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Protein

Prolactin

Gene

PRL

Organism
Gallus gallus (Chicken)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at transcript leveli

Functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Hormone

Enzyme and pathway databases

ReactomeiR-GGA-1170546. Prolactin receptor signaling.
R-GGA-982772. Growth hormone receptor signaling.

Names & Taxonomyi

Protein namesi
Recommended name:
Prolactin
Short name:
PRL
Gene namesi
Name:PRL
OrganismiGallus gallus (Chicken)
Taxonomic identifieri9031 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiArchelosauriaArchosauriaDinosauriaSaurischiaTheropodaCoelurosauriaAvesNeognathaeGalloanseraeGalliformesPhasianidaePhasianinaeGallus
Proteomesi
  • UP000000539 Componenti: Chromosome 2

Subcellular locationi

GO - Cellular componenti

  • extracellular space Source: AgBase
Complete GO annotation...

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 3030Add
BLAST
Chaini31 – 229199ProlactinPRO_0000032928Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Disulfide bondi34 ↔ 41By similarity
Disulfide bondi88 ↔ 204By similarity
Disulfide bondi221 ↔ 229By similarity

Keywords - PTMi

Disulfide bond

Proteomic databases

PaxDbiP14676.

Expressioni

Gene expression databases

ExpressionAtlasiP14676. baseline.

Interactioni

Protein-protein interaction databases

STRINGi9031.ENSGALP00000020651.

Structurei

3D structure databases

ProteinModelPortaliP14676.
SMRiP14676. Positions 31-229.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the somatotropin/prolactin family.Curated

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiENOG410II74. Eukaryota.
ENOG410XU1S. LUCA.
GeneTreeiENSGT00730000110805.
HOGENOMiHOG000264241.
HOVERGENiHBG104895.
InParanoidiP14676.
KOiK05439.
OMAiLHCLRRD.
OrthoDBiEOG74FF24.
PhylomeDBiP14676.
TreeFamiTF332592.

Family and domain databases

Gene3Di1.20.1250.10. 1 hit.
InterProiIPR009079. 4_helix_cytokine-like_core.
IPR012351. 4_helix_cytokine_core.
IPR001400. Somatotropin.
IPR018116. Somatotropin_CS.
[Graphical view]
PANTHERiPTHR11417. PTHR11417. 1 hit.
PfamiPF00103. Hormone_1. 1 hit.
[Graphical view]
PRINTSiPR00836. SOMATOTROPIN.
SUPFAMiSSF47266. SSF47266. 1 hit.
PROSITEiPS00266. SOMATOTROPIN_1. 1 hit.
PS00338. SOMATOTROPIN_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P14676-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSNRGASLKG LFLAVLLVSN TLLTKEGVTS LPICPIGSVN CQVSLGELFD
60 70 80 90 100
RAVKLSHYIH YLSSEIFNEF DERYAQGRGF ITKAVNGCHT SSLTTPEDKE
110 120 130 140 150
QAQQIHHEDL LNLVVGVLRS WNDPLIHLAS EVQRIKEAPD TILWKAVEIE
160 170 180 190 200
EQNKRLLEGM EKIVGRVHSG DAGNEIYSHW DGLPSLQLAD EDSRLFAFYN
210 220
LLHCLRRDSH KIDNYLKVLK CRLIHDSNC
Length:229
Mass (Da):25,863
Last modified:November 16, 2001 - v2
Checksum:i11314FEF65F775AE
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti171 – 1711D → H (PubMed:2925618).Curated
Sequence conflicti171 – 1711D → H (Ref. 4) Curated
Sequence conflicti180 – 1801W → S (PubMed:2925618).Curated
Sequence conflicti180 – 1801W → S (Ref. 4) Curated
Sequence conflicti205 – 2051L → H (PubMed:2925618).Curated
Sequence conflicti205 – 2051L → H (Ref. 4) Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
J04614 mRNA. Translation: AAA49040.1.
AB011438 Genomic DNA. Translation: BAB18728.1.
AF288765 Genomic DNA. Translation: AAG01026.1.
AY588297
, AY588296, AY588295, AY588294 Genomic DNA. Translation: AAT02222.1.
AY588304
, AY588301, AY588302, AY588303 Genomic DNA. Translation: AAT02223.1.
AY588311
, AY588308, AY588309, AY588310 Genomic DNA. Translation: AAT02224.1.
AY588318
, AY588316, AY588317, AY588315 Genomic DNA. Translation: AAT02225.1.
PIRiA60972.
RefSeqiNP_990797.2. NM_205466.2.
UniGeneiGga.1802.

Genome annotation databases

EnsembliENSGALT00000020680; ENSGALP00000020651; ENSGALG00000012671.
GeneIDi396453.
KEGGigga:396453.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
J04614 mRNA. Translation: AAA49040.1.
AB011438 Genomic DNA. Translation: BAB18728.1.
AF288765 Genomic DNA. Translation: AAG01026.1.
AY588297
, AY588296, AY588295, AY588294 Genomic DNA. Translation: AAT02222.1.
AY588304
, AY588301, AY588302, AY588303 Genomic DNA. Translation: AAT02223.1.
AY588311
, AY588308, AY588309, AY588310 Genomic DNA. Translation: AAT02224.1.
AY588318
, AY588316, AY588317, AY588315 Genomic DNA. Translation: AAT02225.1.
PIRiA60972.
RefSeqiNP_990797.2. NM_205466.2.
UniGeneiGga.1802.

3D structure databases

ProteinModelPortaliP14676.
SMRiP14676. Positions 31-229.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9031.ENSGALP00000020651.

Proteomic databases

PaxDbiP14676.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSGALT00000020680; ENSGALP00000020651; ENSGALG00000012671.
GeneIDi396453.
KEGGigga:396453.

Organism-specific databases

CTDi5617.

Phylogenomic databases

eggNOGiENOG410II74. Eukaryota.
ENOG410XU1S. LUCA.
GeneTreeiENSGT00730000110805.
HOGENOMiHOG000264241.
HOVERGENiHBG104895.
InParanoidiP14676.
KOiK05439.
OMAiLHCLRRD.
OrthoDBiEOG74FF24.
PhylomeDBiP14676.
TreeFamiTF332592.

Enzyme and pathway databases

ReactomeiR-GGA-1170546. Prolactin receptor signaling.
R-GGA-982772. Growth hormone receptor signaling.

Miscellaneous databases

PROiP14676.

Gene expression databases

ExpressionAtlasiP14676. baseline.

Family and domain databases

Gene3Di1.20.1250.10. 1 hit.
InterProiIPR009079. 4_helix_cytokine-like_core.
IPR012351. 4_helix_cytokine_core.
IPR001400. Somatotropin.
IPR018116. Somatotropin_CS.
[Graphical view]
PANTHERiPTHR11417. PTHR11417. 1 hit.
PfamiPF00103. Hormone_1. 1 hit.
[Graphical view]
PRINTSiPR00836. SOMATOTROPIN.
SUPFAMiSSF47266. SSF47266. 1 hit.
PROSITEiPS00266. SOMATOTROPIN_1. 1 hit.
PS00338. SOMATOTROPIN_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "Primary structure of chicken pituitary prolactin deduced from the cDNA sequence. Conserved and specific amino acid residues in the domains of the prolactins."
    Watahiki M., Yamamoto M., Yamakawa M., Tanaka M., Nakashima K.
    J. Biol. Chem. 264:5535-5539(1989) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
  2. "Molecular cloning and sequence analysis of putative chicken prolactin cDNA."
    Hanks M.C., Alonzi J.A., Sharp P.J., Sang H.M.
    J. Mol. Endocrinol. 2:21-30(1989) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
  3. "Cloning and characterization of chicken prolactin gene."
    Ohkubo T., Tanaka M., Nakashima K.
    Submitted (FEB-1998) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
  4. "Genomic sequence of chicken prolactin gene."
    Au W.L., Leung F.C.
    Submitted (AUG-2001) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
  5. "Polymorphisms and bioinformatics analysis of chicken prolactin gene."
    Cui J.X., Du H.L., Zhang X.Q.
    Yi Chuan 27:208-214(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    Tissue: Blood.

Entry informationi

Entry nameiPRL_CHICK
AccessioniPrimary (citable) accession number: P14676
Secondary accession number(s): Q66XJ8, Q90ZB1, Q9DEI3
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 1, 1990
Last sequence update: November 16, 2001
Last modified: June 8, 2016
This is version 105 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.