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Protein

C-C motif chemokine 2

Gene

Ccl2

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at transcript leveli

Functioni

Chemotactic factor that attracts monocytes, but not neutrophils.

GO - Molecular functioni

  • CCR2 chemokine receptor binding Source: RGD
  • chemokine activity Source: RGD
  • cytokine activity Source: RGD
  • G-protein coupled receptor binding Source: RGD
  • heparin binding Source: RGD

GO - Biological processi

  • aging Source: RGD
  • animal organ regeneration Source: RGD
  • astrocyte cell migration Source: RGD
  • cellular calcium ion homeostasis Source: RGD
  • cellular response to ATP Source: RGD
  • cellular response to dexamethasone stimulus Source: RGD
  • cellular response to drug Source: RGD
  • cellular response to estradiol stimulus Source: RGD
  • cellular response to fatty acid Source: RGD
  • cellular response to fibroblast growth factor stimulus Source: RGD
  • cellular response to glucose stimulus Source: RGD
  • cellular response to high density lipoprotein particle stimulus Source: RGD
  • cellular response to insulin stimulus Source: RGD
  • cellular response to interferon-gamma Source: RGD
  • cellular response to interleukin-1 Source: RGD
  • cellular response to interleukin-6 Source: RGD
  • cellular response to lipopolysaccharide Source: RGD
  • cellular response to lipoprotein particle stimulus Source: RGD
  • cellular response to macrophage colony-stimulating factor stimulus Source: RGD
  • cellular response to organic cyclic compound Source: RGD
  • cellular response to platelet-derived growth factor stimulus Source: RGD
  • cellular response to retinoic acid Source: RGD
  • cellular response to tumor necrosis factor Source: RGD
  • chemokine-mediated signaling pathway Source: RGD
  • chemokinesis Source: RGD
  • chronic inflammatory response Source: RGD
  • cytokine-mediated signaling pathway Source: RGD
  • cytoskeleton organization Source: RGD
  • glial cell migration Source: RGD
  • G-protein coupled receptor signaling pathway Source: GO_Central
  • helper T cell extravasation Source: RGD
  • inflammatory response Source: RGD
  • leukocyte migration involved in inflammatory response Source: RGD
  • lipopolysaccharide-mediated signaling pathway Source: RGD
  • lymphocyte chemotaxis Source: RGD
  • macrophage chemotaxis Source: RGD
  • MAPK cascade Source: RGD
  • maternal process involved in female pregnancy Source: RGD
  • maternal process involved in parturition Source: RGD
  • monocyte chemotaxis Source: RGD
  • negative regulation of angiogenesis Source: RGD
  • negative regulation of glial cell apoptotic process Source: RGD
  • negative regulation of natural killer cell chemotaxis Source: RGD
  • negative regulation of neuron apoptotic process Source: RGD
  • neutrophil chemotaxis Source: RGD
  • positive regulation of apoptotic cell clearance Source: RGD
  • positive regulation of calcium ion import Source: RGD
  • positive regulation of cell adhesion Source: RGD
  • positive regulation of cell-cell adhesion Source: RGD
  • positive regulation of cellular extravasation Source: RGD
  • positive regulation of collagen biosynthetic process Source: RGD
  • positive regulation of endothelial cell proliferation Source: RGD
  • positive regulation of ERK1 and ERK2 cascade Source: GO_Central
  • positive regulation of GTPase activity Source: GO_Central
  • positive regulation of immune complex clearance by monocytes and macrophages Source: RGD
  • positive regulation of leukocyte mediated cytotoxicity Source: RGD
  • positive regulation of leukocyte migration Source: RGD
  • positive regulation of macrophage chemotaxis Source: RGD
  • positive regulation of monocyte chemotaxis Source: RGD
  • positive regulation of nitric-oxide synthase biosynthetic process Source: RGD
  • positive regulation of protein targeting to membrane Source: RGD
  • positive regulation of synaptic transmission Source: RGD
  • positive regulation of T cell activation Source: RGD
  • positive regulation of tumor necrosis factor production Source: RGD
  • positive regulation of wound healing Source: RGD
  • protein kinase B signaling Source: RGD
  • regulation of cell shape Source: RGD
  • regulation of vascular endothelial growth factor production Source: RGD
  • response to activity Source: RGD
  • response to amino acid Source: RGD
  • response to antibiotic Source: RGD
  • response to cyclosporin A Source: RGD
  • response to drug Source: RGD
  • response to ethanol Source: RGD
  • response to gamma radiation Source: RGD
  • response to glucocorticoid Source: RGD
  • response to heat Source: RGD
  • response to hypoxia Source: RGD
  • response to lipopolysaccharide Source: RGD
  • response to mechanical stimulus Source: RGD
  • response to progesterone Source: RGD
  • response to tumor necrosis factor Source: RGD
  • response to vitamin B3 Source: RGD
  • response to wounding Source: RGD
  • transforming growth factor beta receptor signaling pathway Source: RGD
  • vascular endothelial growth factor receptor signaling pathway Source: RGD

Keywordsi

Molecular functionCytokine
Biological processChemotaxis, Inflammatory response

Enzyme and pathway databases

ReactomeiR-RNO-380108. Chemokine receptors bind chemokines.

Names & Taxonomyi

Protein namesi
Recommended name:
C-C motif chemokine 2
Alternative name(s):
Immediate-early serum-responsive protein JE
Monocyte chemoattractant protein 1
Monocyte chemotactic protein 1
Short name:
MCP-1
Small-inducible cytokine A2
Gene namesi
Name:Ccl2
Synonyms:Je, Mcp1, Scya2
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Chromosome 10

Organism-specific databases

RGDi3645. Ccl2.

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 23By similarityAdd BLAST23
ChainiPRO_000000515124 – 148C-C motif chemokine 2Add BLAST125

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei24Pyrrolidone carboxylic acidBy similarity1
Disulfide bondi34 ↔ 59By similarity
Disulfide bondi35 ↔ 75By similarity
Glycosylationi126N-linked (GlcNAc...) asparagineSequence analysis1

Keywords - PTMi

Disulfide bond, Glycoprotein, Pyrrolidone carboxylic acid

Proteomic databases

PaxDbiP14844.
PRIDEiP14844.

PTM databases

PhosphoSitePlusiP14844.

Expressioni

Inductioni

In pancreatic islets, secretion is stimulated by IL1B. In islets from Zucker diabetic fatty (ZDF) rats, but not lean animals, secretion is also increased by endocannabinoid anandamide/AEA.1 Publication

Gene expression databases

BgeeiENSRNOG00000007159.
GenevisibleiP14844. RN.

Interactioni

Subunit structurei

Monomer or homodimer; in equilibrium.By similarity

GO - Molecular functioni

  • CCR2 chemokine receptor binding Source: RGD
  • chemokine activity Source: RGD
  • cytokine activity Source: RGD
  • G-protein coupled receptor binding Source: RGD

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000009448.

Structurei

3D structure databases

ProteinModelPortaliP14844.
SMRiP14844.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiENOG410J1ST. Eukaryota.
ENOG410YXJU. LUCA.
GeneTreeiENSGT00900000140949.
HOGENOMiHOG000036686.
HOVERGENiHBG017871.
InParanoidiP14844.
KOiK14624.
OMAiNAPLTCC.
OrthoDBiEOG091G14KV.
PhylomeDBiP14844.
TreeFamiTF339372.

Family and domain databases

InterProiView protein in InterPro
IPR000827. Chemokine_CC_CS.
IPR001811. Chemokine_IL8-like_dom.
IPR036048. Interleukin_8-like_sf.
PfamiView protein in Pfam
PF00048. IL8. 1 hit.
SMARTiView protein in SMART
SM00199. SCY. 1 hit.
SUPFAMiSSF54117. SSF54117. 1 hit.
PROSITEiView protein in PROSITE
PS00472. SMALL_CYTOKINES_CC. 1 hit.

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P14844-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MQVSVTLLGL LFTVAACSIH VLSQPDAVNA PLTCCYSFTG KMIPMSRLEN
60 70 80 90 100
YKRITSSRCP KEAVVFVTKL KREICADPNK EWVQKYIRKL DQNQVRSETT
110 120 130 140
VFYKIASTLR TSAPLNVNLT HKSEANASTL FSTTTSSTSV EVTSMTEN
Length:148
Mass (Da):16,460
Last modified:April 1, 1990 - v1
Checksum:i62D4C42BF4B11C9D
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X17053 Genomic DNA. Translation: CAA34901.1.
M57441 mRNA. Translation: AAA63496.1.
AF058786 mRNA. Translation: AAC15187.1.
PIRiS07723.
RefSeqiNP_113718.1. NM_031530.1.
UniGeneiRn.4772.

Genome annotation databases

EnsembliENSRNOT00000009448; ENSRNOP00000009448; ENSRNOG00000007159.
GeneIDi24770.
KEGGirno:24770.

Similar proteinsi

Entry informationi

Entry nameiCCL2_RAT
AccessioniPrimary (citable) accession number: P14844
Secondary accession number(s): Q549R5
Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 1, 1990
Last sequence update: April 1, 1990
Last modified: November 22, 2017
This is version 143 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families