Reviewed,
UniProtKB/Swiss-Prot P14748 (DCE1_FELCA)
Last modified
September 1, 2009.
Version 60.
History...
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90%,
50% identity |
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Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents
Names and origin
| Protein names | Recommended name: Glutamate decarboxylase 1 EC=4.1.1.15 Alternative name(s): Glutamate decarboxylase 67 kDa isoform 67 kDa glutamic acid decarboxylase GAD-67 | ||||
| Gene names |
| ||||
| Organism | Felis catus (Cat) (Felis silvestris catus) | ||||
| Taxonomic identifier | 9685 [NCBI] | ||||
| Taxonomic lineage | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Laurasiatheria › Carnivora › Feliformia › Felidae › Felinae › Felis |
Protein attributes
| Sequence length | 594 AA. |
| Sequence status | Complete. |
| Sequence processing | The displayed sequence is not processed. |
| Protein existence | Evidence at transcript level. |
General annotation (Comments)
| Function | Catalyzes the production of GABA. |
| Catalytic activity | L-glutamate = 4-aminobutanoate + CO2. |
| Cofactor | Pyridoxal phosphate. |
| Subunit structure | Homodimer. |
| Sequence similarities | Belongs to the group II decarboxylase family. |
Ontologies
| Keywords | |
|---|---|
| Biological process | Neurotransmitter biosynthesis |
| Ligand | Pyridoxal phosphate |
| Molecular function | Decarboxylase Lyase |
| Gene Ontology (GO) | |
| Biological process | carboxylic acid metabolic process Inferred from electronic annotation. Source: InterPro neurotransmitter biosynthetic processInferred from electronic annotation. Source: UniProtKB-KW |
| Molecular function | glutamate decarboxylase activity Inferred from electronic annotation. Source: EC pyridoxal phosphate bindingInferred from electronic annotation. Source: InterPro |
| Complete GO annotation... | |
Sequence annotation (Features)
| Feature key | Position(s) | Length | Description | Graphical view | Feature identifier | ||||
Molecule processing | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Chain | 1 – 594 | 594 | Glutamate decarboxylase 1 | PRO_0000146962 | |||||
Regions | |||||||||
| Region | 190 – 192 | 3 | Substrate binding By similarity | ||||||
Sites | |||||||||
| Binding site | 567 | 1 | Substrate By similarity | ||||||
Amino acid modifications | |||||||||
| Modified residue | 405 | 1 | N6-(pyridoxal phosphate)lysine By similarity | ||||||
Sequences
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References
| [1] | "Glutamic acid decarboxylase cDNA: nucleotide sequence encoding an enzymatically active fusion protein." Kobayashi Y., Kaufman D.L., Tobin A.J. J. Neurosci. 7:2768-2772(1987) [PubMed: 3453123] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA]. Tissue: Occipital cortex. |
Cross-references
Sequence databases | |
|---|---|
| M18629 mRNA. Translation: AAA51430.1. | |
| PIR | A46758. |
| RefSeq | NP_001009225.1. |
3D structure databases | |
| SMR | P14748. Positions 93-593. |
| ModBase | Search... |
Genome annotation databases | |
| GeneID | 493699. |
Organism-specific databases | |
| CTD | 493699. |
Phylogenomic databases | |
| HOVERGEN | P14748. |
Enzyme and pathway databases | |
| BRENDA | 4.1.1.15. 273949. |
Family and domain databases | |
| InterPro | IPR002129. PyrdxlP-dep_de-COase. IPR015421. PyrdxlP-dep_Trfase_major_sub1. [Graphical view] |
| Gene3D | G3DSA:3.40.640.10. PyrdxlP-dep_Trfase_major_sub1. 1 hit. |
| PANTHER | PTHR11999. Pyridoxal_deC. 1 hit. |
| Pfam | PF00282. Pyridoxal_deC. 1 hit. [Graphical view] |
| PROSITE | PS00392. DDC_GAD_HDC_YDC. 1 hit. [Graphical view] |
| ProtoNet | Search... |
Entry information
| Entry name | DCE1_FELCA | ||||||||
| Accession | Primary (citable) accession number: P14748 | ||||||||
| Entry history |
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| Entry status | Reviewed (UniProtKB/Swiss-Prot) | ||||||||
| Annotation project | HPI (Human Proteome Initiative) | ||||||||

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