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P14824 (ANXA6_MOUSE) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 116. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Annexin A6
Alternative name(s):
67 kDa calelectrin
Annexin VI
Annexin-6
Calphobindin-II
Short name=CPB-II
Chromobindin-20
Lipocortin VI
Protein III
p68
p70
Gene names
Name:Anxa6
Synonyms:Anx6
OrganismMus musculus (Mouse) [Reference proteome]
Taxonomic identifier10090 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus

Protein attributes

Sequence length673 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

May associate with CD21. May regulate the release of Ca2+ from intracellular stores.

Subcellular location

Cytoplasm By similarity. Melanosome By similarity.

Domain

A pair of annexin repeats may form one binding site for calcium and phospholipid.

Miscellaneous

Seems to bind one calcium ion with high affinity.

Sequence similarities

Belongs to the annexin family.

Contains 8 annexin repeats.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Initiator methionine11Removed By similarity
Chain2 – 673672Annexin A6
PRO_0000067495

Regions

Repeat29 – 8961Annexin 1
Repeat101 – 16161Annexin 2
Repeat185 – 24561Annexin 3
Repeat260 – 32061Annexin 4
Repeat372 – 43261Annexin 5
Repeat444 – 50461Annexin 6
Repeat533 – 59361Annexin 7
Repeat608 – 66861Annexin 8

Amino acid modifications

Modified residue21N-acetylalanine By similarity
Modified residue301Phosphotyrosine Ref.5
Modified residue631N6-acetyllysine By similarity
Modified residue681N6-acetyllysine By similarity
Modified residue751N6-acetyllysine By similarity
Modified residue811N6-acetyllysine By similarity
Modified residue2011Phosphotyrosine Ref.4
Modified residue3061N6-acetyllysine By similarity
Modified residue3701N6-acetyllysine By similarity
Modified residue4181N6-acetyllysine By similarity
Modified residue4831N6-acetyllysine By similarity
Modified residue6201N6-acetyllysine Ref.6

Experimental info

Sequence conflict611N → S in CAA31808. Ref.1
Sequence conflict1081V → I in CAA31808. Ref.1
Sequence conflict3291G → A in CAA31808. Ref.1

Sequences

Sequence LengthMass (Da)Tools
P14824 [UniParc].

Last modified July 27, 2011. Version 3.
Checksum: DCC5FC56CBD88809

FASTA67375,885
        10         20         30         40         50         60 
MAKIAQGAMY RGSVHDFPEF DANQDAEALY TAMKGFGSDK ESILELITSR SNKQRQEICQ 

        70         80         90        100        110        120 
NYKSLYGKDL IEDLKYELTG KFERLIVNLM RPLAYCDAKE IKDAISGVGT DEKCLIEILA 

       130        140        150        160        170        180 
SRTNEQMHQL VAAYKDAYER DLESDIIGDT SGHFQKMLVV LLQGTRENDD VVSEDLVQQD 

       190        200        210        220        230        240 
VQDLYEAGEL KWGTDEAQFI YILGNRSKQH LRLVFDEYLK TTGKPIEASI RGELSGDFEK 

       250        260        270        280        290        300 
LMLAVVKCIR STPEYFAERL FKAMKGLGTR DNTLIRIMVS RSELDMLDIR EIFRTKYEKS 

       310        320        330        340        350        360 
LYSMIKNDTS GEYKKALLKL CGGDDDAAGQ FFPEAAQVAY QMWELSAVSR VELKGTVCAA 

       370        380        390        400        410        420 
NDFNPDADAK ALRKAMKGIG TDEATIIDIV THRSNAQRQQ IRQTFKSHFG RDLMADLKSE 

       430        440        450        460        470        480 
ISGDLARLIL GLMMPPAHYD AKQLKKAMEG AGTDEKTLIE ILATRTNAEI RAINEAYKED 

       490        500        510        520        530        540 
YHKSLEDALS SDTSGHFRRI LISLATGNRE EGGENRDQAQ EDAQVAAEIL EIADTPSGDK 

       550        560        570        580        590        600 
TSLETRFMTV LCTRSYPHLR RVFQEFIKKT NYDIEHVIKK EMSGDVKDAF VAIVQSVKNK 

       610        620        630        640        650        660 
PLFFADKLYK SMKGAGTDEK TLTRVMVSRS EIDLLNIRRE FIEKYDKSLH QAIEGDTSGD 

       670 
FMKALLALCG GED 

« Hide

References

« Hide 'large scale' references
[1]"Molecular cloning of murine p68, a Ca2+-binding protein of the lipocortin family."
Moss S.E., Crompton M.R., Crumpton M.J.
Eur. J. Biochem. 177:21-27(1988) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
Strain: BALB/c.
[2]"The transcriptional landscape of the mammalian genome."
Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J. expand/collapse author list , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Strain: C57BL/6J.
Tissue: Embryo and Heart.
[3]Lubec G., Kang S.U.
Submitted (APR-2007) to UniProtKB
Cited for: PROTEIN SEQUENCE OF 35-50; 69-81; 123-135; 282-290; 378-393; 457-465; 484-498; 500-509 AND 630-638, IDENTIFICATION BY MASS SPECTROMETRY.
Strain: C57BL/6.
Tissue: Brain.
[4]"Quantitative time-resolved phosphoproteomic analysis of mast cell signaling."
Cao L., Yu K., Banh C., Nguyen V., Ritz A., Raphael B.J., Kawakami Y., Kawakami T., Salomon A.R.
J. Immunol. 179:5864-5876(2007) [PubMed] [Europe PMC] [Abstract]
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT TYR-201, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
Tissue: Mast cell.
[5]"Large-scale identification and evolution indexing of tyrosine phosphorylation sites from murine brain."
Ballif B.A., Carey G.R., Sunyaev S.R., Gygi S.P.
J. Proteome Res. 7:311-318(2008) [PubMed] [Europe PMC] [Abstract]
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT TYR-30, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
Tissue: Brain.
[6]"SIRT5-mediated lysine desuccinylation impacts diverse metabolic pathways."
Park J., Chen Y., Tishkoff D.X., Peng C., Tan M., Dai L., Xie Z., Zhang Y., Zwaans B.M., Skinner M.E., Lombard D.B., Zhao Y.
Mol. Cell 50:919-930(2013) [PubMed] [Europe PMC] [Abstract]
Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT LYS-620, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
Tissue: Embryonic fibroblast.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
X13460 mRNA. Translation: CAA31808.1.
AK030728 mRNA. Translation: BAC27101.1.
AK146509 mRNA. Translation: BAE27222.1.
AK146592 mRNA. Translation: BAE27287.1.
PIRS01786.
RefSeqNP_001103681.1. NM_001110211.1.
NP_038500.2. NM_013472.4.
UniGeneMm.265347.

3D structure databases

ProteinModelPortalP14824.
SMRP14824. Positions 10-673.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

BioGrid198112. 3 interactions.
IntActP14824. 3 interactions.
MINTMINT-1862250.

PTM databases

PhosphoSiteP14824.

Proteomic databases

PaxDbP14824.
PRIDEP14824.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENSMUST00000108883; ENSMUSP00000104511; ENSMUSG00000018340.
GeneID11749.
KEGGmmu:11749.
UCSCuc007iyr.2. mouse.

Organism-specific databases

CTD309.
MGIMGI:88255. Anxa6.

Phylogenomic databases

eggNOGNOG267770.
GeneTreeENSGT00740000115434.
HOGENOMHOG000158803.
HOVERGENHBG061815.
InParanoidQ8BSS4.
KOK17094.
OMAEKSLYSM.
OrthoDBEOG74XS72.
TreeFamTF105452.

Gene expression databases

ArrayExpressP14824.
BgeeP14824.
CleanExMM_ANXA6.
GenevestigatorP14824.

Family and domain databases

Gene3D1.10.220.10. 8 hits.
InterProIPR001464. Annexin.
IPR018502. Annexin_repeat.
IPR018252. Annexin_repeat_CS.
IPR002393. AnnexinVI.
[Graphical view]
PfamPF00191. Annexin. 8 hits.
[Graphical view]
PRINTSPR00196. ANNEXIN.
PR00202. ANNEXINVI.
SMARTSM00335. ANX. 8 hits.
[Graphical view]
PROSITEPS00223. ANNEXIN. 8 hits.
[Graphical view]
ProtoNetSearch...

Other

NextBio279489.
PROP14824.
SOURCESearch...

Entry information

Entry nameANXA6_MOUSE
AccessionPrimary (citable) accession number: P14824
Secondary accession number(s): Q8BSS4
Entry history
Integrated into UniProtKB/Swiss-Prot: April 1, 1990
Last sequence update: July 27, 2011
Last modified: April 16, 2014
This is version 116 of the entry and version 3 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

MGD cross-references

Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot