent transcription in lymphocytes.
tcrcalciumpathway. Calcium signaling in the CD4+ TCR pathway.
hnf3apathway. FOXA1 transcription factor network.
ar_tf_pathway. Regulation of Androgen receptor activity.

Reactome

REACT_1788. Transcription.

Gene expression databases

ArrayExpress

P14859.

Bgee

P14859.

CleanEx

HS_POU2F1.

Genevestigator

P14859.

GermOnline

ENSG00000143190. Homo sapiens.

Family and domain databases

InterPro

IPR001356. Homeobox.
IPR017970. Homeobox_CS.
IPR009057. Homeodomain-like.
IPR012287. Homeodomain-rel.
IPR010982. Lambda_DNA-bd.
IPR013847. POU.
IPR000327. POU_specific.
IPR000972. TF_octamer.
[Graphical view]

Gene3D

G3DSA:1.10.10.60. Homeodomain-rel. 1 hit.

Pfam

PF00046. Homeobox. 1 hit.
PF00157. Pou. 1 hit.
[Graphical view]

PRINTS

PR00029. OCTAMER.
PR00028. POUDOMAIN.

SMART

SM00389. HOX. 1 hit.
SM00352. POU. 1 hit.
[Graphical view]

SUPFAM

SSF46689. Homeodomain_like. 1 hit.
SSF47413. Lambda_like_DNA. 1 hit.

PROSITE

PS00027. HOMEOBOX_1. 1 hit.
PS50071. HOMEOBOX_2. 1 hit.
PS00035. POU_1. 1 hit.
PS00465. POU_2. 1 hit.
PS51179. POU_3. 1 hit.
[Graphical view]

ProtoNet

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Other Resources

NextBio

21097.

SOURCE

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Entry information

Entry name

PO2F1_HUMAN

Accession

Primary (citable) accession number: P14859
Secondary accession number(s): B1AL91 , B1AL93, Q5TBT7, Q6PK46, Q8NEU9, Q9BPV1

Entry history

Integrated into UniProtKB/Swiss-Prot:	April 1, 1990
Last sequence update:	February 1, 2003
Last modified:	August 10, 2010
This is version 135 of the entry and version 2 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HPI (Human Proteome Initiative)

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.