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Protein

Alaserpin

Gene
N/A
Organism
Manduca sexta (Tobacco hawkmoth) (Tobacco hornworm)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

Inhibits elastase.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sitei359 – 360Reactive bondBy similarity2

GO - Molecular functioni

Complete GO annotation...

Keywords - Molecular functioni

Protease inhibitor, Serine protease inhibitor

Protein family/group databases

MEROPSiI04.031.

Names & Taxonomyi

Protein namesi
Recommended name:
Alaserpin
Alternative name(s):
Serpin-1
OrganismiManduca sexta (Tobacco hawkmoth) (Tobacco hornworm)
Taxonomic identifieri7130 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaArthropodaHexapodaInsectaPterygotaNeopteraEndopterygotaLepidopteraGlossataDitrysiaBombycoideaSphingidaeSphinginaeSphinginiManduca

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 16Sequence analysisAdd BLAST16
ChainiPRO_000003252717 – 392AlaserpinAdd BLAST376

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi85N-linked (GlcNAc...)Sequence analysis1

Keywords - PTMi

Glycoprotein

Expressioni

Tissue specificityi

Hemolymph.

Interactioni

Protein-protein interaction databases

IntActiP14754. 1 interactor.
MINTiMINT-220483.

Structurei

Secondary structure

1392
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Helixi19 – 22Combined sources4
Helixi25 – 41Combined sources17
Beta strandi49 – 51Combined sources3
Helixi54 – 56Combined sources3
Helixi57 – 63Combined sources7
Turni64 – 66Combined sources3
Helixi70 – 78Combined sources9
Helixi86 – 94Combined sources9
Beta strandi102 – 104Combined sources3
Beta strandi107 – 117Combined sources11
Helixi123 – 125Combined sources3
Turni127 – 129Combined sources3
Beta strandi130 – 132Combined sources3
Beta strandi136 – 139Combined sources4
Helixi144 – 158Combined sources15
Turni159 – 161Combined sources3
Helixi169 – 171Combined sources3
Beta strandi178 – 188Combined sources11
Beta strandi190 – 192Combined sources3
Helixi196 – 198Combined sources3
Beta strandi200 – 204Combined sources5
Beta strandi206 – 209Combined sources4
Beta strandi212 – 228Combined sources17
Turni229 – 232Combined sources4
Beta strandi233 – 240Combined sources8
Helixi241 – 243Combined sources3
Beta strandi244 – 254Combined sources11
Turni255 – 257Combined sources3
Helixi258 – 264Combined sources7
Turni268 – 276Combined sources9
Beta strandi279 – 288Combined sources10
Beta strandi290 – 297Combined sources8
Helixi298 – 303Combined sources6
Turni304 – 306Combined sources3
Turni313 – 315Combined sources3
Turni319 – 321Combined sources3
Beta strandi322 – 324Combined sources3
Beta strandi331 – 341Combined sources11
Beta strandi345 – 347Combined sources3
Beta strandi349 – 351Combined sources3
Beta strandi354 – 359Combined sources6
Beta strandi366 – 368Combined sources3
Beta strandi373 – 390Combined sources18

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1K9OX-ray2.30I15-392[»]
1SEKX-ray2.10A15-354[»]
ProteinModelPortaliP14754.
SMRiP14754.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP14754.

Family & Domainsi

Sequence similaritiesi

Belongs to the serpin family.Curated

Keywords - Domaini

Signal

Family and domain databases

InterProiIPR023795. Serpin_CS.
IPR023796. Serpin_dom.
IPR000215. Serpin_fam.
[Graphical view]
PANTHERiPTHR11461. PTHR11461. 1 hit.
PfamiPF00079. Serpin. 1 hit.
[Graphical view]
SMARTiSM00093. SERPIN. 1 hit.
[Graphical view]
SUPFAMiSSF56574. SSF56574. 1 hit.
PROSITEiPS00284. SERPIN. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 1 isoform i produced by alternative splicing. AlignAdd to basket

Note: A number of isoforms are produced.
Isoform 1 (identifier: P14754-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MKIIMCIFGL AALAMAGETD LQKILRESND QFTAQMFSEV VKANPGQNVV
60 70 80 90 100
LSAFSVLPPL GQLALASVGE SHDELLRALA LPNDNVTKDV FADLNRGVRA
110 120 130 140 150
VKGVDLKMAS KIYVAKGLEL NDDFAAVSRD VFGSEVQNVD FVKSVEAAGA
160 170 180 190 200
INKWVEDQTN NRIKNLVDPD ALDETTRSVL VNAIYFKGSW KDKFVKERTM
210 220 230 240 250
DRDFHVSKDK TIKVPTMIGK KDVRYADVPE LDAKMIEMSY EGDQASMIII
260 270 280 290 300
LPNQVDGITA LEQKLKDPKA LSRAEERLYN TEVEIYLPKF KIETTTDLKE
310 320 330 340 350
VLSNMNIKKL FTPGAARLEN LLKTKESLYV DAAIQKAFIE VNEEGAEAAA
360 370 380 390
ANAFGIVPAS LILYPEVHID RPFYFELKID GIPMFNGKVI EP
Length:392
Mass (Da):43,510
Last modified:April 1, 1990 - v1
Checksum:i5138617BDE7EDA7A
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M23438 mRNA. Translation: AAA29327.1.
L20792 mRNA. Translation: AAA29329.1.
U58361 Genomic DNA. Translation: AAC47343.1.
PIRiA38829.

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M23438 mRNA. Translation: AAA29327.1.
L20792 mRNA. Translation: AAA29329.1.
U58361 Genomic DNA. Translation: AAC47343.1.
PIRiA38829.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1K9OX-ray2.30I15-392[»]
1SEKX-ray2.10A15-354[»]
ProteinModelPortaliP14754.
SMRiP14754.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

IntActiP14754. 1 interactor.
MINTiMINT-220483.

Protein family/group databases

MEROPSiI04.031.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Miscellaneous databases

EvolutionaryTraceiP14754.

Family and domain databases

InterProiIPR023795. Serpin_CS.
IPR023796. Serpin_dom.
IPR000215. Serpin_fam.
[Graphical view]
PANTHERiPTHR11461. PTHR11461. 1 hit.
PfamiPF00079. Serpin. 1 hit.
[Graphical view]
SMARTiSM00093. SERPIN. 1 hit.
[Graphical view]
SUPFAMiSSF56574. SSF56574. 1 hit.
PROSITEiPS00284. SERPIN. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiSERA_MANSE
AccessioniPrimary (citable) accession number: P14754
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 1, 1990
Last sequence update: April 1, 1990
Last modified: November 2, 2016
This is version 97 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)

Miscellaneousi

Keywords - Technical termi

3D-structure

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.