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Protein

Bile pigment transporter 1

Gene

BPT1

Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Cooperates for the ATP-dependent vacuolar transport of bilirubin and glutathione conjugates.2 Publications

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi672 – 679ATP 1PROSITE-ProRule annotation8
Nucleotide bindingi1336 – 1343ATP 2PROSITE-ProRule annotation8

GO - Molecular functioni

  • ATPase activity, coupled to transmembrane movement of substances Source: InterPro
  • ATP binding Source: UniProtKB-KW
  • bilirubin transmembrane transporter activity Source: SGD
  • cadmium ion transmembrane transporter activity Source: SGD

GO - Biological processi

  • bilirubin transport Source: SGD
  • cadmium ion transport Source: SGD
  • vacuole fusion, non-autophagic Source: SGD
Complete GO annotation...

Keywords - Biological processi

Transport

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciYEAST:G3O-32120-MONOMER.
ReactomeiR-SCE-114608. Platelet degranulation.
R-SCE-2142850. Hyaluronan biosynthesis and export.
R-SCE-382556. ABC-family proteins mediated transport.
R-SCE-5689880. Ub-specific processing proteases.
R-SCE-8856825. Cargo recognition for clathrin-mediated endocytosis.

Protein family/group databases

TCDBi3.A.1.208.18. the atp-binding cassette (abc) superfamily.

Names & Taxonomyi

Protein namesi
Recommended name:
Bile pigment transporter 1
Gene namesi
Name:BPT1
Ordered Locus Names:YLL015W
ORF Names:L1313
OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Taxonomic identifieri559292 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
Proteomesi
  • UP000002311 Componenti: Chromosome XII

Organism-specific databases

EuPathDBiFungiDB:YLL015W.
SGDiS000003938. BPT1.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 29VacuolarSequence analysisAdd BLAST29
Transmembranei30 – 50Helical; Name=1PROSITE-ProRule annotationAdd BLAST21
Topological domaini51 – 84CytoplasmicSequence analysisAdd BLAST34
Transmembranei85 – 105Helical; Name=2PROSITE-ProRule annotationAdd BLAST21
Topological domaini106 – 110VacuolarSequence analysis5
Transmembranei111 – 127Helical; Name=3PROSITE-ProRule annotationAdd BLAST17
Topological domaini128 – 139CytoplasmicSequence analysisAdd BLAST12
Transmembranei140 – 160Helical; Name=4PROSITE-ProRule annotationAdd BLAST21
Topological domaini161 – 178VacuolarSequence analysisAdd BLAST18
Transmembranei179 – 199Helical; Name=5PROSITE-ProRule annotationAdd BLAST21
Topological domaini200 – 283CytoplasmicSequence analysisAdd BLAST84
Transmembranei284 – 304Helical; Name=6PROSITE-ProRule annotationAdd BLAST21
Topological domaini305 – 333VacuolarSequence analysisAdd BLAST29
Transmembranei334 – 354Helical; Name=7PROSITE-ProRule annotationAdd BLAST21
Topological domaini355 – 410CytoplasmicSequence analysisAdd BLAST56
Transmembranei411 – 431Helical; Name=8PROSITE-ProRule annotationAdd BLAST21
Topological domaini432 – 434VacuolarSequence analysis3
Transmembranei435 – 455Helical; Name=9PROSITE-ProRule annotationAdd BLAST21
Topological domaini456 – 518CytoplasmicSequence analysisAdd BLAST63
Transmembranei519 – 539Helical; Name=10PROSITE-ProRule annotationAdd BLAST21
Topological domaini540 – 560VacuolarSequence analysisAdd BLAST21
Transmembranei561 – 581Helical; Name=11PROSITE-ProRule annotationAdd BLAST21
Topological domaini582 – 972CytoplasmicSequence analysisAdd BLAST391
Transmembranei973 – 993Helical; Name=12PROSITE-ProRule annotationAdd BLAST21
Topological domaini994 – 1030VacuolarSequence analysisAdd BLAST37
Transmembranei1031 – 1052Helical; Name=13PROSITE-ProRule annotationAdd BLAST22
Topological domaini1053 – 1095CytoplasmicSequence analysisAdd BLAST43
Transmembranei1096 – 1116Helical; Name=14PROSITE-ProRule annotationAdd BLAST21
Topological domaini1117VacuolarSequence analysis1
Transmembranei1118 – 1138Helical; Name=15PROSITE-ProRule annotationAdd BLAST21
Topological domaini1139 – 1209CytoplasmicSequence analysisAdd BLAST71
Transmembranei1210 – 1230Helical; Name=16PROSITE-ProRule annotationAdd BLAST21
Topological domaini1231 – 1235VacuolarSequence analysis5
Transmembranei1236 – 1256Helical; Name=17PROSITE-ProRule annotationAdd BLAST21
Topological domaini1257 – 1559CytoplasmicSequence analysisAdd BLAST303

GO - Cellular componenti

  • fungal-type vacuole membrane Source: SGD
  • integral component of membrane Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Membrane, Vacuole

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000934481 – 1559Bile pigment transporter 1Add BLAST1559

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei645PhosphoserineCombined sources1
Modified residuei885PhosphoserineCombined sources1
Modified residuei889PhosphothreonineCombined sources1
Modified residuei893PhosphoserineCombined sources1
Modified residuei895PhosphoserineCombined sources1
Modified residuei916PhosphothreonineCombined sources1
Modified residuei927PhosphoserineCombined sources1
Modified residuei931PhosphoserineCombined sources1
Modified residuei934PhosphothreonineCombined sources1
Glycosylationi1011N-linked (GlcNAc...)Sequence analysis1

Keywords - PTMi

Glycoprotein, Phosphoprotein

Proteomic databases

MaxQBiP14772.
PRIDEiP14772.

PTM databases

iPTMnetiP14772.

Expressioni

Developmental stagei

Levels increase in early stationary phase.1 Publication

Interactioni

Protein-protein interaction databases

BioGridi31236. 35 interactors.
DIPiDIP-2866N.
IntActiP14772. 3 interactors.
MINTiMINT-424844.

Structurei

3D structure databases

ProteinModelPortaliP14772.
SMRiP14772.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini292 – 578ABC transmembrane type-1 1PROSITE-ProRule annotationAdd BLAST287
Domaini639 – 871ABC transporter 1PROSITE-ProRule annotationAdd BLAST233
Domaini980 – 1265ABC transmembrane type-1 2PROSITE-ProRule annotationAdd BLAST286
Domaini1302 – 1553ABC transporter 2PROSITE-ProRule annotationAdd BLAST252

Sequence similaritiesi

Belongs to the ABC transporter superfamily.Curated
Contains 2 ABC transmembrane type-1 domains.PROSITE-ProRule annotation
Contains 2 ABC transporter domains.PROSITE-ProRule annotation

Keywords - Domaini

Repeat, Transmembrane, Transmembrane helix

Phylogenomic databases

GeneTreeiENSGT00860000133722.
InParanoidiP14772.
OrthoDBiEOG092C0QQU.

Family and domain databases

Gene3Di3.40.50.300. 2 hits.
InterProiIPR003593. AAA+_ATPase.
IPR011527. ABC1_TM_dom.
IPR003439. ABC_transporter-like.
IPR017871. ABC_transporter_CS.
IPR027417. P-loop_NTPase.
[Graphical view]
PfamiPF00664. ABC_membrane. 2 hits.
PF00005. ABC_tran. 2 hits.
[Graphical view]
SMARTiSM00382. AAA. 2 hits.
[Graphical view]
SUPFAMiSSF52540. SSF52540. 2 hits.
SSF90123. SSF90123. 2 hits.
PROSITEiPS50929. ABC_TM1F. 2 hits.
PS00211. ABC_TRANSPORTER_1. 2 hits.
PS50893. ABC_TRANSPORTER_2. 2 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P14772-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSSLEVVDGC PYGYRPYPDS GTNALNPCFI SVISAWQAVF FLLIGSYQLW
60 70 80 90 100
KLYKNNKVPP RFKNFPTLPS KINSRHLTHL TNVCFQSTLI ICELALVSQS
110 120 130 140 150
SDRVYPFILK KALYLNLLFN LGISLPTQYL AYFKSTFSMG NQLFYYMFQI
160 170 180 190 200
LLQLFLILQR YYHGSSNERL TVISGQTAMI LEVLLLFNSV AIFIYDLCIF
210 220 230 240 250
EPINELSEYY KKNGWYPPVH VLSYITFIWM NKLIVETYRN KKIKDPNQLP
260 270 280 290 300
LPPVDLNIKS ISKEFKANWE LEKWLNRNSL WRAIWKSFGR TISVAMLYET
310 320 330 340 350
TSDLLSVVQP QFLRIFIDGL NPETSSKYPP LNGVFIALTL FVISVVSVFL
360 370 380 390 400
TNQFYIGIFE AGLGIRGSLA SLVYQKSLRL TLAERNEKST GDILNLMSVD
410 420 430 440 450
VLRIQRFFEN AQTIIGAPIQ IIVVLTSLYW LLGKAVIGGL VTMAIMMPIN
460 470 480 490 500
AFLSRKVKKL SKTQMKYKDM RIKTITELLN AIKSIKLYAW EEPMMARLNH
510 520 530 540 550
VRNDMELKNF RKIGIVSNLI YFAWNCVPLM VTCSTFGLFS LFSDSPLSPA
560 570 580 590 600
IVFPSLSLFN ILNSAIYSVP SMINTIIETS VSMERLKSFL LSDEIDDSFI
610 620 630 640 650
ERIDPSADER ALPAIEMNNI TFLWKSKEVL TSSQSGDNLR TDEESIIGSS
660 670 680 690 700
QIALKNIDHF EAKRGDLVCV VGRVGAGKST FLKAILGQLP CMSGSRDSIP
710 720 730 740 750
PKLIIRSSSV AYCSQESWIM NASVRENILF GHKFDQDYYD LTIKACQLLP
760 770 780 790 800
DLKILPDGDE TLVGEKGISL SGGQKARLSL ARAVYSRADI YLLDDILSAV
810 820 830 840 850
DAEVSKNIIE YVLIGKTALL KNKTIILTTN TVSILKHSQM IYALENGEIV
860 870 880 890 900
EQGNYEDVMN RKNNTSKLKK LLEEFDSPID NGNESDVQTE HRSESEVDEP
910 920 930 940 950
LQLKVTESET EDEVVTESEL ELIKANSRRA SLATLRPRPF VGAQLDSVKK
960 970 980 990 1000
TAQKAEKTEV GRVKTKIYLA YIKACGVLGV VLFFLFMILT RVFDLAENFW
1010 1020 1030 1040 1050
LKYWSESNEK NGSNERVWMF VGVYSLIGVA SAAFNNLRSI MMLLYCSIRG
1060 1070 1080 1090 1100
SKKLHESMAK SVIRSPMTFF ETTPVGRIIN RFSSDMDAVD SNLQYIFSFF
1110 1120 1130 1140 1150
FKSILTYLVT VILVGYNMPW FLVFNMFLVV IYIYYQTFYI VLSRELKRLI
1160 1170 1180 1190 1200
SISYSPIMSL MSESLNGYSI IDAYDHFERF IYLNYEKIQY NVDFVFNFRS
1210 1220 1230 1240 1250
TNRWLSVRLQ TIGATIVLAT AILALATMNT KRQLSSGMVG LLMSYSLEVT
1260 1270 1280 1290 1300
GSLTWIVRTT VTIETNIVSV ERIVEYCELP PEAQSINPEK RPDENWPSKG
1310 1320 1330 1340 1350
GIEFKNYSTK YRENLDPVLN NINVKIEPCE KVGIVGRTGA GKSTLSLALF
1360 1370 1380 1390 1400
RILEPTEGKI IIDGIDISDI GLFDLRSHLA IIPQDAQAFE GTVKTNLDPF
1410 1420 1430 1440 1450
NRYSEDELKR AVEQAHLKPH LEKMLHSKPR GDDSNEEDGN VNDILDVKIN
1460 1470 1480 1490 1500
ENGSNLSVGQ RQLLCLARAL LNRSKILVLD EATASVDMET DKIIQDTIRR
1510 1520 1530 1540 1550
EFKDRTILTI AHRIDTVLDS DKIIVLDQGS VREFDSPSKL LSDKTSIFYS

LCEKGGYLK
Length:1,559
Mass (Da):176,874
Last modified:November 1, 1997 - v2
Checksum:i0460F3561E3125D5
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X97560 Genomic DNA. Translation: CAA66162.1.
Z73120 Genomic DNA. Translation: CAA97460.1.
X91488 Genomic DNA. Translation: CAA62776.1.
M26647 Genomic DNA. Translation: AAA16564.1.
BK006945 Genomic DNA. Translation: DAA09303.1.
PIRiS64757.
RefSeqiNP_013086.1. NM_001181835.1.

Genome annotation databases

EnsemblFungiiYLL015W; YLL015W; YLL015W.
GeneIDi850645.
KEGGisce:YLL015W.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X97560 Genomic DNA. Translation: CAA66162.1.
Z73120 Genomic DNA. Translation: CAA97460.1.
X91488 Genomic DNA. Translation: CAA62776.1.
M26647 Genomic DNA. Translation: AAA16564.1.
BK006945 Genomic DNA. Translation: DAA09303.1.
PIRiS64757.
RefSeqiNP_013086.1. NM_001181835.1.

3D structure databases

ProteinModelPortaliP14772.
SMRiP14772.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi31236. 35 interactors.
DIPiDIP-2866N.
IntActiP14772. 3 interactors.
MINTiMINT-424844.

Protein family/group databases

TCDBi3.A.1.208.18. the atp-binding cassette (abc) superfamily.

PTM databases

iPTMnetiP14772.

Proteomic databases

MaxQBiP14772.
PRIDEiP14772.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblFungiiYLL015W; YLL015W; YLL015W.
GeneIDi850645.
KEGGisce:YLL015W.

Organism-specific databases

EuPathDBiFungiDB:YLL015W.
SGDiS000003938. BPT1.

Phylogenomic databases

GeneTreeiENSGT00860000133722.
InParanoidiP14772.
OrthoDBiEOG092C0QQU.

Enzyme and pathway databases

BioCyciYEAST:G3O-32120-MONOMER.
ReactomeiR-SCE-114608. Platelet degranulation.
R-SCE-2142850. Hyaluronan biosynthesis and export.
R-SCE-382556. ABC-family proteins mediated transport.
R-SCE-5689880. Ub-specific processing proteases.
R-SCE-8856825. Cargo recognition for clathrin-mediated endocytosis.

Miscellaneous databases

PROiP14772.

Family and domain databases

Gene3Di3.40.50.300. 2 hits.
InterProiIPR003593. AAA+_ATPase.
IPR011527. ABC1_TM_dom.
IPR003439. ABC_transporter-like.
IPR017871. ABC_transporter_CS.
IPR027417. P-loop_NTPase.
[Graphical view]
PfamiPF00664. ABC_membrane. 2 hits.
PF00005. ABC_tran. 2 hits.
[Graphical view]
SMARTiSM00382. AAA. 2 hits.
[Graphical view]
SUPFAMiSSF52540. SSF52540. 2 hits.
SSF90123. SSF90123. 2 hits.
PROSITEiPS50929. ABC_TM1F. 2 hits.
PS00211. ABC_TRANSPORTER_1. 2 hits.
PS50893. ABC_TRANSPORTER_2. 2 hits.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiBPT1_YEAST
AccessioniPrimary (citable) accession number: P14772
Secondary accession number(s): D6VXY7
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 1, 1990
Last sequence update: November 1, 1997
Last modified: November 30, 2016
This is version 168 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Yeast
    Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD
  3. Yeast chromosome XII
    Yeast (Saccharomyces cerevisiae) chromosome XII: entries and gene names

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.