Reviewed, UniProtKB/Swiss-Prot P14778 (IL1R1_HUMAN)

Names and origin

Protein names

Recommended name:
    Interleukin-1 receptor type 1
      Short name=IL-1RT-1
      Short name=IL-1RT1
      Short name=IL-1R-1
Alternative name(s):
    Interleukin-1 receptor type I
    Interleukin-1 receptor alpha
      Short name=IL-1R-alpha
    p80
    CD121 antigen-like family member A
    CD_antigen=CD121a

Gene names

Name:	IL1R1
Synonyms:	IL1R, IL1RA, IL1RT1

Organism

Homo sapiens (Human) [Complete proteome]

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo

Protein attributes

Sequence length	569 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is further processed into a mature form.
Protein existence	Evidence at protein level.

General annotation (Comments)

Function	Receptor for interleukin-1 alpha (IL-1A), beta (IL-1B), and interleukin-1 receptor antagonist protein (IL-1RA). Binding to the agonist leads to the activation of NF-kappa-B. Signaling involves formation of a ternary complex containing IL1RAP, TOLLIP, MYD88, and IRAK1 or IRAK2.
Subunit structure	Binds IL1RAP.
Subcellular location	Membrane; Single-pass type I membrane protein.
Sequence similarities	Belongs to the interleukin-1 receptor family. Contains 3 Ig-like C2-type (immunoglobulin-like) domains. Contains 1 TIR domain.

Ontologies

Keywords
Cellular component	Membrane
Coding sequence diversity	Polymorphism
Domain	Immunoglobulin domain Repeat Signal Transmembrane
Molecular function	Receptor
PTM	Disulfide bond Glycoprotein Phosphoprotein
Technical term	3D-structure Complete proteome
Gene Ontology (GO)
Biological process	innate immune response Inferred from electronic annotation. Source: InterPro interleukin-1-mediated signaling pathway Inferred from direct assay. Source: UniProtKB response to interleukin-1 Inferred from direct assay. Source: UniProtKB
Cellular component	integral to plasma membrane Ref.2 Traceable author statement. Source: ProtInc
Molecular function	interleukin-1, Type I, activating receptor activity Traceable author statement. Source: ProtInc platelet-derived growth factor receptor binding Inferred from physical interaction. Source: UniProtKB
Complete GO annotation...

Binary interactions

With	Entry	#Exp.	IntAct	Notes
IL1B	P01584	1	EBI-525905,EBI-1026290
IL1RN	P18510	1	EBI-525905,EBI-1026330
TICAM2	Q86XR7	1	EBI-525905,EBI-525927
TRAF6	Q9Y4K3	1	EBI-525905,EBI-359276

Sequence annotation (Features)

Feature key

Position(s)

Length

Description

Graphical view

Feature identifier

Molecule processing

Signal peptide

1 – 17

17

Chain

18 – 569

552

Interleukin-1 receptor type 1

PRO_0000015435

Regions

Topological domain

18 – 336

319

Extracellular Potential

Transmembrane

337 – 356

20

Potential

Topological domain

357 – 569

213

Cytoplasmic Potential

Domain

23 – 110

88

Ig-like C2-type 1

Domain

118 – 210

93

Ig-like C2-type 2

Domain

226 – 328

103

Ig-like C2-type 3

Domain

383 – 541

159

TIR

Amino acid modifications

Modified residue

556

1

Phosphothreonine Ref.6

Glycosylation

100

1

N-linked (GlcNAc...) Potential

Glycosylation

193

1

N-linked (GlcNAc...) Potential

Glycosylation

233

1

N-linked (GlcNAc...) Potential

Glycosylation

249

1

N-linked (GlcNAc...) Potential

Glycosylation

263

1

N-linked (GlcNAc...) Potential

Glycosylation

297

1

N-linked (GlcNAc...) Potential

Disulfide bond

23 ↔ 104

Disulfide bond

44 ↔ 96

Disulfide bond

121 ↔ 164

Disulfide bond

142 ↔ 196

Disulfide bond

248 ↔ 312

Natural variations

Natural variant

124

1

A → G: dbSNP rs2228139. Ref.3

VAR_019131

Natural variant

344

1

T → M: dbSNP rs28362304.

VAR_029189

Secondary structure

1

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569

Helix Strand Turn

Details...

Beta strand

25 – 28

4

Beta strand

32 – 38

7

Beta strand

40 – 42

3

Turn

48 – 50

3

Beta strand

55 – 64

10

Beta strand

70 – 77

8

Beta strand

80 – 85

6

Helix

88 – 90

3

Beta strand

95 – 99

5

Beta strand

104 – 108

5

Beta strand

111 – 114

4

Beta strand

120 – 122

3

Helix

124 – 126

3

Beta strand

128 – 132

5

Beta strand

135 – 137

3

Helix

146 – 148

3

Beta strand

159 – 162

4

Beta strand

171 – 177

7

Beta strand

180 – 183

4

Beta strand

192 – 201

10

Beta strand

206 – 215

10

Beta strand

233 – 237

5

Beta strand

244 – 252

9

Beta strand

256 – 262

7

Beta strand

272 – 281

10

Beta strand

289 – 300

12

Turn

303 – 306

4

Beta strand

310 – 315

6

Beta strand

320 – 328

9

Sequences

	Sequence		Length	Mass (Da)
	P14778-1 [UniParc]. Last modified April 1, 1990. Version 1. Checksum: 5BAA83F8F0225C25	FASTA	569	65,402
	10 20 30 40 50 60 MKVLLRLICF IALLISSLEA DKCKEREEKI ILVSSANEID VRPCPLNPNE HKGTITWYKD 70 80 90 100 110 120 DSKTPVSTEQ ASRIHQHKEK LWFVPAKVED SGHYYCVVRN SSYCLRIKIS AKFVENEPNL 130 140 150 160 170 180 CYNAQAIFKQ KLPVAGDGGL VCPYMEFFKN ENNELPKLQW YKDCKPLLLD NIHFSGVKDR 190 200 210 220 230 240 LIVMNVAEKH RGNYTCHASY TYLGKQYPIT RVIEFITLEE NKPTRPVIVS PANETMEVDL 250 260 270 280 290 300 GSQIQLICNV TGQLSDIAYW KWNGSVIDED DPVLGEDYYS VENPANKRRS TLITVLNISE 310 320 330 340 350 360 IESRFYKHPF TCFAKNTHGI DAAYIQLIYP VTNFQKHMIG ICVTLTVIIV CSVFIYKIFK 370 380 390 400 410 420 IDIVLWYRDS CYDFLPIKAS DGKTYDAYIL YPKTVGEGST SDCDIFVFKV LPEVLEKQCG 430 440 450 460 470 480 YKLFIYGRDD YVGEDIVEVI NENVKKSRRL IIILVRETSG FSWLGGSSEE QIAMYNALVQ 490 500 510 520 530 540 DGIKVVLLEL EKIQDYEKMP ESIKFIKQKH GAIRWSGDFT QGPQSAKTRF WKNVRYHMPV 550 560 QRRSPSSKHQ LLSPATKEKL QREAHVPLG

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Sequence of the cDNA for the human fibroblast type interleukin-1 receptor." Chua A.O., Gubler U. Nucleic Acids Res. 17:10114-10114(1989) [PubMed: 2532321] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA]. Tissue: Liver.
[2]	"Cloning the interleukin 1 receptor from human T cells." Sims J.E., Acres R.B., Grubin C.E., McMahan C.J., Wignall J.M., March C.J., Dower S.K. Proc. Natl. Acad. Sci. U.S.A. 86:8946-8950(1989) [PubMed: 2530587] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA]. Tissue: T-cell.
[3]	SeattleSNPs variation discovery resource Submitted (JUL-2002) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], VARIANT GLY-124.
[4]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed: 15489334] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Tissue: Brain.
[5]	"Recruitment of IRAK to the interleukin 1 receptor complex requires interleukin 1 receptor accessory protein." Huang J., Gao X., Li S., Cao Z. Proc. Natl. Acad. Sci. U.S.A. 94:12829-12832(1997) [PubMed: 9371760] [Abstract] Cited for: INTERACTION WITH IL1RAP AND IRAK1. Tissue: Placenta.
[6]	"Improved titanium dioxide enrichment of phosphopeptides from HeLa cells and high confident phosphopeptide identification by cross-validation of MS/MS and MS/MS/MS spectra." Yu L.-R., Zhu Z., Chan K.C., Issaq H.J., Dimitrov D.S., Veenstra T.D. J. Proteome Res. 6:4150-4162(2007) [PubMed: 17924679] [Abstract] Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT THR-556, MASS SPECTROMETRY. Tissue: Epithelium.
[7]	"Crystal structure of the type-I interleukin-1 receptor complexed with interleukin-1beta." Vigers G.P.A., Anderson L.J., Caffes P., Brandhuber B.J. Nature 386:190-194(1997) [PubMed: 9062193] [Abstract] Cited for: X-RAY CRYSTALLOGRAPHY (2.5 ANGSTROMS) OF 23-332 IN COMPLEX WITH IL1B.
[8]	"A new cytokine-receptor binding mode revealed by the crystal structure of the IL-1 receptor with an antagonist." Schreuder H., Tardif C., Trump-Kallmeyer S., Soffientini A., Sarubbi E., Akeson A., Bowlin T., Yanofsky S., Barrett R.W. Nature 386:194-200(1997) [PubMed: 9062194] [Abstract] Cited for: X-RAY CRYSTALLOGRAPHY (2.7 ANGSTROMS) OF 21-331 IN COMPLEX WITH IL1RA.
[9]	"X-ray crystal structure of a small antagonist peptide bound to interleukin-1 receptor type 1." Vigers G.P.A., Dripps D.J., Edwards C.K. III, Brandhuber B.J. J. Biol. Chem. 275:36927-36933(2000) [PubMed: 10903327] [Abstract] Cited for: X-RAY CRYSTALLOGRAPHY (3.0 ANGSTROMS) OF 4-315 IN COMPLEX WITH THE ANTAGONIST PEPTIDE AF10847.
+	Additional computationally mapped references.

Web resources

SeattleSNPs

Cross-references

Sequence databases

EMBL
GenBank
DDBJ

X16896 mRNA. Translation: CAA34773.1.
M27492 mRNA. Translation: AAA59137.1.
AF531102 Genomic DNA. Translation: AAM88423.1.
BC067506 mRNA. Translation: AAH67506.1.
BC075062 mRNA. Translation: AAH75062.1.
BC075063 mRNA. Translation: AAH75063.1.

IPI

IPI00027508.

PIR

A36187.

RefSeq

NP_000868.1.

UniGene

Hs.701982

3D structure databases

PDBe
RCSB PDB
PDBj

Entry	Method	Resolution (Å)	Chain	Positions	PDBsum
1G0Y	X-ray	3.00	R	21-332	[»]
1IRA	X-ray	2.70	Y	18-336	[»]
1ITB	X-ray	2.50	B	18-332	[»]

SMR

P14778. Positions 42-370, 151-401, 383-540.

ModBase

Search...

Protein-protein interaction databases

DIP

DIP-93N.

IntAct

P14778. 5 interactions.

STRING

P14778.

PTM databases

PhosphoSite

P14778.

Proteomic databases

PRIDE

P14778.

Genome annotation databases

Ensembl

ENST00000233946; ENSP00000233946; ENSG00000115594; Homo sapiens. [Genome view]
ENST00000410023; ENSP00000386380; ENSG00000115594; Homo sapiens. [Genome view]

GeneID

3554.

KEGG

hsa:3554.

UCSC

uc002tbq.1. human.

Organism-specific databases

CTD

3554.

GeneCards

GC02P102053.

H-InvDB

HIX0002331.

HGNC

HGNC:5993. IL1R1.

HPA

CAB007779.

MIM

147810. gene.

PharmGKB

PA29809.

GenAtlas

Search...

Phylogenomic databases

eggNOG

prNOG19194.

HOGENOM

HBG282747.

HOVERGEN

P14778.

InParanoid

P14778.

OMA

SEEQIAM.

OrthoDB

EOG92RGSG.

PhylomeDB

P14778.

Enzyme and pathway databases

Pathway_Interaction_DB

il1pathway. IL1-mediated signaling events.
il12_2pathway. IL12-mediated signaling events.

Gene expression databases

ArrayExpress

P14778.

Bgee

P14778.

CleanEx

HS_IL1R1.

Genevestigator

P14778.

GermOnline

ENSG00000115594. Homo sapiens.

Family and domain databases

InterPro

IPR007110. Ig-like.
IPR013783. Ig-like_fold.
IPR003599. Ig_sub.
IPR015621. IL1-receptor.
IPR004075. IL1_rcpt_1.
IPR004074. IL1_rcpt_I/II.
IPR004076. IL1R_rcpt.
IPR000157. Toll-Interleukin_rcpt.
[Graphical view]

Gene3D

G3DSA:2.60.40.10. Ig-like_fold. 3 hits.

PANTHER

PTHR11890. IL1-receptor. 1 hit.

Pfam

PF01582. TIR. 1 hit.
[Graphical view]

PRINTS

PR01538. INTRLEUKN1R1.
PR01536. INTRLKN1R12F.
PR01537. INTRLKN1R1F.

SMART

SM00409. IG. 2 hits.
SM00255. TIR. 1 hit.
[Graphical view]

PROSITE

PS50835. IG_LIKE. 3 hits.
PS50104. TIR. 1 hit.
[Graphical view]

ProtoNet

Search...

Other Resources

DrugBank

DB00026. Anakinra.

NextBio

13876.

SOURCE

Search...

Entry information

Entry name

IL1R1_HUMAN

Accession

Primary (citable) accession number: P14778

Entry history

Integrated into UniProtKB/Swiss-Prot:	April 1, 1990
Last sequence update:	April 1, 1990
Last modified:	February 9, 2010
This is version 134 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HPI (Human Proteome Initiative)

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.