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P14844 (CCL2_RAT) Reviewed, UniProtKB/Swiss-Prot

Last modified June 11, 2014. Version 117. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
C-C motif chemokine 2
Alternative name(s):
Immediate-early serum-responsive protein JE
Monocyte chemoattractant protein 1
Monocyte chemotactic protein 1
Short name=MCP-1
Small-inducible cytokine A2
Gene names
Name:Ccl2
Synonyms:Je, Mcp1, Scya2
OrganismRattus norvegicus (Rat) [Reference proteome]
Taxonomic identifier10116 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus

Protein attributes

Sequence length148 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

Chemotactic factor that attracts monocytes, but not neutrophils.

Subunit structure

Monomer or homodimer; in equilibrium By similarity.

Subcellular location

Secreted.

Sequence similarities

Belongs to the intercrine beta (chemokine CC) family.

Ontologies

Keywords
   Biological processChemotaxis
Inflammatory response
   Cellular componentSecreted
   DomainSignal
   Molecular functionCytokine
   PTMDisulfide bond
Glycoprotein
Pyrrolidone carboxylic acid
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Biological_processMAPK cascade

Inferred from electronic annotation. Source: Ensembl

aging

Inferred from expression pattern PubMed 20335145. Source: RGD

astrocyte cell migration

Inferred from electronic annotation. Source: Ensembl

cellular calcium ion homeostasis

Inferred from direct assay PubMed 15978006. Source: RGD

cellular response to ATP

Inferred from expression pattern PubMed 19125410. Source: RGD

cellular response to dexamethasone stimulus

Inferred from expression pattern PubMed 14512159. Source: RGD

cellular response to drug

Inferred from expression pattern PubMed 16331110. Source: RGD

cellular response to fibroblast growth factor stimulus

Inferred from electronic annotation. Source: Ensembl

cellular response to high density lipoprotein particle stimulus

Inferred from expression pattern PubMed 18483405. Source: RGD

cellular response to insulin stimulus

Inferred from expression pattern PubMed 17180354. Source: RGD

cellular response to interferon-gamma

Inferred from expression pattern PubMed 14512159. Source: RGD

cellular response to interleukin-1

Inferred from expression pattern PubMed 14512159. Source: RGD

cellular response to interleukin-6

Inferred from expression pattern PubMed 8921263. Source: RGD

cellular response to lipopolysaccharide

Inferred from expression pattern PubMed 8921263. Source: RGD

cellular response to lipoprotein particle stimulus

Inferred from expression pattern PubMed 11473635. Source: RGD

cellular response to macrophage colony-stimulating factor stimulus

Inferred from expression pattern PubMed 8921263. Source: RGD

cellular response to platelet-derived growth factor stimulus

Inferred from expression pattern PubMed 7589574. Source: RGD

cellular response to retinoic acid

Inferred from expression pattern PubMed 11274229. Source: RGD

cellular response to tumor necrosis factor

Inferred from expression pattern PubMed 14512159. Source: RGD

chemokine-mediated signaling pathway

Inferred from mutant phenotype PubMed 18584881. Source: RGD

chemokinesis

Traceable author statement PubMed 12540607. Source: RGD

cytokine-mediated signaling pathway

Inferred from mutant phenotype PubMed 16174730. Source: RGD

cytoskeleton organization

Inferred from electronic annotation. Source: Ensembl

glial cell migration

Inferred from mutant phenotype PubMed 23010641. Source: RGD

helper T cell extravasation

Inferred from electronic annotation. Source: Ensembl

inflammatory response

Inferred from expression pattern PubMed 11751160PubMed 12144807PubMed 16127145. Source: RGD

leukocyte migration involved in inflammatory response

Inferred from mutant phenotype PubMed 8774140. Source: RGD

lipopolysaccharide-mediated signaling pathway

Inferred from electronic annotation. Source: Ensembl

lymphocyte chemotaxis

Inferred from direct assay PubMed 11104723. Source: RGD

macrophage chemotaxis

Inferred from direct assay PubMed 16127145. Source: RGD

maternal process involved in female pregnancy

Inferred from expression pattern PubMed 8788206. Source: RGD

maternal process involved in parturition

Inferred from expression pattern PubMed 18606702. Source: RGD

monocyte chemotaxis

Inferred from electronic annotation. Source: Ensembl

negative regulation of angiogenesis

Inferred from electronic annotation. Source: Ensembl

negative regulation of glial cell apoptotic process

Inferred from electronic annotation. Source: Ensembl

negative regulation of natural killer cell chemotaxis

Inferred from electronic annotation. Source: Ensembl

negative regulation of neuron apoptotic process

Inferred from electronic annotation. Source: Ensembl

neutrophil chemotaxis

Inferred from mutant phenotype PubMed 16127145. Source: RGD

organ regeneration

Inferred from expression pattern PubMed 19420110. Source: RGD

positive regulation of T cell activation

Inferred from electronic annotation. Source: Ensembl

positive regulation of apoptotic cell clearance

Inferred from electronic annotation. Source: Ensembl

positive regulation of cell adhesion

Inferred from direct assay PubMed 8103296. Source: RGD

positive regulation of cell-cell adhesion

Inferred from direct assay PubMed 10225970. Source: RGD

positive regulation of cellular extravasation

Inferred from direct assay PubMed 10225970. Source: RGD

positive regulation of collagen biosynthetic process

Inferred from direct assay PubMed 8663511. Source: RGD

positive regulation of endothelial cell proliferation

Inferred from mutant phenotype PubMed 14693680. Source: RGD

positive regulation of immune complex clearance by monocytes and macrophages

Inferred from electronic annotation. Source: Ensembl

positive regulation of leukocyte mediated cytotoxicity

Inferred from mutant phenotype PubMed 8103296. Source: RGD

positive regulation of leukocyte migration

Inferred from direct assay PubMed 7943176. Source: RGD

positive regulation of macrophage chemotaxis

Inferred from direct assay PubMed 9430491. Source: RGD

positive regulation of monocyte chemotaxis

Inferred from direct assay PubMed 1387671. Source: RGD

positive regulation of nitric-oxide synthase biosynthetic process

Inferred from electronic annotation. Source: Ensembl

positive regulation of synaptic transmission

Inferred from direct assay PubMed 18584881. Source: RGD

protein kinase B signaling

Inferred from electronic annotation. Source: Ensembl

regulation of cell shape

Inferred from electronic annotation. Source: Ensembl

regulation of vascular endothelial growth factor production

Inferred from electronic annotation. Source: Ensembl

response to activity

Inferred from expression pattern PubMed 18797164. Source: RGD

response to amino acid

Inferred from expression pattern PubMed 18475188. Source: RGD

response to antibiotic

Inferred from expression pattern PubMed 17304115. Source: RGD

response to drug

Inferred from expression pattern PubMed 18388116PubMed 18413153PubMed 19390220. Source: RGD

response to ethanol

Inferred from expression pattern PubMed 17935147. Source: RGD

response to gamma radiation

Inferred from expression pattern PubMed 19084914. Source: RGD

response to glucocorticoid

Inferred from expression pattern PubMed 19210118. Source: RGD

response to heat

Inferred from direct assay PubMed 18419759. Source: RGD

response to hypoxia

Inferred from expression pattern PubMed 19278353. Source: RGD

response to lipopolysaccharide

Inferred from expression pattern PubMed 19111613. Source: RGD

response to mechanical stimulus

Inferred from expression pattern PubMed 18606702. Source: RGD

response to progesterone

Inferred from expression pattern PubMed 18606702. Source: RGD

response to vitamin B3

Inferred from expression pattern PubMed 19420110. Source: RGD

transforming growth factor beta receptor signaling pathway

Inferred from mutant phenotype PubMed 14505427. Source: RGD

vascular endothelial growth factor receptor signaling pathway

Inferred from mutant phenotype PubMed 14693680. Source: RGD

   Cellular_componentaxon terminus

Inferred from direct assay PubMed 19059387. Source: RGD

cytoplasm

Inferred from direct assay PubMed 14638441. Source: RGD

dendrite

Inferred from direct assay PubMed 16025454. Source: RGD

endocytic vesicle

Inferred from direct assay PubMed 12080327. Source: RGD

extracellular space

Inferred from direct assay PubMed 19060786. Source: RGD

neuronal cell body

Inferred from direct assay PubMed 15978006. Source: RGD

perikaryon

Inferred from direct assay PubMed 16025454. Source: RGD

perinuclear region of cytoplasm

Inferred from direct assay PubMed 14512159. Source: RGD

rough endoplasmic reticulum

Inferred from direct assay PubMed 12080327. Source: RGD

synapse

Inferred from direct assay PubMed 23010641. Source: RGD

   Molecular_functionCCR2 chemokine receptor binding

Inferred from mutant phenotype PubMed 16196033PubMed 18584881. Source: RGD

chemokine activity

Inferred from direct assay PubMed 11104723PubMed 12953273PubMed 16127145. Source: RGD

heparin binding

Inferred from physical interaction PubMed 16127145. Source: RGD

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Signal peptide1 – 2323 By similarity
Chain24 – 148125C-C motif chemokine 2
PRO_0000005151

Amino acid modifications

Modified residue241Pyrrolidone carboxylic acid By similarity
Glycosylation1261N-linked (GlcNAc...) Potential
Disulfide bond34 ↔ 59 By similarity
Disulfide bond35 ↔ 75 By similarity

Sequences

Sequence LengthMass (Da)Tools
P14844 [UniParc].

Last modified April 1, 1990. Version 1.
Checksum: 62D4C42BF4B11C9D

FASTA14816,460
        10         20         30         40         50         60 
MQVSVTLLGL LFTVAACSIH VLSQPDAVNA PLTCCYSFTG KMIPMSRLEN YKRITSSRCP 

        70         80         90        100        110        120 
KEAVVFVTKL KREICADPNK EWVQKYIRKL DQNQVRSETT VFYKIASTLR TSAPLNVNLT 

       130        140 
HKSEANASTL FSTTTSSTSV EVTSMTEN 

« Hide

References

[1]"Analysis of the rat JE gene promoter identifies an AP-1 binding site essential for basal expression but not for TPA induction."
Timmers H.T.M., Pronk G.J., Bos J.L., van der Eb A.J.
Nucleic Acids Res. 18:23-34(1990) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
Strain: WAG/RIJ.
Tissue: Kidney.
[2]"Molecular cloning of rat monocyte chemoattractant protein-1 (MCP-1) and its expression in rat spleen cells and tumor cell lines."
Yoshimura T., Takeya M., Takahashi K.
Biochem. Biophys. Res. Commun. 174:504-509(1991) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
[3]"Cloning of the full-length rat JE/MCP-1 cDNA."
Poon M., Taubman M.B.
Submitted (APR-1998) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
Strain: Sprague-Dawley.
Tissue: Aortic smooth muscle.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
X17053 Genomic DNA. Translation: CAA34901.1.
M57441 mRNA. Translation: AAA63496.1.
AF058786 mRNA. Translation: AAC15187.1.
PIRS07723.
RefSeqNP_113718.1. NM_031530.1.
UniGeneRn.4772.

3D structure databases

ProteinModelPortalP14844.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING10116.ENSRNOP00000009448.

PTM databases

PhosphoSiteP14844.

Proteomic databases

PaxDbP14844.
PRIDEP14844.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENSRNOT00000009448; ENSRNOP00000009448; ENSRNOG00000007159.
GeneID24770.
KEGGrno:24770.

Organism-specific databases

CTD6347.
RGD3645. Ccl2.

Phylogenomic databases

eggNOGNOG46819.
GeneTreeENSGT00730000110714.
HOGENOMHOG000036686.
HOVERGENHBG017871.
InParanoidP14844.
KOK14624.
OMATHKSEAN.
OrthoDBEOG7673DP.
PhylomeDBP14844.
TreeFamTF339372.

Gene expression databases

GenevestigatorP14844.

Family and domain databases

InterProIPR000827. Chemokine_CC_CS.
IPR001811. Chemokine_IL8-like_dom.
[Graphical view]
PfamPF00048. IL8. 1 hit.
[Graphical view]
SMARTSM00199. SCY. 1 hit.
[Graphical view]
SUPFAMSSF54117. SSF54117. 1 hit.
PROSITEPS00472. SMALL_CYTOKINES_CC. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

NextBio604340.
PROP14844.

Entry information

Entry nameCCL2_RAT
AccessionPrimary (citable) accession number: P14844
Secondary accession number(s): Q549R5
Entry history
Integrated into UniProtKB/Swiss-Prot: April 1, 1990
Last sequence update: April 1, 1990
Last modified: June 11, 2014
This is version 117 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families