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Protein

Phosphoglycerate kinase

Gene

PGK

Organism
Kluyveromyces lactis (strain ATCC 8585 / CBS 2359 / DSM 70799 / NBRC 1267 / NRRL Y-1140 / WM37) (Yeast) (Candida sphaerica)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Catalytic activityi

ATP + 3-phospho-D-glycerate = ADP + 3-phospho-D-glyceroyl phosphate.

Pathwayi: glycolysis

This protein is involved in step 2 of the subpathway that synthesizes pyruvate from D-glyceraldehyde 3-phosphate.
Proteins known to be involved in the 5 steps of the subpathway in this organism are:
  1. Glyceraldehyde-3-phosphate dehydrogenase (KLLA0_F09141g), Glyceraldehyde-3-phosphate dehydrogenase 1 (GAP1), Glyceraldehyde-3-phosphate dehydrogenase 2 (GAP2)
  2. Phosphoglycerate kinase (PGK)
  3. Phosphoglycerate mutase (KLLA0_E11859g), Phosphoglycerate mutase (KLLA0_C04081g)
  4. Enolase (ENO)
  5. Pyruvate kinase (PYK1)
This subpathway is part of the pathway glycolysis, which is itself part of Carbohydrate degradation.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes pyruvate from D-glyceraldehyde 3-phosphate, the pathway glycolysis and in Carbohydrate degradation.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei39SubstrateBy similarity1
Binding sitei122SubstrateBy similarity1
Binding sitei169SubstrateBy similarity1
Binding sitei218ATPBy similarity1
Binding sitei311ATP; via carbonyl oxygenBy similarity1
Binding sitei342ATPBy similarity1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi371 – 374ATPBy similarity4

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionKinase, Transferase
Biological processGlycolysis
LigandATP-binding, Nucleotide-binding

Enzyme and pathway databases

UniPathwayiUPA00109; UER00185

Names & Taxonomyi

Protein namesi
Recommended name:
Phosphoglycerate kinase (EC:2.7.2.3)
Gene namesi
Name:PGK
Ordered Locus Names:KLLA0A11011g
OrganismiKluyveromyces lactis (strain ATCC 8585 / CBS 2359 / DSM 70799 / NBRC 1267 / NRRL Y-1140 / WM37) (Yeast) (Candida sphaerica)
Taxonomic identifieri284590 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeKluyveromyces
Proteomesi
  • UP000000598 Componenti: Chromosome A

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cell wall Cytoskeleton Vacuole Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001458821 – 416Phosphoglycerate kinaseAdd BLAST416

Proteomic databases

PRIDEiP14828

Interactioni

Subunit structurei

Monomer.By similarity

Protein-protein interaction databases

STRINGi284590.XP_451479.1

Structurei

3D structure databases

ProteinModelPortaliP14828
SMRiP14828
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni24 – 26Substrate bindingBy similarity3
Regioni63 – 66Substrate bindingBy similarity4

Sequence similaritiesi

Belongs to the phosphoglycerate kinase family.Curated

Phylogenomic databases

eggNOGiKOG1367 Eukaryota
COG0126 LUCA
HOGENOMiHOG000227107
InParanoidiP14828
KOiK00927
OMAiDMIFDIG
OrthoDBiEOG092C2GKC

Family and domain databases

CDDicd00318 Phosphoglycerate_kinase, 1 hit
Gene3Di3.40.50.1260, 4 hits
HAMAPiMF_00145 Phosphoglyc_kinase, 1 hit
InterProiView protein in InterPro
IPR001576 Phosphoglycerate_kinase
IPR015911 Phosphoglycerate_kinase_CS
IPR015824 Phosphoglycerate_kinase_N
IPR036043 Phosphoglycerate_kinase_sf
PANTHERiPTHR11406 PTHR11406, 1 hit
PfamiView protein in Pfam
PF00162 PGK, 1 hit
PIRSFiPIRSF000724 Pgk, 1 hit
PRINTSiPR00477 PHGLYCKINASE
SUPFAMiSSF53748 SSF53748, 1 hit
PROSITEiView protein in PROSITE
PS00111 PGLYCERATE_KINASE, 1 hit

Sequencei

Sequence statusi: Complete.

P14828-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSLSSKLTVK DLDVTGKRVF IRVDFNVPLD GKKITSNQRI VAALPTIQYV
60 70 80 90 100
LEKKPKAIVL ASHLGRPNGE VNDKYSLAPV ADELSRLLQK PVTFLHDCVG
110 120 130 140 150
EEVTNAVNNA KDGEVFLLEN LRFHIEEEGS RKVDGNKVKA DKAAVTKFRE
160 170 180 190 200
QLSSLADVYV NDAFGTAHRA HSSIVGFDLP NRAAGFLLSK ELQYFAKALE
210 220 230 240 250
NPTRPFLAIL GGAKVADKIQ LIDNLLDKVD SLIIGGGMAF TFKKVLENTE
260 270 280 290 300
IGDSIYDAAG AELVPKLVEK AKKNNVKIVL PTDFVIGDKF SADANTKVVT
310 320 330 340 350
DKEGIPSGWQ GLDNGPESRK AFAATVAEAK TIVWNGPPGV FEFAPFAKGT
360 370 380 390 400
EALLDAVVAS SQAGNTVIIG GGDTATVAKK YGVVDKISHV STGGGASLEL
410
LEGKELPGVT FLSNKQ
Length:416
Mass (Da):44,514
Last modified:September 27, 2004 - v2
Checksum:i9CFF5724C67AB850
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti366T → N in CAA35646 (PubMed:2326170).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X17654 Genomic DNA Translation: CAA35646.1
CR382121 Genomic DNA Translation: CAH03067.1
PIRiS07878 KIVKGL
RefSeqiXP_451479.1, XM_451479.1

Genome annotation databases

EnsemblFungiiCAH03067; CAH03067; KLLA0_A11011g
GeneIDi2896489
KEGGikla:KLLA0A11011g

Similar proteinsi

Entry informationi

Entry nameiPGK_KLULA
AccessioniPrimary (citable) accession number: P14828
Secondary accession number(s): Q6CX60
Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 1, 1990
Last sequence update: September 27, 2004
Last modified: February 28, 2018
This is version 114 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

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