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Protein

Dihydroflavonol 4-reductase

Gene

DFRA

Organism
Petunia hybrida (Petunia)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Bifunctional enzyme involved in flavonoid metabolism.By similarity

Catalytic activityi

A (2R,3S,4S)-leucoanthocyanidin + NADP+ = a (2R,3R)-dihydroflavonol + NADPH.By similarity
(2S)-flavan-4-ol + NADP+ = (2S)-flavanone + NADPH.By similarity

Pathwayi: anthocyanin biosynthesis

This protein is involved in the pathway anthocyanin biosynthesis, which is part of Pigment biosynthesis.
View all proteins of this organism that are known to be involved in the pathway anthocyanin biosynthesis and in Pigment biosynthesis.

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionOxidoreductase
Biological processFlavonoid biosynthesis
LigandNADP

Enzyme and pathway databases

UniPathwayiUPA00009

Names & Taxonomyi

Protein namesi
Recommended name:
Dihydroflavonol 4-reductase (EC:1.1.1.219By similarity)
Short name:
DFR
Alternative name(s):
Dihydrokaempferol 4-reductase
Flavanone 4-reductase (EC:1.1.1.234By similarity)
Short name:
FNR
Gene namesi
Name:DFRA
Synonyms:AN6
OrganismiPetunia hybrida (Petunia)
Taxonomic identifieri4102 [NCBI]
Taxonomic lineageiEukaryotaViridiplantaeStreptophytaEmbryophytaTracheophytaSpermatophytaMagnoliophytaeudicotyledonsGunneridaePentapetalaeasteridslamiidsSolanalesSolanaceaePetunioideaePetunia

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002155711 – 380Dihydroflavonol 4-reductaseAdd BLAST380

Proteomic databases

PRIDEiP14720

Structurei

3D structure databases

ProteinModelPortaliP14720
SMRiP14720
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Family and domain databases

InterProiView protein in InterPro
IPR001509 Epimerase_deHydtase
IPR036291 NAD(P)-bd_dom_sf
PfamiView protein in Pfam
PF01370 Epimerase, 1 hit
SUPFAMiSSF51735 SSF51735, 1 hit

Sequencei

Sequence statusi: Complete.

P14720-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MASEAVHAPS PPVAVPTVCV TGAAGFIGSW LVMRLLERGY NVHATVRDPE
60 70 80 90 100
NKKKVKHLLE LPKADTNLTL WKADLTVEGS FDEAIQGCQG VFHVATPMDF
110 120 130 140 150
ESKDPENEVI KPTVRGMLSI IESCAKANTV KRLVFTSSAG TLDVQEQQKL
160 170 180 190 200
FYDQTSWSDL DFIYAKKMTG WMYFASKILA EKAAMEEAKK KNIDFISIIP
210 220 230 240 250
PLVVGPFITP TFPPSLITAL SLITGNEAHY CIIKQGQYVH LDDLCEAHIF
260 270 280 290 300
LYEHPKADGR FICSSHHAII YDVAKMVREK WPEYYVPTEF KGIDKDLPVV
310 320 330 340 350
SFSSKKLTDM GFQFKYTLED MYKGAIDTCR QKQLLPFSTR SAEDNGHNRE
360 370 380
AIAISAQNYA SGKENAPVAN HTEMLSNVEV
Length:380
Mass (Da):42,435
Last modified:October 1, 1996 - v2
Checksum:i6D7138AD5126868A
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti1 – 16MASEA…PVAVP → MPLHLRCSA (PubMed:2491667).CuratedAdd BLAST16
Sequence conflicti71W → L in CAA33544 (PubMed:2491667).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X79723 Genomic DNA Translation: CAA56160.1
X15537 mRNA Translation: CAA33544.1
PIRiS07463

Similar proteinsi

Entry informationi

Entry nameiDFRA_PETHY
AccessioniPrimary (citable) accession number: P14720
Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 1, 1990
Last sequence update: October 1, 1996
Last modified: May 23, 2018
This is version 79 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programPlant Protein Annotation Program

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