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P14821

- GLB2A_ANAIN

UniProt

P14821 - GLB2A_ANAIN

Protein

Globin-2 A chain

Gene
N/A
Organism
Anadara inaequivalvis (Inequivalve ark) (Scapharca inaequivalvis)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at protein leveli
  1. Functioni

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Metal bindingi102 – 1021Iron (heme proximal ligand)

    GO - Molecular functioni

    1. heme binding Source: InterPro
    2. iron ion binding Source: InterPro
    3. oxygen binding Source: InterPro
    4. oxygen transporter activity Source: UniProtKB-KW

    Keywords - Biological processi

    Oxygen transport, Transport

    Keywords - Ligandi

    Heme, Iron, Metal-binding

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Globin-2 A chain
    Alternative name(s):
    Globin II A chain
    HBII-A
    OrganismiAnadara inaequivalvis (Inequivalve ark) (Scapharca inaequivalvis)
    Taxonomic identifieri6561 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaLophotrochozoaMolluscaBivalviaPteriomorphiaArcoidaArcoideaArcidaeScapharca

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Initiator methioninei1 – 11Removed1 Publication
    Chaini2 – 150149Globin-2 A chainPRO_0000052488Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei2 – 21Blocked amino end (Val)1 Publication

    Interactioni

    Subunit structurei

    Heterotetramer of two alpha chains and two beta chains.1 Publication

    Structurei

    Secondary structure

    1
    150
    Legend: HelixTurnBeta strand
    Show more details
    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Helixi3 – 108
    Helixi13 – 2614
    Helixi27 – 293
    Helixi30 – 4415
    Helixi46 – 516
    Beta strandi54 – 563
    Helixi58 – 636
    Helixi65 – 8319
    Turni84 – 863
    Helixi88 – 10316
    Turni104 – 1063
    Helixi109 – 1124
    Helixi113 – 1153
    Helixi116 – 12712
    Helixi128 – 1303
    Helixi133 – 14917

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    EntryMethodResolution (Å)ChainPositionsPDBsum
    4HRRX-ray1.25A/C/E/G2-150[»]
    4HRTX-ray1.46A/C/E/G5-150[»]
    ProteinModelPortaliP14821.
    SMRiP14821. Positions 2-150.
    ModBaseiSearch...
    MobiDBiSearch...

    Miscellaneous databases

    EvolutionaryTraceiP14821.

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the globin family.PROSITE-ProRule annotation

    Family and domain databases

    Gene3Di1.10.490.10. 1 hit.
    InterProiIPR000971. Globin.
    IPR009050. Globin-like.
    IPR012292. Globin_dom.
    [Graphical view]
    PfamiPF00042. Globin. 1 hit.
    [Graphical view]
    SUPFAMiSSF46458. SSF46458. 1 hit.
    PROSITEiPS01033. GLOBIN. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    P14821-1 [UniParc]FASTAAdd to Basket

    « Hide

    MVADAVAKVC GSEAIKANLR RSWGVLSADI EATGLMLMSN LFTLRPDTKT    50
    YFTRLGDVQK GKANSKLRGH AITLTYALNN FVDSLDDPSR LKCVVEKFAV 100
    NHINRKISGD AFGAIVEPMK ETLKARMGNY YSDDVAGAWA ALVGVVQAAL 150
    Length:150
    Mass (Da):16,238
    Last modified:January 23, 2007 - v2
    Checksum:i39B996380CBC0315
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    X71386 mRNA. Translation: CAA50509.1.
    S83524 Genomic DNA. Translation: AAL96376.1.
    X98566 Genomic DNA. Translation: CAA67176.1.
    PIRiS39980.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    X71386 mRNA. Translation: CAA50509.1 .
    S83524 Genomic DNA. Translation: AAL96376.1 .
    X98566 Genomic DNA. Translation: CAA67176.1 .
    PIRi S39980.

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    Entry Method Resolution (Å) Chain Positions PDBsum
    4HRR X-ray 1.25 A/C/E/G 2-150 [» ]
    4HRT X-ray 1.46 A/C/E/G 5-150 [» ]
    ProteinModelPortali P14821.
    SMRi P14821. Positions 2-150.
    ModBasei Search...
    MobiDBi Search...

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Miscellaneous databases

    EvolutionaryTracei P14821.

    Family and domain databases

    Gene3Di 1.10.490.10. 1 hit.
    InterProi IPR000971. Globin.
    IPR009050. Globin-like.
    IPR012292. Globin_dom.
    [Graphical view ]
    Pfami PF00042. Globin. 1 hit.
    [Graphical view ]
    SUPFAMi SSF46458. SSF46458. 1 hit.
    PROSITEi PS01033. GLOBIN. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Cooperative homodimeric hemoglobin from Scapharca inaequivalvis. cDNA cloning and expression of the fully functional protein in E. coli."
      Gambacurta A., Piro M.C., Ascoli F.
      FEBS Lett. 330:90-94(1993) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    2. "Scapharca inaequivalvis tetrameric hemoglobin A and B chains: cDNA sequencing and genomic organization."
      Piro M.C., Gambacurta A., Ascoli F.
      J. Mol. Evol. 43:594-601(1996) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    3. "Scapharca hemoglobins, type cases of a novel mode of chain assembly and heme-heme communication. Amino acid sequence and subunit interactions of the tetrameric component."
      Petruzzelli R., Boffi A., Barra D., Bossa F., Ascoli F., Chiancone E.
      FEBS Lett. 259:133-136(1989) [PubMed] [Europe PMC] [Abstract]
      Cited for: PROTEIN SEQUENCE OF 2-150.
    4. Gambacurta A.
      Submitted (OCT-1996) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE OF 41-113.
    5. "The 2.0 A crystal structure of Scapharca tetrameric hemoglobin: cooperative dimers within an allosteric tetramer."
      Royer W.E. Jr., Heard K.S., Harrington D.J., Chiancone E.
      J. Mol. Biol. 253:168-186(1995) [PubMed] [Europe PMC] [Abstract]
      Cited for: X-RAY CRYSTALLOGRAPHY (2.0 ANGSTROMS) IN COMPLEX WITH HEME, SUBUNIT.

    Entry informationi

    Entry nameiGLB2A_ANAIN
    AccessioniPrimary (citable) accession number: P14821
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: April 1, 1990
    Last sequence update: January 23, 2007
    Last modified: October 1, 2014
    This is version 88 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)

    Miscellaneousi

    Keywords - Technical termi

    3D-structure, Direct protein sequencing

    Documents

    1. PDB cross-references
      Index of Protein Data Bank (PDB) cross-references
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3