SubmitCancel

Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.

P14821

- GLB2A_ANAIN

UniProt

P14821 - GLB2A_ANAIN

(max 400 entries)x

Your basket is currently empty.

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

Protein
Globin-2 A chain
Gene
N/A
Organism
Anadara inaequivalvis (Inequivalve ark) (Scapharca inaequivalvis)
Status
Reviewed - Annotation score: 4 out of 5 - Experimental evidence at protein leveli

Functioni

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi102 – 1021Iron (heme proximal ligand)

GO - Molecular functioni

  1. heme binding Source: InterPro
  2. iron ion binding Source: InterPro
  3. oxygen binding Source: InterPro
  4. oxygen transporter activity Source: UniProtKB-KW
Complete GO annotation...

Keywords - Biological processi

Oxygen transport, Transport

Keywords - Ligandi

Heme, Iron, Metal-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Globin-2 A chain
Alternative name(s):
Globin II A chain
HBII-A
OrganismiAnadara inaequivalvis (Inequivalve ark) (Scapharca inaequivalvis)
Taxonomic identifieri6561 [NCBI]
Taxonomic lineageiEukaryotaMetazoaLophotrochozoaMolluscaBivalviaPteriomorphiaArcoidaArcoideaArcidaeScapharca

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Initiator methioninei1 – 11Removed1 Publication
Chaini2 – 150149Globin-2 A chain
PRO_0000052488Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei2 – 21Blocked amino end (Val)1 Publication

Interactioni

Subunit structurei

Heterotetramer of two alpha chains and two beta chains.1 Publication

Structurei

Secondary structure

Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Helixi3 – 108
Helixi13 – 2614
Helixi27 – 293
Helixi30 – 4415
Helixi46 – 516
Beta strandi54 – 563
Helixi58 – 636
Helixi65 – 8319
Turni84 – 863
Helixi88 – 10316
Turni104 – 1063
Helixi109 – 1124
Helixi113 – 1153
Helixi116 – 12712
Helixi128 – 1303
Helixi133 – 14917

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
4HRRX-ray1.25A/C/E/G2-150[»]
4HRTX-ray1.46A/C/E/G5-150[»]
ProteinModelPortaliP14821.
SMRiP14821. Positions 2-150.

Miscellaneous databases

EvolutionaryTraceiP14821.

Family & Domainsi

Sequence similaritiesi

Belongs to the globin family.

Family and domain databases

Gene3Di1.10.490.10. 1 hit.
InterProiIPR000971. Globin.
IPR009050. Globin-like.
IPR012292. Globin_dom.
[Graphical view]
PfamiPF00042. Globin. 1 hit.
[Graphical view]
SUPFAMiSSF46458. SSF46458. 1 hit.
PROSITEiPS01033. GLOBIN. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P14821-1 [UniParc]FASTAAdd to Basket

« Hide

MVADAVAKVC GSEAIKANLR RSWGVLSADI EATGLMLMSN LFTLRPDTKT    50
YFTRLGDVQK GKANSKLRGH AITLTYALNN FVDSLDDPSR LKCVVEKFAV 100
NHINRKISGD AFGAIVEPMK ETLKARMGNY YSDDVAGAWA ALVGVVQAAL 150
Length:150
Mass (Da):16,238
Last modified:January 23, 2007 - v2
Checksum:i39B996380CBC0315
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
X71386 mRNA. Translation: CAA50509.1.
S83524 Genomic DNA. Translation: AAL96376.1.
X98566 Genomic DNA. Translation: CAA67176.1.
PIRiS39980.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
X71386 mRNA. Translation: CAA50509.1 .
S83524 Genomic DNA. Translation: AAL96376.1 .
X98566 Genomic DNA. Translation: CAA67176.1 .
PIRi S39980.

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
Entry Method Resolution (Å) Chain Positions PDBsum
4HRR X-ray 1.25 A/C/E/G 2-150 [» ]
4HRT X-ray 1.46 A/C/E/G 5-150 [» ]
ProteinModelPortali P14821.
SMRi P14821. Positions 2-150.
ModBasei Search...
MobiDBi Search...

Protocols and materials databases

Structural Biology Knowledgebase Search...

Miscellaneous databases

EvolutionaryTracei P14821.

Family and domain databases

Gene3Di 1.10.490.10. 1 hit.
InterProi IPR000971. Globin.
IPR009050. Globin-like.
IPR012292. Globin_dom.
[Graphical view ]
Pfami PF00042. Globin. 1 hit.
[Graphical view ]
SUPFAMi SSF46458. SSF46458. 1 hit.
PROSITEi PS01033. GLOBIN. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Cooperative homodimeric hemoglobin from Scapharca inaequivalvis. cDNA cloning and expression of the fully functional protein in E. coli."
    Gambacurta A., Piro M.C., Ascoli F.
    FEBS Lett. 330:90-94(1993) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
  2. "Scapharca inaequivalvis tetrameric hemoglobin A and B chains: cDNA sequencing and genomic organization."
    Piro M.C., Gambacurta A., Ascoli F.
    J. Mol. Evol. 43:594-601(1996) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
  3. "Scapharca hemoglobins, type cases of a novel mode of chain assembly and heme-heme communication. Amino acid sequence and subunit interactions of the tetrameric component."
    Petruzzelli R., Boffi A., Barra D., Bossa F., Ascoli F., Chiancone E.
    FEBS Lett. 259:133-136(1989) [PubMed] [Europe PMC] [Abstract]
    Cited for: PROTEIN SEQUENCE OF 2-150.
  4. Gambacurta A.
    Submitted (OCT-1996) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE OF 41-113.
  5. "The 2.0 A crystal structure of Scapharca tetrameric hemoglobin: cooperative dimers within an allosteric tetramer."
    Royer W.E. Jr., Heard K.S., Harrington D.J., Chiancone E.
    J. Mol. Biol. 253:168-186(1995) [PubMed] [Europe PMC] [Abstract]
    Cited for: X-RAY CRYSTALLOGRAPHY (2.0 ANGSTROMS) IN COMPLEX WITH HEME, SUBUNIT.

Entry informationi

Entry nameiGLB2A_ANAIN
AccessioniPrimary (citable) accession number: P14821
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 1, 1990
Last sequence update: January 23, 2007
Last modified: July 9, 2014
This is version 87 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)

Miscellaneousi

Keywords - Technical termi

3D-structure, Direct protein sequencing

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi