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P14822

- GLB2B_ANAIN

UniProt

P14822 - GLB2B_ANAIN

Protein

Globin-2 B chain

Gene
N/A
Organism
Anadara inaequivalvis (Inequivalve ark) (Scapharca inaequivalvis)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at protein leveli
  1. Functioni

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Metal bindingi103 – 1031Iron (heme proximal ligand)

    GO - Molecular functioni

    1. heme binding Source: InterPro
    2. iron ion binding Source: InterPro
    3. oxygen binding Source: InterPro
    4. oxygen transporter activity Source: UniProtKB-KW

    Keywords - Biological processi

    Oxygen transport, Transport

    Keywords - Ligandi

    Heme, Iron, Metal-binding

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Globin-2 B chain
    Alternative name(s):
    Globin II B chain
    HBII-B
    OrganismiAnadara inaequivalvis (Inequivalve ark) (Scapharca inaequivalvis)
    Taxonomic identifieri6561 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaLophotrochozoaMolluscaBivalviaPteriomorphiaArcoidaArcoideaArcidaeScapharca

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 151151Globin-2 B chainPRO_0000052489Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei1 – 11N-acetylserineCurated

    Keywords - PTMi

    Acetylation

    Interactioni

    Subunit structurei

    Heterotetramer of two alpha chains and two beta chains.1 Publication

    Structurei

    Secondary structure

    1
    151
    Legend: HelixTurnBeta strand
    Show more details
    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Helixi3 – 119
    Helixi14 – 2714
    Turni28 – 303
    Helixi31 – 4515
    Helixi49 – 524
    Helixi53 – 564
    Helixi62 – 643
    Helixi66 – 8419
    Turni85 – 873
    Helixi89 – 10416
    Turni105 – 1073
    Helixi110 – 1134
    Helixi114 – 1163
    Helixi117 – 12812
    Helixi129 – 1313
    Helixi134 – 14916

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    EntryMethodResolution (Å)ChainPositionsPDBsum
    4HRRX-ray1.25B/D/F/H3-149[»]
    4HRTX-ray1.46B/D/F/H3-149[»]
    ProteinModelPortaliP14822.
    SMRiP14822. Positions 2-151.
    ModBaseiSearch...
    MobiDBiSearch...

    Miscellaneous databases

    EvolutionaryTraceiP14822.

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the globin family.PROSITE-ProRule annotation

    Family and domain databases

    Gene3Di1.10.490.10. 1 hit.
    InterProiIPR000971. Globin.
    IPR009050. Globin-like.
    IPR012292. Globin_dom.
    [Graphical view]
    PfamiPF00042. Globin. 1 hit.
    [Graphical view]
    SUPFAMiSSF46458. SSF46458. 1 hit.
    PROSITEiPS01033. GLOBIN. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    P14822-1 [UniParc]FASTAAdd to Basket

    « Hide

    SKVAELANAV VSNADQKDLL RMSWGVLSVD MEGTGLMLMA NLFKTSPSAK    50
    GKFARLGDVS AGKDNSKLRG HSITLMYALQ NFVDALDDVE RLKCVVEKFA 100
    VNHINRQISA DEFGEIVGPL RQTLKARMGN YFDEDTVSAW ASLVAVVQAS 150
    L 151
    Length:151
    Mass (Da):16,436
    Last modified:April 1, 1990 - v1
    Checksum:i2F246A7F5A173EC0
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    X98565 Genomic DNA. Translation: CAA67175.1.
    PIRiS09068.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    X98565 Genomic DNA. Translation: CAA67175.1 .
    PIRi S09068.

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    Entry Method Resolution (Å) Chain Positions PDBsum
    4HRR X-ray 1.25 B/D/F/H 3-149 [» ]
    4HRT X-ray 1.46 B/D/F/H 3-149 [» ]
    ProteinModelPortali P14822.
    SMRi P14822. Positions 2-151.
    ModBasei Search...
    MobiDBi Search...

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Miscellaneous databases

    EvolutionaryTracei P14822.

    Family and domain databases

    Gene3Di 1.10.490.10. 1 hit.
    InterProi IPR000971. Globin.
    IPR009050. Globin-like.
    IPR012292. Globin_dom.
    [Graphical view ]
    Pfami PF00042. Globin. 1 hit.
    [Graphical view ]
    SUPFAMi SSF46458. SSF46458. 1 hit.
    PROSITEi PS01033. GLOBIN. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Scapharca hemoglobins, type cases of a novel mode of chain assembly and heme-heme communication. Amino acid sequence and subunit interactions of the tetrameric component."
      Petruzzelli R., Boffi A., Barra D., Bossa F., Ascoli F., Chiancone E.
      FEBS Lett. 259:133-136(1989) [PubMed] [Europe PMC] [Abstract]
      Cited for: PROTEIN SEQUENCE.
    2. Gambacurta A.
      Submitted (OCT-1996) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 42-114.
    3. "The 2.0 A crystal structure of Scapharca tetrameric hemoglobin: cooperative dimers within an allosteric tetramer."
      Royer W.E. Jr., Heard K.S., Harrington D.J., Chiancone E.
      J. Mol. Biol. 253:168-186(1995) [PubMed] [Europe PMC] [Abstract]
      Cited for: X-RAY CRYSTALLOGRAPHY (2.0 ANGSTROMS) IN COMPLEX WITH HEME, SUBUNIT.

    Entry informationi

    Entry nameiGLB2B_ANAIN
    AccessioniPrimary (citable) accession number: P14822
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: April 1, 1990
    Last sequence update: April 1, 1990
    Last modified: October 1, 2014
    This is version 85 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)

    Miscellaneousi

    Keywords - Technical termi

    3D-structure, Direct protein sequencing

    Documents

    1. PDB cross-references
      Index of Protein Data Bank (PDB) cross-references
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3