Reviewed, UniProtKB/Swiss-Prot P14791 (HMOX1_CHICK)

Names and origin

Protein names

Recommended name:
    Heme oxygenase 1
      Short name=HO-1
    EC=1.14.99.3

Gene names

Name:

HMOX1

Organism

Gallus gallus (Chicken)

Taxonomic identifier

9031 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Archosauria › Dinosauria › Saurischia › Theropoda › Coelurosauria › Aves › Neognathae › Galliformes › Phasianidae › Phasianinae › Gallus

Protein attributes

Sequence length	296 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Evidence at protein level.

General annotation (Comments)

Function	Heme oxygenase cleaves the heme ring at the alpha methene bridge to form biliverdin. Biliverdin is subsequently converted to bilirubin by biliverdin reductase. Under physiological conditions, the activity of heme oxygenase is highest in the spleen, where senescent erythrocytes are sequestrated and destroyed.
Catalytic activity	Heme + 3 AH2 + 3 O2 = biliverdin + Fe2+ + CO + 3 A + 3 H2O.
Subcellular location	Microsome. Endoplasmic reticulum.
Sequence similarities	Belongs to the heme oxygenase family.

Ontologies

Keywords
Cellular component	Endoplasmic reticulum Microsome
Ligand	Heme Iron Metal-binding
Molecular function	Oxidoreductase
Technical term	Direct protein sequencing
Gene Ontology (GO)
Biological process	heme oxidation Inferred from electronic annotation. Source: InterPro oxidation reduction Inferred from electronic annotation. Source: UniProtKB-KW
Cellular component	endoplasmic reticulum Inferred from electronic annotation. Source: UniProtKB-SubCell microsome Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	heme oxygenase (decyclizing) activity Inferred from electronic annotation. Source: EC iron ion binding Inferred from electronic annotation. Source: UniProtKB-KW
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 296	296	Heme oxygenase 1		PRO_0000209696
Sites
	Metal binding	28	1	Iron (heme axial ligand) By similarity

Sequences

	Sequence		Length	Mass (Da)
	P14791-1 [UniParc]. Last modified March 1, 1992. Version 2. Checksum: 22DAA9324494CC0E	FASTA	296	33,509
	10 20 30 40 50 60 METSQPHNAE SMSQDLSELL KEATKEVHEQ AENTPFMKNF QKGQVSLHEF KLVTASLYFI 70 80 90 100 110 120 YSALEEEIER NKDNPVYAPV YFPMELHRKA ALEKDLEYFY GSNWRAEIPC PEATQKYVER 130 140 150 160 170 180 LHVVGKKHPE LLVAHAYTRY LGDLSGGQVL KKIAQKALQL PSTGEGLAFF TFDGVSNATK 190 200 210 220 230 240 FKQLYRSRMN ALEMDHATKK RVLEEAKKAF LLNIQVFEAL QKLVSKSQEN GHAVQPKAEL 250 260 270 280 290 RTRSVNKSHE NSPAAGKESE RTSRMQADML TTSPLVRWLL ALGFIATTVA VGLFAM

References

[1]	"Cloning, sequencing and expression of cDNA for chick liver haem oxygenase. Comparison of avian and mammalian cDNAs and deduced proteins." Evans C.O., Healey J.F., Greene Y., Bonkovsky H.L. Biochem. J. 273:659-666(1991) [PubMed: 1996964] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA]. Tissue: Liver.
[2]	"Purification and characterization of heme oxygenase from chick liver. Comparison of the avian and mammalian enzymes." Bonkovsky H.L., Healey J.F., Pohl J. Eur. J. Biochem. 189:155-166(1990) [PubMed: 2158889] [Abstract] Cited for: PARTIAL PROTEIN SEQUENCE. Tissue: Liver.

Cross-references

Sequence databases
EMBLGenBankDDBJ	X56201 mRNA. Translation: CAA39661.1.
IPI	IPI00580654.
PIR	S15123.
RefSeq	NP_990675.1.
UniGene	Gga.2039
3D structure databases
HSSP	HSSP built from PDB template 1N45 based on UniProtKB P09601.
SMR	P14791. Positions 4-225.
ModBase	Search...
Proteomic databases
PRIDE	P14791.
Genome annotation databases
Ensembl	ENSGALG00000012550. Gallus gallus. [Contig view]
GeneID	396287.
KEGG	gga:396287.
Phylogenomic databases
HOVERGEN	P14791.
Enzyme and pathway databases
BRENDA	1.14.99.3. 4.
Family and domain databases
InterPro	IPR002051. Haem_Oase. IPR016053. Haem_Oase-like. IPR016084. Haem_Oase-like_multi-hlx. IPR018207. Haem_oxygenase_CS. [Graphical view]
Gene3D	G3DSA:1.20.910.10. Haem_Oase-like_multi-hlx. 1 hit.
PANTHER	PTHR10720. Haem_Oase. 1 hit.
Pfam	PF01126. Heme_oxygenase. 1 hit. [Graphical view]
PIRSF	PIRSF000343. Haem_Oase. 1 hit.
PRINTS	PR00088. HAEMOXYGNASE.
PROSITE	PS00593. HEME_OXYGENASE. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

HMOX1_CHICK

Accession

Primary (citable) accession number: P14791

Entry history

Integrated into UniProtKB/Swiss-Prot:	April 1, 1990
Last sequence update:	March 1, 1992
Last modified:	June 16, 2009
This is version 61 of the entry and version 2 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)