P14847 (CRP_MOUSE) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
C-reactive protein

Gene names

Name:	Crp
Synonyms:	Ptx1

Organism

Mus musculus (Mouse)

Taxonomic identifier

10090 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Sciurognathi › Muroidea › Muridae › Murinae › Mus › Mus

Protein attributes

Sequence length	225 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is further processed into a mature form.
Protein existence	Evidence at transcript level

General annotation (Comments)

Function	Displays several functions associated with host defense: it promotes agglutination, bacterial capsular swelling, phagocytosis and complement fixation through its calcium-dependent binding to phosphorylcholine. Can interact with DNA and histones and may scavenge nuclear material released from damaged circulating cells.
Cofactor	Binds 2 calcium ions per subunit By similarity.
Subunit structure	Homopentamer. Pentaxin (or pentraxin) have a discoid arrangement of 5 non-covalently bound subunits By similarity.
Subcellular location	Secreted.
Tissue specificity	Found in plasma.
Induction	The concentration of CRP in plasma increases greatly during acute phase response to tissue injury, infection or other inflammatory stimuli.
Sequence similarities	Belongs to the pentaxin family. Contains 1 pentaxin domain.

Ontologies

Keywords
Biological process	Acute phase
Cellular component	Secreted
Domain	Signal
Ligand	Calcium Metal-binding
PTM	Disulfide bond
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological process	acute-phase response Inferred from electronic annotation. Source: UniProtKB-KW
Cellular component	extracellular region Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	metal ion binding Inferred from electronic annotation. Source: UniProtKB-KW
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Signal peptide	1 – 19	19
	Chain	20 – 225	206	C-reactive protein		PRO_0000023529
Regions
	Domain	20 – 225	206	Pentaxin
Sites
	Metal binding	80	1	Calcium 1 By similarity
	Metal binding	157	1	Calcium 1 By similarity
	Metal binding	157	1	Calcium 2 By similarity
	Metal binding	158	1	Calcium 1; via carbonyl oxygen By similarity
	Metal binding	159	1	Calcium 1 By similarity
	Metal binding	159	1	Calcium 2 By similarity
	Metal binding	169	1	Calcium 2 By similarity
Amino acid modifications
	Disulfide bond	55 ↔ 116		By similarity
Experimental info
	Sequence conflict	134	1	A → P in CAA35531. Ref.2

Sequences

	Sequence		Length	Mass (Da)
	P14847 [UniParc]. Last modified April 1, 1990. Version 1. Checksum: 155E6785E46043D9	FASTA	225	25,361
	10 20 30 40 50 60 MEKLLWCLLI MISFSRTFGH EDMFKKAFVF PKESDTSYVS LEAESKKPLN TFTVCLHFYT 70 80 90 100 110 120 ALSTVRSFSV FSYATKKNSN DILIFWNKDK QYTFGVGGAE VRFMVSEIPE APTHICASWE 130 140 150 160 170 180 SATGIVEFWI DGKAKVRKSL HKGYTVGPDA SIILGQEQDS YGGDFDAKQS LVGDIGDVNM 190 200 210 220 WDFVLSPEQI NTVYVGGTLS PNVLNWRALN YKAQGDVFIK PQLWS

References

[1]	"Structure of the mouse C-reactive protein gene." Ohnishi S., Maeda S., Nishiguchi S., Arao T., Shimada K. Biochem. Biophys. Res. Commun. 156:814-822(1988) [PubMed: 3190681] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
[2]	"Mouse C-reactive protein. Generation of cDNA clones, structural analysis, and induction of mRNA during inflammation." Whitehead A.S., Zahedi K., Rits M., Mortensen R.F., Lelias J.M. Biochem. J. 266:283-290(1990) [PubMed: 2310378] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA]. Strain: CBA/J. Tissue: Liver.
+	Additional computationally mapped references.

Web resources

Protein Spotlight

No more Christmas pudding? - Issue 30 of January 2003

Cross-references

Sequence databases
EMBL GenBank DDBJ	X13588 Genomic DNA. Translation: CAA31928.1. X17496 mRNA. Translation: CAA35531.1.
IPI	IPI00314936.
PIR	A31583.
UniGene	Mm.28767.
3D structure databases
ProteinModelPortal	P14847.
SMR	P14847. Positions 22-224.
ModBase	Search...
Protein-protein interaction databases
STRING	P14847.
Proteomic databases
PRIDE	P14847.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Organism-specific databases
MGI	MGI:88512. Crp.
Phylogenomic databases
eggNOG	roNOG08751.
HOGENOM	HBG716040.
HOVERGEN	HBG005405.
InParanoid	P14847.
OrthoDB	EOG4R23VS.
Gene expression databases
ArrayExpress	P14847.
Bgee	P14847.
CleanEx	MM_CRP.
Genevestigator	P14847.
GermOnline	ENSMUSG00000037942. Mus musculus.
Family and domain databases
InterPro	IPR008985. ConA-like_lec_gl. IPR013320. ConA-like_subgrp. IPR001759. Pentaxin. [Graphical view]
Gene3D	G3DSA:2.60.120.200. ConA_like_subgrp. 1 hit.
Pfam	PF00354. Pentaxin. 1 hit. [Graphical view]
PRINTS	PR00895. PENTAXIN.
SMART	SM00159. PTX. 1 hit. [Graphical view]
SUPFAM	SSF49899. ConA_like_lec_gl. 1 hit.
PROSITE	PS00289. PENTAXIN. 1 hit. [Graphical view]
ProtoNet	Search...
Other
SOURCE	Search...

Entry information

Entry name

CRP_MOUSE

Accession

Primary (citable) accession number: P14847

Entry history

Integrated into UniProtKB/Swiss-Prot:	April 1, 1990
Last sequence update:	April 1, 1990
Last modified:	October 19, 2011
This is version 101 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program