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Protein

C-reactive protein

Gene

Crp

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

Displays several functions associated with host defense: it promotes agglutination, bacterial capsular swelling, phagocytosis and complement fixation through its calcium-dependent binding to phosphorylcholine. Can interact with DNA and histones and may scavenge nuclear material released from damaged circulating cells.

Cofactori

Ca2+By similarityNote: Binds 2 calcium ions per subunit.By similarity

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi80Calcium 1By similarity1
Metal bindingi157Calcium 1By similarity1
Metal bindingi157Calcium 2By similarity1
Metal bindingi158Calcium 1; via carbonyl oxygenBy similarity1
Metal bindingi159Calcium 1By similarity1
Metal bindingi159Calcium 2By similarity1
Metal bindingi169Calcium 2By similarity1

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Acute phase

Keywords - Ligandi

Calcium, Metal-binding

Enzyme and pathway databases

ReactomeiR-MMU-173623. Classical antibody-mediated complement activation.

Names & Taxonomyi

Protein namesi
Recommended name:
C-reactive protein
Gene namesi
Name:Crp
Synonyms:Ptx1
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 1

Organism-specific databases

MGIiMGI:88512. Crp.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 19Add BLAST19
ChainiPRO_000002352920 – 225C-reactive proteinAdd BLAST206

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi55 ↔ 116By similarity

Keywords - PTMi

Disulfide bond

Proteomic databases

MaxQBiP14847.
PaxDbiP14847.
PRIDEiP14847.

PTM databases

PhosphoSitePlusiP14847.

Expressioni

Tissue specificityi

Found in plasma.

Inductioni

The concentration of CRP in plasma increases greatly during acute phase response to tissue injury, infection or other inflammatory stimuli.

Gene expression databases

BgeeiENSMUSG00000037942.
CleanExiMM_CRP.
GenevisibleiP14847. MM.

Interactioni

Subunit structurei

Homopentamer. Pentaxin (or pentraxin) have a discoid arrangement of 5 non-covalently bound subunits. Interacts with FCN1; may regulate monocyte activation by FCN1 (By similarity).By similarity

GO - Molecular functioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000044665.

Structurei

3D structure databases

ProteinModelPortaliP14847.
SMRiP14847.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini20 – 225PentaxinAdd BLAST206

Sequence similaritiesi

Belongs to the pentaxin family.Curated
Contains 1 pentaxin domain.Curated

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiENOG410J9V0. Eukaryota.
ENOG410YIJN. LUCA.
GeneTreeiENSGT00760000119128.
HOGENOMiHOG000247043.
HOVERGENiHBG005405.
InParanoidiP14847.
KOiK16143.
OMAiTKPLKAF.
OrthoDBiEOG091G0H6X.
TreeFamiTF330208.

Family and domain databases

CDDicd00152. PTX. 1 hit.
Gene3Di2.60.120.200. 1 hit.
InterProiIPR013320. ConA-like_dom.
IPR001759. Pentaxin-related.
IPR030476. Pentaxin_CS.
[Graphical view]
PfamiPF00354. Pentaxin. 1 hit.
[Graphical view]
PRINTSiPR00895. PENTAXIN.
SMARTiSM00159. PTX. 1 hit.
[Graphical view]
SUPFAMiSSF49899. SSF49899. 1 hit.
PROSITEiPS00289. PENTAXIN. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P14847-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MEKLLWCLLI MISFSRTFGH EDMFKKAFVF PKESDTSYVS LEAESKKPLN
60 70 80 90 100
TFTVCLHFYT ALSTVRSFSV FSYATKKNSN DILIFWNKDK QYTFGVGGAE
110 120 130 140 150
VRFMVSEIPE APTHICASWE SATGIVEFWI DGKPKVRKSL HKGYTVGPDA
160 170 180 190 200
SIILGQEQDS YGGDFDAKQS LVGDIGDVNM WDFVLSPEQI STVYVGGTLS
210 220
PNVLNWRALN YKAQGDVFIK PQLWS
Length:225
Mass (Da):25,360
Last modified:October 3, 2012 - v2
Checksum:i0E5FC77BEB8052D8
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti134P → A in CAA31928 (PubMed:3190681).Curated1
Sequence conflicti191S → N in CAA31928 (PubMed:3190681).Curated1
Sequence conflicti191S → N in CAA35531 (PubMed:2310378).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X13588 Genomic DNA. Translation: CAA31928.1.
AC131177 Genomic DNA. No translation available.
X17496 mRNA. Translation: CAA35531.1.
CCDSiCCDS35787.1.
PIRiA31583.
RefSeqiNP_031794.3. NM_007768.4.
UniGeneiMm.28767.

Genome annotation databases

EnsembliENSMUST00000038495; ENSMUSP00000044665; ENSMUSG00000037942.
GeneIDi12944.
KEGGimmu:12944.
UCSCiuc011wwq.1. mouse.

Cross-referencesi

Web resourcesi

Protein Spotlight

No more Christmas pudding? - Issue 30 of January 2003

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X13588 Genomic DNA. Translation: CAA31928.1.
AC131177 Genomic DNA. No translation available.
X17496 mRNA. Translation: CAA35531.1.
CCDSiCCDS35787.1.
PIRiA31583.
RefSeqiNP_031794.3. NM_007768.4.
UniGeneiMm.28767.

3D structure databases

ProteinModelPortaliP14847.
SMRiP14847.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000044665.

PTM databases

PhosphoSitePlusiP14847.

Proteomic databases

MaxQBiP14847.
PaxDbiP14847.
PRIDEiP14847.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000038495; ENSMUSP00000044665; ENSMUSG00000037942.
GeneIDi12944.
KEGGimmu:12944.
UCSCiuc011wwq.1. mouse.

Organism-specific databases

CTDi1401.
MGIiMGI:88512. Crp.

Phylogenomic databases

eggNOGiENOG410J9V0. Eukaryota.
ENOG410YIJN. LUCA.
GeneTreeiENSGT00760000119128.
HOGENOMiHOG000247043.
HOVERGENiHBG005405.
InParanoidiP14847.
KOiK16143.
OMAiTKPLKAF.
OrthoDBiEOG091G0H6X.
TreeFamiTF330208.

Enzyme and pathway databases

ReactomeiR-MMU-173623. Classical antibody-mediated complement activation.

Miscellaneous databases

PROiP14847.
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000037942.
CleanExiMM_CRP.
GenevisibleiP14847. MM.

Family and domain databases

CDDicd00152. PTX. 1 hit.
Gene3Di2.60.120.200. 1 hit.
InterProiIPR013320. ConA-like_dom.
IPR001759. Pentaxin-related.
IPR030476. Pentaxin_CS.
[Graphical view]
PfamiPF00354. Pentaxin. 1 hit.
[Graphical view]
PRINTSiPR00895. PENTAXIN.
SMARTiSM00159. PTX. 1 hit.
[Graphical view]
SUPFAMiSSF49899. SSF49899. 1 hit.
PROSITEiPS00289. PENTAXIN. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiCRP_MOUSE
AccessioniPrimary (citable) accession number: P14847
Secondary accession number(s): E9PZ20
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 1, 1990
Last sequence update: October 3, 2012
Last modified: November 30, 2016
This is version 138 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. Protein Spotlight
    Protein Spotlight articles and cited UniProtKB/Swiss-Prot entries
  3. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.