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Protein

Methanol dehydrogenase [cytochrome c] subunit 2

Gene

moxI

Organism
Methylobacterium extorquens (strain ATCC 14718 / DSM 1338 / JCM 2805 / NCIMB 9133 / AM1)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

Catalyzes the oxidation of primary alcohols including methanol.

Catalytic activityi

A primary alcohol + 2 cytochrome c(L) = an aldehyde + 2 reduced cytochrome c(L) + 2 H+.1 Publication

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Keywords - Biological processi

Methanol utilization

Enzyme and pathway databases

BioCyciMetaCyc:MONOMER-3922.
BRENDAi1.1.2.7. 3296.

Names & Taxonomyi

Protein namesi
Recommended name:
Methanol dehydrogenase [cytochrome c] subunit 2 (EC:1.1.2.7)
Alternative name(s):
MDH small subunit beta
MDH-associated peptide
MEDH
Gene namesi
Name:moxI
Synonyms:mxaI
Ordered Locus Names:MexAM1_META1p4535
OrganismiMethylobacterium extorquens (strain ATCC 14718 / DSM 1338 / JCM 2805 / NCIMB 9133 / AM1)
Taxonomic identifieri272630 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaAlphaproteobacteriaRhizobialesMethylobacteriaceaeMethylobacterium
Proteomesi
  • UP000009081 Componenti: Chromosome

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Periplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 22Add BLAST22
ChainiPRO_000002556923 – 96Methanol dehydrogenase [cytochrome c] subunit 2Add BLAST74

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi28 ↔ 341 Publication

Keywords - PTMi

Disulfide bond

Interactioni

Subunit structurei

Heterotetramer composed of 2 alpha and 2 beta subunits.

Protein-protein interaction databases

STRINGi272630.MexAM1_META1p4535.

Structurei

Secondary structure

196
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Helixi56 – 59Combined sources4
Helixi61 – 83Combined sources23
Helixi90 – 92Combined sources3

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1H4IX-ray1.94B/D23-96[»]
1H4JX-ray3.00B/D/F/H23-96[»]
1W6SX-ray1.20B/D23-96[»]
ProteinModelPortaliP14775.
SMRiP14775.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP14775.

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiENOG4105P0N. Bacteria.
ENOG4111V4Q. LUCA.
HOGENOMiHOG000144327.
KOiK14029.
OMAiPGNCWEP.

Family and domain databases

Gene3Di4.10.160.10. 1 hit.
InterProiIPR003420. Meth_DH_bsu.
[Graphical view]
PfamiPF02315. MDH. 1 hit.
[Graphical view]
PIRSFiPIRSF029163. Meth_DH_beta. 1 hit.
SUPFAMiSSF48666. SSF48666. 1 hit.

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P14775-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MKTTLIAAAI VALSGLAAPA LAYDGTKCKA AGNCWEPKPG FPEKIAGSKY
60 70 80 90
DPKHDPKELN KQADSIKQME ERNKKRVENF KKTGKFEYDV AKISAN
Length:96
Mass (Da):10,512
Last modified:April 1, 1990 - v1
Checksum:i9C082124F26F3159
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X15792 Genomic DNA. Translation: CAA33796.1.
X07856 Genomic DNA. Translation: CAA30705.1.
CP001510 Genomic DNA. Translation: ACS42166.1.
RefSeqiWP_003599120.1. NC_012808.1.

Genome annotation databases

EnsemblBacteriaiACS42166; ACS42166; MexAM1_META1p4535.
KEGGimea:Mex_1p4535.
PATRICi22514713. VBIMetExt101010_4411.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X15792 Genomic DNA. Translation: CAA33796.1.
X07856 Genomic DNA. Translation: CAA30705.1.
CP001510 Genomic DNA. Translation: ACS42166.1.
RefSeqiWP_003599120.1. NC_012808.1.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1H4IX-ray1.94B/D23-96[»]
1H4JX-ray3.00B/D/F/H23-96[»]
1W6SX-ray1.20B/D23-96[»]
ProteinModelPortaliP14775.
SMRiP14775.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi272630.MexAM1_META1p4535.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiACS42166; ACS42166; MexAM1_META1p4535.
KEGGimea:Mex_1p4535.
PATRICi22514713. VBIMetExt101010_4411.

Phylogenomic databases

eggNOGiENOG4105P0N. Bacteria.
ENOG4111V4Q. LUCA.
HOGENOMiHOG000144327.
KOiK14029.
OMAiPGNCWEP.

Enzyme and pathway databases

BioCyciMetaCyc:MONOMER-3922.
BRENDAi1.1.2.7. 3296.

Miscellaneous databases

EvolutionaryTraceiP14775.

Family and domain databases

Gene3Di4.10.160.10. 1 hit.
InterProiIPR003420. Meth_DH_bsu.
[Graphical view]
PfamiPF02315. MDH. 1 hit.
[Graphical view]
PIRSFiPIRSF029163. Meth_DH_beta. 1 hit.
SUPFAMiSSF48666. SSF48666. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiDHM2_METEA
AccessioniPrimary (citable) accession number: P14775
Secondary accession number(s): C5AQA6
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 1, 1990
Last sequence update: April 1, 1990
Last modified: November 2, 2016
This is version 111 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.