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Protein

Interleukin-2 receptor subunit beta

Gene

IL2RB

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Receptor for interleukin-2. This beta subunit is involved in receptor mediated endocytosis and transduces the mitogenic signals of IL2.

GO - Molecular functioni

GO - Biological processi

  • cytokine-mediated signaling pathway Source: MGI
  • MAPK cascade Source: Reactome
  • negative regulation of apoptotic process Source: MGI
  • protein complex assembly Source: ProtInc
  • signal transduction Source: ProtInc
  • viral process Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Receptor

Keywords - Biological processi

Host-virus interaction

Enzyme and pathway databases

BioCyciZFISH:ENSG00000100385-MONOMER.
ReactomeiR-HSA-114604. GPVI-mediated activation cascade.
R-HSA-392451. G beta:gamma signalling through PI3Kgamma.
R-HSA-449147. Signaling by Interleukins.
R-HSA-451927. Interleukin-2 signaling.
R-HSA-5673001. RAF/MAP kinase cascade.
R-HSA-912526. Interleukin receptor SHC signaling.
SignaLinkiP14784.
SIGNORiP14784.

Names & Taxonomyi

Protein namesi
Recommended name:
Interleukin-2 receptor subunit beta
Short name:
IL-2 receptor subunit beta
Short name:
IL-2R subunit beta
Short name:
IL-2RB
Alternative name(s):
High affinity IL-2 receptor subunit beta
p70-75
Short name:
p75
CD_antigen: CD122
Gene namesi
Name:IL2RB
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 22

Organism-specific databases

HGNCiHGNC:6009. IL2RB.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini27 – 240ExtracellularSequence analysisAdd BLAST214
Transmembranei241 – 265HelicalSequence analysisAdd BLAST25
Topological domaini266 – 551CytoplasmicSequence analysisAdd BLAST286

GO - Cellular componenti

  • external side of plasma membrane Source: UniProtKB
  • integral component of plasma membrane Source: ProtInc
  • intracellular Source: GOC
  • membrane Source: UniProtKB
  • plasma membrane Source: Reactome
Complete GO annotation...

Keywords - Cellular componenti

Membrane

Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Mutagenesisi418Y → F: Partial loss of interaction with SHB; when associated with F-536. 1 Publication1
Mutagenesisi536Y → F: Partial loss of interaction with SHB; when associated with F-418. 1 Publication1

Organism-specific databases

DisGeNETi3560.
MalaCardsiIL2RB.
OpenTargetsiENSG00000100385.
Orphaneti85408. Juvenile rheumatoid factor-negative polyarthritis.
85410. Oligoarticular juvenile arthritis.
PharmGKBiPA29829.

Chemistry databases

ChEMBLiCHEMBL3276.
DrugBankiDB00041. Aldesleukin.
DB00074. Basiliximab.
DB00111. Daclizumab.
DB00004. Denileukin diftitox.

Polymorphism and mutation databases

BioMutaiIL2RB.
DMDMi124321.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 26Add BLAST26
ChainiPRO_000001087827 – 551Interleukin-2 receptor subunit betaAdd BLAST525

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi29N-linked (GlcNAc...)Sequence analysis1
Disulfide bondi36 ↔ 46
Glycosylationi43N-linked (GlcNAc...)1 Publication1
Disulfide bondi59 ↔ 110
Glycosylationi71N-linked (GlcNAc...)1 Publication1
Disulfide bondi74 ↔ 86
Glycosylationi149N-linked (GlcNAc...)2 Publications1

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PaxDbiP14784.
PeptideAtlasiP14784.
PRIDEiP14784.

PTM databases

iPTMnetiP14784.
PhosphoSitePlusiP14784.

Expressioni

Gene expression databases

BgeeiENSG00000100385.
CleanExiHS_IL2RB.
ExpressionAtlasiP14784. baseline and differential.
GenevisibleiP14784. HS.

Organism-specific databases

HPAiHPA051627.
HPA062657.

Interactioni

Subunit structurei

Non-covalent dimer of an alpha and a beta subunit. IL2R exists in 3 different forms: a high affinity dimer, an intermediate affinity monomer (beta subunit), and a low affinity monomer (alpha subunit). The high and intermediate affinity forms also associate with a gamma subunit. Interacts with SHB upon interleukin stimulation. Interacts with HTLV-1 accessory protein p12I.4 Publications

Binary interactionsi

WithEntry#Exp.IntActNotes
IL15P409333EBI-2866779,EBI-980274

GO - Molecular functioni

Protein-protein interaction databases

BioGridi109775. 18 interactors.
DIPiDIP-43N.
IntActiP14784. 8 interactors.
MINTiMINT-273361.
STRINGi9606.ENSP00000216223.

Structurei

Secondary structure

1551
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Beta strandi33 – 38Combined sources6
Beta strandi40 – 49Combined sources10
Beta strandi59 – 65Combined sources7
Beta strandi72 – 75Combined sources4
Beta strandi77 – 80Combined sources4
Beta strandi84 – 89Combined sources6
Beta strandi104 – 110Combined sources7
Beta strandi117 – 124Combined sources8
Helixi126 – 128Combined sources3
Beta strandi136 – 143Combined sources8
Beta strandi148 – 153Combined sources6
Helixi159 – 161Combined sources3
Beta strandi165 – 172Combined sources8
Helixi178 – 180Combined sources3
Beta strandi184 – 186Combined sources3
Beta strandi192 – 195Combined sources4
Beta strandi203 – 213Combined sources11
Beta strandi227 – 230Combined sources4

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1ILMmodel-B31-230[»]
1ILNmodel-B31-230[»]
2B5IX-ray2.30B27-240[»]
2ERJX-ray3.00B/F27-232[»]
3QAZX-ray3.80B/E/H/K/N/Q/T/W/Z/c/f/i24-240[»]
4GS7X-ray2.35B27-240[»]
ProteinModelPortaliP14784.
SMRiP14784.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP14784.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini134 – 234Fibronectin type-IIIPROSITE-ProRule annotationAdd BLAST101

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi220 – 224WSXWS motif5
Motifi278 – 286Box 1 motif9

Domaini

The WSXWS motif appears to be necessary for proper protein folding and thereby efficient intracellular transport and cell-surface receptor binding.
The box 1 motif is required for JAK interaction and/or activation.

Sequence similaritiesi

Contains 1 fibronectin type-III domain.PROSITE-ProRule annotation

Keywords - Domaini

Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410II5H. Eukaryota.
ENOG410YXT9. LUCA.
GeneTreeiENSGT00510000049239.
HOGENOMiHOG000038003.
HOVERGENiHBG052110.
InParanoidiP14784.
KOiK05069.
OMAiACQVYFT.
OrthoDBiEOG091G046N.
PhylomeDBiP14784.
TreeFamiTF337874.

Family and domain databases

CDDicd00063. FN3. 1 hit.
Gene3Di2.60.40.10. 1 hit.
InterProiIPR003961. FN3_dom.
IPR003531. Hempt_rcpt_S_F1_CS.
IPR013783. Ig-like_fold.
[Graphical view]
SMARTiSM00060. FN3. 1 hit.
[Graphical view]
SUPFAMiSSF49265. SSF49265. 2 hits.
PROSITEiPS50853. FN3. 1 hit.
PS01355. HEMATOPO_REC_S_F1. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P14784-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAAPALSWRL PLLILLLPLA TSWASAAVNG TSQFTCFYNS RANISCVWSQ
60 70 80 90 100
DGALQDTSCQ VHAWPDRRRW NQTCELLPVS QASWACNLIL GAPDSQKLTT
110 120 130 140 150
VDIVTLRVLC REGVRWRVMA IQDFKPFENL RLMAPISLQV VHVETHRCNI
160 170 180 190 200
SWEISQASHY FERHLEFEAR TLSPGHTWEE APLLTLKQKQ EWICLETLTP
210 220 230 240 250
DTQYEFQVRV KPLQGEFTTW SPWSQPLAFR TKPAALGKDT IPWLGHLLVG
260 270 280 290 300
LSGAFGFIIL VYLLINCRNT GPWLKKVLKC NTPDPSKFFS QLSSEHGGDV
310 320 330 340 350
QKWLSSPFPS SSFSPGGLAP EISPLEVLER DKVTQLLLQQ DKVPEPASLS
360 370 380 390 400
SNHSLTSCFT NQGYFFFHLP DALEIEACQV YFTYDPYSEE DPDEGVAGAP
410 420 430 440 450
TGSSPQPLQP LSGEDDAYCT FPSRDDLLLF SPSLLGGPSP PSTAPGGSGA
460 470 480 490 500
GEERMPPSLQ ERVPRDWDPQ PLGPPTPGVP DLVDFQPPPE LVLREAGEEV
510 520 530 540 550
PDAGPREGVS FPWSRPPGQG EFRALNARLP LNTDAYLSLQ ELQGQDPTHL

V
Length:551
Mass (Da):61,117
Last modified:April 1, 1990 - v1
Checksum:i1A76FA1936BB7EE6
GO

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_06118610L → V.Corresponds to variant rs57770674dbSNPEnsembl.1
Natural variantiVAR_02199483S → F.1 PublicationCorresponds to variant rs2228143dbSNPEnsembl.1
Natural variantiVAR_019998391D → E.1 PublicationCorresponds to variant rs228942dbSNPEnsembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M26062 mRNA. Translation: AAA59143.1.
CR456506 mRNA. Translation: CAG30392.1.
AF517934 Genomic DNA. Translation: AAM54040.1.
AK312860 mRNA. Translation: BAG35712.1.
AL022314 Genomic DNA. Translation: CAA18444.1.
CH471095 Genomic DNA. Translation: EAW60144.1.
BC025691 mRNA. Translation: AAH25691.1.
CCDSiCCDS13942.1.
PIRiA30342.
RefSeqiNP_000869.1. NM_000878.4.
UniGeneiHs.474787.

Genome annotation databases

EnsembliENST00000216223; ENSP00000216223; ENSG00000100385.
GeneIDi3560.
KEGGihsa:3560.
UCSCiuc003aqv.2. human.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Web resourcesi

SeattleSNPs

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M26062 mRNA. Translation: AAA59143.1.
CR456506 mRNA. Translation: CAG30392.1.
AF517934 Genomic DNA. Translation: AAM54040.1.
AK312860 mRNA. Translation: BAG35712.1.
AL022314 Genomic DNA. Translation: CAA18444.1.
CH471095 Genomic DNA. Translation: EAW60144.1.
BC025691 mRNA. Translation: AAH25691.1.
CCDSiCCDS13942.1.
PIRiA30342.
RefSeqiNP_000869.1. NM_000878.4.
UniGeneiHs.474787.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1ILMmodel-B31-230[»]
1ILNmodel-B31-230[»]
2B5IX-ray2.30B27-240[»]
2ERJX-ray3.00B/F27-232[»]
3QAZX-ray3.80B/E/H/K/N/Q/T/W/Z/c/f/i24-240[»]
4GS7X-ray2.35B27-240[»]
ProteinModelPortaliP14784.
SMRiP14784.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi109775. 18 interactors.
DIPiDIP-43N.
IntActiP14784. 8 interactors.
MINTiMINT-273361.
STRINGi9606.ENSP00000216223.

Chemistry databases

ChEMBLiCHEMBL3276.
DrugBankiDB00041. Aldesleukin.
DB00074. Basiliximab.
DB00111. Daclizumab.
DB00004. Denileukin diftitox.

PTM databases

iPTMnetiP14784.
PhosphoSitePlusiP14784.

Polymorphism and mutation databases

BioMutaiIL2RB.
DMDMi124321.

Proteomic databases

PaxDbiP14784.
PeptideAtlasiP14784.
PRIDEiP14784.

Protocols and materials databases

DNASUi3560.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000216223; ENSP00000216223; ENSG00000100385.
GeneIDi3560.
KEGGihsa:3560.
UCSCiuc003aqv.2. human.

Organism-specific databases

CTDi3560.
DisGeNETi3560.
GeneCardsiIL2RB.
HGNCiHGNC:6009. IL2RB.
HPAiHPA051627.
HPA062657.
MalaCardsiIL2RB.
MIMi146710. gene.
neXtProtiNX_P14784.
OpenTargetsiENSG00000100385.
Orphaneti85408. Juvenile rheumatoid factor-negative polyarthritis.
85410. Oligoarticular juvenile arthritis.
PharmGKBiPA29829.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410II5H. Eukaryota.
ENOG410YXT9. LUCA.
GeneTreeiENSGT00510000049239.
HOGENOMiHOG000038003.
HOVERGENiHBG052110.
InParanoidiP14784.
KOiK05069.
OMAiACQVYFT.
OrthoDBiEOG091G046N.
PhylomeDBiP14784.
TreeFamiTF337874.

Enzyme and pathway databases

BioCyciZFISH:ENSG00000100385-MONOMER.
ReactomeiR-HSA-114604. GPVI-mediated activation cascade.
R-HSA-392451. G beta:gamma signalling through PI3Kgamma.
R-HSA-449147. Signaling by Interleukins.
R-HSA-451927. Interleukin-2 signaling.
R-HSA-5673001. RAF/MAP kinase cascade.
R-HSA-912526. Interleukin receptor SHC signaling.
SignaLinkiP14784.
SIGNORiP14784.

Miscellaneous databases

EvolutionaryTraceiP14784.
GeneWikiiIL2RB.
GenomeRNAii3560.
PROiP14784.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000100385.
CleanExiHS_IL2RB.
ExpressionAtlasiP14784. baseline and differential.
GenevisibleiP14784. HS.

Family and domain databases

CDDicd00063. FN3. 1 hit.
Gene3Di2.60.40.10. 1 hit.
InterProiIPR003961. FN3_dom.
IPR003531. Hempt_rcpt_S_F1_CS.
IPR013783. Ig-like_fold.
[Graphical view]
SMARTiSM00060. FN3. 1 hit.
[Graphical view]
SUPFAMiSSF49265. SSF49265. 2 hits.
PROSITEiPS50853. FN3. 1 hit.
PS01355. HEMATOPO_REC_S_F1. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiIL2RB_HUMAN
AccessioniPrimary (citable) accession number: P14784
Secondary accession number(s): B2R765
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 1, 1990
Last sequence update: April 1, 1990
Last modified: November 30, 2016
This is version 190 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Human cell differentiation molecules
    CD nomenclature of surface proteins of human leucocytes and list of entries
  2. Human chromosome 22
    Human chromosome 22: entries, gene names and cross-references to MIM
  3. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  4. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  5. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  6. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  7. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.