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Protein

Interleukin-1 receptor type 1

Gene

IL1R1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Receptor for IL1A, IL1B and IL1RN. After binding to interleukin-1 associates with the coreceptor IL1RAP to form the high affinity interleukin-1 receptor complex which mediates interleukin-1-dependent activation of NF-kappa-B, MAPK and other pathways. Signaling involves the recruitment of adapter molecules such as TOLLIP, MYD88, and IRAK1 or IRAK2 via the respective TIR domains of the receptor/coreceptor subunits. Binds ligands with comparable affinity and binding of antagonist IL1RN prevents association with IL1RAP to form a signaling complex.1 Publication

GO - Molecular functioni

  • interleukin-1, Type I, activating receptor activity Source: ProtInc
  • interleukin-1 receptor activity Source: BHF-UCL
  • platelet-derived growth factor receptor binding Source: BHF-UCL
  • signal transducer activity Source: ProtInc
  • transmembrane signaling receptor activity Source: ProtInc

GO - Biological processi

  • cell surface receptor signaling pathway Source: ProtInc
  • immune response Source: ProtInc
  • interleukin-1-mediated signaling pathway Source: BHF-UCL
  • positive regulation of interleukin-1-mediated signaling pathway Source: Ensembl
  • positive regulation of neutrophil extravasation Source: Ensembl
  • regulation of inflammatory response Source: Ensembl
  • response to interleukin-1 Source: BHF-UCL
Complete GO annotation...

Keywords - Molecular functioni

Receptor

Enzyme and pathway databases

BioCyciZFISH:ENSG00000115594-MONOMER.
ReactomeiR-HSA-446652. Interleukin-1 signaling.
SignaLinkiP14778.
SIGNORiP14778.

Names & Taxonomyi

Protein namesi
Recommended name:
Interleukin-1 receptor type 1
Short name:
IL-1R-1
Short name:
IL-1RT-1
Short name:
IL-1RT1
Alternative name(s):
CD121 antigen-like family member A
Interleukin-1 receptor alpha
Short name:
IL-1R-alpha
Interleukin-1 receptor type I
p80
CD_antigen: CD121a
Cleaved into the following 2 chains:
Interleukin-1 receptor type 1, membrane form
Short name:
mIL-1R1
Short name:
mIL-1RI
Interleukin-1 receptor type 1, soluble form
Short name:
sIL-1R1
Short name:
sIL-1RI
Gene namesi
Name:IL1R1
Synonyms:IL1R, IL1RA, IL1RT1
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 2

Organism-specific databases

HGNCiHGNC:5993. IL1R1.

Subcellular locationi

  • Membrane 1 Publication; Single-pass type I membrane protein 1 Publication
  • Cell membrane 1 Publication
  • Secreted 1 Publication

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini18 – 336ExtracellularSequence analysisAdd BLAST319
Transmembranei337 – 356HelicalSequence analysisAdd BLAST20
Topological domaini357 – 569CytoplasmicSequence analysisAdd BLAST213

GO - Cellular componenti

  • cell surface Source: Ensembl
  • extracellular region Source: UniProtKB-SubCell
  • integral component of plasma membrane Source: ProtInc
  • membrane Source: BHF-UCL
  • plasma membrane Source: Reactome
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane, Secreted

Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Mutagenesisi369D → A: Reduces NF-kappa-B activation. 1 Publication1
Mutagenesisi428R → A: Reduces NF-kappa-B activation and receptor-associated kinase activation. 1 Publication1

Organism-specific databases

DisGeNETi3554.
OpenTargetsiENSG00000115594.
PharmGKBiPA29809.

Chemistry databases

ChEMBLiCHEMBL1959.
DrugBankiDB00026. Anakinra.

Polymorphism and mutation databases

BioMutaiIL1R1.
DMDMi124308.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 17Add BLAST17
ChainiPRO_000001543518 – 569Interleukin-1 receptor type 1, membrane formAdd BLAST552
ChainiPRO_000041534418 – ?Interleukin-1 receptor type 1, soluble form

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi23 ↔ 104
Disulfide bondi44 ↔ 96
Glycosylationi100N-linked (GlcNAc...)Sequence analysis1
Disulfide bondi121 ↔ 164
Disulfide bondi142 ↔ 196
Glycosylationi193N-linked (GlcNAc...)Sequence analysis1
Glycosylationi233N-linked (GlcNAc...)Sequence analysis1
Disulfide bondi248 ↔ 312
Glycosylationi249N-linked (GlcNAc...)Sequence analysis1
Glycosylationi263N-linked (GlcNAc...)Sequence analysis1
Glycosylationi297N-linked (GlcNAc...)Sequence analysis1
Modified residuei496Phosphotyrosine1 Publication1

Post-translational modificationi

A soluble form (sIL1R1) is probably produced by proteolytic cleavage at the cell surface (shedding).1 Publication
Rapidly phosphorylated on Tyr-496 in response to IL-1, which creates a SH2 binding site for the PI 3-kinase regulatory subunit PIK3R1.1 Publication

Keywords - PTMi

Disulfide bond, Glycoprotein, Phosphoprotein

Proteomic databases

MaxQBiP14778.
PaxDbiP14778.
PeptideAtlasiP14778.
PRIDEiP14778.

PTM databases

iPTMnetiP14778.
PhosphoSitePlusiP14778.

Expressioni

Gene expression databases

BgeeiENSG00000115594.
CleanExiHS_IL1R1.
ExpressionAtlasiP14778. baseline and differential.
GenevisibleiP14778. HS.

Organism-specific databases

HPAiCAB007779.
HPA005823.
HPA029560.

Interactioni

Subunit structurei

The interleukin-1 receptor complex is a heterodimer of IL1R1 and IL1RAP. Interacts with PIK3R1.5 Publications

Binary interactionsi

WithEntry#Exp.IntActNotes
TRAF6Q9Y4K32EBI-525905,EBI-359276

GO - Molecular functioni

  • platelet-derived growth factor receptor binding Source: BHF-UCL

Protein-protein interaction databases

BioGridi109770. 22 interactors.
DIPiDIP-93N.
IntActiP14778. 6 interactors.
MINTiMINT-262640.
STRINGi9606.ENSP00000233946.

Structurei

Secondary structure

1569
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Beta strandi24 – 27Combined sources4
Beta strandi32 – 35Combined sources4
Beta strandi40 – 43Combined sources4
Helixi48 – 50Combined sources3
Beta strandi56 – 59Combined sources4
Beta strandi72 – 77Combined sources6
Beta strandi80 – 83Combined sources4
Helixi88 – 90Combined sources3
Beta strandi92 – 97Combined sources6
Beta strandi100 – 102Combined sources3
Beta strandi105 – 114Combined sources10
Beta strandi120 – 122Combined sources3
Helixi124 – 126Combined sources3
Beta strandi127 – 133Combined sources7
Beta strandi135 – 137Combined sources3
Beta strandi138 – 141Combined sources4
Helixi146 – 148Combined sources3
Turni151 – 153Combined sources3
Beta strandi159 – 162Combined sources4
Beta strandi171 – 177Combined sources7
Beta strandi180 – 183Combined sources4
Helixi188 – 190Combined sources3
Beta strandi192 – 202Combined sources11
Beta strandi205 – 218Combined sources14
Beta strandi227 – 230Combined sources4
Beta strandi233 – 237Combined sources5
Beta strandi240 – 242Combined sources3
Beta strandi244 – 252Combined sources9
Beta strandi256 – 262Combined sources7
Beta strandi272 – 281Combined sources10
Helixi287 – 289Combined sources3
Beta strandi290 – 300Combined sources11
Helixi303 – 306Combined sources4
Beta strandi310 – 316Combined sources7
Beta strandi319 – 328Combined sources10

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1G0YX-ray3.00R21-332[»]
1IRAX-ray2.70Y18-336[»]
1ITBX-ray2.50B18-332[»]
4DEPX-ray3.10B/E18-336[»]
4GAFX-ray2.15B18-336[»]
ProteinModelPortaliP14778.
SMRiP14778.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP14778.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini23 – 110Ig-like C2-type 1Add BLAST88
Domaini118 – 210Ig-like C2-type 2Add BLAST93
Domaini226 – 328Ig-like C2-type 3Add BLAST103
Domaini383 – 541TIRPROSITE-ProRule annotationAdd BLAST159

Sequence similaritiesi

Belongs to the interleukin-1 receptor family.Curated
Contains 1 TIR domain.PROSITE-ProRule annotation

Keywords - Domaini

Immunoglobulin domain, Repeat, Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410IQBC. Eukaryota.
ENOG410Z3W1. LUCA.
GeneTreeiENSGT00760000119071.
HOGENOMiHOG000253916.
HOVERGENiHBG052103.
InParanoidiP14778.
KOiK04386.
OMAiIQDYEKM.
OrthoDBiEOG091G03IT.
PhylomeDBiP14778.
TreeFamiTF325519.

Family and domain databases

Gene3Di2.60.40.10. 3 hits.
3.40.50.10140. 1 hit.
InterProiIPR007110. Ig-like_dom.
IPR013783. Ig-like_fold.
IPR013098. Ig_I-set.
IPR003599. Ig_sub.
IPR015621. IL-1_rcpt_fam.
IPR004076. IL-1_rcpt_I-typ.
IPR004074. IL-1_rcpt_I/II-typ.
IPR000157. TIR_dom.
[Graphical view]
PANTHERiPTHR11890. PTHR11890. 1 hit.
PfamiPF07679. I-set. 1 hit.
PF13895. Ig_2. 1 hit.
PF01582. TIR. 1 hit.
[Graphical view]
PRINTSiPR01538. INTRLEUKN1R1.
PR01536. INTRLKN1R12F.
SMARTiSM00409. IG. 3 hits.
SM00255. TIR. 1 hit.
[Graphical view]
SUPFAMiSSF48726. SSF48726. 3 hits.
SSF52200. SSF52200. 1 hit.
PROSITEiPS50835. IG_LIKE. 3 hits.
PS50104. TIR. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P14778-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MKVLLRLICF IALLISSLEA DKCKEREEKI ILVSSANEID VRPCPLNPNE
60 70 80 90 100
HKGTITWYKD DSKTPVSTEQ ASRIHQHKEK LWFVPAKVED SGHYYCVVRN
110 120 130 140 150
SSYCLRIKIS AKFVENEPNL CYNAQAIFKQ KLPVAGDGGL VCPYMEFFKN
160 170 180 190 200
ENNELPKLQW YKDCKPLLLD NIHFSGVKDR LIVMNVAEKH RGNYTCHASY
210 220 230 240 250
TYLGKQYPIT RVIEFITLEE NKPTRPVIVS PANETMEVDL GSQIQLICNV
260 270 280 290 300
TGQLSDIAYW KWNGSVIDED DPVLGEDYYS VENPANKRRS TLITVLNISE
310 320 330 340 350
IESRFYKHPF TCFAKNTHGI DAAYIQLIYP VTNFQKHMIG ICVTLTVIIV
360 370 380 390 400
CSVFIYKIFK IDIVLWYRDS CYDFLPIKAS DGKTYDAYIL YPKTVGEGST
410 420 430 440 450
SDCDIFVFKV LPEVLEKQCG YKLFIYGRDD YVGEDIVEVI NENVKKSRRL
460 470 480 490 500
IIILVRETSG FSWLGGSSEE QIAMYNALVQ DGIKVVLLEL EKIQDYEKMP
510 520 530 540 550
ESIKFIKQKH GAIRWSGDFT QGPQSAKTRF WKNVRYHMPV QRRSPSSKHQ
560
LLSPATKEKL QREAHVPLG
Length:569
Mass (Da):65,402
Last modified:April 1, 1990 - v1
Checksum:i5BAA83F8F0225C25
GO

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_019131124A → G.1 PublicationCorresponds to variant rs2228139dbSNPEnsembl.1
Natural variantiVAR_029189344T → M.Corresponds to variant rs28362304dbSNPEnsembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X16896 mRNA. Translation: CAA34773.1.
M27492 mRNA. Translation: AAA59137.1.
AF531102 Genomic DNA. Translation: AAM88423.1.
AC007271 Genomic DNA. Translation: AAX81988.1.
CH471127 Genomic DNA. Translation: EAX01799.1.
BC067506 mRNA. Translation: AAH67506.1.
BC075062 mRNA. Translation: AAH75062.1.
BC075063 mRNA. Translation: AAH75063.1.
CCDSiCCDS2055.1.
PIRiA36187.
RefSeqiNP_000868.1. NM_000877.3.
NP_001275635.1. NM_001288706.1.
NP_001307907.1. NM_001320978.1.
NP_001307909.1. NM_001320980.1.
NP_001307910.1. NM_001320981.1.
NP_001307911.1. NM_001320982.1.
NP_001307912.1. NM_001320983.1.
NP_001307913.1. NM_001320984.1.
NP_001307914.1. NM_001320985.1.
XP_005263987.1. XM_005263930.4.
XP_005263991.1. XM_005263934.4.
XP_011509417.1. XM_011511115.2.
XP_011509418.1. XM_011511116.1.
XP_011509419.1. XM_011511117.1.
XP_011509420.1. XM_011511118.2.
XP_016859478.1. XM_017003989.1.
UniGeneiHs.701982.

Genome annotation databases

EnsembliENST00000410023; ENSP00000386380; ENSG00000115594.
GeneIDi3554.
KEGGihsa:3554.
UCSCiuc002tbq.5. human.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Web resourcesi

SeattleSNPs

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X16896 mRNA. Translation: CAA34773.1.
M27492 mRNA. Translation: AAA59137.1.
AF531102 Genomic DNA. Translation: AAM88423.1.
AC007271 Genomic DNA. Translation: AAX81988.1.
CH471127 Genomic DNA. Translation: EAX01799.1.
BC067506 mRNA. Translation: AAH67506.1.
BC075062 mRNA. Translation: AAH75062.1.
BC075063 mRNA. Translation: AAH75063.1.
CCDSiCCDS2055.1.
PIRiA36187.
RefSeqiNP_000868.1. NM_000877.3.
NP_001275635.1. NM_001288706.1.
NP_001307907.1. NM_001320978.1.
NP_001307909.1. NM_001320980.1.
NP_001307910.1. NM_001320981.1.
NP_001307911.1. NM_001320982.1.
NP_001307912.1. NM_001320983.1.
NP_001307913.1. NM_001320984.1.
NP_001307914.1. NM_001320985.1.
XP_005263987.1. XM_005263930.4.
XP_005263991.1. XM_005263934.4.
XP_011509417.1. XM_011511115.2.
XP_011509418.1. XM_011511116.1.
XP_011509419.1. XM_011511117.1.
XP_011509420.1. XM_011511118.2.
XP_016859478.1. XM_017003989.1.
UniGeneiHs.701982.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1G0YX-ray3.00R21-332[»]
1IRAX-ray2.70Y18-336[»]
1ITBX-ray2.50B18-332[»]
4DEPX-ray3.10B/E18-336[»]
4GAFX-ray2.15B18-336[»]
ProteinModelPortaliP14778.
SMRiP14778.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi109770. 22 interactors.
DIPiDIP-93N.
IntActiP14778. 6 interactors.
MINTiMINT-262640.
STRINGi9606.ENSP00000233946.

Chemistry databases

ChEMBLiCHEMBL1959.
DrugBankiDB00026. Anakinra.

PTM databases

iPTMnetiP14778.
PhosphoSitePlusiP14778.

Polymorphism and mutation databases

BioMutaiIL1R1.
DMDMi124308.

Proteomic databases

MaxQBiP14778.
PaxDbiP14778.
PeptideAtlasiP14778.
PRIDEiP14778.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000410023; ENSP00000386380; ENSG00000115594.
GeneIDi3554.
KEGGihsa:3554.
UCSCiuc002tbq.5. human.

Organism-specific databases

CTDi3554.
DisGeNETi3554.
GeneCardsiIL1R1.
HGNCiHGNC:5993. IL1R1.
HPAiCAB007779.
HPA005823.
HPA029560.
MIMi147810. gene.
neXtProtiNX_P14778.
OpenTargetsiENSG00000115594.
PharmGKBiPA29809.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410IQBC. Eukaryota.
ENOG410Z3W1. LUCA.
GeneTreeiENSGT00760000119071.
HOGENOMiHOG000253916.
HOVERGENiHBG052103.
InParanoidiP14778.
KOiK04386.
OMAiIQDYEKM.
OrthoDBiEOG091G03IT.
PhylomeDBiP14778.
TreeFamiTF325519.

Enzyme and pathway databases

BioCyciZFISH:ENSG00000115594-MONOMER.
ReactomeiR-HSA-446652. Interleukin-1 signaling.
SignaLinkiP14778.
SIGNORiP14778.

Miscellaneous databases

ChiTaRSiIL1R1. human.
EvolutionaryTraceiP14778.
GeneWikiiInterleukin_1_receptor,_type_I.
GenomeRNAii3554.
PROiP14778.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000115594.
CleanExiHS_IL1R1.
ExpressionAtlasiP14778. baseline and differential.
GenevisibleiP14778. HS.

Family and domain databases

Gene3Di2.60.40.10. 3 hits.
3.40.50.10140. 1 hit.
InterProiIPR007110. Ig-like_dom.
IPR013783. Ig-like_fold.
IPR013098. Ig_I-set.
IPR003599. Ig_sub.
IPR015621. IL-1_rcpt_fam.
IPR004076. IL-1_rcpt_I-typ.
IPR004074. IL-1_rcpt_I/II-typ.
IPR000157. TIR_dom.
[Graphical view]
PANTHERiPTHR11890. PTHR11890. 1 hit.
PfamiPF07679. I-set. 1 hit.
PF13895. Ig_2. 1 hit.
PF01582. TIR. 1 hit.
[Graphical view]
PRINTSiPR01538. INTRLEUKN1R1.
PR01536. INTRLKN1R12F.
SMARTiSM00409. IG. 3 hits.
SM00255. TIR. 1 hit.
[Graphical view]
SUPFAMiSSF48726. SSF48726. 3 hits.
SSF52200. SSF52200. 1 hit.
PROSITEiPS50835. IG_LIKE. 3 hits.
PS50104. TIR. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiIL1R1_HUMAN
AccessioniPrimary (citable) accession number: P14778
Secondary accession number(s): Q587I7
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 1, 1990
Last sequence update: April 1, 1990
Last modified: November 2, 2016
This is version 199 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Human cell differentiation molecules
    CD nomenclature of surface proteins of human leucocytes and list of entries
  2. Human chromosome 2
    Human chromosome 2: entries, gene names and cross-references to MIM
  3. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  4. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  5. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  6. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  7. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.