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P14828 (PGK_KLULA) Reviewed, UniProtKB/Swiss-Prot

Last modified May 1, 2013. Version 89. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
Phosphoglycerate kinase
EC=2.7.2.3
Gene names
Name:PGK
Ordered Locus Names:KLLA0A11011g
OrganismKluyveromyces lactis (strain ATCC 8585 / CBS 2359 / DSM 70799 / NBRC 1267 / NRRL Y-1140 / WM37) (Yeast) (Candida sphaerica) [Complete proteome]
Taxonomic identifier284590 [NCBI]
Taxonomic lineageEukaryota › Fungi › Dikarya › Ascomycota › Saccharomycotina › Saccharomycetes › Saccharomycetales › Saccharomycetaceae › Kluyveromyces ›

Protein attributes

Sequence length416 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Catalytic activity

ATP + 3-phospho-D-glycerate = ADP + 3-phospho-D-glyceroyl phosphate.

Pathway

Carbohydrate degradation; glycolysis; pyruvate from D-glyceraldehyde 3-phosphate: step 2/5.

Subunit structure

Monomer By similarity.

Subcellular location

Cytoplasm By similarity.

Sequence similarities

Belongs to the phosphoglycerate kinase family.

Ontologies

Keywords
   Biological processGlycolysis
   Cellular componentCytoplasm
   LigandATP-binding
Nucleotide-binding
   Molecular functionKinase
Transferase
   Technical termComplete proteome
Gene Ontology (GO)
   Biological_processglycolysis

Inferred from electronic annotation. Source: UniProtKB-UniPathway

   Cellular_componentcytoplasm

Inferred from electronic annotation. Source: UniProtKB-SubCell

   Molecular_functionATP binding

Inferred from electronic annotation. Source: UniProtKB-KW

phosphoglycerate kinase activity

Inferred from electronic annotation. Source: EC

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 416416Phosphoglycerate kinase
PRO_0000145882

Regions

Nucleotide binding371 – 3744ATP By similarity
Region24 – 263Substrate binding By similarity
Region63 – 664Substrate binding By similarity

Sites

Binding site391Substrate By similarity
Binding site1221Substrate By similarity
Binding site1691Substrate By similarity
Binding site2181ATP By similarity
Binding site3111ATP; via carbonyl oxygen By similarity
Binding site3421ATP By similarity

Experimental info

Sequence conflict3661T → N in CAA35646. Ref.1

Sequences

Sequence LengthMass (Da)Tools
P14828 [UniParc].

Last modified September 27, 2004. Version 2.
Checksum: 9CFF5724C67AB850

FASTA41644,514
        10         20         30         40         50         60 
MSLSSKLTVK DLDVTGKRVF IRVDFNVPLD GKKITSNQRI VAALPTIQYV LEKKPKAIVL 

        70         80         90        100        110        120 
ASHLGRPNGE VNDKYSLAPV ADELSRLLQK PVTFLHDCVG EEVTNAVNNA KDGEVFLLEN 

       130        140        150        160        170        180 
LRFHIEEEGS RKVDGNKVKA DKAAVTKFRE QLSSLADVYV NDAFGTAHRA HSSIVGFDLP 

       190        200        210        220        230        240 
NRAAGFLLSK ELQYFAKALE NPTRPFLAIL GGAKVADKIQ LIDNLLDKVD SLIIGGGMAF 

       250        260        270        280        290        300 
TFKKVLENTE IGDSIYDAAG AELVPKLVEK AKKNNVKIVL PTDFVIGDKF SADANTKVVT 

       310        320        330        340        350        360 
DKEGIPSGWQ GLDNGPESRK AFAATVAEAK TIVWNGPPGV FEFAPFAKGT EALLDAVVAS 

       370        380        390        400        410 
SQAGNTVIIG GGDTATVAKK YGVVDKISHV STGGGASLEL LEGKELPGVT FLSNKQ

« Hide

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		X17654 Genomic DNA. Translation: CAA35646.1.
CR382121 Genomic DNA. Translation: CAH03067.1.
PIRKIVKGL. S07878.
RefSeqXP_451479.1. XM_451479.1.

3D structure databases

ProteinModelPortalP14828.
SMRP14828. Positions 2-416.
ModBaseSearch...

Protein-protein interaction databases

STRING28985.P14828.

Proteomic databases

PRIDEP14828.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

GeneID2896489.
KEGGkla:KLLA0A11011g.

Phylogenomic databases

eggNOGCOG0126.
HOGENOMHOG000227107.
KOK00927.
OMANSCIGDE.
OrthoDBEOG4F4WKK.

Enzyme and pathway databases

UniPathwayUPA00109; UER00185.

Family and domain databases

Gene3D3.40.50.1260. 1 hit.
3.40.50.1270. 1 hit.
InterProIPR001576. Phosphoglycerate_kinase.
IPR015901. Phosphoglycerate_kinase_C.
IPR015911. Phosphoglycerate_kinase_CS.
IPR015824. Phosphoglycerate_kinase_N.
[Graphical view]
PANTHERPTHR11406. PTHR11406. 1 hit.
PfamPF00162. PGK. 1 hit.
[Graphical view]
PIRSFPIRSF000724. Pgk. 1 hit.
PRINTSPR00477. PHGLYCKINASE.
SUPFAMSSF53748. PGK. 1 hit.
PROSITEPS00111. PGLYCERATE_KINASE. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry namePGK_KLULA
AccessionPrimary (citable) accession number: P14828
Secondary accession number(s): Q6CX60
Entry history
Integrated into UniProtKB/Swiss-Prot: April 1, 1990
Last sequence update: September 27, 2004
Last modified: May 1, 2013
This is version 89 of the entry and version 2 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Relevant documents

PATHWAY comments

Index of metabolic and biosynthesis pathways

SIMILARITY comments

Index of protein domains and families

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