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P14844

- CCL2_RAT

UniProt

P14844 - CCL2_RAT

Protein

C-C motif chemokine 2

Gene

Ccl2

Organism
Rattus norvegicus (Rat)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at transcript leveli
  1. Functioni

    Chemotactic factor that attracts monocytes, but not neutrophils.

    GO - Molecular functioni

    1. CCR2 chemokine receptor binding Source: RGD
    2. chemokine activity Source: RGD
    3. heparin binding Source: RGD

    GO - Biological processi

    1. aging Source: RGD
    2. astrocyte cell migration Source: Ensembl
    3. cellular calcium ion homeostasis Source: RGD
    4. cellular response to ATP Source: RGD
    5. cellular response to dexamethasone stimulus Source: RGD
    6. cellular response to drug Source: RGD
    7. cellular response to fibroblast growth factor stimulus Source: Ensembl
    8. cellular response to high density lipoprotein particle stimulus Source: RGD
    9. cellular response to insulin stimulus Source: RGD
    10. cellular response to interferon-gamma Source: RGD
    11. cellular response to interleukin-1 Source: RGD
    12. cellular response to interleukin-6 Source: RGD
    13. cellular response to lipopolysaccharide Source: RGD
    14. cellular response to lipoprotein particle stimulus Source: RGD
    15. cellular response to macrophage colony-stimulating factor stimulus Source: RGD
    16. cellular response to platelet-derived growth factor stimulus Source: RGD
    17. cellular response to retinoic acid Source: RGD
    18. cellular response to tumor necrosis factor Source: RGD
    19. chemokine-mediated signaling pathway Source: RGD
    20. chemokinesis Source: RGD
    21. cytokine-mediated signaling pathway Source: RGD
    22. cytoskeleton organization Source: Ensembl
    23. glial cell migration Source: RGD
    24. helper T cell extravasation Source: Ensembl
    25. inflammatory response Source: RGD
    26. leukocyte migration involved in inflammatory response Source: RGD
    27. lipopolysaccharide-mediated signaling pathway Source: Ensembl
    28. lymphocyte chemotaxis Source: RGD
    29. macrophage chemotaxis Source: RGD
    30. MAPK cascade Source: Ensembl
    31. maternal process involved in female pregnancy Source: RGD
    32. maternal process involved in parturition Source: RGD
    33. monocyte chemotaxis Source: Ensembl
    34. negative regulation of angiogenesis Source: Ensembl
    35. negative regulation of glial cell apoptotic process Source: Ensembl
    36. negative regulation of natural killer cell chemotaxis Source: Ensembl
    37. negative regulation of neuron apoptotic process Source: Ensembl
    38. neutrophil chemotaxis Source: RGD
    39. organ regeneration Source: RGD
    40. positive regulation of apoptotic cell clearance Source: Ensembl
    41. positive regulation of cell adhesion Source: RGD
    42. positive regulation of cell-cell adhesion Source: RGD
    43. positive regulation of cellular extravasation Source: RGD
    44. positive regulation of collagen biosynthetic process Source: RGD
    45. positive regulation of endothelial cell proliferation Source: RGD
    46. positive regulation of immune complex clearance by monocytes and macrophages Source: Ensembl
    47. positive regulation of leukocyte mediated cytotoxicity Source: RGD
    48. positive regulation of leukocyte migration Source: RGD
    49. positive regulation of macrophage chemotaxis Source: RGD
    50. positive regulation of monocyte chemotaxis Source: RGD
    51. positive regulation of nitric-oxide synthase biosynthetic process Source: Ensembl
    52. positive regulation of synaptic transmission Source: RGD
    53. positive regulation of T cell activation Source: Ensembl
    54. positive regulation of tumor necrosis factor production Source: RGD
    55. protein kinase B signaling Source: Ensembl
    56. regulation of cell shape Source: Ensembl
    57. regulation of vascular endothelial growth factor production Source: Ensembl
    58. response to activity Source: RGD
    59. response to amino acid Source: RGD
    60. response to antibiotic Source: RGD
    61. response to drug Source: RGD
    62. response to ethanol Source: RGD
    63. response to gamma radiation Source: RGD
    64. response to glucocorticoid Source: RGD
    65. response to heat Source: RGD
    66. response to hypoxia Source: RGD
    67. response to lipopolysaccharide Source: RGD
    68. response to mechanical stimulus Source: RGD
    69. response to progesterone Source: RGD
    70. response to vitamin B3 Source: RGD
    71. transforming growth factor beta receptor signaling pathway Source: RGD
    72. vascular endothelial growth factor receptor signaling pathway Source: RGD

    Keywords - Molecular functioni

    Cytokine

    Keywords - Biological processi

    Chemotaxis, Inflammatory response

    Enzyme and pathway databases

    ReactomeiREACT_100810. ATF4 activates genes.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    C-C motif chemokine 2
    Alternative name(s):
    Immediate-early serum-responsive protein JE
    Monocyte chemoattractant protein 1
    Monocyte chemotactic protein 1
    Short name:
    MCP-1
    Small-inducible cytokine A2
    Gene namesi
    Name:Ccl2
    Synonyms:Je, Mcp1, Scya2
    OrganismiRattus norvegicus (Rat)
    Taxonomic identifieri10116 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
    ProteomesiUP000002494: Chromosome 10

    Organism-specific databases

    RGDi3645. Ccl2.

    Subcellular locationi

    GO - Cellular componenti

    1. axon terminus Source: RGD
    2. cytoplasm Source: RGD
    3. dendrite Source: RGD
    4. endocytic vesicle Source: RGD
    5. extracellular space Source: RGD
    6. neuronal cell body Source: RGD
    7. perikaryon Source: RGD
    8. perinuclear region of cytoplasm Source: RGD
    9. rough endoplasmic reticulum Source: RGD
    10. synapse Source: RGD

    Keywords - Cellular componenti

    Secreted

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Signal peptidei1 – 2323By similarityAdd
    BLAST
    Chaini24 – 148125C-C motif chemokine 2PRO_0000005151Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei24 – 241Pyrrolidone carboxylic acidBy similarity
    Disulfide bondi34 ↔ 59By similarity
    Disulfide bondi35 ↔ 75By similarity
    Glycosylationi126 – 1261N-linked (GlcNAc...)Sequence Analysis

    Keywords - PTMi

    Disulfide bond, Glycoprotein, Pyrrolidone carboxylic acid

    Proteomic databases

    PaxDbiP14844.
    PRIDEiP14844.

    PTM databases

    PhosphoSiteiP14844.

    Expressioni

    Gene expression databases

    GenevestigatoriP14844.

    Interactioni

    Subunit structurei

    Monomer or homodimer; in equilibrium.By similarity

    Protein-protein interaction databases

    STRINGi10116.ENSRNOP00000009448.

    Structurei

    3D structure databases

    ProteinModelPortaliP14844.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Keywords - Domaini

    Signal

    Phylogenomic databases

    eggNOGiNOG46819.
    GeneTreeiENSGT00730000110714.
    HOGENOMiHOG000036686.
    HOVERGENiHBG017871.
    InParanoidiP14844.
    KOiK14624.
    OMAiTHKSEAN.
    OrthoDBiEOG7673DP.
    PhylomeDBiP14844.
    TreeFamiTF339372.

    Family and domain databases

    InterProiIPR000827. Chemokine_CC_CS.
    IPR001811. Chemokine_IL8-like_dom.
    [Graphical view]
    PfamiPF00048. IL8. 1 hit.
    [Graphical view]
    SMARTiSM00199. SCY. 1 hit.
    [Graphical view]
    SUPFAMiSSF54117. SSF54117. 1 hit.
    PROSITEiPS00472. SMALL_CYTOKINES_CC. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    P14844-1 [UniParc]FASTAAdd to Basket

    « Hide

    MQVSVTLLGL LFTVAACSIH VLSQPDAVNA PLTCCYSFTG KMIPMSRLEN    50
    YKRITSSRCP KEAVVFVTKL KREICADPNK EWVQKYIRKL DQNQVRSETT 100
    VFYKIASTLR TSAPLNVNLT HKSEANASTL FSTTTSSTSV EVTSMTEN 148
    Length:148
    Mass (Da):16,460
    Last modified:April 1, 1990 - v1
    Checksum:i62D4C42BF4B11C9D
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    X17053 Genomic DNA. Translation: CAA34901.1.
    M57441 mRNA. Translation: AAA63496.1.
    AF058786 mRNA. Translation: AAC15187.1.
    PIRiS07723.
    RefSeqiNP_113718.1. NM_031530.1.
    UniGeneiRn.4772.

    Genome annotation databases

    EnsembliENSRNOT00000009448; ENSRNOP00000009448; ENSRNOG00000007159.
    GeneIDi24770.
    KEGGirno:24770.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    X17053 Genomic DNA. Translation: CAA34901.1 .
    M57441 mRNA. Translation: AAA63496.1 .
    AF058786 mRNA. Translation: AAC15187.1 .
    PIRi S07723.
    RefSeqi NP_113718.1. NM_031530.1.
    UniGenei Rn.4772.

    3D structure databases

    ProteinModelPortali P14844.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 10116.ENSRNOP00000009448.

    PTM databases

    PhosphoSitei P14844.

    Proteomic databases

    PaxDbi P14844.
    PRIDEi P14844.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSRNOT00000009448 ; ENSRNOP00000009448 ; ENSRNOG00000007159 .
    GeneIDi 24770.
    KEGGi rno:24770.

    Organism-specific databases

    CTDi 6347.
    RGDi 3645. Ccl2.

    Phylogenomic databases

    eggNOGi NOG46819.
    GeneTreei ENSGT00730000110714.
    HOGENOMi HOG000036686.
    HOVERGENi HBG017871.
    InParanoidi P14844.
    KOi K14624.
    OMAi THKSEAN.
    OrthoDBi EOG7673DP.
    PhylomeDBi P14844.
    TreeFami TF339372.

    Enzyme and pathway databases

    Reactomei REACT_100810. ATF4 activates genes.

    Miscellaneous databases

    NextBioi 604340.
    PROi P14844.

    Gene expression databases

    Genevestigatori P14844.

    Family and domain databases

    InterProi IPR000827. Chemokine_CC_CS.
    IPR001811. Chemokine_IL8-like_dom.
    [Graphical view ]
    Pfami PF00048. IL8. 1 hit.
    [Graphical view ]
    SMARTi SM00199. SCY. 1 hit.
    [Graphical view ]
    SUPFAMi SSF54117. SSF54117. 1 hit.
    PROSITEi PS00472. SMALL_CYTOKINES_CC. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Analysis of the rat JE gene promoter identifies an AP-1 binding site essential for basal expression but not for TPA induction."
      Timmers H.T.M., Pronk G.J., Bos J.L., van der Eb A.J.
      Nucleic Acids Res. 18:23-34(1990) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
      Strain: WAG/RIJ.
      Tissue: Kidney.
    2. "Molecular cloning of rat monocyte chemoattractant protein-1 (MCP-1) and its expression in rat spleen cells and tumor cell lines."
      Yoshimura T., Takeya M., Takahashi K.
      Biochem. Biophys. Res. Commun. 174:504-509(1991) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    3. "Cloning of the full-length rat JE/MCP-1 cDNA."
      Poon M., Taubman M.B.
      Submitted (APR-1998) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
      Strain: Sprague-Dawley.
      Tissue: Aortic smooth muscle.

    Entry informationi

    Entry nameiCCL2_RAT
    AccessioniPrimary (citable) accession number: P14844
    Secondary accession number(s): Q549R5
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: April 1, 1990
    Last sequence update: April 1, 1990
    Last modified: October 1, 2014
    This is version 119 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3