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Protein

C-C motif chemokine 2

Gene

Ccl2

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at transcript leveli

Functioni

Chemotactic factor that attracts monocytes, but not neutrophils.

GO - Molecular functioni

  • CCR2 chemokine receptor binding Source: RGD
  • chemokine activity Source: RGD
  • heparin binding Source: RGD

GO - Biological processi

  • aging Source: RGD
  • astrocyte cell migration Source: Ensembl
  • cellular calcium ion homeostasis Source: RGD
  • cellular response to ATP Source: RGD
  • cellular response to dexamethasone stimulus Source: RGD
  • cellular response to drug Source: RGD
  • cellular response to fibroblast growth factor stimulus Source: Ensembl
  • cellular response to high density lipoprotein particle stimulus Source: RGD
  • cellular response to insulin stimulus Source: RGD
  • cellular response to interferon-gamma Source: RGD
  • cellular response to interleukin-1 Source: RGD
  • cellular response to interleukin-6 Source: RGD
  • cellular response to lipopolysaccharide Source: RGD
  • cellular response to lipoprotein particle stimulus Source: RGD
  • cellular response to macrophage colony-stimulating factor stimulus Source: RGD
  • cellular response to platelet-derived growth factor stimulus Source: RGD
  • cellular response to retinoic acid Source: RGD
  • cellular response to tumor necrosis factor Source: RGD
  • chemokine-mediated signaling pathway Source: RGD
  • chemokinesis Source: RGD
  • cytokine-mediated signaling pathway Source: RGD
  • cytoskeleton organization Source: Ensembl
  • glial cell migration Source: RGD
  • helper T cell extravasation Source: Ensembl
  • inflammatory response Source: RGD
  • leukocyte migration involved in inflammatory response Source: RGD
  • lipopolysaccharide-mediated signaling pathway Source: Ensembl
  • lymphocyte chemotaxis Source: RGD
  • macrophage chemotaxis Source: RGD
  • MAPK cascade Source: Ensembl
  • maternal process involved in female pregnancy Source: RGD
  • maternal process involved in parturition Source: RGD
  • monocyte chemotaxis Source: Ensembl
  • negative regulation of angiogenesis Source: Ensembl
  • negative regulation of glial cell apoptotic process Source: Ensembl
  • negative regulation of natural killer cell chemotaxis Source: Ensembl
  • negative regulation of neuron apoptotic process Source: Ensembl
  • neutrophil chemotaxis Source: RGD
  • organ regeneration Source: RGD
  • positive regulation of apoptotic cell clearance Source: Ensembl
  • positive regulation of calcium ion import Source: Ensembl
  • positive regulation of cell adhesion Source: RGD
  • positive regulation of cell-cell adhesion Source: RGD
  • positive regulation of cellular extravasation Source: RGD
  • positive regulation of collagen biosynthetic process Source: RGD
  • positive regulation of endothelial cell proliferation Source: RGD
  • positive regulation of immune complex clearance by monocytes and macrophages Source: Ensembl
  • positive regulation of leukocyte mediated cytotoxicity Source: RGD
  • positive regulation of leukocyte migration Source: RGD
  • positive regulation of macrophage chemotaxis Source: RGD
  • positive regulation of monocyte chemotaxis Source: RGD
  • positive regulation of nitric-oxide synthase biosynthetic process Source: Ensembl
  • positive regulation of protein targeting to membrane Source: RGD
  • positive regulation of synaptic transmission Source: RGD
  • positive regulation of T cell activation Source: Ensembl
  • positive regulation of tumor necrosis factor production Source: RGD
  • protein kinase B signaling Source: Ensembl
  • regulation of cell shape Source: Ensembl
  • regulation of vascular endothelial growth factor production Source: Ensembl
  • response to activity Source: RGD
  • response to amino acid Source: RGD
  • response to antibiotic Source: RGD
  • response to drug Source: RGD
  • response to ethanol Source: RGD
  • response to gamma radiation Source: RGD
  • response to glucocorticoid Source: RGD
  • response to heat Source: RGD
  • response to hypoxia Source: RGD
  • response to lipopolysaccharide Source: RGD
  • response to mechanical stimulus Source: RGD
  • response to progesterone Source: RGD
  • response to vitamin B3 Source: RGD
  • response to wounding Source: Ensembl
  • transforming growth factor beta receptor signaling pathway Source: RGD
  • vascular endothelial growth factor receptor signaling pathway Source: RGD
Complete GO annotation...

Keywords - Molecular functioni

Cytokine

Keywords - Biological processi

Chemotaxis, Inflammatory response

Enzyme and pathway databases

ReactomeiREACT_278843. Chemokine receptors bind chemokines.

Names & Taxonomyi

Protein namesi
Recommended name:
C-C motif chemokine 2
Alternative name(s):
Immediate-early serum-responsive protein JE
Monocyte chemoattractant protein 1
Monocyte chemotactic protein 1
Short name:
MCP-1
Small-inducible cytokine A2
Gene namesi
Name:Ccl2
Synonyms:Je, Mcp1, Scya2
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
ProteomesiUP000002494 Componenti: Chromosome 10

Organism-specific databases

RGDi3645. Ccl2.

Subcellular locationi

GO - Cellular componenti

  • axon terminus Source: RGD
  • cytoplasm Source: RGD
  • dendrite Source: RGD
  • endocytic vesicle Source: RGD
  • extracellular space Source: RGD
  • neuronal cell body Source: RGD
  • perikaryon Source: RGD
  • perinuclear region of cytoplasm Source: RGD
  • rough endoplasmic reticulum Source: RGD
  • synapse Source: RGD
Complete GO annotation...

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2323By similarityAdd
BLAST
Chaini24 – 148125C-C motif chemokine 2PRO_0000005151Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei24 – 241Pyrrolidone carboxylic acidBy similarity
Disulfide bondi34 ↔ 59By similarity
Disulfide bondi35 ↔ 75By similarity
Glycosylationi126 – 1261N-linked (GlcNAc...)Sequence Analysis

Keywords - PTMi

Disulfide bond, Glycoprotein, Pyrrolidone carboxylic acid

Proteomic databases

PaxDbiP14844.
PRIDEiP14844.

PTM databases

PhosphoSiteiP14844.

Expressioni

Gene expression databases

GenevisibleiP14844. RN.

Interactioni

Subunit structurei

Monomer or homodimer; in equilibrium.By similarity

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000009448.

Structurei

3D structure databases

ProteinModelPortaliP14844.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiNOG46819.
GeneTreeiENSGT00730000110714.
HOGENOMiHOG000036686.
HOVERGENiHBG017871.
InParanoidiP14844.
KOiK14624.
OMAiNAPLTCC.
OrthoDBiEOG7673DP.
PhylomeDBiP14844.
TreeFamiTF339372.

Family and domain databases

InterProiIPR000827. Chemokine_CC_CS.
IPR001811. Chemokine_IL8-like_dom.
[Graphical view]
PfamiPF00048. IL8. 1 hit.
[Graphical view]
SMARTiSM00199. SCY. 1 hit.
[Graphical view]
SUPFAMiSSF54117. SSF54117. 1 hit.
PROSITEiPS00472. SMALL_CYTOKINES_CC. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P14844-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MQVSVTLLGL LFTVAACSIH VLSQPDAVNA PLTCCYSFTG KMIPMSRLEN
60 70 80 90 100
YKRITSSRCP KEAVVFVTKL KREICADPNK EWVQKYIRKL DQNQVRSETT
110 120 130 140
VFYKIASTLR TSAPLNVNLT HKSEANASTL FSTTTSSTSV EVTSMTEN
Length:148
Mass (Da):16,460
Last modified:April 1, 1990 - v1
Checksum:i62D4C42BF4B11C9D
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X17053 Genomic DNA. Translation: CAA34901.1.
M57441 mRNA. Translation: AAA63496.1.
AF058786 mRNA. Translation: AAC15187.1.
PIRiS07723.
RefSeqiNP_113718.1. NM_031530.1.
UniGeneiRn.4772.

Genome annotation databases

EnsembliENSRNOT00000009448; ENSRNOP00000009448; ENSRNOG00000007159.
GeneIDi24770.
KEGGirno:24770.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X17053 Genomic DNA. Translation: CAA34901.1.
M57441 mRNA. Translation: AAA63496.1.
AF058786 mRNA. Translation: AAC15187.1.
PIRiS07723.
RefSeqiNP_113718.1. NM_031530.1.
UniGeneiRn.4772.

3D structure databases

ProteinModelPortaliP14844.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000009448.

PTM databases

PhosphoSiteiP14844.

Proteomic databases

PaxDbiP14844.
PRIDEiP14844.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSRNOT00000009448; ENSRNOP00000009448; ENSRNOG00000007159.
GeneIDi24770.
KEGGirno:24770.

Organism-specific databases

CTDi6347.
RGDi3645. Ccl2.

Phylogenomic databases

eggNOGiNOG46819.
GeneTreeiENSGT00730000110714.
HOGENOMiHOG000036686.
HOVERGENiHBG017871.
InParanoidiP14844.
KOiK14624.
OMAiNAPLTCC.
OrthoDBiEOG7673DP.
PhylomeDBiP14844.
TreeFamiTF339372.

Enzyme and pathway databases

ReactomeiREACT_278843. Chemokine receptors bind chemokines.

Miscellaneous databases

NextBioi604340.
PROiP14844.

Gene expression databases

GenevisibleiP14844. RN.

Family and domain databases

InterProiIPR000827. Chemokine_CC_CS.
IPR001811. Chemokine_IL8-like_dom.
[Graphical view]
PfamiPF00048. IL8. 1 hit.
[Graphical view]
SMARTiSM00199. SCY. 1 hit.
[Graphical view]
SUPFAMiSSF54117. SSF54117. 1 hit.
PROSITEiPS00472. SMALL_CYTOKINES_CC. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "Analysis of the rat JE gene promoter identifies an AP-1 binding site essential for basal expression but not for TPA induction."
    Timmers H.T.M., Pronk G.J., Bos J.L., van der Eb A.J.
    Nucleic Acids Res. 18:23-34(1990) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    Strain: WAG/RIJ.
    Tissue: Kidney.
  2. "Molecular cloning of rat monocyte chemoattractant protein-1 (MCP-1) and its expression in rat spleen cells and tumor cell lines."
    Yoshimura T., Takeya M., Takahashi K.
    Biochem. Biophys. Res. Commun. 174:504-509(1991) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
  3. "Cloning of the full-length rat JE/MCP-1 cDNA."
    Poon M., Taubman M.B.
    Submitted (APR-1998) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Strain: Sprague-Dawley.
    Tissue: Aortic smooth muscle.

Entry informationi

Entry nameiCCL2_RAT
AccessioniPrimary (citable) accession number: P14844
Secondary accession number(s): Q549R5
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 1, 1990
Last sequence update: April 1, 1990
Last modified: June 24, 2015
This is version 125 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.