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P14673 (ADH1_SOLTU) Reviewed, UniProtKB/Swiss-Prot

Last modified December 14, 2011. Version 78. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
Alcohol dehydrogenase 1
EC=1.1.1.1
Gene names
Name:ADH1
OrganismSolanum tuberosum (Potato)
Taxonomic identifier4113 [NCBI]
Taxonomic lineageEukaryota › Viridiplantae › Streptophyta › Embryophyta › Tracheophyta › Spermatophyta › Magnoliophyta › eudicotyledons › core eudicotyledons › asterids › lamiids › Solanales › Solanaceae › Solanoideae › Solaneae › Solanum

Protein attributes

Sequence length380 AA.
Sequence statusComplete.
Protein existenceEvidence at transcript level

General annotation (Comments)

Catalytic activity

An alcohol + NAD+ = an aldehyde or ketone + NADH.

Cofactor

Binds 2 zinc ions per subunit.

Subunit structure

Homotetramer.

Subcellular location

Cytoplasm.

Induction

By fungal elicitor.

Sequence similarities

Belongs to the zinc-containing alcohol dehydrogenase family.

Ontologies

Keywords
   Cellular componentCytoplasm
   LigandMetal-binding
NAD
Zinc
   Molecular functionOxidoreductase
Gene Ontology (GO)
   Cellular componentcytoplasm

Inferred from electronic annotation. Source: UniProtKB-SubCell

   Molecular functionalcohol dehydrogenase (NAD) activity

Inferred from electronic annotation. Source: EC

nucleotide binding

Inferred from electronic annotation. Source: InterPro

zinc ion binding

Inferred from electronic annotation. Source: InterPro

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 380380Alcohol dehydrogenase 1
PRO_0000160712

Regions

Nucleotide binding203 – 2086NAD By similarity
Nucleotide binding296 – 2983NAD By similarity

Sites

Metal binding481Zinc 1; catalytic By similarity
Metal binding701Zinc 1; catalytic By similarity
Metal binding1001Zinc 2 By similarity
Metal binding1031Zinc 2 By similarity
Metal binding1061Zinc 2 By similarity
Metal binding1141Zinc 2 By similarity
Metal binding1781Zinc 1; catalytic By similarity
Binding site2271NAD By similarity
Binding site2321NAD By similarity
Binding site3731NAD By similarity

Experimental info

Sequence conflict871G → A in CAA37333. Ref.1

Sequences

Sequence LengthMass (Da)Tools
P14673 [UniParc].

Last modified April 1, 1990. Version 1.
Checksum: 624E75A168BCA9B3

FASTA38041,094
        10         20         30         40         50         60 
MSTTVGQVIR CKAAVAWEAG KPLVMEEVDV APPQKMEVRL KILYTSLCHT DVYFWEAKGQ 

        70         80         90        100        110        120 
NPVFPRILGH EAAGIVESVG EGVTELGPGD HVLPVFTGEC KDCAHCKSEE SNMCSLLRIN 

       130        140        150        160        170        180 
TDRGVMINDG QSRFSINGKP IYHFVGTSTF SEYTVVHVGC VAKINPLAPL DKVCVLSCGI 

       190        200        210        220        230        240 
STGLGATLNV AKPTKGSSVA IFGLGAVGLA AAEGARIAGA SRIIGVDLNA SRFEQAKKFG 

       250        260        270        280        290        300 
VTEFVNPKDY SKPVQEVIAE MTDGGVDRSV ECTGHIDAMI SAFECVHDGW GVAVLVGVPH 

       310        320        330        340        350        360 
KEAVFKTHPM NLLNERTLKG TFFGNYKPRS DIPSVVEKYM NKELELEKFI THTLPFAEIN 

       370        380 
KAFDLMLKGE GLRCIITMED

« Hide

References

[1]"Alcohol dehydrogenase gene expression in potato following elicitor and stress treatment."
Matton D.P., Constabel P., Brisson N.
Plant Mol. Biol. 14:775-783(1990) [PubMed: 2102855] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		M25154 mRNA. Translation: AAA33806.1.
X53242 mRNA. Translation: CAA37333.1.
PIRDEPOA1. S11853.

3D structure databases

ProteinModelPortalP14673.
SMRP14673. Positions 6-378.
ModBaseSearch...

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Enzyme and pathway databases

BioCycMetaCyc:MONOMER-15099.

Family and domain databases

InterProIPR013149. ADH_C.
IPR013154. ADH_GroES-like.
IPR002085. ADH_SF_Zn-type.
IPR002328. ADH_Zn_CS.
IPR011032. GroES-like.
IPR016040. NAD(P)-bd_dom.
[Graphical view]
Gene3DG3DSA:3.40.50.720. NAD(P)-bd. 1 hit.
PANTHERPTHR11695. ADH_Sf_Zn. 1 hit.
PfamPF08240. ADH_N. 1 hit.
PF00107. ADH_zinc_N. 1 hit.
[Graphical view]
SUPFAMSSF50129. GroES_like. 2 hits.
PROSITEPS00059. ADH_ZINC. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameADH1_SOLTU
AccessionPrimary (citable) accession number: P14673
Entry history
Integrated into UniProtKB/Swiss-Prot: April 1, 1990
Last sequence update: April 1, 1990
Last modified: December 14, 2011
This is version 78 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programPlant Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

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