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P14824

- ANXA6_MOUSE

UniProt

P14824 - ANXA6_MOUSE

Protein

Annexin A6

Gene

Anxa6

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 119 (01 Oct 2014)
      Sequence version 3 (27 Jul 2011)
      Previous versions | rss
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    Functioni

    May associate with CD21. May regulate the release of Ca2+ from intracellular stores.

    GO - Molecular functioni

    1. calcium-dependent phospholipid binding Source: UniProtKB-KW
    2. calcium ion binding Source: InterPro

    GO - Biological processi

    1. calcium ion transport Source: MGI
    2. regulation of muscle contraction Source: MGI

    Keywords - Ligandi

    Calcium, Calcium/phospholipid-binding

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Annexin A6
    Alternative name(s):
    67 kDa calelectrin
    Annexin VI
    Annexin-6
    Calphobindin-II
    Short name:
    CPB-II
    Chromobindin-20
    Lipocortin VI
    Protein III
    p68
    p70
    Gene namesi
    Name:Anxa6
    Synonyms:Anx6
    OrganismiMus musculus (Mouse)
    Taxonomic identifieri10090 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
    ProteomesiUP000000589: Chromosome 11

    Organism-specific databases

    MGIiMGI:88255. Anxa6.

    Subcellular locationi

    Cytoplasm By similarity. Melanosome By similarity

    GO - Cellular componenti

    1. extracellular vesicular exosome Source: Ensembl
    2. melanosome Source: UniProtKB-SubCell
    3. perinuclear region of cytoplasm Source: MGI

    Keywords - Cellular componenti

    Cytoplasm

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Initiator methioninei1 – 11RemovedBy similarity
    Chaini2 – 673672Annexin A6PRO_0000067495Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei2 – 21N-acetylalanineBy similarity
    Modified residuei30 – 301Phosphotyrosine1 Publication
    Modified residuei63 – 631N6-acetyllysineBy similarity
    Modified residuei68 – 681N6-acetyllysineBy similarity
    Modified residuei75 – 751N6-acetyllysineBy similarity
    Modified residuei81 – 811N6-acetyllysineBy similarity
    Modified residuei201 – 2011Phosphotyrosine1 Publication
    Modified residuei306 – 3061N6-acetyllysineBy similarity
    Modified residuei370 – 3701N6-acetyllysineBy similarity
    Modified residuei418 – 4181N6-acetyllysineBy similarity
    Modified residuei483 – 4831N6-acetyllysineBy similarity
    Modified residuei620 – 6201N6-acetyllysine1 Publication

    Keywords - PTMi

    Acetylation, Phosphoprotein

    Proteomic databases

    MaxQBiP14824.
    PaxDbiP14824.
    PRIDEiP14824.

    PTM databases

    PhosphoSiteiP14824.

    Expressioni

    Gene expression databases

    ArrayExpressiP14824.
    BgeeiP14824.
    CleanExiMM_ANXA6.
    GenevestigatoriP14824.

    Interactioni

    Protein-protein interaction databases

    BioGridi198112. 3 interactions.
    IntActiP14824. 3 interactions.
    MINTiMINT-1862250.

    Structurei

    3D structure databases

    ProteinModelPortaliP14824.
    SMRiP14824. Positions 10-673.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Repeati29 – 8961Annexin 1Add
    BLAST
    Repeati101 – 16161Annexin 2Add
    BLAST
    Repeati185 – 24561Annexin 3Add
    BLAST
    Repeati260 – 32061Annexin 4Add
    BLAST
    Repeati372 – 43261Annexin 5Add
    BLAST
    Repeati444 – 50461Annexin 6Add
    BLAST
    Repeati533 – 59361Annexin 7Add
    BLAST
    Repeati608 – 66861Annexin 8Add
    BLAST

    Domaini

    A pair of annexin repeats may form one binding site for calcium and phospholipid.

    Sequence similaritiesi

    Belongs to the annexin family.Curated
    Contains 8 annexin repeats.Curated

    Keywords - Domaini

    Annexin, Repeat

    Phylogenomic databases

    eggNOGiNOG267770.
    GeneTreeiENSGT00740000115434.
    HOGENOMiHOG000158803.
    HOVERGENiHBG061815.
    InParanoidiQ8BSS4.
    KOiK17094.
    OMAiEKSLYSM.
    OrthoDBiEOG74XS72.
    TreeFamiTF105452.

    Family and domain databases

    Gene3Di1.10.220.10. 8 hits.
    InterProiIPR001464. Annexin.
    IPR018502. Annexin_repeat.
    IPR018252. Annexin_repeat_CS.
    IPR002393. AnnexinVI.
    [Graphical view]
    PfamiPF00191. Annexin. 8 hits.
    [Graphical view]
    PRINTSiPR00196. ANNEXIN.
    PR00202. ANNEXINVI.
    SMARTiSM00335. ANX. 8 hits.
    [Graphical view]
    PROSITEiPS00223. ANNEXIN. 8 hits.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    P14824-1 [UniParc]FASTAAdd to Basket

    « Hide

    MAKIAQGAMY RGSVHDFPEF DANQDAEALY TAMKGFGSDK ESILELITSR    50
    SNKQRQEICQ NYKSLYGKDL IEDLKYELTG KFERLIVNLM RPLAYCDAKE 100
    IKDAISGVGT DEKCLIEILA SRTNEQMHQL VAAYKDAYER DLESDIIGDT 150
    SGHFQKMLVV LLQGTRENDD VVSEDLVQQD VQDLYEAGEL KWGTDEAQFI 200
    YILGNRSKQH LRLVFDEYLK TTGKPIEASI RGELSGDFEK LMLAVVKCIR 250
    STPEYFAERL FKAMKGLGTR DNTLIRIMVS RSELDMLDIR EIFRTKYEKS 300
    LYSMIKNDTS GEYKKALLKL CGGDDDAAGQ FFPEAAQVAY QMWELSAVSR 350
    VELKGTVCAA NDFNPDADAK ALRKAMKGIG TDEATIIDIV THRSNAQRQQ 400
    IRQTFKSHFG RDLMADLKSE ISGDLARLIL GLMMPPAHYD AKQLKKAMEG 450
    AGTDEKTLIE ILATRTNAEI RAINEAYKED YHKSLEDALS SDTSGHFRRI 500
    LISLATGNRE EGGENRDQAQ EDAQVAAEIL EIADTPSGDK TSLETRFMTV 550
    LCTRSYPHLR RVFQEFIKKT NYDIEHVIKK EMSGDVKDAF VAIVQSVKNK 600
    PLFFADKLYK SMKGAGTDEK TLTRVMVSRS EIDLLNIRRE FIEKYDKSLH 650
    QAIEGDTSGD FMKALLALCG GED 673
    Length:673
    Mass (Da):75,885
    Last modified:July 27, 2011 - v3
    Checksum:iDCC5FC56CBD88809
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti61 – 611N → S in CAA31808. (PubMed:2972541)Curated
    Sequence conflicti108 – 1081V → I in CAA31808. (PubMed:2972541)Curated
    Sequence conflicti329 – 3291G → A in CAA31808. (PubMed:2972541)Curated

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    X13460 mRNA. Translation: CAA31808.1.
    AK030728 mRNA. Translation: BAC27101.1.
    AK146509 mRNA. Translation: BAE27222.1.
    AK146592 mRNA. Translation: BAE27287.1.
    CCDSiCCDS24705.1.
    PIRiS01786.
    RefSeqiNP_001103681.1. NM_001110211.1.
    NP_038500.2. NM_013472.4.
    UniGeneiMm.265347.

    Genome annotation databases

    EnsembliENSMUST00000108883; ENSMUSP00000104511; ENSMUSG00000018340.
    GeneIDi11749.
    KEGGimmu:11749.
    UCSCiuc007iyr.2. mouse.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    X13460 mRNA. Translation: CAA31808.1 .
    AK030728 mRNA. Translation: BAC27101.1 .
    AK146509 mRNA. Translation: BAE27222.1 .
    AK146592 mRNA. Translation: BAE27287.1 .
    CCDSi CCDS24705.1.
    PIRi S01786.
    RefSeqi NP_001103681.1. NM_001110211.1.
    NP_038500.2. NM_013472.4.
    UniGenei Mm.265347.

    3D structure databases

    ProteinModelPortali P14824.
    SMRi P14824. Positions 10-673.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 198112. 3 interactions.
    IntActi P14824. 3 interactions.
    MINTi MINT-1862250.

    PTM databases

    PhosphoSitei P14824.

    Proteomic databases

    MaxQBi P14824.
    PaxDbi P14824.
    PRIDEi P14824.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSMUST00000108883 ; ENSMUSP00000104511 ; ENSMUSG00000018340 .
    GeneIDi 11749.
    KEGGi mmu:11749.
    UCSCi uc007iyr.2. mouse.

    Organism-specific databases

    CTDi 309.
    MGIi MGI:88255. Anxa6.

    Phylogenomic databases

    eggNOGi NOG267770.
    GeneTreei ENSGT00740000115434.
    HOGENOMi HOG000158803.
    HOVERGENi HBG061815.
    InParanoidi Q8BSS4.
    KOi K17094.
    OMAi EKSLYSM.
    OrthoDBi EOG74XS72.
    TreeFami TF105452.

    Miscellaneous databases

    NextBioi 279489.
    PROi P14824.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi P14824.
    Bgeei P14824.
    CleanExi MM_ANXA6.
    Genevestigatori P14824.

    Family and domain databases

    Gene3Di 1.10.220.10. 8 hits.
    InterProi IPR001464. Annexin.
    IPR018502. Annexin_repeat.
    IPR018252. Annexin_repeat_CS.
    IPR002393. AnnexinVI.
    [Graphical view ]
    Pfami PF00191. Annexin. 8 hits.
    [Graphical view ]
    PRINTSi PR00196. ANNEXIN.
    PR00202. ANNEXINVI.
    SMARTi SM00335. ANX. 8 hits.
    [Graphical view ]
    PROSITEi PS00223. ANNEXIN. 8 hits.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Molecular cloning of murine p68, a Ca2+-binding protein of the lipocortin family."
      Moss S.E., Crompton M.R., Crumpton M.J.
      Eur. J. Biochem. 177:21-27(1988) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
      Strain: BALB/c.
    2. "The transcriptional landscape of the mammalian genome."
      Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
      , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
      Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Strain: C57BL/6J.
      Tissue: Embryo and Heart.
    3. Lubec G., Kang S.U.
      Submitted (APR-2007) to UniProtKB
      Cited for: PROTEIN SEQUENCE OF 35-50; 69-81; 123-135; 282-290; 378-393; 457-465; 484-498; 500-509 AND 630-638, IDENTIFICATION BY MASS SPECTROMETRY.
      Strain: C57BL/6.
      Tissue: Brain.
    4. "Quantitative time-resolved phosphoproteomic analysis of mast cell signaling."
      Cao L., Yu K., Banh C., Nguyen V., Ritz A., Raphael B.J., Kawakami Y., Kawakami T., Salomon A.R.
      J. Immunol. 179:5864-5876(2007) [PubMed] [Europe PMC] [Abstract]
      Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT TYR-201, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
      Tissue: Mast cell.
    5. "Large-scale identification and evolution indexing of tyrosine phosphorylation sites from murine brain."
      Ballif B.A., Carey G.R., Sunyaev S.R., Gygi S.P.
      J. Proteome Res. 7:311-318(2008) [PubMed] [Europe PMC] [Abstract]
      Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT TYR-30, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
      Tissue: Brain.
    6. "SIRT5-mediated lysine desuccinylation impacts diverse metabolic pathways."
      Park J., Chen Y., Tishkoff D.X., Peng C., Tan M., Dai L., Xie Z., Zhang Y., Zwaans B.M., Skinner M.E., Lombard D.B., Zhao Y.
      Mol. Cell 50:919-930(2013) [PubMed] [Europe PMC] [Abstract]
      Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT LYS-620, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
      Tissue: Embryonic fibroblast.

    Entry informationi

    Entry nameiANXA6_MOUSE
    AccessioniPrimary (citable) accession number: P14824
    Secondary accession number(s): Q8BSS4
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: April 1, 1990
    Last sequence update: July 27, 2011
    Last modified: October 1, 2014
    This is version 119 of the entry and version 3 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Miscellaneous

    Seems to bind one calcium ion with high affinity.

    Keywords - Technical termi

    Complete proteome, Direct protein sequencing, Reference proteome

    Documents

    1. MGD cross-references
      Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3