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P14696

- LACG_LACCA

UniProt

P14696 - LACG_LACCA

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Protein
6-phospho-beta-galactosidase
Gene
lacG
Organism
Lactobacillus casei
Status
Reviewed - Annotation score: 2 out of 5 - Protein inferred from homologyi

Functioni

Catalytic activityi

A 6-phospho-beta-D-galactoside + H2O = 6-phospho-D-galactose + an alcohol.UniRule annotation

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei160 – 1601Proton donor By similarity
Active sitei375 – 3751Nucleophile By similarity

GO - Molecular functioni

  1. 6-phospho-beta-galactosidase activity Source: UniProtKB-HAMAP
Complete GO annotation...

GO - Biological processi

  1. lactose catabolic process via tagatose-6-phosphate Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

Glycosidase, Hydrolase

Enzyme and pathway databases

SABIO-RKP14696.
UniPathwayiUPA00542; UER00605.

Protein family/group databases

CAZyiGH1. Glycoside Hydrolase Family 1.

Names & Taxonomyi

Protein namesi
Recommended name:
6-phospho-beta-galactosidase (EC:3.2.1.85)
Alternative name(s):
Beta-D-phosphogalactoside galactohydrolase
Short name:
PGALase
P-beta-Gal
Short name:
PBG
Gene namesi
Name:lacG
OrganismiLactobacillus casei
Taxonomic identifieri1582 [NCBI]
Taxonomic lineageiBacteriaFirmicutesBacilliLactobacillalesLactobacillaceaeLactobacillus

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 4744746-phospho-beta-galactosidaseUniRule annotation
PRO_0000063882Add
BLAST

Structurei

3D structure databases

ProteinModelPortaliP14696.

Family & Domainsi

Sequence similaritiesi

Family and domain databases

Gene3Di3.20.20.80. 1 hit.
HAMAPiMF_01574. LacG.
InterProiIPR005928. 6P-beta-galactosidase.
IPR001360. Glyco_hydro_1.
IPR018120. Glyco_hydro_1_AS.
IPR013781. Glyco_hydro_catalytic_dom.
IPR017853. Glycoside_hydrolase_SF.
[Graphical view]
PANTHERiPTHR10353. PTHR10353. 1 hit.
PfamiPF00232. Glyco_hydro_1. 1 hit.
[Graphical view]
PRINTSiPR00131. GLHYDRLASE1.
SUPFAMiSSF51445. SSF51445. 1 hit.
TIGRFAMsiTIGR01233. lacG. 1 hit.
PROSITEiPS00572. GLYCOSYL_HYDROL_F1_1. 1 hit.
PS00653. GLYCOSYL_HYDROL_F1_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P14696-1 [UniParc]FASTAAdd to Basket

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MSKQLPQDFV MGGATAAYQV EGATKEDGKG RVLWDDFLDK QGRFKPDPAA    50
DFYHRYDEDL ALAEKYGHQV IRVSIAWSRI FPDGAGEVEP RGVAFYHKLF 100
ADCAAHHIEP FVTLHHFDTP ERLHEAGDWL SQEMLDDFVA YAKFCFEEFS 150
EVKYWITINE PTSMAVQQYT TGTFPPAESG RFDKTFQAEH NQMVAHARIV 200
NLYKSMQLGG QIGIVHALQT VYPYSDSAVD HHAAELQDAL ENRLYLDGTL 250
AGEYHQETLA LVKEILDANH QPMFQSTPQE MKAIDEAAHQ LDFVGVNNYF 300
SKWLRAYHGK SETIHNGDGT KGSSVARLQG VGEEKLPDGI ETTDWDWSIY 350
PRGMYDILMR IHNDYPLVPV TYVTENGIGL KESLPENATP DTVIEDPKRI 400
DYVKKYLSAM ADAIHDGANV KGYFIWSLQD QFSWTNGYSK RYGLFFVDFP 450
TQNRYIKQSA EWFKSVSETH IIPD 474
Length:474
Mass (Da):53,982
Last modified:April 1, 1990 - v1
Checksum:i1FF1B185E3549A9F
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
M20151 Genomic DNA. Translation: AAD15134.1.
Z80834 Genomic DNA. Translation: CAB02557.1.
M20150 Genomic DNA. Translation: AAA25238.1. Sequence problems.
PIRiA29897.
A29898.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
M20151 Genomic DNA. Translation: AAD15134.1 .
Z80834 Genomic DNA. Translation: CAB02557.1 .
M20150 Genomic DNA. Translation: AAA25238.1 . Sequence problems.
PIRi A29897.
A29898.

3D structure databases

ProteinModelPortali P14696.
ModBasei Search...

Protein family/group databases

CAZyi GH1. Glycoside Hydrolase Family 1.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Enzyme and pathway databases

UniPathwayi UPA00542 ; UER00605 .
SABIO-RK P14696.

Family and domain databases

Gene3Di 3.20.20.80. 1 hit.
HAMAPi MF_01574. LacG.
InterProi IPR005928. 6P-beta-galactosidase.
IPR001360. Glyco_hydro_1.
IPR018120. Glyco_hydro_1_AS.
IPR013781. Glyco_hydro_catalytic_dom.
IPR017853. Glycoside_hydrolase_SF.
[Graphical view ]
PANTHERi PTHR10353. PTHR10353. 1 hit.
Pfami PF00232. Glyco_hydro_1. 1 hit.
[Graphical view ]
PRINTSi PR00131. GLHYDRLASE1.
SUPFAMi SSF51445. SSF51445. 1 hit.
TIGRFAMsi TIGR01233. lacG. 1 hit.
PROSITEi PS00572. GLYCOSYL_HYDROL_F1_1. 1 hit.
PS00653. GLYCOSYL_HYDROL_F1_2. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Nucleotide sequence of the beta-D-phosphogalactoside galactohydrolase gene of Lactobacillus casei: comparison to analogous pbg genes of other Gram-positive organisms."
    Porter E.V., Chassy B.M.
    Gene 62:263-276(1988) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
  2. "Establishing a model to study the regulation of the lactose operon in Lactobacillus casei."
    Gosalbes M.J., Monedero V., Alpert C.-A., Perez-Martinez G.
    FEMS Microbiol. Lett. 148:83-89(1997) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    Strain: ATCC 393 / DSM 20011 / JCM 1134 / NBRC 15883 / NCIMB 11970 / NCDO 161.
  3. "Molecular cloning and nucleotide sequence of the factor IIIlac gene of Lactobacillus casei."
    Alpert C.-A., Chassy B.M.
    Gene 62:277-288(1988) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 384-474.

Entry informationi

Entry nameiLACG_LACCA
AccessioniPrimary (citable) accession number: P14696
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 1, 1990
Last sequence update: April 1, 1990
Last modified: June 11, 2014
This is version 86 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Documents

  1. Glycosyl hydrolases
    Classification of glycosyl hydrolase families and list of entries
  2. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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