P14672Q05BQ3Q14CX2GLUT4_HUMANSolute carrier family 2, facilitated glucose transporter member 4Glucose transporter type 4, insulin-responsiveGLUT-4SLC2A4GLUT4Homo sapiensHumanEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomoCloning and characterization of the major insulin-responsive glucose transporter expressed in human skeletal muscle and other insulin-responsive tissues.NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1)Human GLUT4/muscle-fat glucose-transporter gene. Characterization and genetic variation.NUCLEOTIDE SEQUENCE [GENOMIC DNA]VARIANT THR-385DNA sequence of human chromosome 17 and analysis of rearrangement in the human lineage.NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2)Identification of the 5' end of the gene encoding a human insulin-responsive glucose transporter.NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 1-11A Leu-Leu sequence is essential for COOH-terminal targeting signal of GLUT4 glucose transporter in fibroblasts.SUBCELLULAR LOCATIONMUTAGENESIS OF 489-LEU-LEU-490The insulin-sensitive glucose transporter, GLUT4, interacts physically with Daxx. Two proteins with capacity to bind Ubc9 and conjugated to SUMO1.INTERACTION WITH DAXXSUMOYLATIONIdentification and characterization of p49/STRAP as a novel GLUT4-binding protein.INTERACTION WITH SRFBP1Role of SGK1 kinase in regulating glucose transport via glucose transporter GLUT4.PHOSPHORYLATION AT SER-274 BY SGK1A quantitative atlas of mitotic phosphorylation.IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]Mass-spectrometric identification and relative quantification of N-linked cell surface glycoproteins.GLYCOSYLATION [LARGE SCALE ANALYSIS] AT ASN-57DHHC7 Palmitoylates Glucose Transporter 4 (Glut4) and Regulates Glut4 Membrane Translocation.PALMITOYLATION AT CYS-223MUTAGENESIS OF CYS-223Analysis of the gene sequences of the insulin receptor and the insulin-sensitive glucose transporter (GLUT-4) in patients with common-type non-insulin-dependent diabetes mellitus.VARIANT T2D ILE-383Molecular scanning of insulin-responsive glucose transporter (GLUT4) gene in NIDDM subjects.VARIANT T2D ILE-383Insulin receptor and insulin-responsive glucose transporter (GLUT 4) mutations and polymorphisms in a Welsh type 2 (non-insulin-dependent) diabetic population.VARIANT T2D ILE-383Insulin-regulated facilitative glucose transporter, which plays a key role in removal of glucose from circulation. Response to insulin is regulated by its intracellular localization: in the absence of insulin, it is efficiently retained intracellularly within storage compartments in muscle and fat cells. Upon insulin stimulation, translocates from these compartments to the cell surface where it transports glucose from the extracellular milieu into the cell.D-glucose(out) = D-glucose(in)Interacts with NDUFA9 (By similarity). Binds to DAXX (PubMed:11842083). Interacts via its N-terminus with SRFBP1 (PubMed:16647043). Interacts with TRARG1; the interaction is required for proper SLC2A4 recycling after insulin stimulation (By similarity).P14672O43889-2false3Cell membraneMulti-pass membrane proteinEndomembrane systemMulti-pass membrane proteinCytoplasmPerinuclear regionLocalizes primarily to the perinuclear region, undergoing continued recycling to the plasma membrane where it is rapidly reinternalized (PubMed:8300557). The dileucine internalization motif is critical for intracellular sequestration (PubMed:8300557). Insulin stimulation induces translocation to the cell membrane (By similarity).P14672-11P14672-22Skeletal and cardiac muscles; brown and white fat.The dileucine internalization motif is critical for intracellular sequestration.Sumoylated.Palmitoylated (PubMed:28057756). Palmitoylation by ZDHHC7 controls the insulin-dependent translocation of GLUT4 to the plasma membrane (PubMed:28057756).Type 2 diabetes mellitus
T2D
A multifactorial disorder of glucose homeostasis caused by a lack of sensitivity to the body's own insulin. Affected individuals usually have an obese body habitus and manifestations of a metabolic syndrome characterized by diabetes, insulin resistance, hypertension and hypertriglyceridemia. The disease results in long-term complications that affect the eyes, kidneys, nerves, and blood vessels.The disease may be caused by variants affecting the gene represented in this entry.Insulin-stimulated phosphorylation of TBC1D4 is required for GLUT4 translocation.Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family. Glucose transporter subfamily.GLUT4 entry3D-structureAlternative splicingCell membraneCytoplasmDiabetes mellitusDisease variantGlycoproteinLipoproteinMembranePalmitatePhosphoproteinReference proteomeSugar transportTransmembraneTransmembrane helixTransportUbl conjugationD-glucoseD-glucoseD-glucoseD-glucoseD-glucoseD-glucoseLLVERAGRRTLHLLGLAGMCGCAILMTVALLLLERVPAMSYVSIVAIFGFVAFFEIGPGPIPWFIVAELFSQGPTAHLWNGPSHWLHLPGCPGGVVGGAGGAPDAPSPGPGGHVWLCHPDDCGSAPAGASSSHELRLHCGHLWLRGIFSRTSAVVIITCSLLAAMPSGFQQIGSEDGEPPQQRVTGTLVLAVFSAVLGSLQFGYNIGVINAPQKVIEQSYNETWLGRQGPEGPSSIPPGTLTTLWALSVAIFSVGGMISSFLIGIISQWLGRKRAMLVNNVLAVLGGSLMGLANAAASYEMLILGRFLIGAYSGLTSGLVPMYVGEIAPTHLRGALGTLNQLAIVIGILIAQVLGLESLLGTASLWPLLLGLTVLPALLQLVLLPFCPESPRYLYIIQNLEGPARKSLKRLTGWADVSGVLAELKDEKRKLERERPLSLLQLLGSRTHRQPLIIAVVLQLSQQLSGINAVFYYSTSIFETAGVGQPAYATIGAGVVNTVFTLVSVLLVERAGRRTLHLLGLAGMCGCAILMTVALLLLERVPAMSYVSIVAIFGFVAFFEIGPGPIPWFIVAELFSQGPRPAAMAVAGFSNWTSNFIIGMGFQYVAEAMGPYVFLLFAVLLLGFFIFTFLRVPETRGRTFDQISAAFHRTPSLLEQEVKPSTELEYLGPDEND
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