Reviewed, UniProtKB/Swiss-Prot P14748 (DCE1_FELCA)

Names and origin

Protein names

Recommended name:
    Glutamate decarboxylase 1
    EC=4.1.1.15
Alternative name(s):
    Glutamate decarboxylase 67 kDa isoform
    67 kDa glutamic acid decarboxylase
    GAD-67

Gene names

Name:	GAD1
Synonyms:	GAD67

Organism

Felis catus (Cat) (Felis silvestris catus)

Taxonomic identifier

9685 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Laurasiatheria › Carnivora › Feliformia › Felidae › Felinae › Felis

Protein attributes

Sequence length	594 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Evidence at transcript level.

General annotation (Comments)

Function	Catalyzes the production of GABA.
Catalytic activity	L-glutamate = 4-aminobutanoate + CO2.
Cofactor	Pyridoxal phosphate.
Subunit structure	Homodimer.
Sequence similarities	Belongs to the group II decarboxylase family.

Ontologies

Keywords
Biological process	Neurotransmitter biosynthesis
Ligand	Pyridoxal phosphate
Molecular function	Decarboxylase Lyase
Gene Ontology (GO)
Biological process	carboxylic acid metabolic process Inferred from electronic annotation. Source: InterPro neurotransmitter biosynthetic process Inferred from electronic annotation. Source: UniProtKB-KW
Molecular function	glutamate decarboxylase activity Inferred from electronic annotation. Source: EC pyridoxal phosphate binding Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 594	594	Glutamate decarboxylase 1		PRO_0000146962
Regions
	Region	190 – 192	3	Substrate binding By similarity
Sites
	Binding site	567	1	Substrate By similarity
Amino acid modifications
	Modified residue	405	1	N6-(pyridoxal phosphate)lysine By similarity

Sequences

	Sequence		Length	Mass (Da)
	P14748-1 [UniParc]. Last modified October 1, 1993. Version 3. Checksum: EE1C8D928BC0BD02	FASTA	594	66,825
	10 20 30 40 50 60 MASSTPSSSA TSSNAGADPN TTNLRPTTYD TWCGVAHGCT RKLGLKICGF LQRTNSLEEK 70 80 90 100 110 120 SRLVSAFKER QSSKNLLSCE NSDRDGRFRR TETDFSNLFA RDLLPAKNGE EQTVQFLLEV 130 140 150 160 170 180 VDILLNYVRK TFDRSTKVLD FHHPHQLLEG MEGFNLELSD HPESLEQILV DCRDTLKYGV 190 200 210 220 230 240 RTGHPRFFNQ LSTGLDIIGL AGEWLTSTAN TNMFTYEIAP VFVLMEQITL KKMREIVGWS 250 260 270 280 290 300 SKDGDGIFSP GGAISNMYSI MAARYKFFPE VKTKGMAAVP KLVLFTSEHS HYSIKKAGAA 310 320 330 340 350 360 LGFGTDNVIL IKCNERGKII PADLEAKILE AKQKGYVPLY VNATAGTTVY GAFDPIQEIA 370 380 390 400 410 420 DICEKYNLWL HVDAAWGGGL LMSRKHRHKL SGIERANSVT WNPHKMMGVL LQCSAILVKE 430 440 450 460 470 480 KGILQGCNQM CAGYLFQPDK QYDVSYDTGD KAIQCGRHVD IFKFWLMWKA KGTVGFENQI 490 500 510 520 530 540 NKCLELAEYL YAKIKNREEF EMVFDGEPEH TNVCFWYIPQ SLRGIPDSPE RREKLHRVAP 550 560 570 580 590 KIKALMMESG TTMVGYQPQG DKANFFRMVI SNPAATQSDI DFLIEEIERL GQDL

References

[1]	"Glutamic acid decarboxylase cDNA: nucleotide sequence encoding an enzymatically active fusion protein." Kobayashi Y., Kaufman D.L., Tobin A.J. J. Neurosci. 7:2768-2772(1987) [PubMed: 3453123] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA]. Tissue: Occipital cortex.

Cross-references

Sequence databases
EMBLGenBankDDBJ	M18629 mRNA. Translation: AAA51430.1.
PIR	A46758.
RefSeq	NP_001009225.1.
3D structure databases
SMR	P14748. Positions 93-593.
ModBase	Search...
Genome annotation databases
GeneID	493699.
Organism-specific databases
CTD	493699.
Phylogenomic databases
HOVERGEN	P14748.
Enzyme and pathway databases
BRENDA	4.1.1.15. 273949.
Family and domain databases
InterPro	IPR002129. PyrdxlP-dep_de-COase. IPR015421. PyrdxlP-dep_Trfase_major_sub1. [Graphical view]
Gene3D	G3DSA:3.40.640.10. PyrdxlP-dep_Trfase_major_sub1. 1 hit.
PANTHER	PTHR11999. Pyridoxal_deC. 1 hit.
Pfam	PF00282. Pyridoxal_deC. 1 hit. [Graphical view]
PROSITE	PS00392. DDC_GAD_HDC_YDC. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

DCE1_FELCA

Accession

Primary (citable) accession number: P14748

Entry history

Integrated into UniProtKB/Swiss-Prot:	April 1, 1990
Last sequence update:	October 1, 1993
Last modified:	September 1, 2009
This is version 60 of the entry and version 3 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HPI (Human Proteome Initiative)