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P14720

- DFRA_PETHY

UniProt

P14720 - DFRA_PETHY

Protein

Dihydroflavonol-4-reductase

Gene

DFRA

Organism
Petunia hybrida (Petunia)
Status
Reviewed - Annotation score: 2 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 67 (01 Oct 2014)
      Sequence version 2 (01 Oct 1996)
      Previous versions | rss
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    Functioni

    Catalytic activityi

    Cis-3,4-leucopelargonidin + NADP+ = (+)-dihydrokaempferol + NADPH.

    Pathwayi

    GO - Molecular functioni

    1. coenzyme binding Source: InterPro
    2. dihydrokaempferol 4-reductase activity Source: UniProtKB-EC

    GO - Biological processi

    1. anthocyanin-containing compound biosynthetic process Source: UniProtKB-UniPathway
    2. cellular metabolic process Source: InterPro

    Keywords - Molecular functioni

    Oxidoreductase

    Keywords - Biological processi

    Flavonoid biosynthesis

    Keywords - Ligandi

    NADP

    Enzyme and pathway databases

    UniPathwayiUPA00009.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Dihydroflavonol-4-reductase (EC:1.1.1.219)
    Short name:
    DFR
    Alternative name(s):
    Dihydrokaempferol 4-reductase
    Gene namesi
    Name:DFRA
    Synonyms:AN6
    OrganismiPetunia hybrida (Petunia)
    Taxonomic identifieri4102 [NCBI]
    Taxonomic lineageiEukaryotaViridiplantaeStreptophytaEmbryophytaTracheophytaSpermatophytaMagnoliophytaeudicotyledonsGunneridaePentapetalaeasteridslamiidsSolanalesSolanaceaePetunioideaePetunia

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 380380Dihydroflavonol-4-reductasePRO_0000215571Add
    BLAST

    Structurei

    3D structure databases

    ProteinModelPortaliP14720.
    SMRiP14720. Positions 17-338.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Family and domain databases

    Gene3Di3.40.50.720. 1 hit.
    InterProiIPR001509. Epimerase_deHydtase.
    IPR016040. NAD(P)-bd_dom.
    [Graphical view]
    PfamiPF01370. Epimerase. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    P14720-1 [UniParc]FASTAAdd to Basket

    « Hide

    MASEAVHAPS PPVAVPTVCV TGAAGFIGSW LVMRLLERGY NVHATVRDPE    50
    NKKKVKHLLE LPKADTNLTL WKADLTVEGS FDEAIQGCQG VFHVATPMDF 100
    ESKDPENEVI KPTVRGMLSI IESCAKANTV KRLVFTSSAG TLDVQEQQKL 150
    FYDQTSWSDL DFIYAKKMTG WMYFASKILA EKAAMEEAKK KNIDFISIIP 200
    PLVVGPFITP TFPPSLITAL SLITGNEAHY CIIKQGQYVH LDDLCEAHIF 250
    LYEHPKADGR FICSSHHAII YDVAKMVREK WPEYYVPTEF KGIDKDLPVV 300
    SFSSKKLTDM GFQFKYTLED MYKGAIDTCR QKQLLPFSTR SAEDNGHNRE 350
    AIAISAQNYA SGKENAPVAN HTEMLSNVEV 380
    Length:380
    Mass (Da):42,435
    Last modified:October 1, 1996 - v2
    Checksum:i6D7138AD5126868A
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti1 – 1616MASEA…PVAVP → MPLHLRCSA(PubMed:2491667)CuratedAdd
    BLAST
    Sequence conflicti71 – 711W → L in CAA33544. (PubMed:2491667)Curated

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    X79723 Genomic DNA. Translation: CAA56160.1.
    X15537 mRNA. Translation: CAA33544.1.
    PIRiS07463.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    X79723 Genomic DNA. Translation: CAA56160.1 .
    X15537 mRNA. Translation: CAA33544.1 .
    PIRi S07463.

    3D structure databases

    ProteinModelPortali P14720.
    SMRi P14720. Positions 17-338.
    ModBasei Search...
    MobiDBi Search...

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Enzyme and pathway databases

    UniPathwayi UPA00009 .

    Family and domain databases

    Gene3Di 3.40.50.720. 1 hit.
    InterProi IPR001509. Epimerase_deHydtase.
    IPR016040. NAD(P)-bd_dom.
    [Graphical view ]
    Pfami PF01370. Epimerase. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Genetic control of dihydroflavonol 4-reductase gene expression in Petunia hybrida."
      Huits H., Gerats A.G.M., Kreike M.M., Mol J.N., Koes R.E.
      Plant J. 6:295-310(1994) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
      Strain: cv. Violet 30.
      Tissue: Leaf.
    2. "Flavonoid synthesis in Petunia hybrida: partial characterization of dihydroflavonol-4-reductase genes."
      Beld M., Martin C., Huits H., Stuitje A.R., Gerats A.G.M.
      Plant Mol. Biol. 13:491-502(1989) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
      Strain: cv. R27.

    Entry informationi

    Entry nameiDFRA_PETHY
    AccessioniPrimary (citable) accession number: P14720
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: April 1, 1990
    Last sequence update: October 1, 1996
    Last modified: October 1, 2014
    This is version 67 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programPlant Protein Annotation Program

    Miscellaneousi

    Documents

    1. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3