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P14696

- LACG_LACCA

UniProt

P14696 - LACG_LACCA

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Protein

6-phospho-beta-galactosidase

Gene

lacG

Organism
Lactobacillus casei
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi

Functioni

Catalytic activityi

A 6-phospho-beta-D-galactoside + H2O = 6-phospho-D-galactose + an alcohol.UniRule annotation

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei160 – 1601Proton donorUniRule annotation
Active sitei375 – 3751NucleophileUniRule annotation

GO - Molecular functioni

  1. 6-phospho-beta-galactosidase activity Source: UniProtKB-HAMAP

GO - Biological processi

  1. lactose catabolic process via tagatose-6-phosphate Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

Glycosidase, Hydrolase

Enzyme and pathway databases

SABIO-RKP14696.
UniPathwayiUPA00542; UER00605.

Protein family/group databases

CAZyiGH1. Glycoside Hydrolase Family 1.

Names & Taxonomyi

Protein namesi
Recommended name:
6-phospho-beta-galactosidaseUniRule annotation (EC:3.2.1.85UniRule annotation)
Alternative name(s):
Beta-D-phosphogalactoside galactohydrolaseUniRule annotation
Short name:
PGALaseUniRule annotation
P-beta-GalUniRule annotation
Short name:
PBGUniRule annotation
Gene namesi
Name:lacGUniRule annotation
OrganismiLactobacillus casei
Taxonomic identifieri1582 [NCBI]
Taxonomic lineageiBacteriaFirmicutesBacilliLactobacillalesLactobacillaceaeLactobacillus

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 4744746-phospho-beta-galactosidasePRO_0000063882Add
BLAST

Structurei

3D structure databases

ProteinModelPortaliP14696.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the glycosyl hydrolase 1 family.UniRule annotation

Family and domain databases

Gene3Di3.20.20.80. 1 hit.
HAMAPiMF_01574. LacG.
InterProiIPR005928. 6P-beta-galactosidase.
IPR001360. Glyco_hydro_1.
IPR018120. Glyco_hydro_1_AS.
IPR013781. Glyco_hydro_catalytic_dom.
IPR017853. Glycoside_hydrolase_SF.
[Graphical view]
PANTHERiPTHR10353. PTHR10353. 1 hit.
PfamiPF00232. Glyco_hydro_1. 1 hit.
[Graphical view]
PRINTSiPR00131. GLHYDRLASE1.
SUPFAMiSSF51445. SSF51445. 1 hit.
TIGRFAMsiTIGR01233. lacG. 1 hit.
PROSITEiPS00572. GLYCOSYL_HYDROL_F1_1. 1 hit.
PS00653. GLYCOSYL_HYDROL_F1_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P14696-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MSKQLPQDFV MGGATAAYQV EGATKEDGKG RVLWDDFLDK QGRFKPDPAA
60 70 80 90 100
DFYHRYDEDL ALAEKYGHQV IRVSIAWSRI FPDGAGEVEP RGVAFYHKLF
110 120 130 140 150
ADCAAHHIEP FVTLHHFDTP ERLHEAGDWL SQEMLDDFVA YAKFCFEEFS
160 170 180 190 200
EVKYWITINE PTSMAVQQYT TGTFPPAESG RFDKTFQAEH NQMVAHARIV
210 220 230 240 250
NLYKSMQLGG QIGIVHALQT VYPYSDSAVD HHAAELQDAL ENRLYLDGTL
260 270 280 290 300
AGEYHQETLA LVKEILDANH QPMFQSTPQE MKAIDEAAHQ LDFVGVNNYF
310 320 330 340 350
SKWLRAYHGK SETIHNGDGT KGSSVARLQG VGEEKLPDGI ETTDWDWSIY
360 370 380 390 400
PRGMYDILMR IHNDYPLVPV TYVTENGIGL KESLPENATP DTVIEDPKRI
410 420 430 440 450
DYVKKYLSAM ADAIHDGANV KGYFIWSLQD QFSWTNGYSK RYGLFFVDFP
460 470
TQNRYIKQSA EWFKSVSETH IIPD
Length:474
Mass (Da):53,982
Last modified:April 1, 1990 - v1
Checksum:i1FF1B185E3549A9F
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M20151 Genomic DNA. Translation: AAD15134.1.
Z80834 Genomic DNA. Translation: CAB02557.1.
M20150 Genomic DNA. Translation: AAA25238.1. Sequence problems.
PIRiA29897.
A29898.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M20151 Genomic DNA. Translation: AAD15134.1 .
Z80834 Genomic DNA. Translation: CAB02557.1 .
M20150 Genomic DNA. Translation: AAA25238.1 . Sequence problems.
PIRi A29897.
A29898.

3D structure databases

ProteinModelPortali P14696.
ModBasei Search...
MobiDBi Search...

Protein family/group databases

CAZyi GH1. Glycoside Hydrolase Family 1.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Enzyme and pathway databases

UniPathwayi UPA00542 ; UER00605 .
SABIO-RK P14696.

Family and domain databases

Gene3Di 3.20.20.80. 1 hit.
HAMAPi MF_01574. LacG.
InterProi IPR005928. 6P-beta-galactosidase.
IPR001360. Glyco_hydro_1.
IPR018120. Glyco_hydro_1_AS.
IPR013781. Glyco_hydro_catalytic_dom.
IPR017853. Glycoside_hydrolase_SF.
[Graphical view ]
PANTHERi PTHR10353. PTHR10353. 1 hit.
Pfami PF00232. Glyco_hydro_1. 1 hit.
[Graphical view ]
PRINTSi PR00131. GLHYDRLASE1.
SUPFAMi SSF51445. SSF51445. 1 hit.
TIGRFAMsi TIGR01233. lacG. 1 hit.
PROSITEi PS00572. GLYCOSYL_HYDROL_F1_1. 1 hit.
PS00653. GLYCOSYL_HYDROL_F1_2. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Nucleotide sequence of the beta-D-phosphogalactoside galactohydrolase gene of Lactobacillus casei: comparison to analogous pbg genes of other Gram-positive organisms."
    Porter E.V., Chassy B.M.
    Gene 62:263-276(1988) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
  2. "Establishing a model to study the regulation of the lactose operon in Lactobacillus casei."
    Gosalbes M.J., Monedero V., Alpert C.-A., Perez-Martinez G.
    FEMS Microbiol. Lett. 148:83-89(1997) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    Strain: ATCC 393 / DSM 20011 / JCM 1134 / NBRC 15883 / NCIMB 11970 / NCDO 161.
  3. "Molecular cloning and nucleotide sequence of the factor IIIlac gene of Lactobacillus casei."
    Alpert C.-A., Chassy B.M.
    Gene 62:277-288(1988) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 384-474.

Entry informationi

Entry nameiLACG_LACCA
AccessioniPrimary (citable) accession number: P14696
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 1, 1990
Last sequence update: April 1, 1990
Last modified: October 1, 2014
This is version 87 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Documents

  1. Glycosyl hydrolases
    Classification of glycosyl hydrolase families and list of entries
  2. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3