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Protein

Uracil-DNA glycosylase inhibitor

Gene

UGI

Organism
Bacillus phage PBS2 (Bacteriophage PBS2)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at protein leveli

Functioni

This protein binds specifically and reversibly to the host uracil-DNA glycosylase, preventing removal of uracil residues from PBS2 DNA by the host uracil-excision repair system.

Enzyme and pathway databases

SABIO-RKP14739.

Names & Taxonomyi

Protein namesi
Recommended name:
Uracil-DNA glycosylase inhibitor
Gene namesi
Name:UGI
OrganismiBacillus phage PBS2 (Bacteriophage PBS2)
Taxonomic identifieri10684 [NCBI]
Taxonomic lineageiVirusesdsDNA viruses, no RNA stageCaudoviralesMyoviridae
Virus hostiBacillus subtilis [TaxID: 1423]

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000657221 – 84Uracil-DNA glycosylase inhibitorAdd BLAST84

Interactioni

Binary interactionsi

WithEntry#Exp.IntActNotes
ungP122954EBI-1025973,EBI-559403From a different organism.

Protein-protein interaction databases

IntActiP14739. 2 interactors.
MINTiMINT-1506611.

Structurei

Secondary structure

184
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Helixi3 – 12Combined sources10
Beta strandi22 – 24Combined sources3
Helixi26 – 33Combined sources8
Beta strandi41 – 48Combined sources8
Turni49 – 52Combined sources4
Beta strandi53 – 60Combined sources8
Turni62 – 64Combined sources3
Beta strandi67 – 73Combined sources7
Beta strandi79 – 83Combined sources5

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1EUIX-ray3.20C/D1-84[»]
1LQGX-ray2.90C/D1-84[»]
1LQMX-ray3.20B/D/F/H1-84[»]
1UDIX-ray2.70I2-84[»]
1UGHX-ray1.90I3-84[»]
1UGIX-ray1.55A/B/C/D/E/F/G/H1-84[»]
1UUGX-ray2.40B/D1-84[»]
2J8XX-ray2.30B/D1-84[»]
2UGIX-ray2.20A/B1-84[»]
2UUGX-ray2.60C/D1-84[»]
2ZHXX-ray3.10B/D/F/H/J/L/N1-84[»]
4LYLX-ray1.93B/D/F/H/J/L/N/P1-84[»]
ProteinModelPortaliP14739.
SMRiP14739.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP14739.

Family & Domainsi

Family and domain databases

Gene3Di3.10.450.20. 1 hit.
InterProiIPR024062. Phage_PBS2_Ugi.
[Graphical view]
SUPFAMiSSF54441. SSF54441. 1 hit.

Sequencei

Sequence statusi: Complete.

P14739-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MTNLSDIIEK ETGKQLVIQE SILMLPEEVE EVIGNKPESD ILVHTAYDES
60 70 80
TDENVMLLTS DAPEYKPWAL VIQDSNGENK IKML
Length:84
Mass (Da):9,476
Last modified:April 1, 1990 - v1
Checksum:iC07DCF9DB101BC2A
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
J04434 Genomic DNA. Translation: AAA91582.1.
PIRiA32206. QIBPS2.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
J04434 Genomic DNA. Translation: AAA91582.1.
PIRiA32206. QIBPS2.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1EUIX-ray3.20C/D1-84[»]
1LQGX-ray2.90C/D1-84[»]
1LQMX-ray3.20B/D/F/H1-84[»]
1UDIX-ray2.70I2-84[»]
1UGHX-ray1.90I3-84[»]
1UGIX-ray1.55A/B/C/D/E/F/G/H1-84[»]
1UUGX-ray2.40B/D1-84[»]
2J8XX-ray2.30B/D1-84[»]
2UGIX-ray2.20A/B1-84[»]
2UUGX-ray2.60C/D1-84[»]
2ZHXX-ray3.10B/D/F/H/J/L/N1-84[»]
4LYLX-ray1.93B/D/F/H/J/L/N/P1-84[»]
ProteinModelPortaliP14739.
SMRiP14739.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

IntActiP14739. 2 interactors.
MINTiMINT-1506611.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Enzyme and pathway databases

SABIO-RKP14739.

Miscellaneous databases

EvolutionaryTraceiP14739.

Family and domain databases

Gene3Di3.10.450.20. 1 hit.
InterProiIPR024062. Phage_PBS2_Ugi.
[Graphical view]
SUPFAMiSSF54441. SSF54441. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiUNGI_BPPB2
AccessioniPrimary (citable) accession number: P14739
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 1, 1990
Last sequence update: April 1, 1990
Last modified: November 2, 2016
This is version 68 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programViral Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Direct protein sequencing

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.