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P14844

- CCL2_RAT

UniProt

P14844 - CCL2_RAT

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Protein

C-C motif chemokine 2

Gene

Ccl2

Organism
Rattus norvegicus (Rat)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at transcript leveli

Functioni

Chemotactic factor that attracts monocytes, but not neutrophils.

GO - Molecular functioni

  1. CCR2 chemokine receptor binding Source: RGD
  2. chemokine activity Source: RGD
  3. heparin binding Source: RGD

GO - Biological processi

  1. aging Source: RGD
  2. astrocyte cell migration Source: Ensembl
  3. cellular calcium ion homeostasis Source: RGD
  4. cellular response to ATP Source: RGD
  5. cellular response to dexamethasone stimulus Source: RGD
  6. cellular response to drug Source: RGD
  7. cellular response to fibroblast growth factor stimulus Source: Ensembl
  8. cellular response to high density lipoprotein particle stimulus Source: RGD
  9. cellular response to insulin stimulus Source: RGD
  10. cellular response to interferon-gamma Source: RGD
  11. cellular response to interleukin-1 Source: RGD
  12. cellular response to interleukin-6 Source: RGD
  13. cellular response to lipopolysaccharide Source: RGD
  14. cellular response to lipoprotein particle stimulus Source: RGD
  15. cellular response to macrophage colony-stimulating factor stimulus Source: RGD
  16. cellular response to platelet-derived growth factor stimulus Source: RGD
  17. cellular response to retinoic acid Source: RGD
  18. cellular response to tumor necrosis factor Source: RGD
  19. chemokine-mediated signaling pathway Source: RGD
  20. chemokinesis Source: RGD
  21. cytokine-mediated signaling pathway Source: RGD
  22. cytoskeleton organization Source: Ensembl
  23. glial cell migration Source: RGD
  24. helper T cell extravasation Source: Ensembl
  25. inflammatory response Source: RGD
  26. leukocyte migration involved in inflammatory response Source: RGD
  27. lipopolysaccharide-mediated signaling pathway Source: Ensembl
  28. lymphocyte chemotaxis Source: RGD
  29. macrophage chemotaxis Source: RGD
  30. MAPK cascade Source: Ensembl
  31. maternal process involved in female pregnancy Source: RGD
  32. maternal process involved in parturition Source: RGD
  33. monocyte chemotaxis Source: Ensembl
  34. negative regulation of angiogenesis Source: Ensembl
  35. negative regulation of glial cell apoptotic process Source: Ensembl
  36. negative regulation of natural killer cell chemotaxis Source: Ensembl
  37. negative regulation of neuron apoptotic process Source: Ensembl
  38. neutrophil chemotaxis Source: RGD
  39. organ regeneration Source: RGD
  40. positive regulation of apoptotic cell clearance Source: Ensembl
  41. positive regulation of calcium ion import Source: Ensembl
  42. positive regulation of cell adhesion Source: RGD
  43. positive regulation of cell-cell adhesion Source: RGD
  44. positive regulation of cellular extravasation Source: RGD
  45. positive regulation of collagen biosynthetic process Source: RGD
  46. positive regulation of endothelial cell proliferation Source: RGD
  47. positive regulation of immune complex clearance by monocytes and macrophages Source: Ensembl
  48. positive regulation of leukocyte mediated cytotoxicity Source: RGD
  49. positive regulation of leukocyte migration Source: RGD
  50. positive regulation of macrophage chemotaxis Source: RGD
  51. positive regulation of monocyte chemotaxis Source: RGD
  52. positive regulation of nitric-oxide synthase biosynthetic process Source: Ensembl
  53. positive regulation of synaptic transmission Source: RGD
  54. positive regulation of T cell activation Source: Ensembl
  55. positive regulation of tumor necrosis factor production Source: RGD
  56. protein kinase B signaling Source: Ensembl
  57. regulation of cell shape Source: Ensembl
  58. regulation of vascular endothelial growth factor production Source: Ensembl
  59. response to activity Source: RGD
  60. response to amino acid Source: RGD
  61. response to antibiotic Source: RGD
  62. response to drug Source: RGD
  63. response to ethanol Source: RGD
  64. response to gamma radiation Source: RGD
  65. response to glucocorticoid Source: RGD
  66. response to heat Source: RGD
  67. response to hypoxia Source: RGD
  68. response to lipopolysaccharide Source: RGD
  69. response to mechanical stimulus Source: RGD
  70. response to progesterone Source: RGD
  71. response to vitamin B3 Source: RGD
  72. response to wounding Source: Ensembl
  73. transforming growth factor beta receptor signaling pathway Source: RGD
  74. vascular endothelial growth factor receptor signaling pathway Source: RGD
Complete GO annotation...

Keywords - Molecular functioni

Cytokine

Keywords - Biological processi

Chemotaxis, Inflammatory response

Enzyme and pathway databases

ReactomeiREACT_100810. ATF4 activates genes.

Names & Taxonomyi

Protein namesi
Recommended name:
C-C motif chemokine 2
Alternative name(s):
Immediate-early serum-responsive protein JE
Monocyte chemoattractant protein 1
Monocyte chemotactic protein 1
Short name:
MCP-1
Small-inducible cytokine A2
Gene namesi
Name:Ccl2
Synonyms:Je, Mcp1, Scya2
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
ProteomesiUP000002494: Chromosome 10

Organism-specific databases

RGDi3645. Ccl2.

Subcellular locationi

GO - Cellular componenti

  1. axon terminus Source: RGD
  2. cytoplasm Source: RGD
  3. dendrite Source: RGD
  4. endocytic vesicle Source: RGD
  5. extracellular space Source: RGD
  6. neuronal cell body Source: RGD
  7. perikaryon Source: RGD
  8. perinuclear region of cytoplasm Source: RGD
  9. rough endoplasmic reticulum Source: RGD
  10. synapse Source: RGD
Complete GO annotation...

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2323By similarityAdd
BLAST
Chaini24 – 148125C-C motif chemokine 2PRO_0000005151Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei24 – 241Pyrrolidone carboxylic acidBy similarity
Disulfide bondi34 ↔ 59By similarity
Disulfide bondi35 ↔ 75By similarity
Glycosylationi126 – 1261N-linked (GlcNAc...)Sequence Analysis

Keywords - PTMi

Disulfide bond, Glycoprotein, Pyrrolidone carboxylic acid

Proteomic databases

PaxDbiP14844.
PRIDEiP14844.

PTM databases

PhosphoSiteiP14844.

Expressioni

Gene expression databases

GenevestigatoriP14844.

Interactioni

Subunit structurei

Monomer or homodimer; in equilibrium.By similarity

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000009448.

Structurei

3D structure databases

ProteinModelPortaliP14844.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiNOG46819.
GeneTreeiENSGT00730000110714.
HOGENOMiHOG000036686.
HOVERGENiHBG017871.
InParanoidiP14844.
KOiK14624.
OMAiTHKSEAN.
OrthoDBiEOG7673DP.
PhylomeDBiP14844.
TreeFamiTF339372.

Family and domain databases

InterProiIPR000827. Chemokine_CC_CS.
IPR001811. Chemokine_IL8-like_dom.
[Graphical view]
PfamiPF00048. IL8. 1 hit.
[Graphical view]
SMARTiSM00199. SCY. 1 hit.
[Graphical view]
SUPFAMiSSF54117. SSF54117. 1 hit.
PROSITEiPS00472. SMALL_CYTOKINES_CC. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P14844-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MQVSVTLLGL LFTVAACSIH VLSQPDAVNA PLTCCYSFTG KMIPMSRLEN
60 70 80 90 100
YKRITSSRCP KEAVVFVTKL KREICADPNK EWVQKYIRKL DQNQVRSETT
110 120 130 140
VFYKIASTLR TSAPLNVNLT HKSEANASTL FSTTTSSTSV EVTSMTEN
Length:148
Mass (Da):16,460
Last modified:April 1, 1990 - v1
Checksum:i62D4C42BF4B11C9D
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
X17053 Genomic DNA. Translation: CAA34901.1.
M57441 mRNA. Translation: AAA63496.1.
AF058786 mRNA. Translation: AAC15187.1.
PIRiS07723.
RefSeqiNP_113718.1. NM_031530.1.
UniGeneiRn.4772.

Genome annotation databases

EnsembliENSRNOT00000009448; ENSRNOP00000009448; ENSRNOG00000007159.
GeneIDi24770.
KEGGirno:24770.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
X17053 Genomic DNA. Translation: CAA34901.1 .
M57441 mRNA. Translation: AAA63496.1 .
AF058786 mRNA. Translation: AAC15187.1 .
PIRi S07723.
RefSeqi NP_113718.1. NM_031530.1.
UniGenei Rn.4772.

3D structure databases

ProteinModelPortali P14844.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 10116.ENSRNOP00000009448.

PTM databases

PhosphoSitei P14844.

Proteomic databases

PaxDbi P14844.
PRIDEi P14844.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSRNOT00000009448 ; ENSRNOP00000009448 ; ENSRNOG00000007159 .
GeneIDi 24770.
KEGGi rno:24770.

Organism-specific databases

CTDi 6347.
RGDi 3645. Ccl2.

Phylogenomic databases

eggNOGi NOG46819.
GeneTreei ENSGT00730000110714.
HOGENOMi HOG000036686.
HOVERGENi HBG017871.
InParanoidi P14844.
KOi K14624.
OMAi THKSEAN.
OrthoDBi EOG7673DP.
PhylomeDBi P14844.
TreeFami TF339372.

Enzyme and pathway databases

Reactomei REACT_100810. ATF4 activates genes.

Miscellaneous databases

NextBioi 604340.
PROi P14844.

Gene expression databases

Genevestigatori P14844.

Family and domain databases

InterProi IPR000827. Chemokine_CC_CS.
IPR001811. Chemokine_IL8-like_dom.
[Graphical view ]
Pfami PF00048. IL8. 1 hit.
[Graphical view ]
SMARTi SM00199. SCY. 1 hit.
[Graphical view ]
SUPFAMi SSF54117. SSF54117. 1 hit.
PROSITEi PS00472. SMALL_CYTOKINES_CC. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Analysis of the rat JE gene promoter identifies an AP-1 binding site essential for basal expression but not for TPA induction."
    Timmers H.T.M., Pronk G.J., Bos J.L., van der Eb A.J.
    Nucleic Acids Res. 18:23-34(1990) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    Strain: WAG/RIJ.
    Tissue: Kidney.
  2. "Molecular cloning of rat monocyte chemoattractant protein-1 (MCP-1) and its expression in rat spleen cells and tumor cell lines."
    Yoshimura T., Takeya M., Takahashi K.
    Biochem. Biophys. Res. Commun. 174:504-509(1991) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
  3. "Cloning of the full-length rat JE/MCP-1 cDNA."
    Poon M., Taubman M.B.
    Submitted (APR-1998) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Strain: Sprague-Dawley.
    Tissue: Aortic smooth muscle.

Entry informationi

Entry nameiCCL2_RAT
AccessioniPrimary (citable) accession number: P14844
Secondary accession number(s): Q549R5
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 1, 1990
Last sequence update: April 1, 1990
Last modified: October 29, 2014
This is version 120 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3