P14822 (GLB2B_ANAIN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names	Recommended name: Globin-2 B chain Alternative name(s): Globin II B chain HBII-B
Organism	Anadara inaequivalvis (Inequivalve ark) (Scapharca inaequivalvis)
Taxonomic identifier	6561 [NCBI]
Taxonomic lineage	cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Protostomia › Lophotrochozoa › Mollusca › Bivalvia › Pteriomorphia › Arcoida › Arcoidea › Arcidae › Scapharca

Protein attributes

Sequence length	151 AA.
Sequence status	Complete.
Protein existence	Evidence at protein level

General annotation (Comments)

Subunit structure	Heterotetramer of two alpha chains and two beta chains. Ref.3
Sequence similarities	Belongs to the globin family.

Ontologies

Keywords
Biological process	Oxygen transport Transport
Ligand	Heme Iron Metal-binding
PTM	Acetylation
Technical term	3D-structure Direct protein sequencing
Gene Ontology (GO)
Molecular_function	heme binding Inferred from electronic annotation. Source: InterPro iron ion binding Inferred from electronic annotation. Source: InterPro oxygen binding Inferred from electronic annotation. Source: InterPro oxygen transporter activity Inferred from electronic annotation. Source: UniProtKB-KW
Complete GO annotation...

Sequence annotation (Features)

Feature key

Position(s)

Length

Description

Graphical view

Feature identifier

Molecule processing

Chain

1 – 151

151

Globin-2 B chain

PRO_0000052489

Sites

Metal binding

103

1

Iron (heme proximal ligand)

Amino acid modifications

Modified residue

1

1

N-acetylserine Probable

Secondary structure

1

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151

Helix Strand Turn

Details...

Helix

3 – 12

10

Helix

14 – 27

14

Turn

28 – 30

3

Helix

31 – 45

15

Helix

48 – 52

5

Helix

54 – 56

3

Helix

59 – 64

6

Helix

66 – 84

19

Turn

85 – 87

3

Helix

89 – 105

17

Helix

110 – 113

4

Helix

114 – 116

3

Helix

117 – 128

12

Helix

129 – 131

3

Helix

134 – 149

16

Sequences

	Sequence		Length	Mass (Da)
	P14822 [UniParc]. Last modified April 1, 1990. Version 1. Checksum: 2F246A7F5A173EC0	FASTA	151	16,436
	10 20 30 40 50 60 SKVAELANAV VSNADQKDLL RMSWGVLSVD MEGTGLMLMA NLFKTSPSAK GKFARLGDVS 70 80 90 100 110 120 AGKDNSKLRG HSITLMYALQ NFVDALDDVE RLKCVVEKFA VNHINRQISA DEFGEIVGPL 130 140 150 RQTLKARMGN YFDEDTVSAW ASLVAVVQAS L

References

[1]	"Scapharca hemoglobins, type cases of a novel mode of chain assembly and heme-heme communication. Amino acid sequence and subunit interactions of the tetrameric component." Petruzzelli R., Boffi A., Barra D., Bossa F., Ascoli F., Chiancone E. FEBS Lett. 259:133-136(1989) [PubMed] [Europe PMC] [Abstract] Cited for: PROTEIN SEQUENCE.
[2]	Gambacurta A. Submitted (OCT-1996) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 42-114.
[3]	"The 2.0 A crystal structure of Scapharca tetrameric hemoglobin: cooperative dimers within an allosteric tetramer." Royer W.E. Jr., Heard K.S., Harrington D.J., Chiancone E. J. Mol. Biol. 253:168-186(1995) [PubMed] [Europe PMC] [Abstract] Cited for: X-RAY CRYSTALLOGRAPHY (2.0 ANGSTROMS) IN COMPLEX WITH HEME, SUBUNIT.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ

X98565 Genomic DNA. Translation: CAA67175.1.

PIR

S09068.

3D structure databases

PDBe
RCSB PDB
PDBj

Entry	Method	Resolution (Å)	Chain	Positions	PDBsum
4HRR	X-ray	2.00	B/D/F/H	1-151	[»]
4HRT	X-ray	1.46	B/D/F/H	3-149	[»]

ProteinModelPortal

P14822.

SMR

P14822. Positions 2-151.

ModBase

Search...

Protocols and materials databases

StructuralBiologyKnowledgebase

Search...

Family and domain databases

Gene3D

1.10.490.10. 1 hit.

InterPro

IPR000971. Globin.
IPR009050. Globin-like.
IPR012292. Globin_dom.
[Graphical view]

Pfam

PF00042. Globin. 1 hit.
[Graphical view]

SUPFAM

SSF46458. Globin_like. 1 hit.

PROSITE

PS01033. GLOBIN. 1 hit.
[Graphical view]

ProtoNet

Search...

Other

EvolutionaryTrace

P14822.

Entry information

Entry name

GLB2B_ANAIN

Accession

Primary (citable) accession number: P14822

Entry history

Integrated into UniProtKB/Swiss-Prot:	April 1, 1990
Last sequence update:	April 1, 1990
Last modified:	May 1, 2013
This is version 79 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)