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Protein

Interleukin-1 receptor-like 1

Gene

Il1rl1

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Receptor for interleukin-33 (IL-33); signaling requires association of the coreceptor IL1RAP (PubMed:18450470, PubMed:17675517). Its stimulation recruits MYD88, IRAK1, IRAK4, and TRAF6, followed by phosphorylation of MAPK3/ERK1 and/or MAPK1/ERK2, MAPK14, and MAPK8 (By similarity). Possibly involved in helper T-cell function.By similarity2 Publications
Isoform B: Inhibits IL-33 signaling.1 Publication

GO - Molecular functioni

  • interleukin-1 receptor activity Source: InterPro
  • interleukin-33 binding Source: MGI
  • interleukin-33 receptor activity Source: MGI

GO - Biological processi

  • negative regulation of I-kappaB kinase/NF-kappaB signaling Source: MGI
  • negative regulation of interferon-gamma production Source: BHF-UCL
  • negative regulation of T-helper 1 type immune response Source: BHF-UCL
  • positive regulation of chemokine secretion Source: BHF-UCL
  • positive regulation of inflammatory response Source: BHF-UCL
  • positive regulation of interleukin-5 production Source: BHF-UCL
  • positive regulation of macrophage activation Source: BHF-UCL
Complete GO annotation...

Keywords - Molecular functioni

Receptor

Enzyme and pathway databases

ReactomeiR-MMU-449147. Signaling by Interleukins.

Names & Taxonomyi

Protein namesi
Recommended name:
Interleukin-1 receptor-like 1
Alternative name(s):
Interleukin-33 receptor alpha chain1 Publication
Lymphocyte antigen 84
Protein ST2
Protein T1
Gene namesi
Name:Il1rl1
Synonyms:Ly84, St2, Ste2
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 1

Organism-specific databases

MGIiMGI:98427. Il1rl1.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini27 – 332ExtracellularSequence analysisAdd BLAST306
Transmembranei333 – 355HelicalSequence analysisAdd BLAST23
Topological domaini356 – 567CytoplasmicSequence analysisAdd BLAST212

GO - Cellular componenti

  • external side of plasma membrane Source: MGI
  • integral component of membrane Source: UniProtKB-KW
  • membrane Source: MGI
  • plasma membrane Source: Reactome
  • proteinaceous extracellular matrix Source: MGI
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane, Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 26Sequence analysisAdd BLAST26
ChainiPRO_000001544327 – 567Interleukin-1 receptor-like 1Add BLAST541

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi42 ↔ 93PROSITE-ProRule annotation
Glycosylationi60N-linked (GlcNAc...)Sequence analysis1
Glycosylationi101N-linked (GlcNAc...)Sequence analysis1
Glycosylationi107N-linked (GlcNAc...)Sequence analysis1
Disulfide bondi117 ↔ 157PROSITE-ProRule annotation
Disulfide bondi139 ↔ 187PROSITE-ProRule annotation
Glycosylationi146N-linked (GlcNAc...)Sequence analysis1
Glycosylationi176N-linked (GlcNAc...)Sequence analysis1
Glycosylationi194N-linked (GlcNAc...)Sequence analysis1
Glycosylationi225N-linked (GlcNAc...)Sequence analysis1
Disulfide bondi240 ↔ 308PROSITE-ProRule annotation
Disulfide bondi243 ↔ 287PROSITE-ProRule annotation
Glycosylationi259N-linked (GlcNAc...)Sequence analysis1
Glycosylationi278N-linked (GlcNAc...)Sequence analysis1

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

EPDiP14719.
MaxQBiP14719.
PaxDbiP14719.
PRIDEiP14719.

PTM databases

iPTMnetiP14719.
PhosphoSitePlusiP14719.

Expressioni

Tissue specificityi

Predominantly expressed in hematopoietic tissues, and in macrophage, erythroid, epithelial and fibroblast cell lines. Isoform A is expressed in brain astrocytes and microglia. Isoform B is expressed in brain endothelial cells.2 Publications

Developmental stagei

Expressed first in the fetal liver and then in lung and hematopoietic tissues.

Gene expression databases

BgeeiENSMUSG00000026069.
CleanExiMM_IL1RL1.
ExpressionAtlasiP14719. baseline and differential.
GenevisibleiP14719. MM.

Interactioni

Subunit structurei

Interacts with MYD88, IRAK1, IRAK4, and TRAF6 (By similarity). Bound to its ligand IL-33, interacts with IL1RAP to form the minimal interleukin-33 signaling complex with a 1:1:1 stoechiometry. Interacts with KIT (bound to KITLG/SCF). A mast cell-specific KITLG/SCF-induced interleukin-33 signaling complex contains IL1RL1, IL1RAP, KIT and MYD88.By similarity4 Publications

Binary interactionsi

WithEntry#Exp.IntActNotes
FBXL19Q6PCT23EBI-525078,EBI-6664563From a different organism.

GO - Molecular functioni

  • interleukin-33 binding Source: MGI

Protein-protein interaction databases

BioGridi201248. 2 interactors.
DIPiDIP-34958N.
IntActiP14719. 4 interactors.
STRINGi10090.ENSMUSP00000054914.

Structurei

3D structure databases

ProteinModelPortaliP14719.
SMRiP14719.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini27 – 109Ig-like C2-type 1Add BLAST83
Domaini120 – 203Ig-like C2-type 2Add BLAST84
Domaini217 – 324Ig-like C2-type 3Add BLAST108
Domaini375 – 538TIRPROSITE-ProRule annotationAdd BLAST164

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni204 – 216Flexible linkerBy similarityAdd BLAST13

Sequence similaritiesi

Belongs to the interleukin-1 receptor family.Curated
Contains 1 TIR domain.PROSITE-ProRule annotation

Keywords - Domaini

Immunoglobulin domain, Repeat, Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410IPTT. Eukaryota.
ENOG4110Z8K. LUCA.
GeneTreeiENSGT00760000119071.
HOGENOMiHOG000113054.
HOVERGENiHBG098401.
InParanoidiP14719.
KOiK05171.
OMAiKVQGTIK.
OrthoDBiEOG091G0GXW.
PhylomeDBiP14719.
TreeFamiTF325519.

Family and domain databases

Gene3Di2.60.40.10. 3 hits.
3.40.50.10140. 1 hit.
InterProiIPR007110. Ig-like_dom.
IPR013783. Ig-like_fold.
IPR003599. Ig_sub.
IPR003598. Ig_sub2.
IPR015621. IL-1_rcpt_fam.
IPR004074. IL-1_rcpt_I/II-typ.
IPR000157. TIR_dom.
[Graphical view]
PANTHERiPTHR11890. PTHR11890. 1 hit.
PfamiPF13895. Ig_2. 1 hit.
PF01582. TIR. 1 hit.
[Graphical view]
PRINTSiPR01536. INTRLKN1R12F.
SMARTiSM00409. IG. 3 hits.
SM00408. IGc2. 2 hits.
SM00255. TIR. 1 hit.
[Graphical view]
SUPFAMiSSF48726. SSF48726. 3 hits.
SSF52200. SSF52200. 1 hit.
PROSITEiPS50835. IG_LIKE. 3 hits.
PS50104. TIR. 1 hit.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform A (identifier: P14719-1) [UniParc]FASTAAdd to basket
Also known as: Membrane-bound, ST2L

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MIDRQRMGLW ALAILTLPMY LTVTEGSKSS WGLENEALIV RCPQRGRSTY
60 70 80 90 100
PVEWYYSDTN ESIPTQKRNR IFVSRDRLKF LPARVEDSGI YACVIRSPNL
110 120 130 140 150
NKTGYLNVTI HKKPPSCNIP DYLMYSTVRG SDKNFKITCP TIDLYNWTAP
160 170 180 190 200
VQWFKNCKAL QEPRFRAHRS YLFIDNVTHD DEGDYTCQFT HAENGTNYIV
210 220 230 240 250
TATRSFTVEE KGFSMFPVIT NPPYNHTMEV EIGKPASIAC SACFGKGSHF
260 270 280 290 300
LADVLWQINK TVVGNFGEAR IQEEEGRNES SSNDMDCLTS VLRITGVTEK
310 320 330 340 350
DLSLEYDCLA LNLHGMIRHT IRLRRKQPID HRSIYYIVAG CSLLLMFINV
360 370 380 390 400
LVIVLKVFWI EVALFWRDIV TPYKTRNDGK LYDAYIIYPR VFRGSAAGTH
410 420 430 440 450
SVEYFVHHTL PDVLENKCGY KLCIYGRDLL PGQDAATVVE SSIQNSRRQV
460 470 480 490 500
FVLAPHMMHS KEFAYEQEIA LHSALIQNNS KVILIEMEPL GEASRLQVGD
510 520 530 540 550
LQDSLQHLVK IQGTIKWRED HVADKQSLSS KFWKHVRYQM PVPERASKTA
560
SVAAPLSGKA CLDLKHF
Length:567
Mass (Da):64,801
Last modified:December 6, 2002 - v2
Checksum:i9228CE227D95B0BC
GO
Isoform B (identifier: P14719-2) [UniParc]FASTAAdd to basket
Also known as: Soluble, ST2

The sequence of this isoform differs from the canonical sequence as follows:
     329-337: IDHRSIYYI → SKECPSHIA
     338-567: Missing.

Show »
Length:337
Mass (Da):38,502
Checksum:i7574372722486926
GO

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural varianti192A → V in strain: C3H/He. 1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_002668329 – 337IDHRSIYYI → SKECPSHIA in isoform B. 2 Publications9
Alternative sequenceiVSP_002669338 – 567Missing in isoform B. 2 PublicationsAdd BLAST230

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Y07519 mRNA. Translation: CAA68812.1.
X60184 Genomic DNA. Translation: CAA42742.1.
M24843 mRNA. Translation: AAA40160.1.
D13695 mRNA. Translation: BAA02854.1.
CCDSiCCDS35548.1. [P14719-1]
CCDS56626.1. [P14719-2]
PIRiS29498.
RefSeqiNP_001020773.1. NM_001025602.3. [P14719-1]
NP_001281100.1. NM_001294171.1. [P14719-2]
NP_034873.2. NM_010743.3. [P14719-2]
XP_006495804.1. XM_006495741.1. [P14719-1]
XP_006495807.1. XM_006495744.2. [P14719-1]
XP_017174571.1. XM_017319082.1. [P14719-1]
UniGeneiMm.289824.

Genome annotation databases

EnsembliENSMUST00000053043; ENSMUSP00000054914; ENSMUSG00000026069. [P14719-1]
ENSMUST00000097772; ENSMUSP00000095379; ENSMUSG00000026069. [P14719-1]
ENSMUST00000173514; ENSMUSP00000133784; ENSMUSG00000026069. [P14719-2]
ENSMUST00000174335; ENSMUSP00000134351; ENSMUSG00000026069. [P14719-2]
GeneIDi17082.
KEGGimmu:17082.
UCSCiuc007aub.3. mouse. [P14719-1]

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Y07519 mRNA. Translation: CAA68812.1.
X60184 Genomic DNA. Translation: CAA42742.1.
M24843 mRNA. Translation: AAA40160.1.
D13695 mRNA. Translation: BAA02854.1.
CCDSiCCDS35548.1. [P14719-1]
CCDS56626.1. [P14719-2]
PIRiS29498.
RefSeqiNP_001020773.1. NM_001025602.3. [P14719-1]
NP_001281100.1. NM_001294171.1. [P14719-2]
NP_034873.2. NM_010743.3. [P14719-2]
XP_006495804.1. XM_006495741.1. [P14719-1]
XP_006495807.1. XM_006495744.2. [P14719-1]
XP_017174571.1. XM_017319082.1. [P14719-1]
UniGeneiMm.289824.

3D structure databases

ProteinModelPortaliP14719.
SMRiP14719.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi201248. 2 interactors.
DIPiDIP-34958N.
IntActiP14719. 4 interactors.
STRINGi10090.ENSMUSP00000054914.

PTM databases

iPTMnetiP14719.
PhosphoSitePlusiP14719.

Proteomic databases

EPDiP14719.
MaxQBiP14719.
PaxDbiP14719.
PRIDEiP14719.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000053043; ENSMUSP00000054914; ENSMUSG00000026069. [P14719-1]
ENSMUST00000097772; ENSMUSP00000095379; ENSMUSG00000026069. [P14719-1]
ENSMUST00000173514; ENSMUSP00000133784; ENSMUSG00000026069. [P14719-2]
ENSMUST00000174335; ENSMUSP00000134351; ENSMUSG00000026069. [P14719-2]
GeneIDi17082.
KEGGimmu:17082.
UCSCiuc007aub.3. mouse. [P14719-1]

Organism-specific databases

CTDi9173.
MGIiMGI:98427. Il1rl1.

Phylogenomic databases

eggNOGiENOG410IPTT. Eukaryota.
ENOG4110Z8K. LUCA.
GeneTreeiENSGT00760000119071.
HOGENOMiHOG000113054.
HOVERGENiHBG098401.
InParanoidiP14719.
KOiK05171.
OMAiKVQGTIK.
OrthoDBiEOG091G0GXW.
PhylomeDBiP14719.
TreeFamiTF325519.

Enzyme and pathway databases

ReactomeiR-MMU-449147. Signaling by Interleukins.

Miscellaneous databases

PROiP14719.
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000026069.
CleanExiMM_IL1RL1.
ExpressionAtlasiP14719. baseline and differential.
GenevisibleiP14719. MM.

Family and domain databases

Gene3Di2.60.40.10. 3 hits.
3.40.50.10140. 1 hit.
InterProiIPR007110. Ig-like_dom.
IPR013783. Ig-like_fold.
IPR003599. Ig_sub.
IPR003598. Ig_sub2.
IPR015621. IL-1_rcpt_fam.
IPR004074. IL-1_rcpt_I/II-typ.
IPR000157. TIR_dom.
[Graphical view]
PANTHERiPTHR11890. PTHR11890. 1 hit.
PfamiPF13895. Ig_2. 1 hit.
PF01582. TIR. 1 hit.
[Graphical view]
PRINTSiPR01536. INTRLKN1R12F.
SMARTiSM00409. IG. 3 hits.
SM00408. IGc2. 2 hits.
SM00255. TIR. 1 hit.
[Graphical view]
SUPFAMiSSF48726. SSF48726. 3 hits.
SSF52200. SSF52200. 1 hit.
PROSITEiPS50835. IG_LIKE. 3 hits.
PS50104. TIR. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiILRL1_MOUSE
AccessioniPrimary (citable) accession number: P14719
Secondary accession number(s): Q05208
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 1, 1990
Last sequence update: December 6, 2002
Last modified: November 2, 2016
This is version 166 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.