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P14791

- HMOX1_CHICK

UniProt

P14791 - HMOX1_CHICK

Protein

Heme oxygenase 1

Gene

HMOX1

Organism
Gallus gallus (Chicken)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 91 (01 Oct 2014)
      Sequence version 2 (01 Mar 1992)
      Previous versions | rss
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    Functioni

    Heme oxygenase cleaves the heme ring at the alpha methene bridge to form biliverdin. Biliverdin is subsequently converted to bilirubin by biliverdin reductase. Under physiological conditions, the activity of heme oxygenase is highest in the spleen, where senescent erythrocytes are sequestrated and destroyed.

    Catalytic activityi

    Protoheme + 3 AH2 + 3 O2 = biliverdin + Fe2+ + CO + 3 A + 3 H2O.

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Metal bindingi28 – 281Iron (heme axial ligand)By similarity

    GO - Molecular functioni

    1. heme oxygenase (decyclizing) activity Source: UniProtKB-EC
    2. metal ion binding Source: UniProtKB-KW

    GO - Biological processi

    1. heme oxidation Source: InterPro

    Keywords - Molecular functioni

    Oxidoreductase

    Keywords - Ligandi

    Heme, Iron, Metal-binding

    Enzyme and pathway databases

    SABIO-RKP14791.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Heme oxygenase 1 (EC:1.14.99.3)
    Short name:
    HO-1
    Gene namesi
    Name:HMOX1
    OrganismiGallus gallus (Chicken)
    Taxonomic identifieri9031 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiTestudines + Archosauria groupArchosauriaDinosauriaSaurischiaTheropodaCoelurosauriaAvesNeognathaeGalliformesPhasianidaePhasianinaeGallus
    ProteomesiUP000000539: Unplaced

    Subcellular locationi

    GO - Cellular componenti

    1. endoplasmic reticulum Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Endoplasmic reticulum, Microsome

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 296296Heme oxygenase 1PRO_0000209696Add
    BLAST

    Proteomic databases

    PaxDbiP14791.
    PRIDEiP14791.

    Interactioni

    Protein-protein interaction databases

    STRINGi9031.ENSGALP00000036970.

    Structurei

    3D structure databases

    ProteinModelPortaliP14791.
    SMRiP14791. Positions 1-225.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the heme oxygenase family.Curated

    Phylogenomic databases

    eggNOGiCOG5398.
    HOGENOMiHOG000233221.
    HOVERGENiHBG005982.
    InParanoidiP14791.
    KOiK00510.
    PhylomeDBiP14791.

    Family and domain databases

    Gene3Di1.20.910.10. 1 hit.
    InterProiIPR002051. Haem_Oase.
    IPR016053. Haem_Oase-like.
    IPR016084. Haem_Oase-like_multi-hlx.
    IPR018207. Haem_oxygenase_CS.
    [Graphical view]
    PANTHERiPTHR10720. PTHR10720. 1 hit.
    PfamiPF01126. Heme_oxygenase. 1 hit.
    [Graphical view]
    PIRSFiPIRSF000343. Haem_Oase. 1 hit.
    PRINTSiPR00088. HAEMOXYGNASE.
    SUPFAMiSSF48613. SSF48613. 1 hit.
    PROSITEiPS00593. HEME_OXYGENASE. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    P14791-1 [UniParc]FASTAAdd to Basket

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    METSQPHNAE SMSQDLSELL KEATKEVHEQ AENTPFMKNF QKGQVSLHEF    50
    KLVTASLYFI YSALEEEIER NKDNPVYAPV YFPMELHRKA ALEKDLEYFY 100
    GSNWRAEIPC PEATQKYVER LHVVGKKHPE LLVAHAYTRY LGDLSGGQVL 150
    KKIAQKALQL PSTGEGLAFF TFDGVSNATK FKQLYRSRMN ALEMDHATKK 200
    RVLEEAKKAF LLNIQVFEAL QKLVSKSQEN GHAVQPKAEL RTRSVNKSHE 250
    NSPAAGKESE RTSRMQADML TTSPLVRWLL ALGFIATTVA VGLFAM 296
    Length:296
    Mass (Da):33,509
    Last modified:March 1, 1992 - v2
    Checksum:i22DAA9324494CC0E
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    X56201 mRNA. Translation: CAA39661.1.
    PIRiS15123.
    RefSeqiNP_990675.1. NM_205344.1.
    UniGeneiGga.2039.

    Genome annotation databases

    GeneIDi396287.
    KEGGigga:396287.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    X56201 mRNA. Translation: CAA39661.1 .
    PIRi S15123.
    RefSeqi NP_990675.1. NM_205344.1.
    UniGenei Gga.2039.

    3D structure databases

    ProteinModelPortali P14791.
    SMRi P14791. Positions 1-225.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 9031.ENSGALP00000036970.

    Proteomic databases

    PaxDbi P14791.
    PRIDEi P14791.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    GeneIDi 396287.
    KEGGi gga:396287.

    Organism-specific databases

    CTDi 3162.

    Phylogenomic databases

    eggNOGi COG5398.
    HOGENOMi HOG000233221.
    HOVERGENi HBG005982.
    InParanoidi P14791.
    KOi K00510.
    PhylomeDBi P14791.

    Enzyme and pathway databases

    SABIO-RK P14791.

    Miscellaneous databases

    NextBioi 20816338.
    PROi P14791.

    Family and domain databases

    Gene3Di 1.20.910.10. 1 hit.
    InterProi IPR002051. Haem_Oase.
    IPR016053. Haem_Oase-like.
    IPR016084. Haem_Oase-like_multi-hlx.
    IPR018207. Haem_oxygenase_CS.
    [Graphical view ]
    PANTHERi PTHR10720. PTHR10720. 1 hit.
    Pfami PF01126. Heme_oxygenase. 1 hit.
    [Graphical view ]
    PIRSFi PIRSF000343. Haem_Oase. 1 hit.
    PRINTSi PR00088. HAEMOXYGNASE.
    SUPFAMi SSF48613. SSF48613. 1 hit.
    PROSITEi PS00593. HEME_OXYGENASE. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Cloning, sequencing and expression of cDNA for chick liver haem oxygenase. Comparison of avian and mammalian cDNAs and deduced proteins."
      Evans C.O., Healey J.F., Greene Y., Bonkovsky H.L.
      Biochem. J. 273:659-666(1991) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
      Tissue: Liver.
    2. "Purification and characterization of heme oxygenase from chick liver. Comparison of the avian and mammalian enzymes."
      Bonkovsky H.L., Healey J.F., Pohl J.
      Eur. J. Biochem. 189:155-166(1990) [PubMed] [Europe PMC] [Abstract]
      Cited for: PARTIAL PROTEIN SEQUENCE.
      Tissue: Liver.

    Entry informationi

    Entry nameiHMOX1_CHICK
    AccessioniPrimary (citable) accession number: P14791
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: April 1, 1990
    Last sequence update: March 1, 1992
    Last modified: October 1, 2014
    This is version 91 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Direct protein sequencing, Reference proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3