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Protein

Annexin A6

Gene

Anxa6

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

May associate with CD21. May regulate the release of Ca2+ from intracellular stores.

GO - Molecular functioni

GO - Biological processi

  • apoptotic signaling pathway Source: CACAO
  • calcium ion transport Source: MGI
  • ion transmembrane transport Source: MGI
  • mitochondrial calcium ion homeostasis Source: CACAO
  • muscle contraction Source: Reactome
  • protein homooligomerization Source: MGI
  • regulation of muscle contraction Source: MGI
Complete GO annotation...

Keywords - Ligandi

Calcium, Calcium/phospholipid-binding

Enzyme and pathway databases

ReactomeiR-MMU-445355. Smooth Muscle Contraction.

Names & Taxonomyi

Protein namesi
Recommended name:
Annexin A6
Alternative name(s):
67 kDa calelectrin
Annexin VI
Annexin-6
Calphobindin-II
Short name:
CPB-II
Chromobindin-20
Lipocortin VI
Protein III
p68
p70
Gene namesi
Name:Anxa6
Synonyms:Anx6
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 11

Organism-specific databases

MGIiMGI:88255. Anxa6.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Initiator methionineiRemovedBy similarity
ChainiPRO_00000674952 – 673Annexin A6Add BLAST672

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei2N-acetylalanineBy similarity1
Modified residuei13PhosphoserineBy similarity1
Modified residuei30PhosphotyrosineCombined sources1
Modified residuei63N6-acetyllysineBy similarity1
Modified residuei68N6-acetyllysineBy similarity1
Modified residuei75N6-acetyllysineBy similarity1
Modified residuei81N6-acetyllysineBy similarity1
Modified residuei201PhosphotyrosineCombined sources1
Modified residuei306N6-acetyllysineBy similarity1
Modified residuei370N6-acetyllysineBy similarity1
Modified residuei418N6-acetyllysineBy similarity1
Modified residuei422PhosphoserineBy similarity1
Modified residuei483N6-acetyllysineBy similarity1
Modified residuei537PhosphoserineBy similarity1
Modified residuei620N6-acetyllysineCombined sources1

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

EPDiP14824.
MaxQBiP14824.
PaxDbiP14824.
PeptideAtlasiP14824.
PRIDEiP14824.

PTM databases

iPTMnetiP14824.
PhosphoSitePlusiP14824.
SwissPalmiP14824.

Expressioni

Gene expression databases

BgeeiENSMUSG00000018340.
CleanExiMM_ANXA6.
ExpressionAtlasiP14824. baseline and differential.
GenevisibleiP14824. MM.

Interactioni

GO - Molecular functioni

Protein-protein interaction databases

BioGridi198112. 4 interactors.
IntActiP14824. 3 interactors.
MINTiMINT-1862250.
STRINGi10090.ENSMUSP00000104511.

Structurei

3D structure databases

ProteinModelPortaliP14824.
SMRiP14824.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Repeati29 – 89Annexin 1Add BLAST61
Repeati101 – 161Annexin 2Add BLAST61
Repeati185 – 245Annexin 3Add BLAST61
Repeati260 – 320Annexin 4Add BLAST61
Repeati372 – 432Annexin 5Add BLAST61
Repeati444 – 504Annexin 6Add BLAST61
Repeati533 – 593Annexin 7Add BLAST61
Repeati608 – 668Annexin 8Add BLAST61

Domaini

A pair of annexin repeats may form one binding site for calcium and phospholipid.

Sequence similaritiesi

Belongs to the annexin family.Curated
Contains 8 annexin repeats.Curated

Keywords - Domaini

Annexin, Repeat

Phylogenomic databases

eggNOGiKOG0819. Eukaryota.
ENOG410XPUN. LUCA.
GeneTreeiENSGT00760000118972.
HOGENOMiHOG000158803.
HOVERGENiHBG061815.
InParanoidiP14824.
KOiK17094.
OMAiQRQEICQ.
OrthoDBiEOG091G0H6H.
TreeFamiTF105452.

Family and domain databases

Gene3Di1.10.220.10. 8 hits.
InterProiIPR001464. Annexin.
IPR018502. Annexin_repeat.
IPR018252. Annexin_repeat_CS.
IPR002393. AnnexinVI.
[Graphical view]
PANTHERiPTHR10502:SF19. PTHR10502:SF19. 1 hit.
PfamiPF00191. Annexin. 8 hits.
[Graphical view]
PRINTSiPR00196. ANNEXIN.
PR00202. ANNEXINVI.
SMARTiSM00335. ANX. 8 hits.
[Graphical view]
PROSITEiPS00223. ANNEXIN. 8 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P14824-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAKIAQGAMY RGSVHDFPEF DANQDAEALY TAMKGFGSDK ESILELITSR
60 70 80 90 100
SNKQRQEICQ NYKSLYGKDL IEDLKYELTG KFERLIVNLM RPLAYCDAKE
110 120 130 140 150
IKDAISGVGT DEKCLIEILA SRTNEQMHQL VAAYKDAYER DLESDIIGDT
160 170 180 190 200
SGHFQKMLVV LLQGTRENDD VVSEDLVQQD VQDLYEAGEL KWGTDEAQFI
210 220 230 240 250
YILGNRSKQH LRLVFDEYLK TTGKPIEASI RGELSGDFEK LMLAVVKCIR
260 270 280 290 300
STPEYFAERL FKAMKGLGTR DNTLIRIMVS RSELDMLDIR EIFRTKYEKS
310 320 330 340 350
LYSMIKNDTS GEYKKALLKL CGGDDDAAGQ FFPEAAQVAY QMWELSAVSR
360 370 380 390 400
VELKGTVCAA NDFNPDADAK ALRKAMKGIG TDEATIIDIV THRSNAQRQQ
410 420 430 440 450
IRQTFKSHFG RDLMADLKSE ISGDLARLIL GLMMPPAHYD AKQLKKAMEG
460 470 480 490 500
AGTDEKTLIE ILATRTNAEI RAINEAYKED YHKSLEDALS SDTSGHFRRI
510 520 530 540 550
LISLATGNRE EGGENRDQAQ EDAQVAAEIL EIADTPSGDK TSLETRFMTV
560 570 580 590 600
LCTRSYPHLR RVFQEFIKKT NYDIEHVIKK EMSGDVKDAF VAIVQSVKNK
610 620 630 640 650
PLFFADKLYK SMKGAGTDEK TLTRVMVSRS EIDLLNIRRE FIEKYDKSLH
660 670
QAIEGDTSGD FMKALLALCG GED
Length:673
Mass (Da):75,885
Last modified:July 27, 2011 - v3
Checksum:iDCC5FC56CBD88809
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti61N → S in CAA31808 (PubMed:2972541).Curated1
Sequence conflicti108V → I in CAA31808 (PubMed:2972541).Curated1
Sequence conflicti329G → A in CAA31808 (PubMed:2972541).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X13460 mRNA. Translation: CAA31808.1.
AK030728 mRNA. Translation: BAC27101.1.
AK146509 mRNA. Translation: BAE27222.1.
AK146592 mRNA. Translation: BAE27287.1.
CCDSiCCDS24705.1.
PIRiS01786.
RefSeqiNP_038500.2. NM_013472.5.
UniGeneiMm.265347.

Genome annotation databases

EnsembliENSMUST00000108883; ENSMUSP00000104511; ENSMUSG00000018340.
GeneIDi11749.
KEGGimmu:11749.
UCSCiuc007iyr.2. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X13460 mRNA. Translation: CAA31808.1.
AK030728 mRNA. Translation: BAC27101.1.
AK146509 mRNA. Translation: BAE27222.1.
AK146592 mRNA. Translation: BAE27287.1.
CCDSiCCDS24705.1.
PIRiS01786.
RefSeqiNP_038500.2. NM_013472.5.
UniGeneiMm.265347.

3D structure databases

ProteinModelPortaliP14824.
SMRiP14824.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi198112. 4 interactors.
IntActiP14824. 3 interactors.
MINTiMINT-1862250.
STRINGi10090.ENSMUSP00000104511.

PTM databases

iPTMnetiP14824.
PhosphoSitePlusiP14824.
SwissPalmiP14824.

Proteomic databases

EPDiP14824.
MaxQBiP14824.
PaxDbiP14824.
PeptideAtlasiP14824.
PRIDEiP14824.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000108883; ENSMUSP00000104511; ENSMUSG00000018340.
GeneIDi11749.
KEGGimmu:11749.
UCSCiuc007iyr.2. mouse.

Organism-specific databases

CTDi309.
MGIiMGI:88255. Anxa6.

Phylogenomic databases

eggNOGiKOG0819. Eukaryota.
ENOG410XPUN. LUCA.
GeneTreeiENSGT00760000118972.
HOGENOMiHOG000158803.
HOVERGENiHBG061815.
InParanoidiP14824.
KOiK17094.
OMAiQRQEICQ.
OrthoDBiEOG091G0H6H.
TreeFamiTF105452.

Enzyme and pathway databases

ReactomeiR-MMU-445355. Smooth Muscle Contraction.

Miscellaneous databases

PROiP14824.
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000018340.
CleanExiMM_ANXA6.
ExpressionAtlasiP14824. baseline and differential.
GenevisibleiP14824. MM.

Family and domain databases

Gene3Di1.10.220.10. 8 hits.
InterProiIPR001464. Annexin.
IPR018502. Annexin_repeat.
IPR018252. Annexin_repeat_CS.
IPR002393. AnnexinVI.
[Graphical view]
PANTHERiPTHR10502:SF19. PTHR10502:SF19. 1 hit.
PfamiPF00191. Annexin. 8 hits.
[Graphical view]
PRINTSiPR00196. ANNEXIN.
PR00202. ANNEXINVI.
SMARTiSM00335. ANX. 8 hits.
[Graphical view]
PROSITEiPS00223. ANNEXIN. 8 hits.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiANXA6_MOUSE
AccessioniPrimary (citable) accession number: P14824
Secondary accession number(s): Q8BSS4
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 1, 1990
Last sequence update: July 27, 2011
Last modified: November 30, 2016
This is version 139 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Miscellaneous

Seems to bind one calcium ion with high affinity.

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.