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P14821

- GLB2A_ANAIN

UniProt

P14821 - GLB2A_ANAIN

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Protein

Globin-2 A chain

Gene
N/A
Organism
Anadara inaequivalvis (Inequivalve ark) (Scapharca inaequivalvis)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at protein leveli

Functioni

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi102 – 1021Iron (heme proximal ligand)

GO - Molecular functioni

  1. heme binding Source: InterPro
  2. iron ion binding Source: InterPro
  3. oxygen binding Source: InterPro
  4. oxygen transporter activity Source: UniProtKB-KW
Complete GO annotation...

Keywords - Biological processi

Oxygen transport, Transport

Keywords - Ligandi

Heme, Iron, Metal-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Globin-2 A chain
Alternative name(s):
Globin II A chain
HBII-A
OrganismiAnadara inaequivalvis (Inequivalve ark) (Scapharca inaequivalvis)
Taxonomic identifieri6561 [NCBI]
Taxonomic lineageiEukaryotaMetazoaLophotrochozoaMolluscaBivalviaPteriomorphiaArcoidaArcoideaArcidaeScapharca

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Initiator methioninei1 – 11Removed1 Publication
Chaini2 – 150149Globin-2 A chainPRO_0000052488Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei2 – 21Blocked amino end (Val)1 Publication

Interactioni

Subunit structurei

Heterotetramer of two alpha chains and two beta chains.1 Publication

Structurei

Secondary structure

1
150
Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Helixi3 – 108Combined sources
Helixi13 – 2614Combined sources
Helixi27 – 293Combined sources
Helixi30 – 4415Combined sources
Helixi46 – 516Combined sources
Beta strandi54 – 563Combined sources
Helixi58 – 636Combined sources
Helixi65 – 8319Combined sources
Turni84 – 863Combined sources
Helixi88 – 10316Combined sources
Turni104 – 1063Combined sources
Helixi109 – 1124Combined sources
Helixi113 – 1153Combined sources
Helixi116 – 12712Combined sources
Helixi128 – 1303Combined sources
Helixi133 – 14917Combined sources

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
4HRRX-ray1.25A/C/E/G2-150[»]
4HRTX-ray1.46A/C/E/G5-150[»]
ProteinModelPortaliP14821.
SMRiP14821. Positions 2-150.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP14821.

Family & Domainsi

Sequence similaritiesi

Belongs to the globin family.PROSITE-ProRule annotation

Family and domain databases

Gene3Di1.10.490.10. 1 hit.
InterProiIPR000971. Globin.
IPR009050. Globin-like.
IPR012292. Globin_dom.
[Graphical view]
PfamiPF00042. Globin. 1 hit.
[Graphical view]
SUPFAMiSSF46458. SSF46458. 1 hit.
PROSITEiPS01033. GLOBIN. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P14821-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MVADAVAKVC GSEAIKANLR RSWGVLSADI EATGLMLMSN LFTLRPDTKT
60 70 80 90 100
YFTRLGDVQK GKANSKLRGH AITLTYALNN FVDSLDDPSR LKCVVEKFAV
110 120 130 140 150
NHINRKISGD AFGAIVEPMK ETLKARMGNY YSDDVAGAWA ALVGVVQAAL
Length:150
Mass (Da):16,238
Last modified:January 23, 2007 - v2
Checksum:i39B996380CBC0315
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X71386 mRNA. Translation: CAA50509.1.
S83524 Genomic DNA. Translation: AAL96376.1.
X98566 Genomic DNA. Translation: CAA67176.1.
PIRiS39980.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X71386 mRNA. Translation: CAA50509.1 .
S83524 Genomic DNA. Translation: AAL96376.1 .
X98566 Genomic DNA. Translation: CAA67176.1 .
PIRi S39980.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
Entry Method Resolution (Å) Chain Positions PDBsum
4HRR X-ray 1.25 A/C/E/G 2-150 [» ]
4HRT X-ray 1.46 A/C/E/G 5-150 [» ]
ProteinModelPortali P14821.
SMRi P14821. Positions 2-150.
ModBasei Search...
MobiDBi Search...

Protocols and materials databases

Structural Biology Knowledgebase Search...

Miscellaneous databases

EvolutionaryTracei P14821.

Family and domain databases

Gene3Di 1.10.490.10. 1 hit.
InterProi IPR000971. Globin.
IPR009050. Globin-like.
IPR012292. Globin_dom.
[Graphical view ]
Pfami PF00042. Globin. 1 hit.
[Graphical view ]
SUPFAMi SSF46458. SSF46458. 1 hit.
PROSITEi PS01033. GLOBIN. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Cooperative homodimeric hemoglobin from Scapharca inaequivalvis. cDNA cloning and expression of the fully functional protein in E. coli."
    Gambacurta A., Piro M.C., Ascoli F.
    FEBS Lett. 330:90-94(1993) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
  2. "Scapharca inaequivalvis tetrameric hemoglobin A and B chains: cDNA sequencing and genomic organization."
    Piro M.C., Gambacurta A., Ascoli F.
    J. Mol. Evol. 43:594-601(1996) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
  3. "Scapharca hemoglobins, type cases of a novel mode of chain assembly and heme-heme communication. Amino acid sequence and subunit interactions of the tetrameric component."
    Petruzzelli R., Boffi A., Barra D., Bossa F., Ascoli F., Chiancone E.
    FEBS Lett. 259:133-136(1989) [PubMed] [Europe PMC] [Abstract]
    Cited for: PROTEIN SEQUENCE OF 2-150.
  4. Gambacurta A.
    Submitted (OCT-1996) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE OF 41-113.
  5. "The 2.0 A crystal structure of Scapharca tetrameric hemoglobin: cooperative dimers within an allosteric tetramer."
    Royer W.E. Jr., Heard K.S., Harrington D.J., Chiancone E.
    J. Mol. Biol. 253:168-186(1995) [PubMed] [Europe PMC] [Abstract]
    Cited for: X-RAY CRYSTALLOGRAPHY (2.0 ANGSTROMS) IN COMPLEX WITH HEME, SUBUNIT.

Entry informationi

Entry nameiGLB2A_ANAIN
AccessioniPrimary (citable) accession number: P14821
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 1, 1990
Last sequence update: January 23, 2007
Last modified: November 26, 2014
This is version 89 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)

Miscellaneousi

Keywords - Technical termi

3D-structure, Direct protein sequencing

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3