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P14677 (PBPX_STRPN) Reviewed, UniProtKB/Swiss-Prot

Last modified May 1, 2013. Version 113. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
Penicillin-binding protein 2x
Short name=PBP-2x
Short name=PBP2x
Gene names
Name:pbpX
Ordered Locus Names:SP_0336
OrganismStreptococcus pneumoniae serotype 4 (strain ATCC BAA-334 / TIGR4) [Complete proteome] [HAMAP]
Taxonomic identifier170187 [NCBI]
Taxonomic lineageBacteria › Firmicutes › Bacilli › Lactobacillales › Streptococcaceae › Streptococcus ›

Protein attributes

Sequence length750 AA.
Sequence statusComplete.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

Penicillin-binding proteins (PBPs) function in the late steps of murein biosynthesis. Beta-lactams inactivate the PBPs by acylating an essential serine residue in the active site of these proteins.

Subcellular location

Cell membrane; Single-pass membrane protein.

Miscellaneous

The mature form of PBP2x contains an unprocessed signal sequence followed by a membrane-anchoring segment.

Sequence similarities

Belongs to the transpeptidase family.

Contains 2 PASTA domains.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 750750Penicillin-binding protein 2x
PRO_0000195453

Regions

Transmembrane29 – 4921Helical; Potential
Domain632 – 69160PASTA 1
Domain692 – 75059PASTA 2

Sites

Active site3371Acyl-ester intermediate By similarity

Secondary structure

1 .......................................................................................................................... 750
Helix Strand Turn

Details...

Sequences

Sequence LengthMass (Da)Tools
P14677 [UniParc].

Last modified September 26, 2001. Version 2.
Checksum: 9B2BCADBE4E462E4

FASTA75082,313
        10         20         30         40         50         60 
MKWTKRVIRY ATKNRKSPAE NRRRVGKSLS LLSVFVFAIF LVNFAVIIGT GTRFGTDLAK 

        70         80         90        100        110        120 
EAKKVHQTTR TVPAKRGTIY DRNGVPIAED ATSYNVYAVI DENYKSATGK ILYVEKTQFN 

       130        140        150        160        170        180 
KVAEVFHKYL DMEESYVREQ LSQPNLKQVS FGAKGNGITY ANMMSIKKEL EAAEVKGIDF 

       190        200        210        220        230        240 
TTSPNRSYPN GQFASSFIGL AQLHENEDGS KSLLGTSGME SSLNSILAGT DGIITYEKDR 

       250        260        270        280        290        300 
LGNIVPGTEQ VSQRTMDGKD VYTTISSPLQ SFMETQMDAF QEKVKGKYMT ATLVSAKTGE 

       310        320        330        340        350        360 
ILATTQRPTF DADTKEGITE DFVWRDILYQ SNYEPGSTMK VMMLAAAIDN NTFPGGEVFN 

       370        380        390        400        410        420 
SSELKIADAT IRDWDVNEGL TGGRTMTFSQ GFAHSSNVGM TLLEQKMGDA TWLDYLNRFK 

       430        440        450        460        470        480 
FGVPTRFGLT DEYAGQLPAD NIVNIAQSSF GQGISVTQTQ MIRAFTAIAN DGVMLEPKFI 

       490        500        510        520        530        540 
SAIYDPNDQT ARKSQKEIVG NPVSKDAASL TRTNMVLVGT DPVYGTMYNH STGKPTVTVP 

       550        560        570        580        590        600 
GQNVALKSGT AQIADEKNGG YLVGLTDYIF SAVSMSPAEN PDFILYVTVQ QPEHYSGIQL 

       610        620        630        640        650        660 
GEFANPILER ASAMKDSLNL QTTAKALEQV SQQSPYPMPS VKDISPGDLA EELRRNLVQP 

       670        680        690        700        710        720 
IVVGTGTKIK NSSAEEGKNL APNQQVLILS DKAEEVPDMY GWTKETAETL AKWLNIELEF 

       730        740        750 
QGSGSTVQKQ DVRANTAIKD IKKITLTLGD

« Hide

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		AE005672 Genomic DNA. Translation: AAK74511.1.
PIRF95039.
H97909.
S06726.
RefSeqNP_344871.1. NC_003028.3.

3D structure databases

PDBe
RCSB PDB
PDBj
EntryMethodResolution (Å)ChainPositionsPDBsum
1PMDX-ray3.50A76-750[»]
1QMEX-ray2.40A49-750[»]
1QMFX-ray2.80A49-750[»]
1RP5X-ray3.00A/B49-750[»]
2Z2LX-ray2.85A/D71-238[»]
B/E241-625[»]
C/F626-750[»]
2Z2MX-ray2.60A/D71-238[»]
B/E241-625[»]
C/F626-750[»]
2ZC3X-ray2.50A/D71-238[»]
B/E241-625[»]
C/F626-750[»]
2ZC4X-ray2.80A/D71-238[»]
B/E241-625[»]
C/F626-750[»]
ProteinModelPortalP14677.
SMRP14677. Positions 64-750.
ModBaseSearch...

Protein-protein interaction databases

STRING170187.SP_0336.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaAAK74511; AAK74511; SP_0336.
GeneID930153.
KEGGspn:SP_0336.
PATRIC19705009. VBIStrPne105772_0350.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGCOG0768.
HOGENOMHOG000049551.
KOK12556.
OMANGIFASQ.
ProtClustDBCLSK876796.

Family and domain databases

Gene3D3.40.710.10. 1 hit.
InterProIPR012338. Beta-lactam/transpept-like.
IPR005543. PASTA.
IPR005311. PBP_dimer.
IPR001460. PCN-bd_Tpept.
[Graphical view]
PfamPF03793. PASTA. 1 hit.
PF03717. PBP_dimer. 1 hit.
PF00905. Transpeptidase. 1 hit.
[Graphical view]
SMARTSM00740. PASTA. 1 hit.
[Graphical view]
SUPFAMSSF56519. PBP_dimer. 1 hit.
SSF56601. PBP_transp_fold. 1 hit.
PROSITEPS51178. PASTA. 2 hits.
[Graphical view]
ProtoNetSearch...

Other

BindingDBP14677.
ChEMBLCHEMBL6188.
EvolutionaryTraceP14677.

Entry information

Entry namePBPX_STRPN
AccessionPrimary (citable) accession number: P14677
Entry history
Integrated into UniProtKB/Swiss-Prot: April 1, 1990
Last sequence update: September 26, 2001
Last modified: May 1, 2013
This is version 113 of the entry and version 2 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

PDB cross-references

Index of Protein Data Bank (PDB) cross-references

SIMILARITY comments

Index of protein domains and families

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