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Protein

Alaserpin

Gene
N/A
Organism
Manduca sexta (Tobacco hawkmoth) (Tobacco hornworm)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

Inhibits elastase.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sitei359 – 3602Reactive bondBy similarity

GO - Molecular functioni

Complete GO annotation...

Keywords - Molecular functioni

Protease inhibitor, Serine protease inhibitor

Protein family/group databases

MEROPSiI04.031.

Names & Taxonomyi

Protein namesi
Recommended name:
Alaserpin
Alternative name(s):
Serpin-1
OrganismiManduca sexta (Tobacco hawkmoth) (Tobacco hornworm)
Taxonomic identifieri7130 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaArthropodaHexapodaInsectaPterygotaNeopteraEndopterygotaLepidopteraGlossataDitrysiaBombycoideaSphingidaeSphinginaeSphinginiManduca

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 1616Sequence analysisAdd
BLAST
Chaini17 – 392376AlaserpinPRO_0000032527Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi85 – 851N-linked (GlcNAc...)Sequence analysis

Keywords - PTMi

Glycoprotein

Expressioni

Tissue specificityi

Hemolymph.

Interactioni

Protein-protein interaction databases

IntActiP14754. 1 interaction.
MINTiMINT-220483.

Structurei

Secondary structure

1
392
Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Helixi19 – 224Combined sources
Helixi25 – 4117Combined sources
Beta strandi49 – 513Combined sources
Helixi54 – 563Combined sources
Helixi57 – 637Combined sources
Turni64 – 663Combined sources
Helixi70 – 789Combined sources
Helixi86 – 949Combined sources
Beta strandi102 – 1043Combined sources
Beta strandi107 – 11711Combined sources
Helixi123 – 1253Combined sources
Turni127 – 1293Combined sources
Beta strandi130 – 1323Combined sources
Beta strandi136 – 1394Combined sources
Helixi144 – 15815Combined sources
Turni159 – 1613Combined sources
Helixi169 – 1713Combined sources
Beta strandi178 – 18811Combined sources
Beta strandi190 – 1923Combined sources
Helixi196 – 1983Combined sources
Beta strandi200 – 2045Combined sources
Beta strandi206 – 2094Combined sources
Beta strandi212 – 22817Combined sources
Turni229 – 2324Combined sources
Beta strandi233 – 2408Combined sources
Helixi241 – 2433Combined sources
Beta strandi244 – 25411Combined sources
Turni255 – 2573Combined sources
Helixi258 – 2647Combined sources
Turni268 – 2769Combined sources
Beta strandi279 – 28810Combined sources
Beta strandi290 – 2978Combined sources
Helixi298 – 3036Combined sources
Turni304 – 3063Combined sources
Turni313 – 3153Combined sources
Turni319 – 3213Combined sources
Beta strandi322 – 3243Combined sources
Beta strandi331 – 34111Combined sources
Beta strandi345 – 3473Combined sources
Beta strandi349 – 3513Combined sources
Beta strandi354 – 3596Combined sources
Beta strandi366 – 3683Combined sources
Beta strandi373 – 39018Combined sources

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
1K9OX-ray2.30I15-392[»]
1SEKX-ray2.10A15-354[»]
ProteinModelPortaliP14754.
SMRiP14754. Positions 17-392.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP14754.

Family & Domainsi

Sequence similaritiesi

Belongs to the serpin family.Curated

Keywords - Domaini

Signal

Family and domain databases

InterProiIPR023795. Serpin_CS.
IPR023796. Serpin_dom.
IPR000215. Serpin_fam.
[Graphical view]
PANTHERiPTHR11461. PTHR11461. 1 hit.
PfamiPF00079. Serpin. 1 hit.
[Graphical view]
SMARTiSM00093. SERPIN. 1 hit.
[Graphical view]
SUPFAMiSSF56574. SSF56574. 1 hit.
PROSITEiPS00284. SERPIN. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 1 isoform i produced by alternative splicing. AlignAdd to basket

Note: A number of isoforms are produced.
Isoform 1 (identifier: P14754-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MKIIMCIFGL AALAMAGETD LQKILRESND QFTAQMFSEV VKANPGQNVV
60 70 80 90 100
LSAFSVLPPL GQLALASVGE SHDELLRALA LPNDNVTKDV FADLNRGVRA
110 120 130 140 150
VKGVDLKMAS KIYVAKGLEL NDDFAAVSRD VFGSEVQNVD FVKSVEAAGA
160 170 180 190 200
INKWVEDQTN NRIKNLVDPD ALDETTRSVL VNAIYFKGSW KDKFVKERTM
210 220 230 240 250
DRDFHVSKDK TIKVPTMIGK KDVRYADVPE LDAKMIEMSY EGDQASMIII
260 270 280 290 300
LPNQVDGITA LEQKLKDPKA LSRAEERLYN TEVEIYLPKF KIETTTDLKE
310 320 330 340 350
VLSNMNIKKL FTPGAARLEN LLKTKESLYV DAAIQKAFIE VNEEGAEAAA
360 370 380 390
ANAFGIVPAS LILYPEVHID RPFYFELKID GIPMFNGKVI EP
Length:392
Mass (Da):43,510
Last modified:April 1, 1990 - v1
Checksum:i5138617BDE7EDA7A
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M23438 mRNA. Translation: AAA29327.1.
L20792 mRNA. Translation: AAA29329.1.
U58361 Genomic DNA. Translation: AAC47343.1.
PIRiA38829.

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M23438 mRNA. Translation: AAA29327.1.
L20792 mRNA. Translation: AAA29329.1.
U58361 Genomic DNA. Translation: AAC47343.1.
PIRiA38829.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
1K9OX-ray2.30I15-392[»]
1SEKX-ray2.10A15-354[»]
ProteinModelPortaliP14754.
SMRiP14754. Positions 17-392.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

IntActiP14754. 1 interaction.
MINTiMINT-220483.

Protein family/group databases

MEROPSiI04.031.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Miscellaneous databases

EvolutionaryTraceiP14754.

Family and domain databases

InterProiIPR023795. Serpin_CS.
IPR023796. Serpin_dom.
IPR000215. Serpin_fam.
[Graphical view]
PANTHERiPTHR11461. PTHR11461. 1 hit.
PfamiPF00079. Serpin. 1 hit.
[Graphical view]
SMARTiSM00093. SERPIN. 1 hit.
[Graphical view]
SUPFAMiSSF56574. SSF56574. 1 hit.
PROSITEiPS00284. SERPIN. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiSERA_MANSE
AccessioniPrimary (citable) accession number: P14754
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 1, 1990
Last sequence update: April 1, 1990
Last modified: October 14, 2015
This is version 95 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)

Miscellaneousi

Keywords - Technical termi

3D-structure

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.