Annexin A6 - Mus musculus (Mouse)

Contribute

Send feedback

Read comments (?) or add your own

P14824 (ANXA6_MOUSE) Reviewed, UniProtKB/Swiss-Prot

Last modified April 3, 2013. Version 107. History...

Clusters with 100%, 90%, 50% identity |

Documents (2) |

Third-party data

text xml rdf/xml gff fasta

Names·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·Documents Customize order

Names and origin

Protein names

Recommended name:
Annexin A6

Alternative name(s):
67 kDa calelectrin
Annexin VI
Annexin-6
Calphobindin-II
Short name=CPB-II
Chromobindin-20
Lipocortin VI
Protein III
p68
p70

Gene names

Name:	Anxa6
Synonyms:	Anx6

Organism

Mus musculus (Mouse) [Reference proteome]

Taxonomic identifier

10090 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Sciurognathi › Muroidea › Muridae › Murinae › Mus › Mus

Protein attributes

Sequence length	673 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is further processed into a mature form.
Protein existence	Evidence at protein level

General annotation (Comments)

Function	May associate with CD21. May regulate the release of Ca²⁺ from intracellular stores.
Subcellular location	Cytoplasm By similarity. Melanosome By similarity.
Domain	A pair of annexin repeats may form one binding site for calcium and phospholipid.
Miscellaneous	Seems to bind one calcium ion with high affinity.
Sequence similarities	Belongs to the annexin family. Contains 8 annexin repeats.

Ontologies

Keywords
Cellular component	Cytoplasm
Domain	Annexin Repeat
Ligand	Calcium Calcium/phospholipid-binding
PTM	Acetylation Phosphoprotein
Technical term	Complete proteome Direct protein sequencing Reference proteome
Gene Ontology (GO)
Biological_process	calcium ion transport Inferred from mutant phenotype PubMed 11919174. Source: MGI regulation of muscle contraction Inferred from mutant phenotype PubMed 11919174. Source: MGI
Cellular_component	melanosome Inferred from electronic annotation. Source: UniProtKB-SubCell perinuclear region of cytoplasm Inferred from direct assay PubMed 15078881. Source: MGI
Molecular_function	calcium ion binding Inferred from electronic annotation. Source: InterPro calcium-dependent phospholipid binding Inferred from electronic annotation. Source: UniProtKB-KW
Complete GO annotation...

Sequence annotation (Features)

Feature key

Position(s)

Length

Description

Graphical view

Feature identifier

Molecule processing

Initiator methionine

Removed By similarity

Chain

2 – 673

672

Annexin A6

PRO_0000067495

Regions

Repeat

29 – 89

Annexin 1

Repeat

101 – 161

Annexin 2

Repeat

185 – 245

Annexin 3

Repeat

260 – 320

Annexin 4

Repeat

372 – 432

Annexin 5

Repeat

444 – 504

Annexin 6

Repeat

533 – 593

Annexin 7

Repeat

608 – 668

Annexin 8

Amino acid modifications

Modified residue

N-acetylalanine By similarity

Modified residue

Phosphotyrosine Ref.5

Modified residue

N6-acetyllysine By similarity

Modified residue

N6-acetyllysine By similarity

Modified residue

N6-acetyllysine By similarity

Modified residue

N6-acetyllysine By similarity

Modified residue

201

Phosphotyrosine Ref.4

Modified residue

306

N6-acetyllysine By similarity

Modified residue

370

N6-acetyllysine By similarity

Modified residue

418

N6-acetyllysine By similarity

Modified residue

483

N6-acetyllysine By similarity

Modified residue

620

N6-acetyllysine By similarity

Experimental info

Sequence conflict

N → S in CAA31808. Ref.1

Sequence conflict

108

V → I in CAA31808. Ref.1

Sequence conflict

329

G → A in CAA31808. Ref.1

Sequences

Sequence

Length

Mass (Da)

Tools

P14824 [UniParc].

Last modified July 27, 2011. Version 3.
Checksum: DCC5FC56CBD88809
Show »

FASTA

673

75,885

        10         20         30         40         50         60 
MAKIAQGAMY RGSVHDFPEF DANQDAEALY TAMKGFGSDK ESILELITSR SNKQRQEICQ 

        70         80         90        100        110        120 
NYKSLYGKDL IEDLKYELTG KFERLIVNLM RPLAYCDAKE IKDAISGVGT DEKCLIEILA 

       130        140        150        160        170        180 
SRTNEQMHQL VAAYKDAYER DLESDIIGDT SGHFQKMLVV LLQGTRENDD VVSEDLVQQD 

       190        200        210        220        230        240 
VQDLYEAGEL KWGTDEAQFI YILGNRSKQH LRLVFDEYLK TTGKPIEASI RGELSGDFEK 

       250        260        270        280        290        300 
LMLAVVKCIR STPEYFAERL FKAMKGLGTR DNTLIRIMVS RSELDMLDIR EIFRTKYEKS 

       310        320        330        340        350        360 
LYSMIKNDTS GEYKKALLKL CGGDDDAAGQ FFPEAAQVAY QMWELSAVSR VELKGTVCAA 

       370        380        390        400        410        420 
NDFNPDADAK ALRKAMKGIG TDEATIIDIV THRSNAQRQQ IRQTFKSHFG RDLMADLKSE 

       430        440        450        460        470        480 
ISGDLARLIL GLMMPPAHYD AKQLKKAMEG AGTDEKTLIE ILATRTNAEI RAINEAYKED 

       490        500        510        520        530        540 
YHKSLEDALS SDTSGHFRRI LISLATGNRE EGGENRDQAQ EDAQVAAEIL EIADTPSGDK 

       550        560        570        580        590        600 
TSLETRFMTV LCTRSYPHLR RVFQEFIKKT NYDIEHVIKK EMSGDVKDAF VAIVQSVKNK 

       610        620        630        640        650        660 
PLFFADKLYK SMKGAGTDEK TLTRVMVSRS EIDLLNIRRE FIEKYDKSLH QAIEGDTSGD 

       670 
FMKALLALCG GED

« Hide

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Molecular cloning of murine p68, a Ca2+-binding protein of the lipocortin family." Moss S.E., Crompton M.R., Crumpton M.J. Eur. J. Biochem. 177:21-27(1988) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA]. Strain: BALB/c.
[2]	"The transcriptional landscape of the mammalian genome." Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J. Hayashizaki Y. Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Strain: C57BL/6J. Tissue: Embryo and Heart.
[3]	Lubec G., Kang S.U. Submitted (APR-2007) to UniProtKB Cited for: PROTEIN SEQUENCE OF 35-50; 69-81; 123-135; 282-290; 378-393; 457-465; 484-498; 500-509 AND 630-638, MASS SPECTROMETRY. Strain: C57BL/6. Tissue: Brain.
[4]	"Quantitative time-resolved phosphoproteomic analysis of mast cell signaling." Cao L., Yu K., Banh C., Nguyen V., Ritz A., Raphael B.J., Kawakami Y., Kawakami T., Salomon A.R. J. Immunol. 179:5864-5876(2007) [PubMed] [Europe PMC] [Abstract] Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT TYR-201, MASS SPECTROMETRY. Tissue: Mast cell.
[5]	"Large-scale identification and evolution indexing of tyrosine phosphorylation sites from murine brain." Ballif B.A., Carey G.R., Sunyaev S.R., Gygi S.P. J. Proteome Res. 7:311-318(2008) [PubMed] [Europe PMC] [Abstract] Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT TYR-30, MASS SPECTROMETRY. Tissue: Brain.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	X13460 mRNA. Translation: CAA31808.1. AK030728 mRNA. Translation: BAC27101.1. AK146509 mRNA. Translation: BAE27222.1. AK146592 mRNA. Translation: BAE27287.1.
IPI	IPI00554894.
PIR	S01786.
RefSeq	NP_001103681.1. NM_001110211.1. NP_038500.2. NM_013472.4.
UniGene	Mm.265347.
3D structure databases
ProteinModelPortal	P14824.
SMR	P14824. Positions 10-673.
ModBase	Search...
Protein-protein interaction databases
IntAct	P14824. 1 interaction.
PTM databases
PhosphoSite	P14824.
Proteomic databases
PaxDb	P14824.
PRIDE	P14824.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENSMUST00000108883; ENSMUSP00000104511; ENSMUSG00000018340.
GeneID	11749.
KEGG	mmu:11749.
Organism-specific databases
CTD	309.
MGI	MGI:88255. Anxa6.
Phylogenomic databases
eggNOG	NOG267770.
GeneTree	ENSGT00700000104433.
HOGENOM	HOG000158803.
HOVERGEN	HBG061815.
InParanoid	Q8BSS4.
OMA	EKSLYSM.
OrthoDB	EOG4PVNZ6.
Gene expression databases
ArrayExpress	P14824.
Bgee	P14824.
CleanEx	MM_ANXA6.
Genevestigator	P14824.
GermOnline	ENSMUSG00000018340. Mus musculus.
Family and domain databases
Gene3D	1.10.220.10. 8 hits.
InterPro	IPR001464. Annexin. IPR018502. Annexin_repeat. IPR018252. Annexin_repeat_CS. IPR002393. AnnexinVI. [Graphical view]
PANTHER	PTHR10502. PTHR10502. 1 hit.
Pfam	PF00191. Annexin. 8 hits. [Graphical view]
PRINTS	PR00196. ANNEXIN. PR00202. ANNEXINVI.
SMART	SM00335. ANX. 8 hits. [Graphical view]
SUPFAM	SSF47874. Annexin. 2 hits.
PROSITE	PS00223. ANNEXIN. 8 hits. [Graphical view]
ProtoNet	Search...
Other
NextBio	279489.
SOURCE	Search...

Entry information

Entry name

ANXA6_MOUSE

Accession

Primary (citable) accession number: P14824
Secondary accession number(s): Q8BSS4

Entry history

Integrated into UniProtKB/Swiss-Prot:	April 1, 1990
Last sequence update:	July 27, 2011
Last modified:	April 3, 2013
This is version 107 of the entry and version 3 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Relevant documents

MGD cross-references

Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot

SIMILARITY comments

Index of protein domains and families

Names·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·Documents

Preferred order of sections

Names and origin

Protein attributes

General annotation (Comments)

Ontologies

Sequence annotation (Features)

Molecule processing

Regions

Amino acid modifications

Experimental info

Sequences

References

Cross-references

Sequence databases

3D structure databases

Protein-protein interaction databases

PTM databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Gene expression databases

Family and domain databases

Other

Entry information

Relevant documents