P14719 (ILRL1_MOUSE) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Interleukin-1 receptor-like 1

Alternative name(s):
Lymphocyte antigen 84
Protein ST2
Protein T1

Gene names

Name:	Il1rl1
Synonyms:	Ly84, St2, Ste2

Organism

Mus musculus (Mouse)

Taxonomic identifier

10090 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Sciurognathi › Muroidea › Muridae › Murinae › Mus › Mus

Protein attributes

Sequence length	567 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is further processed into a mature form.
Protein existence	Evidence at transcript level

General annotation (Comments)

Function	Receptor for interleukin-33 (IL-33), its stimulation recruits MYD88, IRAK1, IRAK4, and TRAF6, followed by phosphorylation of MAPK3/ERK1 and/or MAPK1/ERK2, MAPK14, and MAPK8 By similarity. Possibly involved in helper T-cell function.
Subunit structure	Interacts with MYD88, IRAK1, IRAK4, and TRAF6 By similarity.
Subcellular location	Cell membrane; Single-pass type I membrane protein. Isoform B: Secreted.
Tissue specificity	Predominantly expressed in hematopoietic tissues, and in macrophage, erythroid, epithelial and fibroblast cell lines. Ref.5
Developmental stage	Expressed first in the fetal liver and then in lung and hematopoietic tissues.
Sequence similarities	Belongs to the interleukin-1 receptor family. Contains 3 Ig-like C2-type (immunoglobulin-like) domains. Contains 1 TIR domain.

Ontologies

Keywords
Cellular component	Cell membrane Membrane Secreted
Coding sequence diversity	Alternative splicing
Domain	Immunoglobulin domain Repeat Signal Transmembrane Transmembrane helix
Molecular function	Receptor
PTM	Disulfide bond Glycoprotein
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological process	innate immune response Inferred from electronic annotation. Source: InterPro negative regulation of I-kappaB kinase/NF-kappaB cascade Inferred from direct assay PubMed 17623648. Source: MGI negative regulation of T-helper 1 type immune response Inferred from genetic interaction PubMed 18268038. Source: BHF-UCL negative regulation of interferon-gamma production Inferred from genetic interaction PubMed 18268038. Source: BHF-UCL positive regulation of chemokine secretion Inferred from mutant phenotype PubMed 19841166. Source: BHF-UCL positive regulation of inflammatory response Inferred from mutant phenotype PubMed 19841166. Source: BHF-UCL positive regulation of interleukin-5 production Inferred from genetic interaction PubMed 18268038. Source: BHF-UCL positive regulation of macrophage activation Inferred from mutant phenotype PubMed 19841166. Source: BHF-UCL
Cellular component	external side of plasma membrane Inferred from direct assay PubMed 12714518PubMed 19666510. Source: MGI integral to membrane Inferred from electronic annotation. Source: UniProtKB-KW intracellular Inferred from electronic annotation. Source: InterPro
Molecular function	interleukin-1 receptor activity Inferred from electronic annotation. Source: InterPro interleukin-33 binding Inferred from physical interaction PubMed 17623648. Source: MGI interleukin-33 receptor activity Inferred from physical interaction PubMed 17623648. Source: MGI
Complete GO annotation...

Alternative products

This entry describes 2 isoforms produced by alternative splicing. [Align] [Select]

Isoform A (identifier: P14719-1)

Also known as: Membrane-bound; ST2L;

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

Isoform B (identifier: P14719-2)

Also known as: Soluble; ST2;

The sequence of this isoform differs from the canonical sequence as follows:
     329-337: IDHRSIYYI → SKECPSHIA
     338-567: Missing.

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Signal peptide	1 – 26	26	Potential
	Chain	27 – 567	541	Interleukin-1 receptor-like 1		PRO_0000015443
Regions
	Topological domain	27 – 332	306	Extracellular Potential
	Transmembrane	333 – 355	23	Helical; Potential
	Topological domain	356 – 567	212	Cytoplasmic Potential
	Domain	27 – 109	83	Ig-like C2-type 1
	Domain	120 – 203	84	Ig-like C2-type 2
	Domain	217 – 324	108	Ig-like C2-type 3
	Domain	375 – 538	164	TIR
Amino acid modifications
	Glycosylation	60	1	N-linked (GlcNAc...) Potential
	Glycosylation	101	1	N-linked (GlcNAc...) Potential
	Glycosylation	107	1	N-linked (GlcNAc...) Potential
	Glycosylation	146	1	N-linked (GlcNAc...) Potential
	Glycosylation	176	1	N-linked (GlcNAc...) Potential
	Glycosylation	194	1	N-linked (GlcNAc...) Potential
	Glycosylation	225	1	N-linked (GlcNAc...) Potential
	Glycosylation	259	1	N-linked (GlcNAc...) Potential
	Glycosylation	278	1	N-linked (GlcNAc...) Potential
	Disulfide bond	42 ↔ 93		By similarity
	Disulfide bond	139 ↔ 187		By similarity
	Disulfide bond	240 ↔ 308		By similarity
Natural variations
	Alternative sequence	329 – 337	9	IDHRSIYYI → SKECPSHIA in isoform B.		VSP_002668
	Alternative sequence	338 – 567	230	Missing in isoform B.		VSP_002669
	Natural variant	192	1	A → V in strain: C3H/He.

Sequences

	Sequence		Length	Mass (Da)
	Isoform A (Membrane-bound) (ST2L) [UniParc]. Last modified December 6, 2002. Version 2. Checksum: 9228CE227D95B0BC	FASTA	567	64,801
	10 20 30 40 50 60 MIDRQRMGLW ALAILTLPMY LTVTEGSKSS WGLENEALIV RCPQRGRSTY PVEWYYSDTN 70 80 90 100 110 120 ESIPTQKRNR IFVSRDRLKF LPARVEDSGI YACVIRSPNL NKTGYLNVTI HKKPPSCNIP 130 140 150 160 170 180 DYLMYSTVRG SDKNFKITCP TIDLYNWTAP VQWFKNCKAL QEPRFRAHRS YLFIDNVTHD 190 200 210 220 230 240 DEGDYTCQFT HAENGTNYIV TATRSFTVEE KGFSMFPVIT NPPYNHTMEV EIGKPASIAC 250 260 270 280 290 300 SACFGKGSHF LADVLWQINK TVVGNFGEAR IQEEEGRNES SSNDMDCLTS VLRITGVTEK 310 320 330 340 350 360 DLSLEYDCLA LNLHGMIRHT IRLRRKQPID HRSIYYIVAG CSLLLMFINV LVIVLKVFWI 370 380 390 400 410 420 EVALFWRDIV TPYKTRNDGK LYDAYIIYPR VFRGSAAGTH SVEYFVHHTL PDVLENKCGY 430 440 450 460 470 480 KLCIYGRDLL PGQDAATVVE SSIQNSRRQV FVLAPHMMHS KEFAYEQEIA LHSALIQNNS 490 500 510 520 530 540 KVILIEMEPL GEASRLQVGD LQDSLQHLVK IQGTIKWRED HVADKQSLSS KFWKHVRYQM 550 560 PVPERASKTA SVAAPLSGKA CLDLKHF
	Isoform B (Soluble) (ST2) [UniParc]. Checksum: 7574372722486926	FASTA	337	38,502
	10 20 30 40 50 60 MIDRQRMGLW ALAILTLPMY LTVTEGSKSS WGLENEALIV RCPQRGRSTY PVEWYYSDTN 70 80 90 100 110 120 ESIPTQKRNR IFVSRDRLKF LPARVEDSGI YACVIRSPNL NKTGYLNVTI HKKPPSCNIP 130 140 150 160 170 180 DYLMYSTVRG SDKNFKITCP TIDLYNWTAP VQWFKNCKAL QEPRFRAHRS YLFIDNVTHD 190 200 210 220 230 240 DEGDYTCQFT HAENGTNYIV TATRSFTVEE KGFSMFPVIT NPPYNHTMEV EIGKPASIAC 250 260 270 280 290 300 SACFGKGSHF LADVLWQINK TVVGNFGEAR IQEEEGRNES SSNDMDCLTS VLRITGVTEK 310 320 330 DLSLEYDCLA LNLHGMIRHT IRLRRKQPSK ECPSHIA

References

[1]	"A putative protein of a growth specific cDNA from BALB/c-3T3 cells is highly similar to the extracellular portion of mouse interleukin 1 receptor." Tominaga S. FEBS Lett. 258:301-304(1989) [PubMed: 2532153] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM B). Strain: BALB/c.
[2]	"Molecular cloning of the murine ST2 gene. Characterization and chromosomal mapping." Tominaga S., Jenkins N.A., Gilbert D.J., Copeland N.G., Tetsuka T. Biochim. Biophys. Acta 1090:1-8(1991) [PubMed: 1832015] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] (ISOFORM B). Strain: C3H/He. Tissue: Spleen.
[3]	"Serum- and oncoprotein-mediated induction of a gene with sequence similarity to the gene encoding carcinoembryonic antigen." Klemenz R., Hoffmann S., Werenskiold A.K. Proc. Natl. Acad. Sci. U.S.A. 86:5708-5712(1989) [PubMed: 2527364] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM B).
[4]	"Presence of a novel primary response gene ST2L, encoding a product highly similar to the interleukin 1 receptor type 1." Yanagisawa K., Takagi T., Tsukamoto T., Tetsuka T., Tominaga S. FEBS Lett. 318:83-87(1993) [PubMed: 7916701] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM A).
[5]	"Alternative promoter usage of the Fos-responsive gene Fit-1 generates mRNA isoforms coding for either secreted or membrane-bound proteins related to the IL-1 receptor." Bergers G., Reikersdorfer A., Braselmann S., Graninger P., Busslinger M. EMBO J. 13:1176-1188(1994) [PubMed: 8131748] [Abstract] Cited for: TISSUE SPECIFICITY.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	Y07519 mRNA. Translation: CAA68812.1. X60184 Genomic DNA. Translation: CAA42742.1. M24843 mRNA. Translation: AAA40160.1. D13695 mRNA. Translation: BAA02854.1.
IPI	IPI00129750. IPI00319792.
PIR	S29498.
RefSeq	NP_001020773.1. NM_001025602.2. NP_034873.2. NM_010743.2.
UniGene	Mm.289824.
3D structure databases
ProteinModelPortal	P14719.
SMR	P14719. Positions 22-326, 380-542.
ModBase	Search...
Protein-protein interaction databases
DIP	DIP-34958N.
IntAct	P14719. 2 interactions.
STRING	P14719.
PTM databases
PhosphoSite	P14719.
Proteomic databases
PRIDE	P14719.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENSMUST00000053043; ENSMUSP00000054914; ENSMUSG00000026069. ENSMUST00000097772; ENSMUSP00000095379; ENSMUSG00000026069. ENSMUST00000173514; ENSMUSP00000133784; ENSMUSG00000026069. ENSMUST00000174335; ENSMUSP00000134351; ENSMUSG00000026069.
GeneID	17082.
KEGG	mmu:17082.
UCSC	uc007aub.2. mouse.
Organism-specific databases
CTD	9173.
MGI	MGI:98427. Il1rl1.
Phylogenomic databases
eggNOG	NOG124917.
GeneTree	ENSGT00630000089663.
HOGENOM	HOG000113054.
HOVERGEN	HBG098401.
InParanoid	P14719.
KO	K05171.
OMA	VQGTIKW.
OrthoDB	EOG4HHP20.
Gene expression databases
ArrayExpress	P14719.
Bgee	P14719.
CleanEx	MM_IL1RL1.
Genevestigator	P14719.
GermOnline	ENSMUSG00000026069. Mus musculus.
Family and domain databases
Gene3D	G3DSA:2.60.40.10. Ig-like_fold. 3 hits.
InterPro	IPR007110. Ig-like. IPR013783. Ig-like_fold. IPR003598. Ig_sub2. IPR015621. IL1-receptor. IPR004075. IL1_rcpt_1. IPR004074. IL1_rcpt_I/II. IPR000157. TIR_dom. [Graphical view]
PANTHER	PTHR11890. IL1-receptor. 1 hit.
Pfam	PF01582. TIR. 1 hit. [Graphical view]
PRINTS	PR01536. INTRLKN1R12F. PR01537. INTRLKN1R1F.
SMART	SM00408. IGc2. 2 hits. SM00255. TIR. 1 hit. [Graphical view]
SUPFAM	SSF52200. TIR. 1 hit.
PROSITE	PS50835. IG_LIKE. 3 hits. PS50104. TIR. 1 hit. [Graphical view]
ProtoNet	Search...
Other
NextBio	291206.
SOURCE	Search...

Entry information

Entry name

ILRL1_MOUSE

Accession

Primary (citable) accession number: P14719
Secondary accession number(s): Q05208

Entry history

Integrated into UniProtKB/Swiss-Prot:	April 1, 1990
Last sequence update:	December 6, 2002
Last modified:	May 16, 2012
This is version 129 of the entry and version 2 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program