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P14859

- PO2F1_HUMAN

UniProt

P14859 - PO2F1_HUMAN

Protein

POU domain, class 2, transcription factor 1

Gene

POU2F1

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 178 (01 Oct 2014)
      Sequence version 2 (01 Feb 2003)
      Previous versions | rss
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    Functioni

    Transcription factor that binds to the octamer motif (5'-ATTTGCAT-3') and activates the promoters of the genes for some small nuclear RNAs (snRNA) and of genes such as those for histone H2B and immunoglobulins. Modulates transcription transactivation by NR3C1, AR and PGR By similarity. In case of human herpes simplex virus (HSV) infection, POU2F1 forms a multiprotein-DNA complex with the viral transactivator protein VP16 and HCFC1 thereby enabling the transcription of the viral immediate early genes.By similarity1 Publication

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    DNA bindingi379 – 43860HomeoboxPROSITE-ProRule annotationAdd
    BLAST

    GO - Molecular functioni

    1. protein binding Source: UniProtKB
    2. sequence-specific DNA binding Source: UniProtKB
    3. sequence-specific DNA binding transcription factor activity Source: ProtInc

    GO - Biological processi

    1. gene expression Source: Reactome
    2. negative regulation of transcription, DNA-templated Source: UniProtKB
    3. transcription from RNA polymerase III promoter Source: Reactome

    Keywords - Molecular functioni

    Activator

    Keywords - Biological processi

    Transcription, Transcription regulation

    Keywords - Ligandi

    DNA-binding

    Enzyme and pathway databases

    ReactomeiREACT_22339. RNA Polymerase III Abortive And Retractive Initiation.
    REACT_571. RNA Polymerase III Transcription Initiation From Type 3 Promoter.
    SignaLinkiP14859.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    POU domain, class 2, transcription factor 1
    Alternative name(s):
    NF-A1
    Octamer-binding protein 1
    Short name:
    Oct-1
    Octamer-binding transcription factor 1
    Short name:
    OTF-1
    Gene namesi
    Name:POU2F1
    Synonyms:OCT1, OTF1
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 1

    Organism-specific databases

    HGNCiHGNC:9212. POU2F1.

    Subcellular locationi

    GO - Cellular componenti

    1. cytoplasm Source: HPA
    2. nucleoplasm Source: Reactome
    3. nucleus Source: HPA

    Keywords - Cellular componenti

    Nucleus

    Pathology & Biotechi

    Mutagenesis

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Mutagenesisi385 – 3851S → A: Loss of inhibition of DNA binding. 1 Publication

    Organism-specific databases

    PharmGKBiPA33536.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 743743POU domain, class 2, transcription factor 1PRO_0000100707Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei270 – 2701Phosphothreonine2 Publications
    Modified residuei283 – 2831Phosphoserine2 Publications
    Modified residuei385 – 3851Phosphoserine2 Publications
    Modified residuei448 – 4481Phosphoserine2 Publications

    Post-translational modificationi

    Phosphorylated by PRKDC.3 Publications

    Keywords - PTMi

    Phosphoprotein

    Proteomic databases

    MaxQBiP14859.
    PaxDbiP14859.
    PRIDEiP14859.

    PTM databases

    PhosphoSiteiP14859.

    Expressioni

    Tissue specificityi

    Ubiquitous. Isoform 2 is lymphocyte-specific.

    Gene expression databases

    ArrayExpressiP14859.
    BgeeiP14859.
    CleanExiHS_POU2F1.
    GenevestigatoriP14859.

    Organism-specific databases

    HPAiCAB002608.
    HPA045784.

    Interactioni

    Subunit structurei

    Interacts with NR3C1, AR, PGR and HCFC1. Associates with the herpes simplex virus VP16-induced complex; binding to HCFC1 activates the viral transcriptional activator VP16 for association with POU2F1, to form a multiprotein-DNA complex responsible for activating transcription of the viral immediate early genes.2 Publications

    Binary interactionsi

    WithEntry#Exp.IntActNotes
    SP1P080477EBI-624770,EBI-298336

    Protein-protein interaction databases

    BioGridi111447. 51 interactions.
    DIPiDIP-226N.
    IntActiP14859. 3 interactions.
    MINTiMINT-149153.
    STRINGi9606.ENSP00000271411.

    Structurei

    Secondary structure

    1
    743
    Legend: HelixTurnBeta strand
    Show more details
    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Helixi285 – 30117
    Helixi306 – 31712
    Helixi323 – 3319
    Helixi336 – 35318
    Helixi388 – 40013
    Helixi406 – 41611
    Helixi420 – 43415

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    EntryMethodResolution (Å)ChainPositionsPDBsum
    1CQTX-ray3.20A/B278-439[»]
    1E3OX-ray1.90C280-438[»]
    1GT0X-ray2.60C280-438[»]
    1HF0X-ray2.70A/B280-438[»]
    1O4XNMR-A280-442[»]
    1OCTX-ray3.00C284-439[»]
    1POGNMR-A378-437[»]
    1POUNMR-A284-354[»]
    DisProtiDP00231.
    ProteinModelPortaliP14859.
    SMRiP14859. Positions 282-438.
    ModBaseiSearch...
    MobiDBiSearch...

    Miscellaneous databases

    EvolutionaryTraceiP14859.

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini280 – 35475POU-specificPROSITE-ProRule annotationAdd
    BLAST

    Sequence similaritiesi

    Contains 1 homeobox DNA-binding domain.PROSITE-ProRule annotation
    Contains 1 POU-specific domain.PROSITE-ProRule annotation

    Keywords - Domaini

    Homeobox

    Phylogenomic databases

    eggNOGiNOG267922.
    HOGENOMiHOG000220842.
    HOVERGENiHBG057016.
    InParanoidiP14859.
    KOiK09364.
    PhylomeDBiP14859.

    Family and domain databases

    Gene3Di1.10.10.60. 1 hit.
    1.10.260.40. 1 hit.
    InterProiIPR017970. Homeobox_CS.
    IPR001356. Homeobox_dom.
    IPR009057. Homeodomain-like.
    IPR010982. Lambda_DNA-bd_dom.
    IPR013847. POU.
    IPR000327. POU_specific.
    IPR000972. TF_octamer.
    [Graphical view]
    PfamiPF00046. Homeobox. 1 hit.
    PF00157. Pou. 1 hit.
    [Graphical view]
    PRINTSiPR00029. OCTAMER.
    PR00028. POUDOMAIN.
    SMARTiSM00389. HOX. 1 hit.
    SM00352. POU. 1 hit.
    [Graphical view]
    SUPFAMiSSF46689. SSF46689. 1 hit.
    SSF47413. SSF47413. 1 hit.
    PROSITEiPS00027. HOMEOBOX_1. 1 hit.
    PS50071. HOMEOBOX_2. 1 hit.
    PS00035. POU_1. 1 hit.
    PS00465. POU_2. 1 hit.
    PS51179. POU_3. 1 hit.
    [Graphical view]

    Sequences (6)i

    Sequence statusi: Complete.

    This entry describes 6 isoformsi produced by alternative splicing. Align

    Isoform 1 (identifier: P14859-1) [UniParc]FASTAAdd to Basket

    This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

    « Hide

    MNNPSETSKP SMESGDGNTG TQTNGLDFQK QPVPVGGAIS TAQAQAFLGH    50
    LHQVQLAGTS LQAAAQSLNV QSKSNEESGD SQQPSQPSQQ PSVQAAIPQT 100
    QLMLAGGQIT GLTLTPAQQQ LLLQQAQAQA QLLAAAVQQH SASQQHSAAG 150
    ATISASAATP MTQIPLSQPI QIAQDLQQLQ QLQQQNLNLQ QFVLVHPTTN 200
    LQPAQFIISQ TPQGQQGLLQ AQNLLTQLPQ QSQANLLQSQ PSITLTSQPA 250
    TPTRTIAATP IQTLPQSQST PKRIDTPSLE EPSDLEELEQ FAKTFKQRRI 300
    KLGFTQGDVG LAMGKLYGND FSQTTISRFE ALNLSFKNMC KLKPLLEKWL 350
    NDAENLSSDS SLSSPSALNS PGIEGLSRRR KKRTSIETNI RVALEKSFLE 400
    NQKPTSEEIT MIADQLNMEK EVIRVWFCNR RQKEKRINPP SSGGTSSSPI 450
    KAIFPSPTSL VATTPSLVTS SAATTLTVSP VLPLTSAAVT NLSVTGTSDT 500
    TSNNTATVIS TAPPASSAVT SPSLSPSPSA SASTSEASSA SETSTTQTTS 550
    TPLSSPLGTS QVMVTASGLQ TAAAAALQGA AQLPANASLA AMAAAAGLNP 600
    SLMAPSQFAA GGALLSLNPG TLSGALSPAL MSNSTLATIQ ALASGGSLPI 650
    TSLDATGNLV FANAGGAPNI VTAPLFLNPQ NLSLLTSNPV SLVSAAAASA 700
    GNSAPVASLH ATSTSAESIQ NSLFTVASAS GAASTTTTAS KAQ 743
    Length:743
    Mass (Da):76,472
    Last modified:February 1, 2003 - v2
    Checksum:iFAB27FFC79CF2276
    GO
    Isoform 2 (identifier: P14859-2) [UniParc]FASTAAdd to Basket

    Also known as: Oct-1L, lymphocyte-specific

    The sequence of this isoform differs from the canonical sequence as follows:
         1-1: M → MLDCSDYVLDSRM

    Show »
    Length:755
    Mass (Da):77,870
    Checksum:i084E222919B616AA
    GO
    Isoform 3 (identifier: P14859-3) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         1-20: MNNPSETSKPSMESGDGNTG → MKTRMKIFVMIHFHLMNS

    Note: No experimental confirmation available.

    Show »
    Length:741
    Mass (Da):76,696
    Checksum:i28E72DF211628CE3
    GO
    Isoform 6 (identifier: P14859-6) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         1-1: M → MADGGAASQDESSAAAAAAADSRM

    Note: No experimental confirmation available.

    Show »
    Length:766
    Mass (Da):78,535
    Checksum:i54C541CD1D6BA426
    GO
    Isoform 4 (identifier: P14859-4) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         641-653: ALASGGSLPITSL → GLLHGLENFLTKN
         654-743: Missing.

    Note: No experimental confirmation available.

    Show »
    Length:653
    Mass (Da):68,143
    Checksum:i1C82E7818D70A368
    GO
    Isoform 5 (identifier: P14859-5) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         1-1: M → MADGGAASQDESSAAAAAAADSRM
         112-174: Missing.

    Note: No experimental confirmation available.

    Show »
    Length:703
    Mass (Da):72,082
    Checksum:i1E6037CDCF41F528
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti225 – 2251L → Q in CAA31767. (PubMed:2905684)Curated
    Sequence conflicti546 – 5461T → I in AAM77920. (PubMed:12663137)Curated

    Natural variant

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti88 – 881S → F in a breast cancer sample; somatic mutation. 1 Publication
    VAR_035816

    Alternative sequence

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Alternative sequencei1 – 2020MNNPS…DGNTG → MKTRMKIFVMIHFHLMNS in isoform 3. CuratedVSP_013421Add
    BLAST
    Alternative sequencei1 – 11M → MLDCSDYVLDSRM in isoform 2. 1 PublicationVSP_002320
    Alternative sequencei1 – 11M → MADGGAASQDESSAAAAAAA DSRM in isoform 5 and isoform 6. 1 PublicationVSP_043195
    Alternative sequencei112 – 17463Missing in isoform 5. 1 PublicationVSP_043196Add
    BLAST
    Alternative sequencei641 – 65313ALASG…PITSL → GLLHGLENFLTKN in isoform 4. 1 PublicationVSP_013422Add
    BLAST
    Alternative sequencei654 – 74390Missing in isoform 4. 1 PublicationVSP_013423Add
    BLAST

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    X13403 mRNA. Translation: CAA31767.1.
    AY113189 mRNA. Translation: AAM77920.1.
    AK303201 mRNA. Translation: BAG64291.1.
    AL136984 Genomic DNA. Translation: CAI15167.1.
    AL136984 Genomic DNA. Translation: CAI15169.1.
    AL136984 Genomic DNA. Translation: CAI15170.1.
    AL136984 Genomic DNA. Translation: CAI15171.1.
    AL359962 Genomic DNA. No translation available.
    AL451050 Genomic DNA. No translation available.
    CH471067 Genomic DNA. Translation: EAW90786.1.
    CH471067 Genomic DNA. Translation: EAW90788.1.
    BC001664 mRNA. Translation: AAH01664.1.
    BC003571 mRNA. Translation: AAH03571.1.
    BC007388 mRNA. Translation: AAH07388.1.
    BC052274 mRNA. Translation: AAH52274.1.
    CCDSiCCDS1259.2. [P14859-6]
    CCDS55655.1. [P14859-5]
    CCDS55656.1. [P14859-2]
    PIRiA47001.
    RefSeqiNP_001185712.1. NM_001198783.1. [P14859-2]
    NP_001185715.1. NM_001198786.1. [P14859-5]
    NP_002688.3. NM_002697.3. [P14859-6]
    UniGeneiHs.283402.

    Genome annotation databases

    EnsembliENST00000367862; ENSP00000356836; ENSG00000143190. [P14859-2]
    ENST00000367866; ENSP00000356840; ENSG00000143190. [P14859-6]
    ENST00000420254; ENSP00000414660; ENSG00000143190. [P14859-4]
    ENST00000429375; ENSP00000401217; ENSG00000143190. [P14859-5]
    ENST00000443275; ENSP00000415993; ENSG00000143190.
    ENST00000541643; ENSP00000441285; ENSG00000143190. [P14859-1]
    GeneIDi5451.
    KEGGihsa:5451.
    UCSCiuc001gec.3. human. [P14859-1]
    uc001ged.3. human. [P14859-3]
    uc001gee.3. human.
    uc001gef.3. human. [P14859-2]
    uc001geg.3. human. [P14859-4]
    uc010plh.2. human. [P14859-5]

    Polymorphism databases

    DMDMi28202257.

    Keywords - Coding sequence diversityi

    Alternative splicing, Polymorphism

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    X13403 mRNA. Translation: CAA31767.1 .
    AY113189 mRNA. Translation: AAM77920.1 .
    AK303201 mRNA. Translation: BAG64291.1 .
    AL136984 Genomic DNA. Translation: CAI15167.1 .
    AL136984 Genomic DNA. Translation: CAI15169.1 .
    AL136984 Genomic DNA. Translation: CAI15170.1 .
    AL136984 Genomic DNA. Translation: CAI15171.1 .
    AL359962 Genomic DNA. No translation available.
    AL451050 Genomic DNA. No translation available.
    CH471067 Genomic DNA. Translation: EAW90786.1 .
    CH471067 Genomic DNA. Translation: EAW90788.1 .
    BC001664 mRNA. Translation: AAH01664.1 .
    BC003571 mRNA. Translation: AAH03571.1 .
    BC007388 mRNA. Translation: AAH07388.1 .
    BC052274 mRNA. Translation: AAH52274.1 .
    CCDSi CCDS1259.2. [P14859-6 ]
    CCDS55655.1. [P14859-5 ]
    CCDS55656.1. [P14859-2 ]
    PIRi A47001.
    RefSeqi NP_001185712.1. NM_001198783.1. [P14859-2 ]
    NP_001185715.1. NM_001198786.1. [P14859-5 ]
    NP_002688.3. NM_002697.3. [P14859-6 ]
    UniGenei Hs.283402.

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    Entry Method Resolution (Å) Chain Positions PDBsum
    1CQT X-ray 3.20 A/B 278-439 [» ]
    1E3O X-ray 1.90 C 280-438 [» ]
    1GT0 X-ray 2.60 C 280-438 [» ]
    1HF0 X-ray 2.70 A/B 280-438 [» ]
    1O4X NMR - A 280-442 [» ]
    1OCT X-ray 3.00 C 284-439 [» ]
    1POG NMR - A 378-437 [» ]
    1POU NMR - A 284-354 [» ]
    DisProti DP00231.
    ProteinModelPortali P14859.
    SMRi P14859. Positions 282-438.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 111447. 51 interactions.
    DIPi DIP-226N.
    IntActi P14859. 3 interactions.
    MINTi MINT-149153.
    STRINGi 9606.ENSP00000271411.

    PTM databases

    PhosphoSitei P14859.

    Polymorphism databases

    DMDMi 28202257.

    Proteomic databases

    MaxQBi P14859.
    PaxDbi P14859.
    PRIDEi P14859.

    Protocols and materials databases

    DNASUi 5451.
    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000367862 ; ENSP00000356836 ; ENSG00000143190 . [P14859-2 ]
    ENST00000367866 ; ENSP00000356840 ; ENSG00000143190 . [P14859-6 ]
    ENST00000420254 ; ENSP00000414660 ; ENSG00000143190 . [P14859-4 ]
    ENST00000429375 ; ENSP00000401217 ; ENSG00000143190 . [P14859-5 ]
    ENST00000443275 ; ENSP00000415993 ; ENSG00000143190 .
    ENST00000541643 ; ENSP00000441285 ; ENSG00000143190 . [P14859-1 ]
    GeneIDi 5451.
    KEGGi hsa:5451.
    UCSCi uc001gec.3. human. [P14859-1 ]
    uc001ged.3. human. [P14859-3 ]
    uc001gee.3. human.
    uc001gef.3. human. [P14859-2 ]
    uc001geg.3. human. [P14859-4 ]
    uc010plh.2. human. [P14859-5 ]

    Organism-specific databases

    CTDi 5451.
    GeneCardsi GC01P167190.
    H-InvDB HIX0018279.
    HGNCi HGNC:9212. POU2F1.
    HPAi CAB002608.
    HPA045784.
    MIMi 164175. gene.
    neXtProti NX_P14859.
    PharmGKBi PA33536.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi NOG267922.
    HOGENOMi HOG000220842.
    HOVERGENi HBG057016.
    InParanoidi P14859.
    KOi K09364.
    PhylomeDBi P14859.

    Enzyme and pathway databases

    Reactomei REACT_22339. RNA Polymerase III Abortive And Retractive Initiation.
    REACT_571. RNA Polymerase III Transcription Initiation From Type 3 Promoter.
    SignaLinki P14859.

    Miscellaneous databases

    ChiTaRSi POU2F1. human.
    EvolutionaryTracei P14859.
    GeneWikii POU2F1.
    GenomeRNAii 5451.
    NextBioi 21097.
    PROi P14859.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi P14859.
    Bgeei P14859.
    CleanExi HS_POU2F1.
    Genevestigatori P14859.

    Family and domain databases

    Gene3Di 1.10.10.60. 1 hit.
    1.10.260.40. 1 hit.
    InterProi IPR017970. Homeobox_CS.
    IPR001356. Homeobox_dom.
    IPR009057. Homeodomain-like.
    IPR010982. Lambda_DNA-bd_dom.
    IPR013847. POU.
    IPR000327. POU_specific.
    IPR000972. TF_octamer.
    [Graphical view ]
    Pfami PF00046. Homeobox. 1 hit.
    PF00157. Pou. 1 hit.
    [Graphical view ]
    PRINTSi PR00029. OCTAMER.
    PR00028. POUDOMAIN.
    SMARTi SM00389. HOX. 1 hit.
    SM00352. POU. 1 hit.
    [Graphical view ]
    SUPFAMi SSF46689. SSF46689. 1 hit.
    SSF47413. SSF47413. 1 hit.
    PROSITEi PS00027. HOMEOBOX_1. 1 hit.
    PS50071. HOMEOBOX_2. 1 hit.
    PS00035. POU_1. 1 hit.
    PS00465. POU_2. 1 hit.
    PS51179. POU_3. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "The ubiquitous octamer-binding protein Oct-1 contains a POU domain with a homeo box subdomain."
      Sturm R.A., Das G., Herr W.
      Genes Dev. 2:1582-1599(1988) [PubMed] [Europe PMC] [Abstract]
      Cited for: PARTIAL NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 6).
      Tissue: Teratocarcinoma.
    2. "Human Oct-1L isoform has tissue-specific expression pattern similar to Oct-2."
      Luchina N.N., Krivega I.V., Pankratova E.V.
      Immunol. Lett. 85:237-241(2003) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 2).
      Tissue: B-cell lymphoma.
    3. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
      Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
      , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
      Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 5).
      Tissue: Thymus.
    4. "The DNA sequence and biological annotation of human chromosome 1."
      Gregory S.G., Barlow K.F., McLay K.E., Kaul R., Swarbreck D., Dunham A., Scott C.E., Howe K.L., Woodfine K., Spencer C.C.A., Jones M.C., Gillson C., Searle S., Zhou Y., Kokocinski F., McDonald L., Evans R., Phillips K.
      , Atkinson A., Cooper R., Jones C., Hall R.E., Andrews T.D., Lloyd C., Ainscough R., Almeida J.P., Ambrose K.D., Anderson F., Andrew R.W., Ashwell R.I.S., Aubin K., Babbage A.K., Bagguley C.L., Bailey J., Beasley H., Bethel G., Bird C.P., Bray-Allen S., Brown J.Y., Brown A.J., Buckley D., Burton J., Bye J., Carder C., Chapman J.C., Clark S.Y., Clarke G., Clee C., Cobley V., Collier R.E., Corby N., Coville G.J., Davies J., Deadman R., Dunn M., Earthrowl M., Ellington A.G., Errington H., Frankish A., Frankland J., French L., Garner P., Garnett J., Gay L., Ghori M.R.J., Gibson R., Gilby L.M., Gillett W., Glithero R.J., Grafham D.V., Griffiths C., Griffiths-Jones S., Grocock R., Hammond S., Harrison E.S.I., Hart E., Haugen E., Heath P.D., Holmes S., Holt K., Howden P.J., Hunt A.R., Hunt S.E., Hunter G., Isherwood J., James R., Johnson C., Johnson D., Joy A., Kay M., Kershaw J.K., Kibukawa M., Kimberley A.M., King A., Knights A.J., Lad H., Laird G., Lawlor S., Leongamornlert D.A., Lloyd D.M., Loveland J., Lovell J., Lush M.J., Lyne R., Martin S., Mashreghi-Mohammadi M., Matthews L., Matthews N.S.W., McLaren S., Milne S., Mistry S., Moore M.J.F., Nickerson T., O'Dell C.N., Oliver K., Palmeiri A., Palmer S.A., Parker A., Patel D., Pearce A.V., Peck A.I., Pelan S., Phelps K., Phillimore B.J., Plumb R., Rajan J., Raymond C., Rouse G., Saenphimmachak C., Sehra H.K., Sheridan E., Shownkeen R., Sims S., Skuce C.D., Smith M., Steward C., Subramanian S., Sycamore N., Tracey A., Tromans A., Van Helmond Z., Wall M., Wallis J.M., White S., Whitehead S.L., Wilkinson J.E., Willey D.L., Williams H., Wilming L., Wray P.W., Wu Z., Coulson A., Vaudin M., Sulston J.E., Durbin R.M., Hubbard T., Wooster R., Dunham I., Carter N.P., McVean G., Ross M.T., Harrow J., Olson M.V., Beck S., Rogers J., Bentley D.R.
      Nature 441:315-321(2006) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    5. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    6. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1), NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 93-653 (ISOFORM 4).
      Tissue: Lung, Lymph and Skin.
    7. "Mitotic phosphorylation of the Oct-1 homeodomain and regulation of Oct-1 DNA binding activity."
      Segil N., Roberts S.B., Heintz N.
      Science 254:1814-1816(1991) [PubMed] [Europe PMC] [Abstract]
      Cited for: PHOSPHORYLATION AT SER-385, MUTAGENESIS OF SER-385, FUNCTION IN DNA-BINDING ACTIVITY.
    8. "Selective binding of steroid hormone receptors to octamer transcription factors determines transcriptional synergism at the mouse mammary tumor virus promoter."
      Prefontaine G.G., Walther R., Giffin W., Lemieux M.E., Pope L., Hache R.J.G.
      J. Biol. Chem. 274:26713-26719(1999) [PubMed] [Europe PMC] [Abstract]
      Cited for: INTERACTION WITH NR3C1; AR AND PGR.
    9. "Mutations in host cell factor 1 separate its role in cell proliferation from recruitment of VP16 and LZIP."
      Mahajan S.S., Wilson A.C.
      Mol. Cell. Biol. 20:919-928(2000) [PubMed] [Europe PMC] [Abstract]
      Cited for: INTERACTION WITH HCFC1.
    10. "Down-regulation of histone H2B by DNA-dependent protein kinase in response to DNA damage through modulation of octamer transcription factor 1."
      Schild-Poulter C., Shih A., Yarymowich N.C., Hache R.J.G.
      Cancer Res. 63:7197-7205(2003) [PubMed] [Europe PMC] [Abstract]
      Cited for: PHOSPHORYLATION.
    11. "The herpes simplex virus VP16-induced complex: the makings of a regulatory switch."
      Wysocka J., Herr W.
      Trends Biochem. Sci. 28:294-304(2003) [PubMed] [Europe PMC] [Abstract]
      Cited for: REVIEW ON HERPES INFECTION.
    12. "A probability-based approach for high-throughput protein phosphorylation analysis and site localization."
      Beausoleil S.A., Villen J., Gerber S.A., Rush J., Gygi S.P.
      Nat. Biotechnol. 24:1285-1292(2006) [PubMed] [Europe PMC] [Abstract]
      Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
      Tissue: Cervix carcinoma.
    13. Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT THR-270; SER-283 AND SER-448, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
      Tissue: Cervix carcinoma.
    14. "Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach."
      Gauci S., Helbig A.O., Slijper M., Krijgsveld J., Heck A.J., Mohammed S.
      Anal. Chem. 81:4493-4501(2009) [PubMed] [Europe PMC] [Abstract]
      Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    15. "Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis."
      Olsen J.V., Vermeulen M., Santamaria A., Kumar C., Miller M.L., Jensen L.J., Gnad F., Cox J., Jensen T.S., Nigg E.A., Brunak S., Mann M.
      Sci. Signal. 3:RA3-RA3(2010) [PubMed] [Europe PMC] [Abstract]
      Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
      Tissue: Cervix carcinoma.
    16. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    17. "System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation."
      Rigbolt K.T., Prokhorova T.A., Akimov V., Henningsen J., Johansen P.T., Kratchmarova I., Kassem M., Mann M., Olsen J.V., Blagoev B.
      Sci. Signal. 4:RS3-RS3(2011) [PubMed] [Europe PMC] [Abstract]
      Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    18. "Solution structure of the POU-specific DNA-binding domain of Oct-1."
      Dekker N., Cox M., Boelens R., Verrijzer C.P., van der Vliet P.C., Kaptein R.
      Nature 362:852-855(1993) [PubMed] [Europe PMC] [Abstract]
      Cited for: STRUCTURE BY NMR OF 284-359.
    19. "The solution structure of the Oct-1 POU-specific domain reveals a striking similarity to the bacteriophage lambda repressor DNA-binding domain."
      Assa-Munt N., Mortishire-Smith R.J., Aurora R., Herr W., Wright P.E.
      Cell 73:193-205(1993) [PubMed] [Europe PMC] [Abstract]
      Cited for: STRUCTURE BY NMR OF 284-354.
    20. "Solution structure of the Oct-1 POU homeodomain determined by NMR and restrained molecular dynamics."
      Cox M., van Tilborg P.J.A., de Laat W., Boelens R., van Leeuwen H.C., van der Vliet P.C., Kaptein R.
      J. Biomol. NMR 6:23-32(1995) [PubMed] [Europe PMC] [Abstract]
      Cited for: STRUCTURE BY NMR OF 378-437.
    21. "Crystal structure of the Oct-1 POU domain bound to an octamer site: DNA recognition with tethered DNA-binding modules."
      Klemm J.D., Rould M.A., Aurora R., Herr W., Pabo C.O.
      Cell 77:21-32(1994) [PubMed] [Europe PMC] [Abstract]
      Cited for: X-RAY CRYSTALLOGRAPHY (3.0 ANGSTROMS) OF 284-439.
    22. Cited for: VARIANT [LARGE SCALE ANALYSIS] PHE-88.

    Entry informationi

    Entry nameiPO2F1_HUMAN
    AccessioniPrimary (citable) accession number: P14859
    Secondary accession number(s): B1AL91
    , B1AL93, B4E029, J3KP77, Q5TBT7, Q6PK46, Q8NEU9, Q9BPV1
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: April 1, 1990
    Last sequence update: February 1, 2003
    Last modified: October 1, 2014
    This is version 178 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    3D-structure, Complete proteome, Reference proteome

    Documents

    1. Human chromosome 1
      Human chromosome 1: entries, gene names and cross-references to MIM
    2. Human entries with polymorphisms or disease mutations
      List of human entries with polymorphisms or disease mutations
    3. Human polymorphisms and disease mutations
      Index of human polymorphisms and disease mutations
    4. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    5. PDB cross-references
      Index of Protein Data Bank (PDB) cross-references
    6. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3