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P14821 (GLB2A_ANAIN) Reviewed, UniProtKB/Swiss-Prot

Last modified July 9, 2014. Version 87. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Globin-2 A chain
Alternative name(s):
Globin II A chain
HBII-A
OrganismAnadara inaequivalvis (Inequivalve ark) (Scapharca inaequivalvis)
Taxonomic identifier6561 [NCBI]
Taxonomic lineageEukaryotaMetazoaLophotrochozoaMolluscaBivalviaPteriomorphiaArcoidaArcoideaArcidaeScapharca

Protein attributes

Sequence length150 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceEvidence at protein level

General annotation (Comments)

Subunit structure

Heterotetramer of two alpha chains and two beta chains. Ref.5

Sequence similarities

Belongs to the globin family.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Initiator methionine11Removed Ref.3
Chain2 – 150149Globin-2 A chain
PRO_0000052488

Sites

Metal binding1021Iron (heme proximal ligand)

Amino acid modifications

Modified residue21Blocked amino end (Val) Ref.3

Secondary structure

.......................... 150
Helix Strand Turn

Details...

Sequences

Sequence LengthMass (Da)Tools
P14821 [UniParc].

Last modified January 23, 2007. Version 2.
Checksum: 39B996380CBC0315

FASTA15016,238
        10         20         30         40         50         60 
MVADAVAKVC GSEAIKANLR RSWGVLSADI EATGLMLMSN LFTLRPDTKT YFTRLGDVQK 

        70         80         90        100        110        120 
GKANSKLRGH AITLTYALNN FVDSLDDPSR LKCVVEKFAV NHINRKISGD AFGAIVEPMK 

       130        140        150 
ETLKARMGNY YSDDVAGAWA ALVGVVQAAL 

« Hide

References

[1]"Cooperative homodimeric hemoglobin from Scapharca inaequivalvis. cDNA cloning and expression of the fully functional protein in E. coli."
Gambacurta A., Piro M.C., Ascoli F.
FEBS Lett. 330:90-94(1993) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
[2]"Scapharca inaequivalvis tetrameric hemoglobin A and B chains: cDNA sequencing and genomic organization."
Piro M.C., Gambacurta A., Ascoli F.
J. Mol. Evol. 43:594-601(1996) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
[3]"Scapharca hemoglobins, type cases of a novel mode of chain assembly and heme-heme communication. Amino acid sequence and subunit interactions of the tetrameric component."
Petruzzelli R., Boffi A., Barra D., Bossa F., Ascoli F., Chiancone E.
FEBS Lett. 259:133-136(1989) [PubMed] [Europe PMC] [Abstract]
Cited for: PROTEIN SEQUENCE OF 2-150.
[4]Gambacurta A.
Submitted (OCT-1996) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE OF 41-113.
[5]"The 2.0 A crystal structure of Scapharca tetrameric hemoglobin: cooperative dimers within an allosteric tetramer."
Royer W.E. Jr., Heard K.S., Harrington D.J., Chiancone E.
J. Mol. Biol. 253:168-186(1995) [PubMed] [Europe PMC] [Abstract]
Cited for: X-RAY CRYSTALLOGRAPHY (2.0 ANGSTROMS) IN COMPLEX WITH HEME, SUBUNIT.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
X71386 mRNA. Translation: CAA50509.1.
S83524 Genomic DNA. Translation: AAL96376.1.
X98566 Genomic DNA. Translation: CAA67176.1.
PIRS39980.

3D structure databases

PDBe
RCSB-PDB
PDBj
EntryMethodResolution (Å)ChainPositionsPDBsum
4HRRX-ray1.25A/C/E/G2-150[»]
4HRTX-ray1.46A/C/E/G5-150[»]
ProteinModelPortalP14821.
SMRP14821. Positions 2-150.
ModBaseSearch...
MobiDBSearch...

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Family and domain databases

Gene3D1.10.490.10. 1 hit.
InterProIPR000971. Globin.
IPR009050. Globin-like.
IPR012292. Globin_dom.
[Graphical view]
PfamPF00042. Globin. 1 hit.
[Graphical view]
SUPFAMSSF46458. SSF46458. 1 hit.
PROSITEPS01033. GLOBIN. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

EvolutionaryTraceP14821.

Entry information

Entry nameGLB2A_ANAIN
AccessionPrimary (citable) accession number: P14821
Entry history
Integrated into UniProtKB/Swiss-Prot: April 1, 1990
Last sequence update: January 23, 2007
Last modified: July 9, 2014
This is version 87 of the entry and version 2 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)

Relevant documents

SIMILARITY comments

Index of protein domains and families

PDB cross-references

Index of Protein Data Bank (PDB) cross-references