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P14762

- CPXI_BACME

UniProt

P14762 - CPXI_BACME

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Protein

Cytochrome P450(BM-1)

Gene

cyp106

Organism
Bacillus megaterium
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at protein leveli

Functioni

Cytochromes P450 are a group of heme-thiolate monooxygenases. They oxidize a variety of structurally unrelated compounds, including steroids, fatty acids, and xenobiotics.

Cofactori

hemeBy similarity

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi356 – 3561Iron (heme axial ligand)

GO - Molecular functioni

  1. heme binding Source: InterPro
  2. iron ion binding Source: InterPro
  3. monooxygenase activity Source: UniProtKB-KW
  4. oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

Monooxygenase, Oxidoreductase

Keywords - Ligandi

Heme, Iron, Metal-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Cytochrome P450(BM-1) (EC:1.14.14.-)
Gene namesi
Name:cyp106
OrganismiBacillus megaterium
Taxonomic identifieri1404 [NCBI]
Taxonomic lineageiBacteriaFirmicutesBacilliBacillalesBacillaceaeBacillus

Subcellular locationi

Cytoplasm By similarity

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 410410Cytochrome P450(BM-1)PRO_0000052218Add
BLAST

Structurei

3D structure databases

ProteinModelPortaliP14762.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the cytochrome P450 family.Curated

Family and domain databases

Gene3Di1.10.630.10. 1 hit.
InterProiIPR001128. Cyt_P450.
IPR002397. Cyt_P450_B.
IPR017972. Cyt_P450_CS.
[Graphical view]
PfamiPF00067. p450. 1 hit.
[Graphical view]
PRINTSiPR00359. BP450.
SUPFAMiSSF48264. SSF48264. 1 hit.
PROSITEiPS00086. CYTOCHROME_P450. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P14762-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MNKEVIPVTE IPKFQSRAEE FFPIQWYKEM LNNSPVYFHE ETNTWNVFQY
60 70 80 90 100
EHVKQVLSNY DFFSSDGQRT TIFVGDNSKK KSTSPITNLT NLDPPDHRKA
110 120 130 140 150
RSLLAAAFTP RSLKNWEPRI KQIAADLVEA IQKNSTINIV DDLSSPFPSL
160 170 180 190 200
VIADLFGVPV KDRYQFKKWV DILFQPYDQE RLEEIEQEKQ RAGAEYFQYL
210 220 230 240 250
YPIVIEKRSN LSDDIISDLI QAEVDGETFT DEEIVHATML LLGAGVETTS
260 270 280 290 300
HAIANMFYSF LYDDKSLYSE LRNNRELAPK AVEEMLRYRF HISRRDRTVK
310 320 330 340 350
QDNELLGVKL KKGDVVIAWM SACNMDETMF ENPFSVDIHR PTNKKHLTFG
360 370 380 390 400
NGPHFCLGAP LARLEMKIIL EAFLEAFSHI EPFEDFELEP HLTASATGQS
410
LTYLPMTVYR
Length:410
Mass (Da):47,461
Last modified:April 1, 1990 - v1
Checksum:iC9AE293E76745387
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X16610 Genomic DNA. Translation: CAA34612.1.
S79230 mRNA. Translation: AAC60495.1.
PIRiS07764. O4BS6M.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X16610 Genomic DNA. Translation: CAA34612.1 .
S79230 mRNA. Translation: AAC60495.1 .
PIRi S07764. O4BS6M.

3D structure databases

ProteinModelPortali P14762.
ModBasei Search...
MobiDBi Search...

Protocols and materials databases

Structural Biology Knowledgebase Search...

Family and domain databases

Gene3Di 1.10.630.10. 1 hit.
InterProi IPR001128. Cyt_P450.
IPR002397. Cyt_P450_B.
IPR017972. Cyt_P450_CS.
[Graphical view ]
Pfami PF00067. p450. 1 hit.
[Graphical view ]
PRINTSi PR00359. BP450.
SUPFAMi SSF48264. SSF48264. 1 hit.
PROSITEi PS00086. CYTOCHROME_P450. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Molecular cloning, coding nucleotides and the deduced amino acid sequence of P-450BM-1 from Bacillus megaterium."
    He J.S., Ruettinger R.T., Liu H.-M., Fulco A.J.
    Biochim. Biophys. Acta 1009:301-303(1989) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], PROTEIN SEQUENCE OF 1-25.
    Strain: ATCC 14581 / DSM 32 / JCM 2506 / NBRC 15308 / NCIMB 9376 / NCTC 10342 / VKM B-512.
  2. "The molecular cloning and characterization of BM1P1 and BM1P2 proteins, putative positive transcription factors involved in barbiturate-mediated induction of the genes encoding cytochrome P450BM-1 of Bacillus megaterium."
    He J.S., Liang Q., Fulco A.J.
    J. Biol. Chem. 270:18615-18625(1995) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 1-25.

Entry informationi

Entry nameiCPXI_BACME
AccessioniPrimary (citable) accession number: P14762
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 1, 1990
Last sequence update: April 1, 1990
Last modified: November 26, 2014
This is version 78 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Direct protein sequencing

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3