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Protein

Prolactin receptor

Gene

PRLR

Organism
Oryctolagus cuniculus (Rabbit)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

This is a receptor for the anterior pituitary hormone prolactin.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi211 – 2111ZincBy similarity
Metal bindingi212 – 2121ZincBy similarity

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Receptor

Keywords - Ligandi

Metal-binding, Zinc

Names & Taxonomyi

Protein namesi
Recommended name:
Prolactin receptor
Short name:
PRL-R
Gene namesi
Name:PRLR
OrganismiOryctolagus cuniculus (Rabbit)
Taxonomic identifieri9986 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresLagomorphaLeporidaeOryctolagus
Proteomesi
  • UP000001811 Componenti: Chromosome 11

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini25 – 234210ExtracellularSequence analysisAdd
BLAST
Transmembranei235 – 25824HelicalSequence analysisAdd
BLAST
Topological domaini259 – 616358CytoplasmicSequence analysisAdd
BLAST

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2424By similarityAdd
BLAST
Chaini25 – 616592Prolactin receptorPRO_0000010980Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Disulfide bondi36 ↔ 46By similarity
Glycosylationi59 – 591N-linked (GlcNAc...)Sequence analysis
Disulfide bondi75 ↔ 86By similarity
Glycosylationi104 – 1041N-linked (GlcNAc...)Sequence analysis
Glycosylationi132 – 1321N-linked (GlcNAc...)Sequence analysis

Keywords - PTMi

Disulfide bond, Glycoprotein

Interactioni

Subunit structurei

Interacts with SMARCA1. Interacts with NEK3 and VAV2 and this interaction is prolactin-dependent.By similarity

Protein-protein interaction databases

STRINGi9986.ENSOCUP00000004567.

Structurei

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
1AN3model-B/C23-228[»]
ProteinModelPortaliP14787.
SMRiP14787. Positions 27-228.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini27 – 128102Fibronectin type-III 1PROSITE-ProRule annotationAdd
BLAST
Domaini129 – 229101Fibronectin type-III 2PROSITE-ProRule annotationAdd
BLAST

Motif

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Motifi215 – 2195WSXWS motif
Motifi267 – 2759Box 1 motif

Domaini

The WSXWS motif appears to be necessary for proper protein folding and thereby efficient intracellular transport and cell-surface receptor binding.
The box 1 motif is required for JAK interaction and/or activation.

Sequence similaritiesi

Contains 2 fibronectin type-III domains.PROSITE-ProRule annotation

Keywords - Domaini

Repeat, Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410IUSW. Eukaryota.
ENOG410XRJS. LUCA.
GeneTreeiENSGT00530000063112.
HOGENOMiHOG000059569.
HOVERGENiHBG007314.
InParanoidiP14787.
KOiK05081.
OMAiSGPNSCY.
OrthoDBiEOG091G07CK.
TreeFamiTF330851.

Family and domain databases

Gene3Di2.60.40.10. 2 hits.
InterProiIPR003961. FN3_dom.
IPR015152. Growth/epo_recpt_lig-bind.
IPR013783. Ig-like_fold.
IPR003528. Long_hematopoietin_rcpt_CS.
IPR033230. PRLR.
[Graphical view]
PANTHERiPTHR23036:SF86. PTHR23036:SF86. 1 hit.
PfamiPF09067. EpoR_lig-bind. 1 hit.
[Graphical view]
SMARTiSM00060. FN3. 2 hits.
[Graphical view]
SUPFAMiSSF49265. SSF49265. 2 hits.
PROSITEiPS50853. FN3. 2 hits.
PS01352. HEMATOPO_REC_L_F1. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P14787-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MKENVASMIV FLLLLFLNIR LLKGQSPPGK PFIFKCRSPE KETFTCWWRP
60 70 80 90 100
GADGGLPTNY TLTYHKEGET ITHECPDYKT GGPNSCYFSK KHTSIWTIYI
110 120 130 140 150
ITVNATNQMG SSVSDPRYVD VTYIVEPDPP VNLTLEVKHP EDRKPYLWVK
160 170 180 190 200
WLPPTLVDVR SGWLTLQYEI RLKPEKAAEW ETHFAGQQTQ FKILSLYPGQ
210 220 230 240 250
KYLVQVRCKP DHGFWSVWSP ESSIQIPNDF TMKDITVWIF VAVLSTIICL
260 270 280 290 300
IMVWAVALKG YSMVTCIFPP VPGPKIKGFD THLLEKGKSE ELLSAFGCQD
310 320 330 340 350
FPPTADCEDL LVEFLEVDDS EDQQLMPAHS KEHSGPGMKP TDLDPDNDSG
360 370 380 390 400
RGSCDSPSLL SEKCEEPQAN PSTFHTPEVI EQPEKPKANV THTWDPQTIS
410 420 430 440 450
LVGKMPYLSV NGSKSSTWPL LQPGQHNTNS PYHNIADMCK LATSLDKIDK
460 470 480 490 500
DALQSSKTTE AAGEEKATKQ REVESSHSKA EQDTGWLLPK EKPPFISPKP
510 520 530 540 550
LDYVEIHKVN KDGALSLLLK QKENGDQTGK AGTPETSKEY AKVSRVMDNN
560 570 580 590 600
ILVLVQDPGA QNVALFEEST KEAPPSPSQN QAEKDLSSFS TAPSDCRLQQ
610
GGLDYLDPAC FMHSLH
Length:616
Mass (Da):68,840
Last modified:April 1, 1990 - v1
Checksum:i800E3166FEF7108C
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti106 – 1061T → N AA sequence (PubMed:2289615).Curated
Sequence conflicti278 – 2781G → P AA sequence (PubMed:2289615).Curated
Sequence conflicti280 – 2801D → F AA sequence (PubMed:2289615).Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
J04510 mRNA. Translation: AAA31457.1.
PIRiA30304.
RefSeqiNP_001075700.1. NM_001082231.1.
XP_008260261.1. XM_008262039.1.
XP_008260262.1. XM_008262040.1.
XP_008260263.1. XM_008262041.1.
XP_008260264.1. XM_008262042.1.
UniGeneiOcu.1956.

Genome annotation databases

EnsembliENSOCUT00000005269; ENSOCUP00000004567; ENSOCUG00000005274.
GeneIDi100009046.
KEGGiocu:100009046.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
J04510 mRNA. Translation: AAA31457.1.
PIRiA30304.
RefSeqiNP_001075700.1. NM_001082231.1.
XP_008260261.1. XM_008262039.1.
XP_008260262.1. XM_008262040.1.
XP_008260263.1. XM_008262041.1.
XP_008260264.1. XM_008262042.1.
UniGeneiOcu.1956.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
1AN3model-B/C23-228[»]
ProteinModelPortaliP14787.
SMRiP14787. Positions 27-228.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9986.ENSOCUP00000004567.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSOCUT00000005269; ENSOCUP00000004567; ENSOCUG00000005274.
GeneIDi100009046.
KEGGiocu:100009046.

Organism-specific databases

CTDi5618.

Phylogenomic databases

eggNOGiENOG410IUSW. Eukaryota.
ENOG410XRJS. LUCA.
GeneTreeiENSGT00530000063112.
HOGENOMiHOG000059569.
HOVERGENiHBG007314.
InParanoidiP14787.
KOiK05081.
OMAiSGPNSCY.
OrthoDBiEOG091G07CK.
TreeFamiTF330851.

Family and domain databases

Gene3Di2.60.40.10. 2 hits.
InterProiIPR003961. FN3_dom.
IPR015152. Growth/epo_recpt_lig-bind.
IPR013783. Ig-like_fold.
IPR003528. Long_hematopoietin_rcpt_CS.
IPR033230. PRLR.
[Graphical view]
PANTHERiPTHR23036:SF86. PTHR23036:SF86. 1 hit.
PfamiPF09067. EpoR_lig-bind. 1 hit.
[Graphical view]
SMARTiSM00060. FN3. 2 hits.
[Graphical view]
SUPFAMiSSF49265. SSF49265. 2 hits.
PROSITEiPS50853. FN3. 2 hits.
PS01352. HEMATOPO_REC_L_F1. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiPRLR_RABIT
AccessioniPrimary (citable) accession number: P14787
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 1, 1990
Last sequence update: April 1, 1990
Last modified: September 7, 2016
This is version 129 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.