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P14847

- CRP_MOUSE

UniProt

P14847 - CRP_MOUSE

Protein

C-reactive protein

Gene

Crp

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 121 (01 Oct 2014)
      Sequence version 2 (03 Oct 2012)
      Previous versions | rss
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    Functioni

    Displays several functions associated with host defense: it promotes agglutination, bacterial capsular swelling, phagocytosis and complement fixation through its calcium-dependent binding to phosphorylcholine. Can interact with DNA and histones and may scavenge nuclear material released from damaged circulating cells.

    Cofactori

    Binds 2 calcium ions per subunit.By similarity

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Metal bindingi80 – 801Calcium 1By similarity
    Metal bindingi157 – 1571Calcium 1By similarity
    Metal bindingi157 – 1571Calcium 2By similarity
    Metal bindingi158 – 1581Calcium 1; via carbonyl oxygenBy similarity
    Metal bindingi159 – 1591Calcium 1By similarity
    Metal bindingi159 – 1591Calcium 2By similarity
    Metal bindingi169 – 1691Calcium 2By similarity

    GO - Molecular functioni

    1. cholesterol binding Source: Ensembl
    2. low-density lipoprotein particle binding Source: Ensembl
    3. metal ion binding Source: UniProtKB-KW

    GO - Biological processi

    1. acute-phase response Source: UniProtKB-KW
    2. aging Source: Ensembl
    3. cellular response to calcium ion Source: Ensembl
    4. complement activation, classical pathway Source: Ensembl
    5. negative regulation of lipid storage Source: Ensembl
    6. negative regulation of macrophage derived foam cell differentiation Source: Ensembl
    7. positive regulation of dendrite development Source: Ensembl
    8. protein polymerization Source: Ensembl
    9. regulation of interleukin-8 secretion Source: UniProtKB
    10. response to ethanol Source: Ensembl
    11. response to hypoxia Source: Ensembl
    12. response to lead ion Source: Ensembl
    13. wound healing Source: Ensembl

    Keywords - Biological processi

    Acute phase

    Keywords - Ligandi

    Calcium, Metal-binding

    Enzyme and pathway databases

    ReactomeiREACT_209334. Classical antibody-mediated complement activation.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    C-reactive protein
    Gene namesi
    Name:Crp
    Synonyms:Ptx1
    OrganismiMus musculus (Mouse)
    Taxonomic identifieri10090 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
    ProteomesiUP000000589: Chromosome 1

    Organism-specific databases

    MGIiMGI:88512. Crp.

    Subcellular locationi

    GO - Cellular componenti

    1. extracellular space Source: Ensembl
    2. filopodium Source: Ensembl
    3. growth cone Source: Ensembl

    Keywords - Cellular componenti

    Secreted

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Signal peptidei1 – 1919Add
    BLAST
    Chaini20 – 225206C-reactive proteinPRO_0000023529Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Disulfide bondi55 ↔ 116By similarity

    Keywords - PTMi

    Disulfide bond

    Proteomic databases

    MaxQBiP14847.
    PaxDbiP14847.
    PRIDEiP14847.

    PTM databases

    PhosphoSiteiP14847.

    Expressioni

    Tissue specificityi

    Found in plasma.

    Inductioni

    The concentration of CRP in plasma increases greatly during acute phase response to tissue injury, infection or other inflammatory stimuli.

    Gene expression databases

    CleanExiMM_CRP.
    GenevestigatoriP14847.

    Interactioni

    Subunit structurei

    Homopentamer. Pentaxin (or pentraxin) have a discoid arrangement of 5 non-covalently bound subunits. Interacts with FCN1; may regulate monocyte activation by FCN1 By similarity.By similarity

    Protein-protein interaction databases

    STRINGi10090.ENSMUSP00000044665.

    Structurei

    3D structure databases

    ProteinModelPortaliP14847.
    SMRiP14847. Positions 22-224.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini20 – 225206PentaxinAdd
    BLAST

    Sequence similaritiesi

    Belongs to the pentaxin family.Curated
    Contains 1 pentaxin domain.Curated

    Keywords - Domaini

    Signal

    Phylogenomic databases

    eggNOGiNOG113288.
    GeneTreeiENSGT00650000093195.
    HOGENOMiHOG000247043.
    HOVERGENiHBG005405.
    InParanoidiP14847.
    KOiK16143.
    OMAiWRALKYE.
    OrthoDBiEOG71RXMB.
    TreeFamiTF330208.

    Family and domain databases

    Gene3Di2.60.120.200. 1 hit.
    InterProiIPR008985. ConA-like_lec_gl_sf.
    IPR013320. ConA-like_subgrp.
    IPR001759. Pentaxin.
    [Graphical view]
    PfamiPF00354. Pentaxin. 1 hit.
    [Graphical view]
    PRINTSiPR00895. PENTAXIN.
    SMARTiSM00159. PTX. 1 hit.
    [Graphical view]
    SUPFAMiSSF49899. SSF49899. 1 hit.
    PROSITEiPS00289. PENTAXIN. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    P14847-1 [UniParc]FASTAAdd to Basket

    « Hide

    MEKLLWCLLI MISFSRTFGH EDMFKKAFVF PKESDTSYVS LEAESKKPLN    50
    TFTVCLHFYT ALSTVRSFSV FSYATKKNSN DILIFWNKDK QYTFGVGGAE 100
    VRFMVSEIPE APTHICASWE SATGIVEFWI DGKPKVRKSL HKGYTVGPDA 150
    SIILGQEQDS YGGDFDAKQS LVGDIGDVNM WDFVLSPEQI STVYVGGTLS 200
    PNVLNWRALN YKAQGDVFIK PQLWS 225
    Length:225
    Mass (Da):25,360
    Last modified:October 3, 2012 - v2
    Checksum:i0E5FC77BEB8052D8
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti134 – 1341P → A in CAA31928. (PubMed:3190681)Curated
    Sequence conflicti191 – 1911S → N in CAA31928. (PubMed:3190681)Curated
    Sequence conflicti191 – 1911S → N in CAA35531. (PubMed:2310378)Curated

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    X13588 Genomic DNA. Translation: CAA31928.1.
    AC131177 Genomic DNA. No translation available.
    X17496 mRNA. Translation: CAA35531.1.
    CCDSiCCDS35787.1.
    PIRiA31583.
    RefSeqiNP_031794.3. NM_007768.4.
    UniGeneiMm.28767.

    Genome annotation databases

    EnsembliENSMUST00000038495; ENSMUSP00000044665; ENSMUSG00000037942.
    GeneIDi12944.
    KEGGimmu:12944.

    Cross-referencesi

    Web resourcesi

    Protein Spotlight

    No more Christmas pudding? - Issue 30 of January 2003

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    X13588 Genomic DNA. Translation: CAA31928.1 .
    AC131177 Genomic DNA. No translation available.
    X17496 mRNA. Translation: CAA35531.1 .
    CCDSi CCDS35787.1.
    PIRi A31583.
    RefSeqi NP_031794.3. NM_007768.4.
    UniGenei Mm.28767.

    3D structure databases

    ProteinModelPortali P14847.
    SMRi P14847. Positions 22-224.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 10090.ENSMUSP00000044665.

    PTM databases

    PhosphoSitei P14847.

    Proteomic databases

    MaxQBi P14847.
    PaxDbi P14847.
    PRIDEi P14847.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSMUST00000038495 ; ENSMUSP00000044665 ; ENSMUSG00000037942 .
    GeneIDi 12944.
    KEGGi mmu:12944.

    Organism-specific databases

    CTDi 1401.
    MGIi MGI:88512. Crp.

    Phylogenomic databases

    eggNOGi NOG113288.
    GeneTreei ENSGT00650000093195.
    HOGENOMi HOG000247043.
    HOVERGENi HBG005405.
    InParanoidi P14847.
    KOi K16143.
    OMAi WRALKYE.
    OrthoDBi EOG71RXMB.
    TreeFami TF330208.

    Enzyme and pathway databases

    Reactomei REACT_209334. Classical antibody-mediated complement activation.

    Miscellaneous databases

    NextBioi 282638.
    PROi P14847.
    SOURCEi Search...

    Gene expression databases

    CleanExi MM_CRP.
    Genevestigatori P14847.

    Family and domain databases

    Gene3Di 2.60.120.200. 1 hit.
    InterProi IPR008985. ConA-like_lec_gl_sf.
    IPR013320. ConA-like_subgrp.
    IPR001759. Pentaxin.
    [Graphical view ]
    Pfami PF00354. Pentaxin. 1 hit.
    [Graphical view ]
    PRINTSi PR00895. PENTAXIN.
    SMARTi SM00159. PTX. 1 hit.
    [Graphical view ]
    SUPFAMi SSF49899. SSF49899. 1 hit.
    PROSITEi PS00289. PENTAXIN. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: C57BL/6J.
    3. "Mouse C-reactive protein. Generation of cDNA clones, structural analysis, and induction of mRNA during inflammation."
      Whitehead A.S., Zahedi K., Rits M., Mortensen R.F., Lelias J.M.
      Biochem. J. 266:283-290(1990) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
      Strain: CBA/J.
      Tissue: Liver.

    Entry informationi

    Entry nameiCRP_MOUSE
    AccessioniPrimary (citable) accession number: P14847
    Secondary accession number(s): E9PZ20
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: April 1, 1990
    Last sequence update: October 3, 2012
    Last modified: October 1, 2014
    This is version 121 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. MGD cross-references
      Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
    2. Protein Spotlight
      Protein Spotlight articles and cited UniProtKB/Swiss-Prot entries
    3. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3