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Protein

Prolactin

Gene

PRL

Organism
Gallus gallus (Chicken)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionHormone

Enzyme and pathway databases

ReactomeiR-GGA-1170546 Prolactin receptor signaling
R-GGA-982772 Growth hormone receptor signaling

Names & Taxonomyi

Protein namesi
Recommended name:
Prolactin
Short name:
PRL
Gene namesi
Name:PRL
OrganismiGallus gallus (Chicken)
Taxonomic identifieri9031 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiArchelosauriaArchosauriaDinosauriaSaurischiaTheropodaCoelurosauriaAvesNeognathaeGalloanseraeGalliformesPhasianidaePhasianinaeGallus
Proteomesi
  • UP000000539 Componenti: Chromosome 2

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 30Add BLAST30
ChainiPRO_000003292831 – 229ProlactinAdd BLAST199

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi34 ↔ 41By similarity
Disulfide bondi88 ↔ 204By similarity
Disulfide bondi221 ↔ 229By similarity

Keywords - PTMi

Disulfide bond

Proteomic databases

PaxDbiP14676

Expressioni

Gene expression databases

BgeeiENSGALG00000012671
ExpressionAtlasiP14676 baseline

Interactioni

GO - Molecular functioni

Protein-protein interaction databases

STRINGi9031.ENSGALP00000020651

Structurei

3D structure databases

ProteinModelPortaliP14676
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the somatotropin/prolactin family.Curated

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiENOG410II74 Eukaryota
ENOG410XU1S LUCA
GeneTreeiENSGT00730000110805
HOGENOMiHOG000264241
HOVERGENiHBG104895
InParanoidiP14676
KOiK05439
OMAiDSHKIDN
OrthoDBiEOG091G0O08
PhylomeDBiP14676
TreeFamiTF332592

Family and domain databases

InterProiView protein in InterPro
IPR009079 4_helix_cytokine-like_core
IPR001400 Somatotropin/Prolactin
IPR018116 Somatotropin_CS
PANTHERiPTHR11417 PTHR11417, 1 hit
PfamiView protein in Pfam
PF00103 Hormone_1, 1 hit
PRINTSiPR00836 SOMATOTROPIN
SUPFAMiSSF47266 SSF47266, 1 hit
PROSITEiView protein in PROSITE
PS00266 SOMATOTROPIN_1, 1 hit
PS00338 SOMATOTROPIN_2, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P14676-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSNRGASLKG LFLAVLLVSN TLLTKEGVTS LPICPIGSVN CQVSLGELFD
60 70 80 90 100
RAVKLSHYIH YLSSEIFNEF DERYAQGRGF ITKAVNGCHT SSLTTPEDKE
110 120 130 140 150
QAQQIHHEDL LNLVVGVLRS WNDPLIHLAS EVQRIKEAPD TILWKAVEIE
160 170 180 190 200
EQNKRLLEGM EKIVGRVHSG DAGNEIYSHW DGLPSLQLAD EDSRLFAFYN
210 220
LLHCLRRDSH KIDNYLKVLK CRLIHDSNC
Length:229
Mass (Da):25,863
Last modified:November 16, 2001 - v2
Checksum:i11314FEF65F775AE
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti171D → H (PubMed:2925618).Curated1
Sequence conflicti171D → H (Ref. 4) Curated1
Sequence conflicti180W → S (PubMed:2925618).Curated1
Sequence conflicti180W → S (Ref. 4) Curated1
Sequence conflicti205L → H (PubMed:2925618).Curated1
Sequence conflicti205L → H (Ref. 4) Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
J04614 mRNA Translation: AAA49040.1
AB011438 Genomic DNA Translation: BAB18728.1
AF288765 Genomic DNA Translation: AAG01026.1
AY588297
, AY588296, AY588295, AY588294 Genomic DNA Translation: AAT02222.1
AY588304
, AY588301, AY588302, AY588303 Genomic DNA Translation: AAT02223.1
AY588311
, AY588308, AY588309, AY588310 Genomic DNA Translation: AAT02224.1
AY588318
, AY588316, AY588317, AY588315 Genomic DNA Translation: AAT02225.1
PIRiA60972
RefSeqiNP_990797.2, NM_205466.2
UniGeneiGga.1802

Genome annotation databases

EnsembliENSGALT00000020680; ENSGALP00000020651; ENSGALG00000012671
GeneIDi396453
KEGGigga:396453

Similar proteinsi

Entry informationi

Entry nameiPRL_CHICK
AccessioniPrimary (citable) accession number: P14676
Secondary accession number(s): Q66XJ8, Q90ZB1, Q9DEI3
Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 1, 1990
Last sequence update: November 16, 2001
Last modified: March 28, 2018
This is version 115 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome
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Main funding by: National Institutes of Health