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P14784

- IL2RB_HUMAN

UniProt

P14784 - IL2RB_HUMAN

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Protein

Interleukin-2 receptor subunit beta

Gene

IL2RB

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli

Functioni

Receptor for interleukin-2. This beta subunit is involved in receptor mediated endocytosis and transduces the mitogenic signals of IL2.

GO - Molecular functioni

  1. interleukin-2 binding Source: UniProtKB
  2. interleukin-2 receptor activity Source: MGI

GO - Biological processi

  1. cytokine-mediated signaling pathway Source: MGI
  2. interleukin-2-mediated signaling pathway Source: GOC
  3. negative regulation of apoptotic process Source: MGI
  4. protein complex assembly Source: ProtInc
  5. signal transduction Source: ProtInc
  6. viral process Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Receptor

Keywords - Biological processi

Host-virus interaction

Enzyme and pathway databases

ReactomeiREACT_23891. Interleukin receptor SHC signaling.
REACT_27283. Interleukin-2 signaling.
SignaLinkiP14784.

Names & Taxonomyi

Protein namesi
Recommended name:
Interleukin-2 receptor subunit beta
Short name:
IL-2 receptor subunit beta
Short name:
IL-2R subunit beta
Short name:
IL-2RB
Alternative name(s):
High affinity IL-2 receptor subunit beta
p70-75
Short name:
p75
CD_antigen: CD122
Gene namesi
Name:IL2RB
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 22

Organism-specific databases

HGNCiHGNC:6009. IL2RB.

Subcellular locationi

GO - Cellular componenti

  1. external side of plasma membrane Source: UniProtKB
  2. integral component of plasma membrane Source: ProtInc
  3. membrane Source: UniProtKB
  4. plasma membrane Source: Reactome
Complete GO annotation...

Keywords - Cellular componenti

Membrane

Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Mutagenesisi418 – 4181Y → F: Partial loss of interaction with SHB; when associated with F-536. 1 Publication
Mutagenesisi536 – 5361Y → F: Partial loss of interaction with SHB; when associated with F-418. 1 Publication

Organism-specific databases

Orphaneti85408. Juvenile rheumatoid factor-negative polyarthritis.
85410. Oligoarticular juvenile arthritis.
PharmGKBiPA29829.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2626Add
BLAST
Chaini27 – 551525Interleukin-2 receptor subunit betaPRO_0000010878Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi29 – 291N-linked (GlcNAc...)Sequence Analysis
Disulfide bondi36 ↔ 46
Glycosylationi43 – 431N-linked (GlcNAc...)1 Publication
Disulfide bondi59 ↔ 110
Glycosylationi71 – 711N-linked (GlcNAc...)1 Publication
Disulfide bondi74 ↔ 86
Glycosylationi149 – 1491N-linked (GlcNAc...)2 Publications

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PaxDbiP14784.
PRIDEiP14784.

PTM databases

PhosphoSiteiP14784.

Expressioni

Gene expression databases

BgeeiP14784.
CleanExiHS_IL2RB.
ExpressionAtlasiP14784. baseline and differential.
GenevestigatoriP14784.

Organism-specific databases

HPAiHPA062657.

Interactioni

Subunit structurei

Non-covalent dimer of an alpha and a beta subunit. IL2R exists in 3 different forms: a high affinity dimer, an intermediate affinity monomer (beta subunit), and a low affinity monomer (alpha subunit). The high and intermediate affinity forms also associate with a gamma subunit. Interacts with SHB upon interleukin stimulation. Interacts with HTLV-1 accessory protein p12I.4 Publications

Protein-protein interaction databases

BioGridi109775. 17 interactions.
DIPiDIP-43N.
IntActiP14784. 4 interactions.
MINTiMINT-273361.
STRINGi9606.ENSP00000216223.

Structurei

Secondary structure

1
551
Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Beta strandi33 – 386
Beta strandi40 – 4910
Beta strandi59 – 657
Beta strandi72 – 754
Beta strandi77 – 804
Beta strandi84 – 896
Beta strandi104 – 1107
Beta strandi117 – 1248
Helixi126 – 1283
Beta strandi136 – 1438
Beta strandi148 – 1536
Helixi159 – 1613
Beta strandi165 – 1728
Helixi178 – 1803
Beta strandi184 – 1863
Beta strandi192 – 1954
Beta strandi203 – 21311
Beta strandi227 – 2304

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
1ILMmodel-B31-230[»]
1ILNmodel-B31-230[»]
2B5IX-ray2.30B27-240[»]
2ERJX-ray3.00B/F27-232[»]
3QAZX-ray3.80B/E/H/K/N/Q/T/W/Z/c/f/i24-240[»]
4GS7X-ray2.35B27-240[»]
ProteinModelPortaliP14784.
SMRiP14784. Positions 32-232.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP14784.

Topological domain

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini27 – 240214ExtracellularSequence AnalysisAdd
BLAST
Topological domaini266 – 551286CytoplasmicSequence AnalysisAdd
BLAST

Transmembrane

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei241 – 26525HelicalSequence AnalysisAdd
BLAST

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini134 – 234101Fibronectin type-IIIPROSITE-ProRule annotationAdd
BLAST

Motif

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Motifi220 – 2245WSXWS motif
Motifi278 – 2869Box 1 motif

Domaini

The WSXWS motif appears to be necessary for proper protein folding and thereby efficient intracellular transport and cell-surface receptor binding.
The box 1 motif is required for JAK interaction and/or activation.

Sequence similaritiesi

Contains 1 fibronectin type-III domain.PROSITE-ProRule annotation

Keywords - Domaini

Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiNOG46659.
GeneTreeiENSGT00510000049239.
HOGENOMiHOG000038003.
HOVERGENiHBG052110.
InParanoidiP14784.
KOiK05069.
OMAiACQVYFT.
OrthoDBiEOG72RMZ6.
PhylomeDBiP14784.
TreeFamiTF337874.

Family and domain databases

Gene3Di2.60.40.10. 1 hit.
InterProiIPR003961. Fibronectin_type3.
IPR003531. Hempt_rcpt_S_F1_CS.
IPR013783. Ig-like_fold.
[Graphical view]
SMARTiSM00060. FN3. 1 hit.
[Graphical view]
SUPFAMiSSF49265. SSF49265. 2 hits.
PROSITEiPS50853. FN3. 1 hit.
PS01355. HEMATOPO_REC_S_F1. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P14784-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MAAPALSWRL PLLILLLPLA TSWASAAVNG TSQFTCFYNS RANISCVWSQ
60 70 80 90 100
DGALQDTSCQ VHAWPDRRRW NQTCELLPVS QASWACNLIL GAPDSQKLTT
110 120 130 140 150
VDIVTLRVLC REGVRWRVMA IQDFKPFENL RLMAPISLQV VHVETHRCNI
160 170 180 190 200
SWEISQASHY FERHLEFEAR TLSPGHTWEE APLLTLKQKQ EWICLETLTP
210 220 230 240 250
DTQYEFQVRV KPLQGEFTTW SPWSQPLAFR TKPAALGKDT IPWLGHLLVG
260 270 280 290 300
LSGAFGFIIL VYLLINCRNT GPWLKKVLKC NTPDPSKFFS QLSSEHGGDV
310 320 330 340 350
QKWLSSPFPS SSFSPGGLAP EISPLEVLER DKVTQLLLQQ DKVPEPASLS
360 370 380 390 400
SNHSLTSCFT NQGYFFFHLP DALEIEACQV YFTYDPYSEE DPDEGVAGAP
410 420 430 440 450
TGSSPQPLQP LSGEDDAYCT FPSRDDLLLF SPSLLGGPSP PSTAPGGSGA
460 470 480 490 500
GEERMPPSLQ ERVPRDWDPQ PLGPPTPGVP DLVDFQPPPE LVLREAGEEV
510 520 530 540 550
PDAGPREGVS FPWSRPPGQG EFRALNARLP LNTDAYLSLQ ELQGQDPTHL

V
Length:551
Mass (Da):61,117
Last modified:April 1, 1990 - v1
Checksum:i1A76FA1936BB7EE6
GO

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti10 – 101L → V.
Corresponds to variant rs57770674 [ dbSNP | Ensembl ].
VAR_061186
Natural varianti83 – 831S → F.1 Publication
Corresponds to variant rs2228143 [ dbSNP | Ensembl ].
VAR_021994
Natural varianti391 – 3911D → E.1 Publication
Corresponds to variant rs228942 [ dbSNP | Ensembl ].
VAR_019998

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
M26062 mRNA. Translation: AAA59143.1.
CR456506 mRNA. Translation: CAG30392.1.
AF517934 Genomic DNA. Translation: AAM54040.1.
AK312860 mRNA. Translation: BAG35712.1.
AL022314 Genomic DNA. Translation: CAA18444.1.
CH471095 Genomic DNA. Translation: EAW60144.1.
BC025691 mRNA. Translation: AAH25691.1.
CCDSiCCDS13942.1.
PIRiA30342.
RefSeqiNP_000869.1. NM_000878.3.
UniGeneiHs.474787.

Genome annotation databases

EnsembliENST00000216223; ENSP00000216223; ENSG00000100385.
GeneIDi3560.
KEGGihsa:3560.
UCSCiuc003aqv.1. human.

Polymorphism databases

DMDMi124321.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Web resourcesi

SeattleSNPs

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
M26062 mRNA. Translation: AAA59143.1 .
CR456506 mRNA. Translation: CAG30392.1 .
AF517934 Genomic DNA. Translation: AAM54040.1 .
AK312860 mRNA. Translation: BAG35712.1 .
AL022314 Genomic DNA. Translation: CAA18444.1 .
CH471095 Genomic DNA. Translation: EAW60144.1 .
BC025691 mRNA. Translation: AAH25691.1 .
CCDSi CCDS13942.1.
PIRi A30342.
RefSeqi NP_000869.1. NM_000878.3.
UniGenei Hs.474787.

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
Entry Method Resolution (Å) Chain Positions PDBsum
1ILM model - B 31-230 [» ]
1ILN model - B 31-230 [» ]
2B5I X-ray 2.30 B 27-240 [» ]
2ERJ X-ray 3.00 B/F 27-232 [» ]
3QAZ X-ray 3.80 B/E/H/K/N/Q/T/W/Z/c/f/i 24-240 [» ]
4GS7 X-ray 2.35 B 27-240 [» ]
ProteinModelPortali P14784.
SMRi P14784. Positions 32-232.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 109775. 17 interactions.
DIPi DIP-43N.
IntActi P14784. 4 interactions.
MINTi MINT-273361.
STRINGi 9606.ENSP00000216223.

Chemistry

BindingDBi P14784.
ChEMBLi CHEMBL2364167.
DrugBanki DB00041. Aldesleukin.
DB00074. Basiliximab.
DB00111. Daclizumab.
DB00004. Denileukin diftitox.

PTM databases

PhosphoSitei P14784.

Polymorphism databases

DMDMi 124321.

Proteomic databases

PaxDbi P14784.
PRIDEi P14784.

Protocols and materials databases

DNASUi 3560.
Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000216223 ; ENSP00000216223 ; ENSG00000100385 .
GeneIDi 3560.
KEGGi hsa:3560.
UCSCi uc003aqv.1. human.

Organism-specific databases

CTDi 3560.
GeneCardsi GC22M037515.
HGNCi HGNC:6009. IL2RB.
HPAi HPA062657.
MIMi 146710. gene.
neXtProti NX_P14784.
Orphaneti 85408. Juvenile rheumatoid factor-negative polyarthritis.
85410. Oligoarticular juvenile arthritis.
PharmGKBi PA29829.
GenAtlasi Search...

Phylogenomic databases

eggNOGi NOG46659.
GeneTreei ENSGT00510000049239.
HOGENOMi HOG000038003.
HOVERGENi HBG052110.
InParanoidi P14784.
KOi K05069.
OMAi ACQVYFT.
OrthoDBi EOG72RMZ6.
PhylomeDBi P14784.
TreeFami TF337874.

Enzyme and pathway databases

Reactomei REACT_23891. Interleukin receptor SHC signaling.
REACT_27283. Interleukin-2 signaling.
SignaLinki P14784.

Miscellaneous databases

EvolutionaryTracei P14784.
GeneWikii IL2RB.
GenomeRNAii 3560.
NextBioi 13904.
PROi P14784.
SOURCEi Search...

Gene expression databases

Bgeei P14784.
CleanExi HS_IL2RB.
ExpressionAtlasi P14784. baseline and differential.
Genevestigatori P14784.

Family and domain databases

Gene3Di 2.60.40.10. 1 hit.
InterProi IPR003961. Fibronectin_type3.
IPR003531. Hempt_rcpt_S_F1_CS.
IPR013783. Ig-like_fold.
[Graphical view ]
SMARTi SM00060. FN3. 1 hit.
[Graphical view ]
SUPFAMi SSF49265. SSF49265. 2 hits.
PROSITEi PS50853. FN3. 1 hit.
PS01355. HEMATOPO_REC_S_F1. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Interleukin-2 receptor beta chain gene: generation of three receptor forms by cloned human alpha and beta chain cDNA's."
    Hatakeyama M., Tsudo M., Minamoto S., Kono T., Doi T., Miyata T., Miyasaka M., Taniguchi T.
    Science 244:551-556(1989) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
  2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
  3. SeattleSNPs variation discovery resource
    Submitted (JUN-2002) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], VARIANTS PHE-83 AND GLU-391.
  4. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Trachea.
  5. "The DNA sequence of human chromosome 22."
    Dunham I., Hunt A.R., Collins J.E., Bruskiewich R., Beare D.M., Clamp M., Smink L.J., Ainscough R., Almeida J.P., Babbage A.K., Bagguley C., Bailey J., Barlow K.F., Bates K.N., Beasley O.P., Bird C.P., Blakey S.E., Bridgeman A.M.
    , Buck D., Burgess J., Burrill W.D., Burton J., Carder C., Carter N.P., Chen Y., Clark G., Clegg S.M., Cobley V.E., Cole C.G., Collier R.E., Connor R., Conroy D., Corby N.R., Coville G.J., Cox A.V., Davis J., Dawson E., Dhami P.D., Dockree C., Dodsworth S.J., Durbin R.M., Ellington A.G., Evans K.L., Fey J.M., Fleming K., French L., Garner A.A., Gilbert J.G.R., Goward M.E., Grafham D.V., Griffiths M.N.D., Hall C., Hall R.E., Hall-Tamlyn G., Heathcott R.W., Ho S., Holmes S., Hunt S.E., Jones M.C., Kershaw J., Kimberley A.M., King A., Laird G.K., Langford C.F., Leversha M.A., Lloyd C., Lloyd D.M., Martyn I.D., Mashreghi-Mohammadi M., Matthews L.H., Mccann O.T., Mcclay J., Mclaren S., McMurray A.A., Milne S.A., Mortimore B.J., Odell C.N., Pavitt R., Pearce A.V., Pearson D., Phillimore B.J.C.T., Phillips S.H., Plumb R.W., Ramsay H., Ramsey Y., Rogers L., Ross M.T., Scott C.E., Sehra H.K., Skuce C.D., Smalley S., Smith M.L., Soderlund C., Spragon L., Steward C.A., Sulston J.E., Swann R.M., Vaudin M., Wall M., Wallis J.M., Whiteley M.N., Willey D.L., Williams L., Williams S.A., Williamson H., Wilmer T.E., Wilming L., Wright C.L., Hubbard T., Bentley D.R., Beck S., Rogers J., Shimizu N., Minoshima S., Kawasaki K., Sasaki T., Asakawa S., Kudoh J., Shintani A., Shibuya K., Yoshizaki Y., Aoki N., Mitsuyama S., Roe B.A., Chen F., Chu L., Crabtree J., Deschamps S., Do A., Do T., Dorman A., Fang F., Fu Y., Hu P., Hua A., Kenton S., Lai H., Lao H.I., Lewis J., Lewis S., Lin S.-P., Loh P., Malaj E., Nguyen T., Pan H., Phan S., Qi S., Qian Y., Ray L., Ren Q., Shaull S., Sloan D., Song L., Wang Q., Wang Y., Wang Z., White J., Willingham D., Wu H., Yao Z., Zhan M., Zhang G., Chissoe S., Murray J., Miller N., Minx P., Fulton R., Johnson D., Bemis G., Bentley D., Bradshaw H., Bourne S., Cordes M., Du Z., Fulton L., Goela D., Graves T., Hawkins J., Hinds K., Kemp K., Latreille P., Layman D., Ozersky P., Rohlfing T., Scheet P., Walker C., Wamsley A., Wohldmann P., Pepin K., Nelson J., Korf I., Bedell J.A., Hillier L.W., Mardis E., Waterston R., Wilson R., Emanuel B.S., Shaikh T., Kurahashi H., Saitta S., Budarf M.L., McDermid H.E., Johnson A., Wong A.C.C., Morrow B.E., Edelmann L., Kim U.J., Shizuya H., Simon M.I., Dumanski J.P., Peyrard M., Kedra D., Seroussi E., Fransson I., Tapia I., Bruder C.E., O'Brien K.P., Wilkinson P., Bodenteich A., Hartman K., Hu X., Khan A.S., Lane L., Tilahun Y., Wright H.
    Nature 402:489-495(1999) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  6. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  7. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Lung.
  8. "The human T-cell leukemia/lymphotropic virus type 1 p12I proteins bind the interleukin-2 receptor beta and gammac chains and affects their expression on the cell surface."
    Mulloy J.C., Crownley R.W., Fullen J., Leonard W.J., Franchini G.
    J. Virol. 70:3599-3605(1996) [PubMed] [Europe PMC] [Abstract]
    Cited for: INTERACTION WITH HTLV-1 ACCESSORY PROTEIN P12I.
  9. "IL-2 receptor signaling through the Shb adapter protein in T and NK cells."
    Lindholm C.K.
    Biochem. Biophys. Res. Commun. 296:929-936(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: INTERACTION WITH SHB, MUTAGENESIS OF TYR-418 AND TYR-536.
  10. "The interleukin-2 and interleukin-4 receptors studied by molecular modelling."
    Bamborough P., Hedgecock C.J., Richards W.G.
    Structure 2:839-851(1994) [PubMed] [Europe PMC] [Abstract]
    Cited for: 3D-STRUCTURE MODELING OF 31-230.
  11. "Structure of the quaternary complex of interleukin-2 with its alpha, beta, and gammac receptors."
    Wang X., Rickert M., Garcia K.C.
    Science 310:1159-1163(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: X-RAY CRYSTALLOGRAPHY (2.3 ANGSTROMS) OF 27-240 IN COMPLEX WITH IL2; IL2RA AND IL2RC, DISULFIDE BONDS, GLYCOSYLATION AT ASN-149.
  12. "Crystal structure of the IL-2 signaling complex: paradigm for a heterotrimeric cytokine receptor."
    Stauber D.J., Debler E.W., Horton P.A., Smith K.A., Wilson I.A.
    Proc. Natl. Acad. Sci. U.S.A. 103:2788-2793(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: X-RAY CRYSTALLOGRAPHY (3.0 ANGSTROMS) OF 25-232 IN COMPLEX WITH IL2; IL2RA AND IL2RC, DISULFIDE BONDS, GLYCOSYLATION AT ASN-43; ASN-71 AND ASN-149.

Entry informationi

Entry nameiIL2RB_HUMAN
AccessioniPrimary (citable) accession number: P14784
Secondary accession number(s): B2R765
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 1, 1990
Last sequence update: April 1, 1990
Last modified: October 29, 2014
This is version 171 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Human cell differentiation molecules
    CD nomenclature of surface proteins of human leucocytes and list of entries
  2. Human chromosome 22
    Human chromosome 22: entries, gene names and cross-references to MIM
  3. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  4. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  5. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  6. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  7. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3