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P14847 (CRP_MOUSE) Reviewed, UniProtKB/Swiss-Prot

Last modified July 9, 2014. Version 119. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (3) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Web links·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
C-reactive protein
Gene names
Name:Crp
Synonyms:Ptx1
OrganismMus musculus (Mouse) [Reference proteome]
Taxonomic identifier10090 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus

Protein attributes

Sequence length225 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

Displays several functions associated with host defense: it promotes agglutination, bacterial capsular swelling, phagocytosis and complement fixation through its calcium-dependent binding to phosphorylcholine. Can interact with DNA and histones and may scavenge nuclear material released from damaged circulating cells.

Cofactor

Binds 2 calcium ions per subunit By similarity.

Subunit structure

Homopentamer. Pentaxin (or pentraxin) have a discoid arrangement of 5 non-covalently bound subunits By similarity.

Subcellular location

Secreted.

Tissue specificity

Found in plasma.

Induction

The concentration of CRP in plasma increases greatly during acute phase response to tissue injury, infection or other inflammatory stimuli.

Sequence similarities

Belongs to the pentaxin family.

Contains 1 pentaxin domain.

Ontologies

Keywords
   Biological processAcute phase
   Cellular componentSecreted
   DomainSignal
   LigandCalcium
Metal-binding
   PTMDisulfide bond
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Biological_processacute-phase response

Inferred from electronic annotation. Source: UniProtKB-KW

aging

Inferred from electronic annotation. Source: Ensembl

cellular response to calcium ion

Inferred from electronic annotation. Source: Ensembl

complement activation, classical pathway

Inferred from electronic annotation. Source: Ensembl

negative regulation of lipid storage

Inferred from electronic annotation. Source: Ensembl

negative regulation of macrophage derived foam cell differentiation

Inferred from electronic annotation. Source: Ensembl

positive regulation of dendrite development

Inferred from electronic annotation. Source: Ensembl

protein polymerization

Inferred from electronic annotation. Source: Ensembl

response to ethanol

Inferred from electronic annotation. Source: Ensembl

response to hypoxia

Inferred from electronic annotation. Source: Ensembl

response to lead ion

Inferred from electronic annotation. Source: Ensembl

wound healing

Inferred from electronic annotation. Source: Ensembl

   Cellular_componentextracellular space

Inferred from electronic annotation. Source: Ensembl

filopodium

Inferred from electronic annotation. Source: Ensembl

growth cone

Inferred from electronic annotation. Source: Ensembl

   Molecular_functioncholesterol binding

Inferred from electronic annotation. Source: Ensembl

low-density lipoprotein particle binding

Inferred from electronic annotation. Source: Ensembl

metal ion binding

Inferred from electronic annotation. Source: UniProtKB-KW

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Signal peptide1 – 1919
Chain20 – 225206C-reactive protein
PRO_0000023529

Regions

Domain20 – 225206Pentaxin

Sites

Metal binding801Calcium 1 By similarity
Metal binding1571Calcium 1 By similarity
Metal binding1571Calcium 2 By similarity
Metal binding1581Calcium 1; via carbonyl oxygen By similarity
Metal binding1591Calcium 1 By similarity
Metal binding1591Calcium 2 By similarity
Metal binding1691Calcium 2 By similarity

Amino acid modifications

Disulfide bond55 ↔ 116 By similarity

Experimental info

Sequence conflict1341P → A in CAA31928. Ref.1
Sequence conflict1911S → N in CAA31928. Ref.1
Sequence conflict1911S → N in CAA35531. Ref.3

Sequences

Sequence LengthMass (Da)Tools
P14847 [UniParc].

Last modified October 3, 2012. Version 2.
Checksum: 0E5FC77BEB8052D8

FASTA22525,360
        10         20         30         40         50         60 
MEKLLWCLLI MISFSRTFGH EDMFKKAFVF PKESDTSYVS LEAESKKPLN TFTVCLHFYT 

        70         80         90        100        110        120 
ALSTVRSFSV FSYATKKNSN DILIFWNKDK QYTFGVGGAE VRFMVSEIPE APTHICASWE 

       130        140        150        160        170        180 
SATGIVEFWI DGKPKVRKSL HKGYTVGPDA SIILGQEQDS YGGDFDAKQS LVGDIGDVNM 

       190        200        210        220 
WDFVLSPEQI STVYVGGTLS PNVLNWRALN YKAQGDVFIK PQLWS 

« Hide

References

« Hide 'large scale' references
[1]"Structure of the mouse C-reactive protein gene."
Ohnishi S., Maeda S., Nishiguchi S., Arao T., Shimada K.
Biochem. Biophys. Res. Commun. 156:814-822(1988) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
[2]"Lineage-specific biology revealed by a finished genome assembly of the mouse."
Church D.M., Goodstadt L., Hillier L.W., Zody M.C., Goldstein S., She X., Bult C.J., Agarwala R., Cherry J.L., DiCuccio M., Hlavina W., Kapustin Y., Meric P., Maglott D., Birtle Z., Marques A.C., Graves T., Zhou S. expand/collapse author list , Teague B., Potamousis K., Churas C., Place M., Herschleb J., Runnheim R., Forrest D., Amos-Landgraf J., Schwartz D.C., Cheng Z., Lindblad-Toh K., Eichler E.E., Ponting C.P.
PLoS Biol. 7:E1000112-E1000112(2009) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: C57BL/6J.
[3]"Mouse C-reactive protein. Generation of cDNA clones, structural analysis, and induction of mRNA during inflammation."
Whitehead A.S., Zahedi K., Rits M., Mortensen R.F., Lelias J.M.
Biochem. J. 266:283-290(1990) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
Strain: CBA/J.
Tissue: Liver.
+Additional computationally mapped references.

Web resources

Protein Spotlight

No more Christmas pudding? - Issue 30 of January 2003

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
X13588 Genomic DNA. Translation: CAA31928.1.
AC131177 Genomic DNA. No translation available.
X17496 mRNA. Translation: CAA35531.1.
CCDSCCDS35787.1.
PIRA31583.
RefSeqNP_031794.3. NM_007768.4.
UniGeneMm.28767.

3D structure databases

ProteinModelPortalP14847.
SMRP14847. Positions 22-224.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING10090.ENSMUSP00000044665.

PTM databases

PhosphoSiteP14847.

Proteomic databases

MaxQBP14847.
PaxDbP14847.
PRIDEP14847.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENSMUST00000038495; ENSMUSP00000044665; ENSMUSG00000037942.
GeneID12944.
KEGGmmu:12944.

Organism-specific databases

CTD1401.
MGIMGI:88512. Crp.

Phylogenomic databases

eggNOGNOG113288.
GeneTreeENSGT00650000093195.
HOGENOMHOG000247043.
HOVERGENHBG005405.
InParanoidP14847.
KOK16143.
OMAWRALKYE.
OrthoDBEOG71RXMB.
TreeFamTF330208.

Gene expression databases

CleanExMM_CRP.
GenevestigatorP14847.

Family and domain databases

Gene3D2.60.120.200. 1 hit.
InterProIPR008985. ConA-like_lec_gl_sf.
IPR013320. ConA-like_subgrp.
IPR001759. Pentaxin.
[Graphical view]
PfamPF00354. Pentaxin. 1 hit.
[Graphical view]
PRINTSPR00895. PENTAXIN.
SMARTSM00159. PTX. 1 hit.
[Graphical view]
SUPFAMSSF49899. SSF49899. 1 hit.
PROSITEPS00289. PENTAXIN. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

NextBio282638.
PROP14847.
SOURCESearch...

Entry information

Entry nameCRP_MOUSE
AccessionPrimary (citable) accession number: P14847
Secondary accession number(s): E9PZ20
Entry history
Integrated into UniProtKB/Swiss-Prot: April 1, 1990
Last sequence update: October 3, 2012
Last modified: July 9, 2014
This is version 119 of the entry and version 2 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

Protein Spotlight

Protein Spotlight articles and cited UniProtKB/Swiss-Prot entries

MGD cross-references

Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot