Reviewed,
UniProtKB/Swiss-Prot P14719 (ILRL1_MOUSE)
Last modified
February 9, 2010.
Version 109.
History...
Clusters with 100%,
90%,
50% identity |
Documents (2) |
Third-party data |
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Names and origin
| Protein names | Recommended name: Interleukin-1 receptor-like 1 Alternative name(s): Protein ST2 Protein T1 Lymphocyte antigen 84 | ||||
| Gene names |
| ||||
| Organism | Mus musculus (Mouse) | ||||
| Taxonomic identifier | 10090 [NCBI] | ||||
| Taxonomic lineage | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Sciurognathi › Muroidea › Muridae › Murinae › Mus |
Protein attributes
| Sequence length | 567 AA. |
| Sequence status | Complete. |
| Sequence processing | The displayed sequence is further processed into a mature form. |
| Protein existence | Evidence at protein level. |
General annotation (Comments)
| Function | Receptor for interleukin-33 (IL-33), its stimulation recruits MYD88, IRAK1, IRAK4, and TRAF6, followed by phosphorylation of MAPK3/ERK1 and/or MAPK1/ERK2, MAPK14, and MAPK8 By similarity. Possibly involved in helper T-cell function. |
| Subunit structure | Interacts with MYD88, IRAK1, IRAK4, and TRAF6 By similarity. |
| Subcellular location | Cell membrane; Single-pass type I membrane protein. Isoform B: Secreted. |
| Tissue specificity | Predominantly expressed in hematopoietic tissues, and in macrophage, erythroid, epithelial and fibroblast cell lines. Ref.5 |
| Developmental stage | Expressed first in the fetal liver and then in lung and hematopoietic tissues. |
| Sequence similarities | Belongs to the interleukin-1 receptor family. Contains 3 Ig-like C2-type (immunoglobulin-like) domains. Contains 1 TIR domain. |
Ontologies
| Keywords | |
|---|---|
| Cellular component | Cell membrane Membrane Secreted |
| Coding sequence diversity | Alternative splicing |
| Domain | Immunoglobulin domain Repeat Signal Transmembrane |
| Molecular function | Receptor |
| PTM | Disulfide bond Glycoprotein |
| Gene Ontology (GO) | |
| Biological process | innate immune response Inferred from electronic annotation. Source: InterPro negative regulation of I-kappaB kinase/NF-kappaB cascadeInferred from direct assay. Source: MGI signal transductionInferred from electronic annotation. Source: InterPro |
| Cellular component | external side of plasma membrane Inferred from direct assay. Source: MGI extracellular regionInferred from electronic annotation. Source: UniProtKB-KW integral to membraneInferred from electronic annotation. Source: UniProtKB-SubCell |
| Molecular function | interleukin-1 receptor activity Inferred from electronic annotation. Source: InterPro interleukin-33 receptor activityInferred from physical interaction. Source: MGI |
| Complete GO annotation... | |
Binary interactions
With | Entry | #Exp. | IntAct | Notes |
|---|---|---|---|---|
| Irak1 | Q62406-2 | 1 | EBI-525078,EBI-488317 | |
| Myd88 | P22366 | 1 | EBI-525078,EBI-525108 | |
| Tollip | Q9QZ06 | 1 | EBI-525078,EBI-74272 |
Alternative products
| This entry describes 2 isoforms produced by alternative splicing. [Align] [Select] | ||||||
| Isoform A (identifier: P14719-1) Also known as: Membrane-bound; ST2L; This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry. | ||||||
| Isoform B (identifier: P14719-2) Also known as: Soluble; ST2; The sequence of this isoform differs from the canonical sequence as follows: 329-337: IDHRSIYYI → SKECPSHIA 338-567: Missing. |
Sequence annotation (Features)
| Feature key | Position(s) | Length | Description | Graphical view | Feature identifier | ||||||
Molecule processing | |||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|
| Signal peptide | 1 – 26 | 26 | Potential | ||||||||
| Chain | 27 – 567 | 541 | Interleukin-1 receptor-like 1 | PRO_0000015443 | |||||||
Regions | |||||||||||
| Topological domain | 27 – 332 | 306 | Extracellular Potential | ||||||||
| Transmembrane | 333 – 355 | 23 | Potential | ||||||||
| Topological domain | 356 – 567 | 212 | Cytoplasmic Potential | ||||||||
| Domain | 27 – 109 | 83 | Ig-like C2-type 1 | ||||||||
| Domain | 120 – 203 | 84 | Ig-like C2-type 2 | ||||||||
| Domain | 217 – 324 | 108 | Ig-like C2-type 3 | ||||||||
| Domain | 375 – 538 | 164 | TIR | ||||||||
Amino acid modifications | |||||||||||
| Glycosylation | 60 | 1 | N-linked (GlcNAc...) Potential | ||||||||
| Glycosylation | 101 | 1 | N-linked (GlcNAc...) Potential | ||||||||
| Glycosylation | 107 | 1 | N-linked (GlcNAc...) Potential | ||||||||
| Glycosylation | 146 | 1 | N-linked (GlcNAc...) Potential | ||||||||
| Glycosylation | 176 | 1 | N-linked (GlcNAc...) Potential | ||||||||
| Glycosylation | 194 | 1 | N-linked (GlcNAc...) Potential | ||||||||
| Glycosylation | 225 | 1 | N-linked (GlcNAc...) Potential | ||||||||
| Glycosylation | 259 | 1 | N-linked (GlcNAc...) Potential | ||||||||
| Glycosylation | 278 | 1 | N-linked (GlcNAc...) Potential | ||||||||
| Disulfide bond | 42 ↔ 93 | By similarity | |||||||||
| Disulfide bond | 139 ↔ 187 | By similarity | |||||||||
| Disulfide bond | 240 ↔ 308 | By similarity | |||||||||
Natural variations | |||||||||||
| Alternative sequence | 329 – 337 | 9 | IDHRSIYYI → SKECPSHIA in isoform B. | VSP_002668 | |||||||
| Alternative sequence | 338 – 567 | 230 | Missing in isoform B. | VSP_002669 | |||||||
| Natural variant | 192 | 1 | A → V in strain: C3H/He. | ||||||||
Sequences
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References
| [1] | "A putative protein of a growth specific cDNA from BALB/c-3T3 cells is highly similar to the extracellular portion of mouse interleukin 1 receptor." Tominaga S. FEBS Lett. 258:301-304(1989) [PubMed: 2532153] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM B). Strain: BALB/c. |
| [2] | "Molecular cloning of the murine ST2 gene. Characterization and chromosomal mapping." Tominaga S., Jenkins N.A., Gilbert D.J., Copeland N.G., Tetsuka T. Biochim. Biophys. Acta 1090:1-8(1991) [PubMed: 1832015] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] (ISOFORM B). Strain: C3H/He. Tissue: Spleen. |
| [3] | "Serum- and oncoprotein-mediated induction of a gene with sequence similarity to the gene encoding carcinoembryonic antigen." Klemenz R., Hoffmann S., Werenskiold A.K. Proc. Natl. Acad. Sci. U.S.A. 86:5708-5712(1989) [PubMed: 2527364] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM B). |
| [4] | "Presence of a novel primary response gene ST2L, encoding a product highly similar to the interleukin 1 receptor type 1." Yanagisawa K., Takagi T., Tsukamoto T., Tetsuka T., Tominaga S. FEBS Lett. 318:83-87(1993) [PubMed: 7916701] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM A). |
| [5] | "Alternative promoter usage of the Fos-responsive gene Fit-1 generates mRNA isoforms coding for either secreted or membrane-bound proteins related to the IL-1 receptor." Bergers G., Reikersdorfer A., Braselmann S., Graninger P., Busslinger M. EMBO J. 13:1176-1188(1994) [PubMed: 8131748] [Abstract] Cited for: TISSUE SPECIFICITY. |
| + | Additional computationally mapped references. |
Cross-references
Sequence databases | |
|---|---|
| EMBL GenBank DDBJ | Y07519 mRNA. Translation: CAA68812.1. X60184 Genomic DNA. Translation: CAA42742.1. M24843 mRNA. Translation: AAA40160.1. D13695 mRNA. Translation: BAA02854.1. |
| IPI | IPI00129750. IPI00319792. |
| PIR | S29498. |
| RefSeq | NP_001020773.1. NP_034873.2. |
| UniGene | Mm.289824 |
3D structure databases | |
| SMR | P14719. Positions 380-542. |
| ModBase | Search... |
Protein-protein interaction databases | |
| DIP | DIP-34958N. |
| IntAct | P14719. 5 interactions. |
| STRING | P14719. |
PTM databases | |
| PhosphoSite | P14719. |
Proteomic databases | |
| PRIDE | P14719. |
Genome annotation databases | |
| Ensembl | ENSMUST00000053043; ENSMUSP00000054914; ENSMUSG00000026069; Mus musculus. [Genome view] ENSMUST00000097772; ENSMUSP00000095379; ENSMUSG00000026069; Mus musculus. [Genome view] |
| GeneID | 17082. |
| KEGG | mmu:17082. |
| UCSC | uc007aub.1. mouse. |
Organism-specific databases | |
| CTD | 17082. |
| MGI | MGI:98427. Il1rl1. |
Phylogenomic databases | |
| eggNOG | roNOG12629. |
| HOGENOM | HBG282748. |
| HOVERGEN | P14719. |
| InParanoid | P14719. |
| OMA | EQEIALH. |
| OrthoDB | EOG92RGSG. |
Gene expression databases | |
| ArrayExpress | P14719. |
| Bgee | P14719. |
| CleanEx | MM_IL1RL1. |
| Genevestigator | P14719. |
| GermOnline | ENSMUSG00000026069. Mus musculus. |
Family and domain databases | |
| InterPro | IPR007110. Ig-like. IPR013783. Ig-like_fold. IPR003598. Ig_sub2. IPR015621. IL1-receptor. IPR004075. IL1_rcpt_1. IPR004074. IL1_rcpt_I/II. IPR000157. Toll-Interleukin_rcpt. [Graphical view] |
| Gene3D | G3DSA:2.60.40.10. Ig-like_fold. 3 hits. |
| PANTHER | PTHR11890. IL1-receptor. 1 hit. |
| Pfam | PF01582. TIR. 1 hit. [Graphical view] |
| PRINTS | PR01536. INTRLKN1R12F. PR01537. INTRLKN1R1F. |
| SMART | SM00408. IGc2. 2 hits. SM00255. TIR. 1 hit. [Graphical view] |
| PROSITE | PS50835. IG_LIKE. 3 hits. PS50104. TIR. 1 hit. [Graphical view] |
| ProtoNet | Search... |
Other Resources | |
| NextBio | 291206. |
| SOURCE | Search... |
Entry information
| Entry name | ILRL1_MOUSE | ||||||||
| Accession | Primary (citable) accession number: P14719 Secondary accession number(s): Q05208 | ||||||||
| Entry history |
| ||||||||
| Entry status | Reviewed (UniProtKB/Swiss-Prot) | ||||||||
| Annotation project | HPI (Human Proteome Initiative) | ||||||||
Relevant documents
| MGD cross-references Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot |
| SIMILARITY comments Index of protein domains and families |

Clusters with


