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Protein

C-reactive protein

Gene

Crp

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at transcript leveli

Functioni

Displays several functions associated with host defense: it promotes agglutination, bacterial capsular swelling, phagocytosis and complement fixation through its calcium-dependent binding to phosphorylcholine. Can interact with DNA and histones and may scavenge nuclear material released from damaged circulating cells.

Cofactori

Ca2+By similarityNote: Binds 2 calcium ions per subunit.By similarity

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi80 – 801Calcium 1By similarity
Metal bindingi157 – 1571Calcium 1By similarity
Metal bindingi157 – 1571Calcium 2By similarity
Metal bindingi158 – 1581Calcium 1; via carbonyl oxygenBy similarity
Metal bindingi159 – 1591Calcium 1By similarity
Metal bindingi159 – 1591Calcium 2By similarity
Metal bindingi169 – 1691Calcium 2By similarity

GO - Molecular functioni

  1. calcium ion binding Source: MGI
  2. cholesterol binding Source: Ensembl
  3. complement component C1q binding Source: MGI
  4. low-density lipoprotein particle binding Source: MGI
  5. low-density lipoprotein particle receptor binding Source: MGI

GO - Biological processi

  1. acute-phase response Source: UniProtKB-KW
  2. aging Source: Ensembl
  3. cellular response to calcium ion Source: Ensembl
  4. complement activation, classical pathway Source: Ensembl
  5. negative regulation of lipid storage Source: MGI
  6. negative regulation of macrophage derived foam cell differentiation Source: MGI
  7. negative regulation of vasodilation Source: MGI
  8. positive regulation of dendrite development Source: Ensembl
  9. positive regulation of gene expression Source: MGI
  10. positive regulation of superoxide anion generation Source: MGI
  11. protein polymerization Source: Ensembl
  12. regulation of interleukin-8 secretion Source: UniProtKB
  13. response to ethanol Source: Ensembl
  14. response to hypoxia Source: Ensembl
  15. response to lead ion Source: Ensembl
  16. wound healing Source: Ensembl
Complete GO annotation...

Keywords - Biological processi

Acute phase

Keywords - Ligandi

Calcium, Metal-binding

Enzyme and pathway databases

ReactomeiREACT_316742. Classical antibody-mediated complement activation.

Names & Taxonomyi

Protein namesi
Recommended name:
C-reactive protein
Gene namesi
Name:Crp
Synonyms:Ptx1
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589 Componenti: Chromosome 1

Organism-specific databases

MGIiMGI:88512. Crp.

Subcellular locationi

GO - Cellular componenti

  1. extracellular space Source: MGI
  2. extracellular vesicular exosome Source: MGI
  3. filopodium Source: Ensembl
  4. growth cone Source: Ensembl
Complete GO annotation...

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 1919Add
BLAST
Chaini20 – 225206C-reactive proteinPRO_0000023529Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Disulfide bondi55 ↔ 116By similarity

Keywords - PTMi

Disulfide bond

Proteomic databases

MaxQBiP14847.
PaxDbiP14847.
PRIDEiP14847.

PTM databases

PhosphoSiteiP14847.

Expressioni

Tissue specificityi

Found in plasma.

Inductioni

The concentration of CRP in plasma increases greatly during acute phase response to tissue injury, infection or other inflammatory stimuli.

Gene expression databases

CleanExiMM_CRP.
GenevestigatoriP14847.

Interactioni

Subunit structurei

Homopentamer. Pentaxin (or pentraxin) have a discoid arrangement of 5 non-covalently bound subunits. Interacts with FCN1; may regulate monocyte activation by FCN1 (By similarity).By similarity

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000044665.

Structurei

3D structure databases

ProteinModelPortaliP14847.
SMRiP14847. Positions 22-224.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini20 – 225206PentaxinAdd
BLAST

Sequence similaritiesi

Belongs to the pentaxin family.Curated
Contains 1 pentaxin domain.Curated

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiNOG113288.
GeneTreeiENSGT00760000119128.
HOGENOMiHOG000247043.
HOVERGENiHBG005405.
InParanoidiP14847.
KOiK16143.
OMAiTKPLKAF.
OrthoDBiEOG71RXMB.
TreeFamiTF330208.

Family and domain databases

Gene3Di2.60.120.200. 1 hit.
InterProiIPR013320. ConA-like_dom.
IPR001759. Pentaxin.
IPR030476. Pentaxin_CS.
[Graphical view]
PfamiPF00354. Pentaxin. 1 hit.
[Graphical view]
PRINTSiPR00895. PENTAXIN.
SMARTiSM00159. PTX. 1 hit.
[Graphical view]
SUPFAMiSSF49899. SSF49899. 1 hit.
PROSITEiPS00289. PENTAXIN. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P14847-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MEKLLWCLLI MISFSRTFGH EDMFKKAFVF PKESDTSYVS LEAESKKPLN
60 70 80 90 100
TFTVCLHFYT ALSTVRSFSV FSYATKKNSN DILIFWNKDK QYTFGVGGAE
110 120 130 140 150
VRFMVSEIPE APTHICASWE SATGIVEFWI DGKPKVRKSL HKGYTVGPDA
160 170 180 190 200
SIILGQEQDS YGGDFDAKQS LVGDIGDVNM WDFVLSPEQI STVYVGGTLS
210 220
PNVLNWRALN YKAQGDVFIK PQLWS
Length:225
Mass (Da):25,360
Last modified:October 2, 2012 - v2
Checksum:i0E5FC77BEB8052D8
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti134 – 1341P → A in CAA31928 (PubMed:3190681).Curated
Sequence conflicti191 – 1911S → N in CAA31928 (PubMed:3190681).Curated
Sequence conflicti191 – 1911S → N in CAA35531 (PubMed:2310378).Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X13588 Genomic DNA. Translation: CAA31928.1.
AC131177 Genomic DNA. No translation available.
X17496 mRNA. Translation: CAA35531.1.
CCDSiCCDS35787.1.
PIRiA31583.
RefSeqiNP_031794.3. NM_007768.4.
UniGeneiMm.28767.

Genome annotation databases

EnsembliENSMUST00000038495; ENSMUSP00000044665; ENSMUSG00000037942.
GeneIDi12944.
KEGGimmu:12944.

Cross-referencesi

Web resourcesi

Protein Spotlight

No more Christmas pudding? - Issue 30 of January 2003

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X13588 Genomic DNA. Translation: CAA31928.1.
AC131177 Genomic DNA. No translation available.
X17496 mRNA. Translation: CAA35531.1.
CCDSiCCDS35787.1.
PIRiA31583.
RefSeqiNP_031794.3. NM_007768.4.
UniGeneiMm.28767.

3D structure databases

ProteinModelPortaliP14847.
SMRiP14847. Positions 22-224.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000044665.

PTM databases

PhosphoSiteiP14847.

Proteomic databases

MaxQBiP14847.
PaxDbiP14847.
PRIDEiP14847.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000038495; ENSMUSP00000044665; ENSMUSG00000037942.
GeneIDi12944.
KEGGimmu:12944.

Organism-specific databases

CTDi1401.
MGIiMGI:88512. Crp.

Phylogenomic databases

eggNOGiNOG113288.
GeneTreeiENSGT00760000119128.
HOGENOMiHOG000247043.
HOVERGENiHBG005405.
InParanoidiP14847.
KOiK16143.
OMAiTKPLKAF.
OrthoDBiEOG71RXMB.
TreeFamiTF330208.

Enzyme and pathway databases

ReactomeiREACT_316742. Classical antibody-mediated complement activation.

Miscellaneous databases

NextBioi282638.
PROiP14847.
SOURCEiSearch...

Gene expression databases

CleanExiMM_CRP.
GenevestigatoriP14847.

Family and domain databases

Gene3Di2.60.120.200. 1 hit.
InterProiIPR013320. ConA-like_dom.
IPR001759. Pentaxin.
IPR030476. Pentaxin_CS.
[Graphical view]
PfamiPF00354. Pentaxin. 1 hit.
[Graphical view]
PRINTSiPR00895. PENTAXIN.
SMARTiSM00159. PTX. 1 hit.
[Graphical view]
SUPFAMiSSF49899. SSF49899. 1 hit.
PROSITEiPS00289. PENTAXIN. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
  2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: C57BL/6J.
  3. "Mouse C-reactive protein. Generation of cDNA clones, structural analysis, and induction of mRNA during inflammation."
    Whitehead A.S., Zahedi K., Rits M., Mortensen R.F., Lelias J.M.
    Biochem. J. 266:283-290(1989) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Strain: CBA/J.
    Tissue: Liver.

Entry informationi

Entry nameiCRP_MOUSE
AccessioniPrimary (citable) accession number: P14847
Secondary accession number(s): E9PZ20
Entry historyi
Integrated into UniProtKB/Swiss-Prot: March 31, 1990
Last sequence update: October 2, 2012
Last modified: March 31, 2015
This is version 127 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. Protein Spotlight
    Protein Spotlight articles and cited UniProtKB/Swiss-Prot entries
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.