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Reviewed, UniProtKB/Swiss-Prot P14719 (ILRL1_MOUSE)

Last modified February 9, 2010. Version 109. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data | Customize display text xml rdf/xml gff fasta
Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Binary interactions · Alternative products · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents

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Names and origin

Protein namesRecommended name:
    Interleukin-1 receptor-like 1
Alternative name(s):
    Protein ST2
    Protein T1
    Lymphocyte antigen 84
Gene names
Name: Il1rl1
Synonyms: Ly84, St2, Ste2
OrganismMus musculus (Mouse)
Taxonomic identifier10090 [NCBI]
Taxonomic lineageEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Sciurognathi › Muroidea › Muridae › Murinae › Mus

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Protein attributes

Sequence length567 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceEvidence at protein level.

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General annotation (Comments)

Function

Receptor for interleukin-33 (IL-33), its stimulation recruits MYD88, IRAK1, IRAK4, and TRAF6, followed by phosphorylation of MAPK3/ERK1 and/or MAPK1/ERK2, MAPK14, and MAPK8 By similarity. Possibly involved in helper T-cell function.

Subunit structure

Interacts with MYD88, IRAK1, IRAK4, and TRAF6 By similarity.

Subcellular location

Cell membrane; Single-pass type I membrane protein.

Isoform B: Secreted.

Tissue specificity

Predominantly expressed in hematopoietic tissues, and in macrophage, erythroid, epithelial and fibroblast cell lines. Ref.5

Developmental stage

Expressed first in the fetal liver and then in lung and hematopoietic tissues.

Sequence similarities

Belongs to the interleukin-1 receptor family.

Contains 3 Ig-like C2-type (immunoglobulin-like) domains.

Contains 1 TIR domain.

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Binary interactions

With

Entry

#Exp.

IntAct

Notes

Irak1Q62406-21EBI-525078,EBI-488317
Myd88P223661EBI-525078,EBI-525108
TollipQ9QZ061EBI-525078,EBI-74272

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Alternative products

This entry describes 2 isoforms produced by alternative splicing. [Align] [Select]
Isoform A (identifier: P14719-1)

Also known as: Membrane-bound; ST2L;

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.
Isoform B (identifier: P14719-2)

Also known as: Soluble; ST2;

The sequence of this isoform differs from the canonical sequence as follows:
     329-337: IDHRSIYYI → SKECPSHIA
     338-567: Missing.

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Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Signal peptide1 – 2626 Potential
Chain27 – 567541Interleukin-1 receptor-like 1
PRO_0000015443

Regions

Topological domain27 – 332306Extracellular Potential
Transmembrane333 – 35523 Potential
Topological domain356 – 567212Cytoplasmic Potential
Domain27 – 10983Ig-like C2-type 1
Domain120 – 20384Ig-like C2-type 2
Domain217 – 324108Ig-like C2-type 3
Domain375 – 538164TIR

Amino acid modifications

Glycosylation601N-linked (GlcNAc...) Potential
Glycosylation1011N-linked (GlcNAc...) Potential
Glycosylation1071N-linked (GlcNAc...) Potential
Glycosylation1461N-linked (GlcNAc...) Potential
Glycosylation1761N-linked (GlcNAc...) Potential
Glycosylation1941N-linked (GlcNAc...) Potential
Glycosylation2251N-linked (GlcNAc...) Potential
Glycosylation2591N-linked (GlcNAc...) Potential
Glycosylation2781N-linked (GlcNAc...) Potential
Disulfide bond42 ↔ 93 By similarity
Disulfide bond139 ↔ 187 By similarity
Disulfide bond240 ↔ 308 By similarity

Natural variations

Alternative sequence329 – 3379IDHRSIYYI → SKECPSHIA in isoform B.
VSP_002668
Alternative sequence338 – 567230Missing in isoform B.
VSP_002669
Natural variant1921A → V in strain: C3H/He.

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Sequences

Sequence LengthMass (Da)Tools
Isoform A (Membrane-bound) (ST2L) [UniParc].

Last modified December 6, 2002. Version 2.
Checksum: 9228CE227D95B0BC

FASTA56764,801
        10         20         30         40         50         60 
MIDRQRMGLW ALAILTLPMY LTVTEGSKSS WGLENEALIV RCPQRGRSTY PVEWYYSDTN 

        70         80         90        100        110        120 
ESIPTQKRNR IFVSRDRLKF LPARVEDSGI YACVIRSPNL NKTGYLNVTI HKKPPSCNIP 

       130        140        150        160        170        180 
DYLMYSTVRG SDKNFKITCP TIDLYNWTAP VQWFKNCKAL QEPRFRAHRS YLFIDNVTHD 

       190        200        210        220        230        240 
DEGDYTCQFT HAENGTNYIV TATRSFTVEE KGFSMFPVIT NPPYNHTMEV EIGKPASIAC 

       250        260        270        280        290        300 
SACFGKGSHF LADVLWQINK TVVGNFGEAR IQEEEGRNES SSNDMDCLTS VLRITGVTEK 

       310        320        330        340        350        360 
DLSLEYDCLA LNLHGMIRHT IRLRRKQPID HRSIYYIVAG CSLLLMFINV LVIVLKVFWI 

       370        380        390        400        410        420 
EVALFWRDIV TPYKTRNDGK LYDAYIIYPR VFRGSAAGTH SVEYFVHHTL PDVLENKCGY 

       430        440        450        460        470        480 
KLCIYGRDLL PGQDAATVVE SSIQNSRRQV FVLAPHMMHS KEFAYEQEIA LHSALIQNNS 

       490        500        510        520        530        540 
KVILIEMEPL GEASRLQVGD LQDSLQHLVK IQGTIKWRED HVADKQSLSS KFWKHVRYQM 

       550        560 
PVPERASKTA SVAAPLSGKA CLDLKHF

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Isoform B (Soluble) (ST2).

Checksum: 7574372722486926
Show »

FASTA33738,502

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References

[1]"A putative protein of a growth specific cDNA from BALB/c-3T3 cells is highly similar to the extracellular portion of mouse interleukin 1 receptor."
Tominaga S.
FEBS Lett. 258:301-304(1989) [PubMed: 2532153] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM B).
Strain: BALB/c.
[2]"Molecular cloning of the murine ST2 gene. Characterization and chromosomal mapping."
Tominaga S., Jenkins N.A., Gilbert D.J., Copeland N.G., Tetsuka T.
Biochim. Biophys. Acta 1090:1-8(1991) [PubMed: 1832015] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] (ISOFORM B).
Strain: C3H/He.
Tissue: Spleen.
[3]"Serum- and oncoprotein-mediated induction of a gene with sequence similarity to the gene encoding carcinoembryonic antigen."
Klemenz R., Hoffmann S., Werenskiold A.K.
Proc. Natl. Acad. Sci. U.S.A. 86:5708-5712(1989) [PubMed: 2527364] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM B).
[4]"Presence of a novel primary response gene ST2L, encoding a product highly similar to the interleukin 1 receptor type 1."
Yanagisawa K., Takagi T., Tsukamoto T., Tetsuka T., Tominaga S.
FEBS Lett. 318:83-87(1993) [PubMed: 7916701] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM A).
[5]"Alternative promoter usage of the Fos-responsive gene Fit-1 generates mRNA isoforms coding for either secreted or membrane-bound proteins related to the IL-1 receptor."
Bergers G., Reikersdorfer A., Braselmann S., Graninger P., Busslinger M.
EMBO J. 13:1176-1188(1994) [PubMed: 8131748] [Abstract]
Cited for: TISSUE SPECIFICITY.
+Additional computationally mapped references.

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Cross-references

Sequence databases

EMBL
GenBank
DDBJ		Y07519 mRNA. Translation: CAA68812.1.
X60184 Genomic DNA. Translation: CAA42742.1.
M24843 mRNA. Translation: AAA40160.1.
D13695 mRNA. Translation: BAA02854.1.
IPIIPI00129750.
IPI00319792.
PIRS29498.
RefSeqNP_001020773.1.
NP_034873.2.
UniGeneMm.289824

3D structure databases

SMRP14719. Positions 380-542.
ModBaseSearch...

Protein-protein interaction databases

DIPDIP-34958N.
IntActP14719. 5 interactions.
STRINGP14719.

PTM databases

PhosphoSiteP14719.

Proteomic databases

PRIDEP14719.

Genome annotation databases

EnsemblENSMUST00000053043; ENSMUSP00000054914; ENSMUSG00000026069; Mus musculus. [Genome view]
ENSMUST00000097772; ENSMUSP00000095379; ENSMUSG00000026069; Mus musculus. [Genome view]
GeneID17082.
KEGGmmu:17082.
UCSCuc007aub.1. mouse.

Organism-specific databases

CTD17082.
MGIMGI:98427. Il1rl1.

Phylogenomic databases

eggNOGroNOG12629.
HOGENOMHBG282748.
HOVERGENP14719.
InParanoidP14719.
OMAEQEIALH.
OrthoDBEOG92RGSG.

Gene expression databases

ArrayExpressP14719.
BgeeP14719.
CleanExMM_IL1RL1.
GenevestigatorP14719.
GermOnlineENSMUSG00000026069. Mus musculus.

Family and domain databases

InterProIPR007110. Ig-like.
IPR013783. Ig-like_fold.
IPR003598. Ig_sub2.
IPR015621. IL1-receptor.
IPR004075. IL1_rcpt_1.
IPR004074. IL1_rcpt_I/II.
IPR000157. Toll-Interleukin_rcpt.
[Graphical view]
Gene3DG3DSA:2.60.40.10. Ig-like_fold. 3 hits.
PANTHERPTHR11890. IL1-receptor. 1 hit.
PfamPF01582. TIR. 1 hit.
[Graphical view]
PRINTSPR01536. INTRLKN1R12F.
PR01537. INTRLKN1R1F.
SMARTSM00408. IGc2. 2 hits.
SM00255. TIR. 1 hit.
[Graphical view]
PROSITEPS50835. IG_LIKE. 3 hits.
PS50104. TIR. 1 hit.
[Graphical view]
ProtoNetSearch...

Other Resources

NextBio291206.
SOURCESearch...

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Entry information

Entry nameILRL1_MOUSE
AccessionPrimary (citable) accession number: P14719
Secondary accession number(s): Q05208
Entry history
Integrated into UniProtKB/Swiss-Prot: April 1, 1990
Last sequence update: December 6, 2002
Last modified: February 9, 2010
This is version 109 of the entry and version 2 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation projectHPI (Human Proteome Initiative)

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Relevant documents

MGD cross-references

Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot

SIMILARITY comments

Index of protein domains and families

Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Binary interactions · Alternative products · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents