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Protein

Cytochrome c-L

Gene

moxG

Organism
Methylobacterium extorquens (strain ATCC 14718 / DSM 1338 / AM1)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

Electron acceptor for MDH. Acts in methanol oxidation.

Redox potential

E0 is about +256 mV.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei90 – 901Heme (covalent)
Binding sitei93 – 931Heme (covalent)
Metal bindingi94 – 941Iron (heme axial ligand)

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Electron transport, Methanol utilization, Transport

Keywords - Ligandi

Heme, Iron, Metal-binding

Enzyme and pathway databases

BioCyciMEXT272630:GBY6-4281-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Cytochrome c-L
Gene namesi
Name:moxG
Synonyms:mxaG
Ordered Locus Names:MexAM1_META1p4536
OrganismiMethylobacterium extorquens (strain ATCC 14718 / DSM 1338 / AM1)
Taxonomic identifieri272630 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaAlphaproteobacteriaRhizobialesMethylobacteriaceaeMethylobacterium
Proteomesi
  • UP000009081 Componenti: Chromosome

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Periplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2525Add
BLAST
Chaini26 – 197172Cytochrome c-LPRO_0000006552Add
BLAST

Post-translational modificationi

Binds 1 heme group per subunit.

Interactioni

Protein-protein interaction databases

STRINGi272630.MexAM1_META1p4536.

Structurei

Secondary structure

1
197
Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Beta strandi55 – 584Combined sources
Helixi59 – 679Combined sources
Turni71 – 744Combined sources
Helixi76 – 8914Combined sources
Helixi91 – 944Combined sources
Beta strandi101 – 1033Combined sources
Beta strandi106 – 1094Combined sources
Helixi114 – 1174Combined sources
Helixi119 – 1279Combined sources
Beta strandi132 – 1343Combined sources
Helixi143 – 15513Combined sources
Helixi161 – 1633Combined sources
Helixi169 – 1746Combined sources
Beta strandi190 – 1923Combined sources

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
2C8SX-ray1.60A26-197[»]
ProteinModelPortaliP14774.
SMRiP14774. Positions 49-197.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP14774.

Family & Domainsi

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiENOG4108VFM. Bacteria.
ENOG4111K7K. LUCA.
HOGENOMiHOG000144316.
KOiK16255.
OMAiIAWIRHL.
OrthoDBiEOG61KBGS.

Family and domain databases

Gene3Di1.10.760.10. 1 hit.
InterProiIPR009056. Cyt_c-like_dom.
IPR009153. Cyt_cL.
[Graphical view]
PfamiPF13442. Cytochrome_CBB3. 1 hit.
[Graphical view]
PIRSFiPIRSF000008. Cytochrome_c551i. 1 hit.
SUPFAMiSSF46626. SSF46626. 2 hits.
TIGRFAMsiTIGR03872. cytochrome_MoxG. 1 hit.
PROSITEiPS51007. CYTC. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P14774-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MMNRVKIGTA LLGLTLAGIA LPALAQPQSG PQTGVVFRNT VTGEALDVSQ
60 70 80 90 100
GKEGGRDTPA VKKFLETGEN LYIDDKSCLR NGESLFATSC SGCHGHLAEG
110 120 130 140 150
KLGPGLNDNY WTYPSNTTDV GLFATIFGGA NGMMGPHNEN LTPDEMLQTI
160 170 180 190
AWIRHLYTGP KQDAVWLNDE QKKAYTPYKQ GEVIPKDAKG QCKPLDE
Length:197
Mass (Da):21,226
Last modified:April 1, 1990 - v1
Checksum:i58F22BACB90258CE
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X07856 Genomic DNA. Translation: CAA30704.1.
CP001510 Genomic DNA. Translation: ACS42167.1.
M31108 Genomic DNA. Translation: AAA25382.1.
RefSeqiWP_003599117.1. NC_012808.1.

Genome annotation databases

EnsemblBacteriaiACS42167; ACS42167; MexAM1_META1p4536.
KEGGimea:Mex_1p4536.
PATRICi22514715. VBIMetExt101010_4412.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X07856 Genomic DNA. Translation: CAA30704.1.
CP001510 Genomic DNA. Translation: ACS42167.1.
M31108 Genomic DNA. Translation: AAA25382.1.
RefSeqiWP_003599117.1. NC_012808.1.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
2C8SX-ray1.60A26-197[»]
ProteinModelPortaliP14774.
SMRiP14774. Positions 49-197.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi272630.MexAM1_META1p4536.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiACS42167; ACS42167; MexAM1_META1p4536.
KEGGimea:Mex_1p4536.
PATRICi22514715. VBIMetExt101010_4412.

Phylogenomic databases

eggNOGiENOG4108VFM. Bacteria.
ENOG4111K7K. LUCA.
HOGENOMiHOG000144316.
KOiK16255.
OMAiIAWIRHL.
OrthoDBiEOG61KBGS.

Enzyme and pathway databases

BioCyciMEXT272630:GBY6-4281-MONOMER.

Miscellaneous databases

EvolutionaryTraceiP14774.

Family and domain databases

Gene3Di1.10.760.10. 1 hit.
InterProiIPR009056. Cyt_c-like_dom.
IPR009153. Cyt_cL.
[Graphical view]
PfamiPF13442. Cytochrome_CBB3. 1 hit.
[Graphical view]
PIRSFiPIRSF000008. Cytochrome_c551i. 1 hit.
SUPFAMiSSF46626. SSF46626. 2 hits.
TIGRFAMsiTIGR03872. cytochrome_MoxG. 1 hit.
PROSITEiPS51007. CYTC. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "The nucleotide sequence and deduced amino acid sequence of the genes for cytochrome cL and a hypothetical second subunit of the methanol dehydrogenase of Methylobacterium AM1."
    Nunn D.N., Anthony C.
    Nucleic Acids Res. 16:7722-7722(1988) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
  2. "The nucleotide sequence and deduced amino acid sequence of the cytochrome cL gene of Methylobacterium extorquens AM1, a novel class of c-type cytochrome."
    Nunn D.N., Anthony C.
    Biochem. J. 256:673-676(1988) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
  3. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 14718 / DSM 1338 / AM1.
  4. "Nucleotide sequence of the Methylobacterium extorquens AM1 moxF and moxJ genes involved in methanol oxidation."
    Anderson D.J., Morris C.J., Nunn D.N., Anthony C., Lidstrom M.E.
    Gene 90:173-176(1990) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 1-8.

Entry informationi

Entry nameiCYCL_METEA
AccessioniPrimary (citable) accession number: P14774
Secondary accession number(s): C5AQA7
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 1, 1990
Last sequence update: April 1, 1990
Last modified: November 11, 2015
This is version 103 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.