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P14847

- CRP_MOUSE

UniProt

P14847 - CRP_MOUSE

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Protein
C-reactive protein
Gene
Crp, Ptx1
Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 5 out of 5 - Experimental evidence at transcript leveli

Functioni

Displays several functions associated with host defense: it promotes agglutination, bacterial capsular swelling, phagocytosis and complement fixation through its calcium-dependent binding to phosphorylcholine. Can interact with DNA and histones and may scavenge nuclear material released from damaged circulating cells.

Cofactori

Binds 2 calcium ions per subunit By similarity.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi80 – 801Calcium 1 By similarity
Metal bindingi157 – 1571Calcium 1 By similarity
Metal bindingi157 – 1571Calcium 2 By similarity
Metal bindingi158 – 1581Calcium 1; via carbonyl oxygen By similarity
Metal bindingi159 – 1591Calcium 1 By similarity
Metal bindingi159 – 1591Calcium 2 By similarity
Metal bindingi169 – 1691Calcium 2 By similarity

GO - Molecular functioni

  1. cholesterol binding Source: Ensembl
  2. low-density lipoprotein particle binding Source: Ensembl
  3. metal ion binding Source: UniProtKB-KW

GO - Biological processi

  1. acute-phase response Source: UniProtKB-KW
  2. aging Source: Ensembl
  3. cellular response to calcium ion Source: Ensembl
  4. complement activation, classical pathway Source: Ensembl
  5. negative regulation of lipid storage Source: Ensembl
  6. negative regulation of macrophage derived foam cell differentiation Source: Ensembl
  7. positive regulation of dendrite development Source: Ensembl
  8. protein polymerization Source: Ensembl
  9. response to ethanol Source: Ensembl
  10. response to hypoxia Source: Ensembl
  11. response to lead ion Source: Ensembl
  12. wound healing Source: Ensembl
Complete GO annotation...

Keywords - Biological processi

Acute phase

Keywords - Ligandi

Calcium, Metal-binding

Enzyme and pathway databases

ReactomeiREACT_209334. Classical antibody-mediated complement activation.

Names & Taxonomyi

Protein namesi
Recommended name:
C-reactive protein
Gene namesi
Name:Crp
Synonyms:Ptx1
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589: Chromosome 1

Organism-specific databases

MGIiMGI:88512. Crp.

Subcellular locationi

GO - Cellular componenti

  1. extracellular space Source: Ensembl
  2. filopodium Source: Ensembl
  3. growth cone Source: Ensembl
Complete GO annotation...

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 1919
Add
BLAST
Chaini20 – 225206C-reactive protein
PRO_0000023529Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Disulfide bondi55 ↔ 116 By similarity

Keywords - PTMi

Disulfide bond

Proteomic databases

MaxQBiP14847.
PaxDbiP14847.
PRIDEiP14847.

PTM databases

PhosphoSiteiP14847.

Expressioni

Tissue specificityi

Found in plasma.

Inductioni

The concentration of CRP in plasma increases greatly during acute phase response to tissue injury, infection or other inflammatory stimuli.

Gene expression databases

CleanExiMM_CRP.
GenevestigatoriP14847.

Interactioni

Subunit structurei

Homopentamer. Pentaxin (or pentraxin) have a discoid arrangement of 5 non-covalently bound subunits By similarity.

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000044665.

Structurei

3D structure databases

ProteinModelPortaliP14847.
SMRiP14847. Positions 22-224.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini20 – 225206Pentaxin
Add
BLAST

Sequence similaritiesi

Belongs to the pentaxin family.
Contains 1 pentaxin domain.

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiNOG113288.
GeneTreeiENSGT00650000093195.
HOGENOMiHOG000247043.
HOVERGENiHBG005405.
InParanoidiP14847.
KOiK16143.
OMAiWRALKYE.
OrthoDBiEOG71RXMB.
TreeFamiTF330208.

Family and domain databases

Gene3Di2.60.120.200. 1 hit.
InterProiIPR008985. ConA-like_lec_gl_sf.
IPR013320. ConA-like_subgrp.
IPR001759. Pentaxin.
[Graphical view]
PfamiPF00354. Pentaxin. 1 hit.
[Graphical view]
PRINTSiPR00895. PENTAXIN.
SMARTiSM00159. PTX. 1 hit.
[Graphical view]
SUPFAMiSSF49899. SSF49899. 1 hit.
PROSITEiPS00289. PENTAXIN. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P14847-1 [UniParc]FASTAAdd to Basket

« Hide

MEKLLWCLLI MISFSRTFGH EDMFKKAFVF PKESDTSYVS LEAESKKPLN    50
TFTVCLHFYT ALSTVRSFSV FSYATKKNSN DILIFWNKDK QYTFGVGGAE 100
VRFMVSEIPE APTHICASWE SATGIVEFWI DGKPKVRKSL HKGYTVGPDA 150
SIILGQEQDS YGGDFDAKQS LVGDIGDVNM WDFVLSPEQI STVYVGGTLS 200
PNVLNWRALN YKAQGDVFIK PQLWS 225
Length:225
Mass (Da):25,360
Last modified:October 3, 2012 - v2
Checksum:i0E5FC77BEB8052D8
GO

Sequence conflict

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti134 – 1341P → A in CAA31928. 1 Publication
Sequence conflicti191 – 1911S → N in CAA31928. 1 Publication
Sequence conflicti191 – 1911S → N in CAA35531. 1 Publication

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
X13588 Genomic DNA. Translation: CAA31928.1.
AC131177 Genomic DNA. No translation available.
X17496 mRNA. Translation: CAA35531.1.
CCDSiCCDS35787.1.
PIRiA31583.
RefSeqiNP_031794.3. NM_007768.4.
UniGeneiMm.28767.

Genome annotation databases

EnsembliENSMUST00000038495; ENSMUSP00000044665; ENSMUSG00000037942.
GeneIDi12944.
KEGGimmu:12944.

Cross-referencesi

Web resourcesi

Protein Spotlight

No more Christmas pudding? - Issue 30 of January 2003

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
X13588 Genomic DNA. Translation: CAA31928.1 .
AC131177 Genomic DNA. No translation available.
X17496 mRNA. Translation: CAA35531.1 .
CCDSi CCDS35787.1.
PIRi A31583.
RefSeqi NP_031794.3. NM_007768.4.
UniGenei Mm.28767.

3D structure databases

ProteinModelPortali P14847.
SMRi P14847. Positions 22-224.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 10090.ENSMUSP00000044665.

PTM databases

PhosphoSitei P14847.

Proteomic databases

MaxQBi P14847.
PaxDbi P14847.
PRIDEi P14847.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSMUST00000038495 ; ENSMUSP00000044665 ; ENSMUSG00000037942 .
GeneIDi 12944.
KEGGi mmu:12944.

Organism-specific databases

CTDi 1401.
MGIi MGI:88512. Crp.

Phylogenomic databases

eggNOGi NOG113288.
GeneTreei ENSGT00650000093195.
HOGENOMi HOG000247043.
HOVERGENi HBG005405.
InParanoidi P14847.
KOi K16143.
OMAi WRALKYE.
OrthoDBi EOG71RXMB.
TreeFami TF330208.

Enzyme and pathway databases

Reactomei REACT_209334. Classical antibody-mediated complement activation.

Miscellaneous databases

NextBioi 282638.
PROi P14847.
SOURCEi Search...

Gene expression databases

CleanExi MM_CRP.
Genevestigatori P14847.

Family and domain databases

Gene3Di 2.60.120.200. 1 hit.
InterProi IPR008985. ConA-like_lec_gl_sf.
IPR013320. ConA-like_subgrp.
IPR001759. Pentaxin.
[Graphical view ]
Pfami PF00354. Pentaxin. 1 hit.
[Graphical view ]
PRINTSi PR00895. PENTAXIN.
SMARTi SM00159. PTX. 1 hit.
[Graphical view ]
SUPFAMi SSF49899. SSF49899. 1 hit.
PROSITEi PS00289. PENTAXIN. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
  2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: C57BL/6J.
  3. "Mouse C-reactive protein. Generation of cDNA clones, structural analysis, and induction of mRNA during inflammation."
    Whitehead A.S., Zahedi K., Rits M., Mortensen R.F., Lelias J.M.
    Biochem. J. 266:283-290(1990) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Strain: CBA/J.
    Tissue: Liver.

Entry informationi

Entry nameiCRP_MOUSE
AccessioniPrimary (citable) accession number: P14847
Secondary accession number(s): E9PZ20
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 1, 1990
Last sequence update: October 3, 2012
Last modified: September 3, 2014
This is version 120 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. Protein Spotlight
    Protein Spotlight articles and cited UniProtKB/Swiss-Prot entries
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi