Skip Header

You are using a version of Internet Explorer that may not display all features of this website. Please upgrade to a modern browser.
Contribute Send feedback
Read comments (?) or add your own

P14748 (DCE1_FELCA) Reviewed, UniProtKB/Swiss-Prot

Last modified October 16, 2013. Version 78. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Glutamate decarboxylase 1

EC=4.1.1.15
Alternative name(s):
67 kDa glutamic acid decarboxylase
Short name=GAD-67
Glutamate decarboxylase 67 kDa isoform
Gene names
Name:GAD1
Synonyms:GAD67
OrganismFelis catus (Cat) (Felis silvestris catus) [Reference proteome]
Taxonomic identifier9685 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCarnivoraFeliformiaFelidaeFelinaeFelis

Protein attributes

Sequence length594 AA.
Sequence statusComplete.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

Catalyzes the production of GABA.

Catalytic activity

L-glutamate = 4-aminobutanoate + CO2.

Cofactor

Pyridoxal phosphate.

Subunit structure

Homodimer.

Sequence similarities

Belongs to the group II decarboxylase family.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 594594Glutamate decarboxylase 1
PRO_0000146962

Regions

Region190 – 1923Substrate binding By similarity

Sites

Binding site5671Substrate By similarity

Amino acid modifications

Modified residue4051N6-(pyridoxal phosphate)lysine By similarity

Sequences

Sequence LengthMass (Da)Tools
P14748 [UniParc].

Last modified October 1, 1993. Version 3.
Checksum: EE1C8D928BC0BD02

FASTA59466,825
        10         20         30         40         50         60 
MASSTPSSSA TSSNAGADPN TTNLRPTTYD TWCGVAHGCT RKLGLKICGF LQRTNSLEEK 

        70         80         90        100        110        120 
SRLVSAFKER QSSKNLLSCE NSDRDGRFRR TETDFSNLFA RDLLPAKNGE EQTVQFLLEV 

       130        140        150        160        170        180 
VDILLNYVRK TFDRSTKVLD FHHPHQLLEG MEGFNLELSD HPESLEQILV DCRDTLKYGV 

       190        200        210        220        230        240 
RTGHPRFFNQ LSTGLDIIGL AGEWLTSTAN TNMFTYEIAP VFVLMEQITL KKMREIVGWS 

       250        260        270        280        290        300 
SKDGDGIFSP GGAISNMYSI MAARYKFFPE VKTKGMAAVP KLVLFTSEHS HYSIKKAGAA 

       310        320        330        340        350        360 
LGFGTDNVIL IKCNERGKII PADLEAKILE AKQKGYVPLY VNATAGTTVY GAFDPIQEIA 

       370        380        390        400        410        420 
DICEKYNLWL HVDAAWGGGL LMSRKHRHKL SGIERANSVT WNPHKMMGVL LQCSAILVKE 

       430        440        450        460        470        480 
KGILQGCNQM CAGYLFQPDK QYDVSYDTGD KAIQCGRHVD IFKFWLMWKA KGTVGFENQI 

       490        500        510        520        530        540 
NKCLELAEYL YAKIKNREEF EMVFDGEPEH TNVCFWYIPQ SLRGIPDSPE RREKLHRVAP 

       550        560        570        580        590 
KIKALMMESG TTMVGYQPQG DKANFFRMVI SNPAATQSDI DFLIEEIERL GQDL 

« Hide

References

[1]"Glutamic acid decarboxylase cDNA: nucleotide sequence encoding an enzymatically active fusion protein."
Kobayashi Y., Kaufman D.L., Tobin A.J.
J. Neurosci. 7:2768-2772(1987) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
Tissue: Occipital cortex.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
M18629 mRNA. Translation: AAA51430.1.
PIRA46758.
RefSeqNP_001009225.1. NM_001009225.1.

3D structure databases

ProteinModelPortalP14748.
SMRP14748. Positions 93-593.
ModBaseSearch...
MobiDBSearch...

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

GeneID493699.
KEGGfca:493699.

Organism-specific databases

CTD2571.

Phylogenomic databases

HOVERGENHBG004980.
KOK01580.

Family and domain databases

Gene3D3.40.640.10. 1 hit.
3.90.1150.10. 1 hit.
InterProIPR002129. PyrdxlP-dep_de-COase.
IPR015424. PyrdxlP-dep_Trfase.
IPR015421. PyrdxlP-dep_Trfase_major_sub1.
IPR015422. PyrdxlP-dep_Trfase_major_sub2.
IPR021115. Pyridoxal-P_BS.
[Graphical view]
PfamPF00282. Pyridoxal_deC. 1 hit.
[Graphical view]
SUPFAMSSF53383. SSF53383. 1 hit.
PROSITEPS00392. DDC_GAD_HDC_YDC. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameDCE1_FELCA
AccessionPrimary (citable) accession number: P14748
Entry history
Integrated into UniProtKB/Swiss-Prot: April 1, 1990
Last sequence update: October 1, 1993
Last modified: October 16, 2013
This is version 78 of the entry and version 3 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families