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Protein

G2/mitotic-specific cyclin-A

Gene

CycA

Organism
Drosophila melanogaster (Fruit fly)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Essential for the control of the cell cycle at the G2/M (mitosis) transition. Interacts with the Cdk1 and Cdk2 protein kinases to form MPF. G2/M cyclins accumulate steadily during G2 and are abruptly destroyed at mitosis.

GO - Molecular functioni

  • cyclin-dependent protein serine/threonine kinase regulator activity Source: FlyBase

GO - Biological processi

  • asymmetric neuroblast division Source: FlyBase
  • mitotic cell cycle Source: FlyBase
  • mitotic sister chromatid segregation Source: FlyBase
  • negative regulation of mitotic metaphase/anaphase transition Source: FlyBase
  • peripheral nervous system development Source: FlyBase
  • positive regulation of cell cycle G1/S phase transition Source: FlyBase
  • regulation of chromatin binding Source: FlyBase
  • regulation of exit from mitosis Source: FlyBase
  • regulation of mitotic cell cycle, embryonic Source: FlyBase
  • regulation of mitotic nuclear division Source: UniProtKB
  • syncytial blastoderm mitotic cell cycle Source: FlyBase

Keywordsi

Molecular functionCyclin
Biological processCell cycle, Cell division, Mitosis

Enzyme and pathway databases

ReactomeiR-DME-1538133 G0 and Early G1
R-DME-174184 Cdc20:Phospho-APC/C mediated degradation of Cyclin A
R-DME-176408 Regulation of APC/C activators between G1/S and early anaphase
R-DME-187577 SCF(Skp2)-mediated degradation of p27/p21
R-DME-2559582 Senescence-Associated Secretory Phenotype (SASP)
R-DME-5689880 Ub-specific processing proteases
R-DME-5693607 Processing of DNA double-strand break ends
R-DME-68911 G2 Phase
R-DME-68949 Orc1 removal from chromatin
R-DME-69273 Cyclin A/B1/B2 associated events during G2/M transition
R-DME-69656 Cyclin A:Cdk2-associated events at S phase entry
SignaLinkiP14785

Names & Taxonomyi

Protein namesi
Recommended name:
G2/mitotic-specific cyclin-A
Gene namesi
Name:CycA
ORF Names:CG5940
OrganismiDrosophila melanogaster (Fruit fly)
Taxonomic identifieri7227 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaArthropodaHexapodaInsectaPterygotaNeopteraHolometabolaDipteraBrachyceraMuscomorphaEphydroideaDrosophilidaeDrosophilaSophophora
Proteomesi
  • UP000000803 Componenti: Chromosome 3L

Organism-specific databases

FlyBaseiFBgn0000404 CycA

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Mutagenesisi235M → A: Abolishes binding to Z600; when associated with A-239 and A-242. 1 Publication1
Mutagenesisi239L → A: Abolishes binding to Z600; when associated with A-235 and A-242. 1 Publication1
Mutagenesisi242W → A: Abolishes binding to Z600; when associated with A-235 and A-239. 1 Publication1

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000803451 – 491G2/mitotic-specific cyclin-AAdd BLAST491

Proteomic databases

PaxDbiP14785
PRIDEiP14785

Expressioni

Gene expression databases

BgeeiFBgn0000404
ExpressionAtlasiP14785 differential
GenevisibleiP14785 DM

Interactioni

Subunit structurei

Component of the Frs-CycA-Cdk1 complex composed of CycA, Cdk1 and Z600. Interacts (via C-terminus) with Z600.1 Publication

Binary interactionsi

Show more details

Protein-protein interaction databases

BioGridi64701, 61 interactors
DIPiDIP-22019N
IntActiP14785, 32 interactors
MINTiP14785
STRINGi7227.FBpp0075807

Structurei

3D structure databases

ProteinModelPortaliP14785
SMRiP14785
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the cyclin family. Cyclin AB subfamily.Curated

Phylogenomic databases

eggNOGiKOG0654 Eukaryota
COG5024 LUCA
GeneTreeiENSGT00760000118939
InParanoidiP14785
KOiK06627
OrthoDBiEOG091G090I
PhylomeDBiP14785

Family and domain databases

CDDicd00043 CYCLIN, 2 hits
InterProiView protein in InterPro
IPR013763 Cyclin-like
IPR036915 Cyclin-like_sf
IPR004367 Cyclin_C-dom
IPR006671 Cyclin_N
PfamiView protein in Pfam
PF02984 Cyclin_C, 1 hit
PF00134 Cyclin_N, 1 hit
SMARTiView protein in SMART
SM00385 CYCLIN, 2 hits
SM01332 Cyclin_C, 1 hit
SUPFAMiSSF47954 SSF47954, 2 hits
PROSITEiView protein in PROSITE
PS00292 CYCLINS, 1 hit

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform A (identifier: P14785-1) [UniParc]FASTAAdd to basket
Also known as: Long

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MASFQIHQDM SNKENPGIKI PAGVKNTKQP LAVIGGKAEK NALAPRANFA
60 70 80 90 100
VLNGNNNVPR PAGKVQVFRD VRNLNVDENV EYGAKKSNVV PVVEQFKTFS
110 120 130 140 150
VYEDNNDTQV APSGKSLASL VDKENHDVKF GAGQKELVDY DLDSTPMSVT
160 170 180 190 200
DVQSPMSVDR SILGVIQSSD ISVGTETGVS PTGRVKELPP RNDRQRFLEV
210 220 230 240 250
VQYQMDILEY FRESEKKHRP KPLYMRRQKD ISHNMRSILI DWLVEVSEEY
260 270 280 290 300
KLDTETLYLS VFYLDRFLSQ MAVVRSKLQL VGTAAMYIAA KYEEIYPPEV
310 320 330 340 350
GEFVFLTDDS YTKAQVLRME QVILKILSFD LCTPTAYVFI NTYAVLCDMP
360 370 380 390 400
EKLKYMTLYI SELSLMEGET YLQYLPSLMS SASVALARHI LGMEMWTPRL
410 420 430 440 450
EEITTYKLED LKTVVLHLCH THKTAKELNT QAMREKYNRD TYKKVAMMES
460 470 480 490
VEMSKDDFDQ LCEAYNCKQK EDEHQQPDIN TKSNVNLFYK F
Length:491
Mass (Da):56,152
Last modified:May 4, 2001 - v3
Checksum:i6B700EB48A18ED99
GO
Isoform B (identifier: P14785-2) [UniParc]FASTAAdd to basket
Also known as: Short

The sequence of this isoform differs from the canonical sequence as follows:
     1-146: Missing.

Note: No experimental confirmation available.
Show »
Length:345
Mass (Da):40,305
Checksum:i176915AA7416E1C7
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti147M → I in BAA01629 (PubMed:1332913).Curated1
Sequence conflicti179V → A in BAA01628 (PubMed:1332913).Curated1
Sequence conflicti179V → A in BAA01629 (PubMed:1332913).Curated1
Sequence conflicti200V → M in BAA01629 (PubMed:1332913).Curated1
Sequence conflicti220P → A in AAN71390 (PubMed:12537569).Curated1
Sequence conflicti223L → R in AAA28435 (PubMed:2564316).Curated1
Sequence conflicti474H → Q in BAA01629 (PubMed:1332913).Curated1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_0012491 – 146Missing in isoform B. 1 PublicationAdd BLAST146

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
D10857 Genomic DNA Translation: BAA01628.1
D10858 mRNA Translation: BAA01629.1
M24841 Genomic RNA Translation: AAA28435.1
AE014296 Genomic DNA Translation: AAF49999.2
AE014296 Genomic DNA Translation: AAF50000.3
AY058712 mRNA Translation: AAL13941.1
BT001635 mRNA Translation: AAN71390.1
PIRiJC1390
RefSeqiNP_524030.2, NM_079306.4 [P14785-1]
UniGeneiDm.2549

Genome annotation databases

EnsemblMetazoaiFBtr0076075; FBpp0075807; FBgn0000404 [P14785-1]
GeneIDi39340
KEGGidme:Dmel_CG5940

Keywords - Coding sequence diversityi

Alternative splicing

Similar proteinsi

Entry informationi

Entry nameiCCNA_DROME
AccessioniPrimary (citable) accession number: P14785
Secondary accession number(s): Q8IGR7, Q9VTP6, Q9VTP7
Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 1, 1990
Last sequence update: May 4, 2001
Last modified: March 28, 2018
This is version 177 of the entry and version 3 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programDrosophila annotation project

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health