P14852 (COX3_ORYSI) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Cytochrome c oxidase subunit 3
EC=1.9.3.1

Alternative name(s):
Cytochrome c oxidase polypeptide III

Gene names

Name:

COX3

Encoded on

Mitochondrion

Organism

Oryza sativa subsp. indica (Rice)

Taxonomic identifier

39946 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Viridiplantae › Streptophyta › Streptophytina › Embryophyta › Tracheophyta › Euphyllophyta › Spermatophyta › Magnoliophyta › Liliopsida › commelinids › Poales › Poaceae › BEP clade › Ehrhartoideae › Oryzeae › Oryza › Oryza sativa

Protein attributes

Sequence length	265 AA.
Sequence status	Complete.
Protein existence	Evidence at transcript level

General annotation (Comments)

Function	Subunits I, II and III form the functional core of the enzyme complex.
Catalytic activity	4 ferrocytochrome c + O2 + 4 H+ = 4 ferricytochrome c + 2 H2O.
Subcellular location	Mitochondrion inner membrane; Multi-pass membrane protein By similarity.
Sequence similarities	Belongs to the cytochrome c oxidase subunit 3 family.

Ontologies

Keywords
Cellular component	Membrane Mitochondrion Mitochondrion inner membrane
Domain	Transmembrane Transmembrane helix
Molecular function	Oxidoreductase
Gene Ontology (GO)
Biological_process	aerobic electron transport chain Inferred from electronic annotation. Source: InterPro
Cellular_component	integral to membrane Inferred from electronic annotation. Source: UniProtKB-KW mitochondrial inner membrane Inferred from electronic annotation. Source: UniProtKB-SubCell mitochondrion Inferred from sequence or structural similarity Ref.2Ref.1. Source: Gramene
Molecular_function	cytochrome-c oxidase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 265	265	Cytochrome c oxidase subunit 3		PRO_0000183822
Regions
	Transmembrane	16 – 36	21	Helical; Potential
	Transmembrane	41 – 61	21	Helical; Potential
	Transmembrane	84 – 104	21	Helical; Potential
	Transmembrane	162 – 182	21	Helical; Potential
	Transmembrane	200 – 220	21	Helical; Potential
	Transmembrane	245 – 265	21	Helical; Potential

Sequences

	Sequence		Length	Mass (Da)
	P14852 [UniParc]. Last modified December 1, 1992. Version 2. Checksum: ECF9B4C53E097C1D	FASTA	265	29,358
	10 20 30 40 50 60 MIESQRHSYH LVDPSPWPIS GSLGALATTV GGVMYMHSFQ GGATLLSLGL IFLLYTMFVW 70 80 90 100 110 120 WRDVLRESTL EGHHTKAVQL GPRYGSILFI VSEVMFLFAF FWASSHSSLA PTVEIGGIWP 130 140 150 160 170 180 PKGIGVLDPW EIPLLNTPIL PSSGAAVTWA HHAILAGKEK RAVYALVATV LLALVSTGFQ 190 200 210 220 230 240 GMEYYQAPST ISDSIYGSTF FLATGFHGFH VIIGTLFLIV CGIRQYLGHL TKKHHVGFEA 250 260 AAWYWHFVDV VRLFPFVSIY WWGGI

References

[1]	"Sequence of the rice mitochondrial gene for cytochrome oxidase subunit 3." Kaleikau E.K., Andre C.P., Walbot V. Nucleic Acids Res. 18:371-371(1990) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA]. Strain: cv. IR36.
[2]	"Co-transcription of orf25 and coxIII in rice mitochondria." Liu A.W., Narayanan K.K., Andre C.P., Kaleikau E.K., Walbot V. Curr. Genet. 21:507-513(1992) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA]. Strain: cv. IR36.

Cross-references

Sequence databases
EMBL GenBank DDBJ	X17040 Genomic DNA. Translation: CAA34898.1. M74241 Genomic DNA. Translation: AAA66048.1.
PIR	OTRZ3M. JQ0166.
3D structure databases
ProteinModelPortal	P14852.
SMR	P14852. Positions 5-263.
ModBase	Search...
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Organism-specific databases
Gramene	P14852.
Gene expression databases
ArrayExpress	P14852.
Family and domain databases
Gene3D	1.20.120.80. 1 hit.
InterPro	IPR024791. Cyt_c/ubiquinol_Oxase_su3. IPR000298. Cyt_c_oxidase_su3. IPR013833. Cyt_c_oxidase_su3_a-hlx. [Graphical view]
PANTHER	PTHR11403. PTHR11403. 1 hit.
Pfam	PF00510. COX3. 1 hit. [Graphical view]
SUPFAM	SSF81452. CytC_oxdse_III. 1 hit.
PROSITE	PS50253. COX3. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

COX3_ORYSI

Accession

Primary (citable) accession number: P14852

Entry history

Integrated into UniProtKB/Swiss-Prot:	April 1, 1990
Last sequence update:	December 1, 1992
Last modified:	April 3, 2013
This is version 73 of the entry and version 2 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Plant Protein Annotation Program