P14847 (CRP_MOUSE) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
C-reactive protein

Gene names

Name:	Crp
Synonyms:	Ptx1

Organism

Mus musculus (Mouse) [Reference proteome]

Taxonomic identifier

10090 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Glires › Rodentia › Sciurognathi › Muroidea › Muridae › Murinae › Mus › Mus

Protein attributes

Sequence length	225 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is further processed into a mature form.
Protein existence	Evidence at transcript level

General annotation (Comments)

Function	Displays several functions associated with host defense: it promotes agglutination, bacterial capsular swelling, phagocytosis and complement fixation through its calcium-dependent binding to phosphorylcholine. Can interact with DNA and histones and may scavenge nuclear material released from damaged circulating cells.
Cofactor	Binds 2 calcium ions per subunit By similarity.
Subunit structure	Homopentamer. Pentaxin (or pentraxin) have a discoid arrangement of 5 non-covalently bound subunits By similarity.
Subcellular location	Secreted.
Tissue specificity	Found in plasma.
Induction	The concentration of CRP in plasma increases greatly during acute phase response to tissue injury, infection or other inflammatory stimuli.
Sequence similarities	Belongs to the pentaxin family. Contains 1 pentaxin domain.

Ontologies

Keywords
Biological process	Acute phase
Cellular component	Secreted
Domain	Signal
Ligand	Calcium Metal-binding
PTM	Disulfide bond
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	acute-phase response Inferred from electronic annotation. Source: UniProtKB-KW aging Inferred from electronic annotation. Source: Compara cellular response to calcium ion Inferred from electronic annotation. Source: Compara cellular response to glucose stimulus Inferred from electronic annotation. Source: Compara complement activation, classical pathway Inferred from electronic annotation. Source: Compara negative regulation of lipid storage Inferred from electronic annotation. Source: Compara negative regulation of macrophage derived foam cell differentiation Inferred from electronic annotation. Source: Compara positive regulation of dendrite development Inferred from electronic annotation. Source: Compara protein polymerization Inferred from electronic annotation. Source: Compara response to ethanol Inferred from electronic annotation. Source: Compara response to hypoxia Inferred from electronic annotation. Source: Compara response to lead ion Inferred from electronic annotation. Source: Compara wound healing Inferred from electronic annotation. Source: Compara
Cellular_component	extracellular space Inferred from electronic annotation. Source: Compara filopodium Inferred from electronic annotation. Source: Compara growth cone Inferred from electronic annotation. Source: Compara mitochondrion Inferred from electronic annotation. Source: Compara plasma membrane Inferred from electronic annotation. Source: Compara
Molecular_function	cholesterol binding Inferred from electronic annotation. Source: Compara low-density lipoprotein particle binding Inferred from electronic annotation. Source: Compara metal ion binding Inferred from electronic annotation. Source: UniProtKB-KW
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Signal peptide	1 – 19	19
	Chain	20 – 225	206	C-reactive protein		PRO_0000023529
Regions
	Domain	20 – 225	206	Pentaxin
Sites
	Metal binding	80	1	Calcium 1 By similarity
	Metal binding	157	1	Calcium 1 By similarity
	Metal binding	157	1	Calcium 2 By similarity
	Metal binding	158	1	Calcium 1; via carbonyl oxygen By similarity
	Metal binding	159	1	Calcium 1 By similarity
	Metal binding	159	1	Calcium 2 By similarity
	Metal binding	169	1	Calcium 2 By similarity
Amino acid modifications
	Disulfide bond	55 ↔ 116		By similarity
Experimental info
	Sequence conflict	134	1	P → A in CAA31928. Ref.1
	Sequence conflict	191	1	S → N in CAA31928. Ref.1
	Sequence conflict	191	1	S → N in CAA35531. Ref.3

Sequences

	Sequence		Length	Mass (Da)
	P14847 [UniParc]. Last modified October 3, 2012. Version 2. Checksum: 0E5FC77BEB8052D8	FASTA	225	25,360
	10 20 30 40 50 60 MEKLLWCLLI MISFSRTFGH EDMFKKAFVF PKESDTSYVS LEAESKKPLN TFTVCLHFYT 70 80 90 100 110 120 ALSTVRSFSV FSYATKKNSN DILIFWNKDK QYTFGVGGAE VRFMVSEIPE APTHICASWE 130 140 150 160 170 180 SATGIVEFWI DGKPKVRKSL HKGYTVGPDA SIILGQEQDS YGGDFDAKQS LVGDIGDVNM 190 200 210 220 WDFVLSPEQI STVYVGGTLS PNVLNWRALN YKAQGDVFIK PQLWS

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Structure of the mouse C-reactive protein gene." Ohnishi S., Maeda S., Nishiguchi S., Arao T., Shimada K. Biochem. Biophys. Res. Commun. 156:814-822(1988) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
[2]	"Lineage-specific biology revealed by a finished genome assembly of the mouse." Church D.M., Goodstadt L., Hillier L.W., Zody M.C., Goldstein S., She X., Bult C.J., Agarwala R., Cherry J.L., DiCuccio M., Hlavina W., Kapustin Y., Meric P., Maglott D., Birtle Z., Marques A.C., Graves T., Zhou S. , Teague B., Potamousis K., Churas C., Place M., Herschleb J., Runnheim R., Forrest D., Amos-Landgraf J., Schwartz D.C., Cheng Z., Lindblad-Toh K., Eichler E.E., Ponting C.P. PLoS Biol. 7:E1000112-E1000112(2009) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: C57BL/6J.
[3]	"Mouse C-reactive protein. Generation of cDNA clones, structural analysis, and induction of mRNA during inflammation." Whitehead A.S., Zahedi K., Rits M., Mortensen R.F., Lelias J.M. Biochem. J. 266:283-290(1990) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA]. Strain: CBA/J. Tissue: Liver.
+	Additional computationally mapped references.

Web resources

Protein Spotlight

No more Christmas pudding? - Issue 30 of January 2003

Cross-references

Sequence databases
EMBL GenBank DDBJ	X13588 Genomic DNA. Translation: CAA31928.1. AC131177 Genomic DNA. No translation available. X17496 mRNA. Translation: CAA35531.1.
IPI	IPI00314936. IPI01008685.
PIR	A31583.
RefSeq	NP_031794.3. NM_007768.4.
UniGene	Mm.28767.
3D structure databases
ProteinModelPortal	P14847.
SMR	P14847. Positions 22-224.
ModBase	Search...
Protein-protein interaction databases
STRING	10090.ENSMUSP00000044665.
PTM databases
PhosphoSite	P14847.
Proteomic databases
PaxDb	P14847.
PRIDE	P14847.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENSMUST00000038495; ENSMUSP00000044665; ENSMUSG00000037942.
GeneID	12944.
KEGG	mmu:12944.
Organism-specific databases
CTD	1401.
MGI	MGI:88512. Crp.
Phylogenomic databases
eggNOG	NOG113288.
GeneTree	ENSGT00650000093195.
HOGENOM	HOG000247043.
HOVERGEN	HBG005405.
InParanoid	P14847.
KO	K16143.
OMA	YSFTVGG.
OrthoDB	EOG4R23VS.
Gene expression databases
CleanEx	MM_CRP.
Genevestigator	P14847.
GermOnline	ENSMUSG00000037942. Mus musculus.
Family and domain databases
Gene3D	2.60.120.200. 1 hit.
InterPro	IPR008985. ConA-like_lec_gl_sf. IPR013320. ConA-like_subgrp. IPR001759. Pentaxin. [Graphical view]
Pfam	PF00354. Pentaxin. 1 hit. [Graphical view]
PRINTS	PR00895. PENTAXIN.
SMART	SM00159. PTX. 1 hit. [Graphical view]
SUPFAM	SSF49899. ConA_like_lec_gl. 1 hit.
PROSITE	PS00289. PENTAXIN. 1 hit. [Graphical view]
ProtoNet	Search...
Other
NextBio	282638.
SOURCE	Search...

Entry information

Entry name

CRP_MOUSE

Accession

Primary (citable) accession number: P14847
Secondary accession number(s): E9PZ20

Entry history

Integrated into UniProtKB/Swiss-Prot:	April 1, 1990
Last sequence update:	October 3, 2012
Last modified:	May 1, 2013
This is version 110 of the entry and version 2 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program