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P14721 (DFRA_ANTMA) Reviewed, UniProtKB/Swiss-Prot

Last modified February 19, 2014. Version 66. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Dihydroflavonol-4-reductase

Short name=DFR
EC=1.1.1.219
Alternative name(s):
Dihydrokaempferol 4-reductase
Gene names
Name:DFRA
OrganismAntirrhinum majus (Garden snapdragon)
Taxonomic identifier4151 [NCBI]
Taxonomic lineageEukaryotaViridiplantaeStreptophytaEmbryophytaTracheophytaSpermatophytaMagnoliophytaeudicotyledonsGunneridaePentapetalaeasteridslamiidsLamialesPlantaginaceaeAntirrhineaeAntirrhinum

Protein attributes

Sequence length446 AA.
Sequence statusComplete.
Protein existenceEvidence at transcript level

General annotation (Comments)

Catalytic activity

Cis-3,4-leucopelargonidin + NADP+ = (+)-dihydrokaempferol + NADPH.

Pathway

Pigment biosynthesis; anthocyanin biosynthesis.

Sequence similarities

Belongs to the NAD(P)-dependent epimerase/dehydratase family. Dihydroflavonol-4-reductase subfamily.

Ontologies

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 446446Dihydroflavonol-4-reductase
PRO_0000215562

Sequences

Sequence LengthMass (Da)Tools
P14721 [UniParc].

Last modified April 1, 1990. Version 1.
Checksum: 8BF4352EFBAC88D8

FASTA44649,633
        10         20         30         40         50         60 
MSPTSLNTSS ETAPPSSTTV CVTGAAGFIG SWLVMRLLER GYTVRATVRD PGNMKKVKHL 

        70         80         90        100        110        120 
IELPKADTNL TLWKADMTVE GSFDEAIQGC EGVFHLATSM EFDSVDPENE VIKPTIDGML 

       130        140        150        160        170        180 
NIIKSCVQAK TVKKFIFTTS GGTVNVEEHQ KPVYDETDSS DMDFINSKKM TGWMYFVSKI 

       190        200        210        220        230        240 
LAEKAGMEAA KENNIDFISI IPPLVVGPFI MPTFPPSLIT ALSPITGNEA HYSIIKQCQY 

       250        260        270        280        290        300 
VHLDDLCEGH IFLFEYPKAE GRYICSSHDA TIYDIAKLIT ENWPEYHIPD EFEGIDKDIP 

       310        320        330        340        350        360 
VVSFSSKKMI GMGFIFKYTL EDMVRGAIDT CREKGMLPYS TKNNKGDEKE PILNSLENNY 

       370        380        390        400        410        420 
NIQDKELFPI SEEKHINGQE NALLSNTQDK ELLPTSEEKR VNGLESALLS KIQDKEVLPT 

       430        440 
SGVKHAKGQE NALLPDIAND HTDGRI 

« Hide

References

[1]"Flavonoid synthesis in Petunia hybrida: partial characterization of dihydroflavonol-4-reductase genes."
Beld M., Martin C., Huits H., Stuitje A.R., Gerats A.G.M.
Plant Mol. Biol. 13:491-502(1989) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
Strain: cv. JI:522.
[2]"Transposable elements generate novel spatial patterns of gene expression in Antirrhinum majus."
Coen E.S., Carpenter R., Martin C.
Cell 47:285-296(1986) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 1-51.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
X15536 mRNA. Translation: CAA33543.1.
M14756 Genomic DNA. Translation: AAA32664.1.
PIRS07464.

3D structure databases

ProteinModelPortalP14721.
SMRP14721. Positions 17-340.
ModBaseSearch...
MobiDBSearch...

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Enzyme and pathway databases

UniPathwayUPA00009.

Family and domain databases

Gene3D3.40.50.720. 1 hit.
InterProIPR001509. Epimerase_deHydtase.
IPR016040. NAD(P)-bd_dom.
[Graphical view]
PfamPF01370. Epimerase. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameDFRA_ANTMA
AccessionPrimary (citable) accession number: P14721
Entry history
Integrated into UniProtKB/Swiss-Prot: April 1, 1990
Last sequence update: April 1, 1990
Last modified: February 19, 2014
This is version 66 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programPlant Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

PATHWAY comments

Index of metabolic and biosynthesis pathways