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P14672

- GTR4_HUMAN

UniProt

P14672 - GTR4_HUMAN

Protein

Solute carrier family 2, facilitated glucose transporter member 4

Gene

SLC2A4

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 173 (01 Oct 2014)
      Sequence version 1 (01 Apr 1990)
      Previous versions | rss
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    Functioni

    Insulin-regulated facilitative glucose transporter.

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Binding sitei333 – 3331MonosaccharideBy similarity
    Binding sitei404 – 4041MonosaccharideBy similarity

    GO - Molecular functioni

    1. D-glucose transmembrane transporter activity Source: Ensembl
    2. glucose transmembrane transporter activity Source: ProtInc
    3. protein binding Source: UniProtKB

    GO - Biological processi

    1. amylopectin biosynthetic process Source: Ensembl
    2. brown fat cell differentiation Source: Ensembl
    3. carbohydrate metabolic process Source: Reactome
    4. cellular response to insulin stimulus Source: UniProtKB
    5. cellular response to osmotic stress Source: Ensembl
    6. glucose homeostasis Source: BHF-UCL
    7. glucose import Source: BHF-UCL
    8. glucose transport Source: UniProtKB
    9. hexose transport Source: Reactome
    10. membrane organization Source: Reactome
    11. response to ethanol Source: Ensembl
    12. small molecule metabolic process Source: Reactome
    13. transmembrane transport Source: Reactome

    Keywords - Biological processi

    Sugar transport, Transport

    Enzyme and pathway databases

    ReactomeiREACT_147867. Translocation of GLUT4 to the plasma membrane.
    REACT_19343. Facilitative Na+-independent glucose transporters.
    REACT_212. Glucose transport.
    REACT_27161. Transcriptional regulation of white adipocyte differentiation.

    Protein family/group databases

    TCDBi2.A.1.1.80. the major facilitator superfamily (mfs).

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Solute carrier family 2, facilitated glucose transporter member 4
    Alternative name(s):
    Glucose transporter type 4, insulin-responsive
    Short name:
    GLUT-4
    Gene namesi
    Name:SLC2A4
    Synonyms:GLUT4
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 17

    Organism-specific databases

    HGNCiHGNC:11009. SLC2A4.

    Subcellular locationi

    Cell membrane By similarity; Multi-pass membrane protein By similarity. Endomembrane system 1 Publication; Multi-pass membrane protein 1 Publication. Cytoplasmperinuclear region 1 Publication
    Note: Localizes primarily to the perinuclear region, undergoing continued recycling to the plasma membrane where it is rapidly reinternalized. The dileucine internalization motif is critical for intracellular sequestration.

    GO - Cellular componenti

    1. clathrin-coated vesicle Source: UniProtKB
    2. coated pit Source: Ensembl
    3. endomembrane system Source: UniProtKB
    4. external side of plasma membrane Source: MGI
    5. extracellular vesicular exosome Source: Ensembl
    6. insulin-responsive compartment Source: UniProtKB
    7. integral component of plasma membrane Source: ProtInc
    8. membrane Source: ProtInc
    9. multivesicular body Source: Ensembl
    10. perinuclear region of cytoplasm Source: UniProtKB
    11. plasma membrane Source: UniProtKB
    12. sarcolemma Source: Ensembl
    13. trans-Golgi network transport vesicle Source: Ensembl
    14. vesicle membrane Source: MGI

    Keywords - Cellular componenti

    Cell membrane, Cytoplasm, Membrane

    Pathology & Biotechi

    Involvement in diseasei

    Diabetes mellitus, non-insulin-dependent (NIDDM) [MIM:125853]: A multifactorial disorder of glucose homeostasis caused by a lack of sensitivity to the body's own insulin. Affected individuals usually have an obese body habitus and manifestations of a metabolic syndrome characterized by diabetes, insulin resistance, hypertension and hypertriglyceridemia. The disease results in long-term complications that affect the eyes, kidneys, nerves, and blood vessels.3 Publications
    Note: The disease may be caused by mutations affecting the gene represented in this entry.
    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti383 – 3831V → I in NIDDM. 3 Publications
    Corresponds to variant rs121434581 [ dbSNP | Ensembl ].
    VAR_007170

    Mutagenesis

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Mutagenesisi489 – 4902LL → AA: Changes subcellular location mainly to the plasma membrane. 1 Publication

    Keywords - Diseasei

    Diabetes mellitus, Disease mutation

    Organism-specific databases

    MIMi125853. phenotype.
    PharmGKBiPA35879.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 509509Solute carrier family 2, facilitated glucose transporter member 4PRO_0000050363Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Glycosylationi57 – 571N-linked (GlcNAc...)1 Publication
    Modified residuei274 – 2741Phosphoserine; by SGK11 Publication

    Post-translational modificationi

    Sumoylated.1 Publication

    Keywords - PTMi

    Glycoprotein, Phosphoprotein, Ubl conjugation

    Proteomic databases

    PaxDbiP14672.
    PRIDEiP14672.

    PTM databases

    PhosphoSiteiP14672.

    Expressioni

    Tissue specificityi

    Skeletal and cardiac muscles; brown and white fat.

    Gene expression databases

    ArrayExpressiP14672.
    BgeeiP14672.
    CleanExiHS_SLC2A4.
    GenevestigatoriP14672.

    Organism-specific databases

    HPAiCAB016544.

    Interactioni

    Subunit structurei

    Interacts with NDUFA9 By similarity. Binds to DAXX. Interacts via its N-terminus with SRFBP1.By similarity2 Publications

    Protein-protein interaction databases

    BioGridi112408. 37 interactions.
    IntActiP14672. 1 interaction.
    MINTiMINT-232088.
    STRINGi9606.ENSP00000320935.

    Structurei

    3D structure databases

    ProteinModelPortaliP14672.
    SMRiP14672. Positions 31-481.
    ModBaseiSearch...
    MobiDBiSearch...

    Topological domain

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Topological domaini1 – 2424CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini46 – 8136ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini103 – 1119CytoplasmicSequence Analysis
    Topological domaini133 – 14210ExtracellularSequence Analysis
    Topological domaini164 – 1718CytoplasmicSequence Analysis
    Topological domaini193 – 2019ExtracellularSequence Analysis
    Topological domaini223 – 28765CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini309 – 32315ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini345 – 3539CytoplasmicSequence Analysis
    Topological domaini375 – 38410ExtracellularSequence Analysis
    Topological domaini406 – 41712CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini439 – 4457ExtracellularSequence Analysis
    Topological domaini467 – 50943CytoplasmicSequence AnalysisAdd
    BLAST

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei25 – 4521Helical; Name=1Sequence AnalysisAdd
    BLAST
    Transmembranei82 – 10221Helical; Name=2Sequence AnalysisAdd
    BLAST
    Transmembranei112 – 13221Helical; Name=3Sequence AnalysisAdd
    BLAST
    Transmembranei143 – 16321Helical; Name=4Sequence AnalysisAdd
    BLAST
    Transmembranei172 – 19221Helical; Name=5Sequence AnalysisAdd
    BLAST
    Transmembranei202 – 22221Helical; Name=6Sequence AnalysisAdd
    BLAST
    Transmembranei288 – 30821Helical; Name=7Sequence AnalysisAdd
    BLAST
    Transmembranei324 – 34421Helical; Name=8Sequence AnalysisAdd
    BLAST
    Transmembranei354 – 37421Helical; Name=9Sequence AnalysisAdd
    BLAST
    Transmembranei385 – 40521Helical; Name=10Sequence AnalysisAdd
    BLAST
    Transmembranei418 – 43821Helical; Name=11Sequence AnalysisAdd
    BLAST
    Transmembranei446 – 46621Helical; Name=12Sequence AnalysisAdd
    BLAST

    Family & Domainsi

    Region

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Regioni7 – 137SRFBP1-binding
    Regioni298 – 3047Monosaccharide bindingBy similarity

    Motif

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Motifi489 – 4902Dileucine internalization motif

    Sequence similaritiesi

    Keywords - Domaini

    Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiCOG0477.
    HOGENOMiHOG000202871.
    HOVERGENiHBG014816.
    InParanoidiP14672.
    KOiK07191.
    OMAiAMLVNNI.
    PhylomeDBiP14672.
    TreeFamiTF313762.

    Family and domain databases

    InterProiIPR002441. Glc_transpt_4.
    IPR020846. MFS_dom.
    IPR016196. MFS_dom_general_subst_transpt.
    IPR005828. Sub_transporter.
    IPR003663. Sugar/inositol_transpt.
    IPR005829. Sugar_transporter_CS.
    [Graphical view]
    PfamiPF00083. Sugar_tr. 1 hit.
    [Graphical view]
    PRINTSiPR01193. GLUCTRSPORT4.
    PR00171. SUGRTRNSPORT.
    SUPFAMiSSF103473. SSF103473. 1 hit.
    TIGRFAMsiTIGR00879. SP. 1 hit.
    PROSITEiPS50850. MFS. 1 hit.
    PS00216. SUGAR_TRANSPORT_1. 1 hit.
    PS00217. SUGAR_TRANSPORT_2. 1 hit.
    [Graphical view]

    Sequences (2)i

    Sequence statusi: Complete.

    This entry describes 2 isoformsi produced by alternative splicing. Align

    Isoform 1 (identifier: P14672-1) [UniParc]FASTAAdd to Basket

    This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

    « Hide

    MPSGFQQIGS EDGEPPQQRV TGTLVLAVFS AVLGSLQFGY NIGVINAPQK    50
    VIEQSYNETW LGRQGPEGPS SIPPGTLTTL WALSVAIFSV GGMISSFLIG 100
    IISQWLGRKR AMLVNNVLAV LGGSLMGLAN AAASYEMLIL GRFLIGAYSG 150
    LTSGLVPMYV GEIAPTHLRG ALGTLNQLAI VIGILIAQVL GLESLLGTAS 200
    LWPLLLGLTV LPALLQLVLL PFCPESPRYL YIIQNLEGPA RKSLKRLTGW 250
    ADVSGVLAEL KDEKRKLERE RPLSLLQLLG SRTHRQPLII AVVLQLSQQL 300
    SGINAVFYYS TSIFETAGVG QPAYATIGAG VVNTVFTLVS VLLVERAGRR 350
    TLHLLGLAGM CGCAILMTVA LLLLERVPAM SYVSIVAIFG FVAFFEIGPG 400
    PIPWFIVAEL FSQGPRPAAM AVAGFSNWTS NFIIGMGFQY VAEAMGPYVF 450
    LLFAVLLLGF FIFTFLRVPE TRGRTFDQIS AAFHRTPSLL EQEVKPSTEL 500
    EYLGPDEND 509
    Length:509
    Mass (Da):54,787
    Last modified:April 1, 1990 - v1
    Checksum:i8E20CD97562C1EBF
    GO
    Isoform 2 (identifier: P14672-2) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         342-415: LLVERAGRRT...IVAELFSQGP → TAHLWNGPSH...CGHLWLRGIF
         416-509: Missing.

    Note: No experimental confirmation available.

    Show »
    Length:415
    Mass (Da):43,760
    Checksum:iA46E00FD028AA5BE
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti151 – 1544Missing in AAA52569. (PubMed:1397719)Curated

    Natural variant

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti55 – 551S → R.
    Corresponds to variant rs35198331 [ dbSNP | Ensembl ].
    VAR_052503
    Natural varianti78 – 781T → S.
    Corresponds to variant rs5434 [ dbSNP | Ensembl ].
    VAR_012060
    Natural varianti358 – 3581A → V.
    Corresponds to variant rs8192702 [ dbSNP | Ensembl ].
    VAR_020336
    Natural varianti383 – 3831V → I in NIDDM. 3 Publications
    Corresponds to variant rs121434581 [ dbSNP | Ensembl ].
    VAR_007170
    Natural varianti385 – 3851I → T.1 Publication
    VAR_007171

    Alternative sequence

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Alternative sequencei342 – 41574LLVER…FSQGP → TAHLWNGPSHWLHLPGCPGG VVGGAGGAPDAPSPGPGGHV WLCHPDDCGSAPAGASSSHE LRLHCGHLWLRGIF in isoform 2. 1 PublicationVSP_056331Add
    BLAST
    Alternative sequencei416 – 50994Missing in isoform 2. 1 PublicationVSP_056332Add
    BLAST

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    M20747 mRNA. Translation: AAA59189.1.
    M91463 Genomic DNA. Translation: AAA52569.1.
    AC003688 Genomic DNA. No translation available.
    BC034387 mRNA. Translation: AAH34387.1.
    BC069615 mRNA. Translation: AAH69615.1.
    BC069621 mRNA. Translation: AAH69621.1.
    BC113592 mRNA. Translation: AAI13593.1.
    BC126164 mRNA. Translation: AAI26165.1.
    X58489 Genomic DNA. Translation: CAA41399.1.
    CCDSiCCDS11097.1.
    PIRiA49158. A33801.
    RefSeqiNP_001033.1. NM_001042.2.
    UniGeneiHs.380691.

    Genome annotation databases

    EnsembliENST00000317370; ENSP00000320935; ENSG00000181856.
    ENST00000572485; ENSP00000461086; ENSG00000181856.
    GeneIDi6517.
    KEGGihsa:6517.
    UCSCiuc002gfp.3. human.

    Polymorphism databases

    DMDMi121761.

    Keywords - Coding sequence diversityi

    Alternative splicing, Polymorphism

    Cross-referencesi

    Web resourcesi

    Wikipedia

    GLUT4 entry

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    M20747 mRNA. Translation: AAA59189.1 .
    M91463 Genomic DNA. Translation: AAA52569.1 .
    AC003688 Genomic DNA. No translation available.
    BC034387 mRNA. Translation: AAH34387.1 .
    BC069615 mRNA. Translation: AAH69615.1 .
    BC069621 mRNA. Translation: AAH69621.1 .
    BC113592 mRNA. Translation: AAI13593.1 .
    BC126164 mRNA. Translation: AAI26165.1 .
    X58489 Genomic DNA. Translation: CAA41399.1 .
    CCDSi CCDS11097.1.
    PIRi A49158. A33801.
    RefSeqi NP_001033.1. NM_001042.2.
    UniGenei Hs.380691.

    3D structure databases

    ProteinModelPortali P14672.
    SMRi P14672. Positions 31-481.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 112408. 37 interactions.
    IntActi P14672. 1 interaction.
    MINTi MINT-232088.
    STRINGi 9606.ENSP00000320935.

    Chemistry

    ChEMBLi CHEMBL5874.
    GuidetoPHARMACOLOGYi 878.

    Protein family/group databases

    TCDBi 2.A.1.1.80. the major facilitator superfamily (mfs).

    PTM databases

    PhosphoSitei P14672.

    Polymorphism databases

    DMDMi 121761.

    Proteomic databases

    PaxDbi P14672.
    PRIDEi P14672.

    Protocols and materials databases

    DNASUi 6517.
    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000317370 ; ENSP00000320935 ; ENSG00000181856 .
    ENST00000572485 ; ENSP00000461086 ; ENSG00000181856 .
    GeneIDi 6517.
    KEGGi hsa:6517.
    UCSCi uc002gfp.3. human.

    Organism-specific databases

    CTDi 6517.
    GeneCardsi GC17P007186.
    HGNCi HGNC:11009. SLC2A4.
    HPAi CAB016544.
    MIMi 125853. phenotype.
    138190. gene.
    neXtProti NX_P14672.
    PharmGKBi PA35879.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi COG0477.
    HOGENOMi HOG000202871.
    HOVERGENi HBG014816.
    InParanoidi P14672.
    KOi K07191.
    OMAi AMLVNNI.
    PhylomeDBi P14672.
    TreeFami TF313762.

    Enzyme and pathway databases

    Reactomei REACT_147867. Translocation of GLUT4 to the plasma membrane.
    REACT_19343. Facilitative Na+-independent glucose transporters.
    REACT_212. Glucose transport.
    REACT_27161. Transcriptional regulation of white adipocyte differentiation.

    Miscellaneous databases

    GeneWikii GLUT4.
    GenomeRNAii 6517.
    NextBioi 25341.
    PROi P14672.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi P14672.
    Bgeei P14672.
    CleanExi HS_SLC2A4.
    Genevestigatori P14672.

    Family and domain databases

    InterProi IPR002441. Glc_transpt_4.
    IPR020846. MFS_dom.
    IPR016196. MFS_dom_general_subst_transpt.
    IPR005828. Sub_transporter.
    IPR003663. Sugar/inositol_transpt.
    IPR005829. Sugar_transporter_CS.
    [Graphical view ]
    Pfami PF00083. Sugar_tr. 1 hit.
    [Graphical view ]
    PRINTSi PR01193. GLUCTRSPORT4.
    PR00171. SUGRTRNSPORT.
    SUPFAMi SSF103473. SSF103473. 1 hit.
    TIGRFAMsi TIGR00879. SP. 1 hit.
    PROSITEi PS50850. MFS. 1 hit.
    PS00216. SUGAR_TRANSPORT_1. 1 hit.
    PS00217. SUGAR_TRANSPORT_2. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Cloning and characterization of the major insulin-responsive glucose transporter expressed in human skeletal muscle and other insulin-responsive tissues."
      Fukumoto H., Kayano T., Buse J.B., Edwards Y., Pilch P.F., Bell G.I., Seino S.
      J. Biol. Chem. 264:7776-7779(1989) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
    2. "Human GLUT4/muscle-fat glucose-transporter gene. Characterization and genetic variation."
      Buse J.B., Yasuda K., Lay T.P., Seo T.S., Olson A.L., Pessin J.E., Karam J.H., Seino S., Bell G.I.
      Diabetes 41:1436-1445(1992) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], VARIANT THR-385.
    3. "DNA sequence of human chromosome 17 and analysis of rearrangement in the human lineage."
      Zody M.C., Garber M., Adams D.J., Sharpe T., Harrow J., Lupski J.R., Nicholson C., Searle S.M., Wilming L., Young S.K., Abouelleil A., Allen N.R., Bi W., Bloom T., Borowsky M.L., Bugalter B.E., Butler J., Chang J.L.
      , Chen C.-K., Cook A., Corum B., Cuomo C.A., de Jong P.J., DeCaprio D., Dewar K., FitzGerald M., Gilbert J., Gibson R., Gnerre S., Goldstein S., Grafham D.V., Grocock R., Hafez N., Hagopian D.S., Hart E., Norman C.H., Humphray S., Jaffe D.B., Jones M., Kamal M., Khodiyar V.K., LaButti K., Laird G., Lehoczky J., Liu X., Lokyitsang T., Loveland J., Lui A., Macdonald P., Major J.E., Matthews L., Mauceli E., McCarroll S.A., Mihalev A.H., Mudge J., Nguyen C., Nicol R., O'Leary S.B., Osoegawa K., Schwartz D.C., Shaw-Smith C., Stankiewicz P., Steward C., Swarbreck D., Venkataraman V., Whittaker C.A., Yang X., Zimmer A.R., Bradley A., Hubbard T., Birren B.W., Rogers J., Lander E.S., Nusbaum C.
      Nature 440:1045-1049(2006) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2).
      Tissue: Colon.
    5. "Identification of the 5' end of the gene encoding a human insulin-responsive glucose transporter."
      Chiaramonte R., Martini R., Taramelli R., Comi P.
      Gene 130:307-308(1993) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 1-11.
    6. "A Leu-Leu sequence is essential for COOH-terminal targeting signal of GLUT4 glucose transporter in fibroblasts."
      Verhey K.J., Birnbaum M.J.
      J. Biol. Chem. 269:2353-2356(1994) [PubMed] [Europe PMC] [Abstract]
      Cited for: SUBCELLULAR LOCATION, MUTAGENESIS OF 489-LEU-LEU-490.
    7. "The insulin-sensitive glucose transporter, GLUT4, interacts physically with Daxx. Two proteins with capacity to bind Ubc9 and conjugated to SUMO1."
      Lalioti V.S., Vergarajauregui S., Pulido D., Sandoval I.V.
      J. Biol. Chem. 277:19783-19791(2002) [PubMed] [Europe PMC] [Abstract]
      Cited for: INTERACTION WITH DAXX, SUMOYLATION.
    8. "Identification and characterization of p49/STRAP as a novel GLUT4-binding protein."
      Lisinski I., Matsumoto H., Yver D.R., Schuermann A., Cushman S.W., Al-Hasani H.
      Biochem. Biophys. Res. Commun. 344:1179-1185(2006) [PubMed] [Europe PMC] [Abstract]
      Cited for: INTERACTION WITH SRFBP1.
    9. "Role of SGK1 kinase in regulating glucose transport via glucose transporter GLUT4."
      Jeyaraj S., Boehmer C., Lang F., Palmada M.
      Biochem. Biophys. Res. Commun. 356:629-635(2007) [PubMed] [Europe PMC] [Abstract]
      Cited for: PHOSPHORYLATION AT SER-274 BY SGK1.
    10. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
      Tissue: Cervix carcinoma.
    11. "Mass-spectrometric identification and relative quantification of N-linked cell surface glycoproteins."
      Wollscheid B., Bausch-Fluck D., Henderson C., O'Brien R., Bibel M., Schiess R., Aebersold R., Watts J.D.
      Nat. Biotechnol. 27:378-386(2009) [PubMed] [Europe PMC] [Abstract]
      Cited for: GLYCOSYLATION [LARGE SCALE ANALYSIS] AT ASN-57.
      Tissue: Leukemic T-cell.
    12. "Analysis of the gene sequences of the insulin receptor and the insulin-sensitive glucose transporter (GLUT-4) in patients with common-type non-insulin-dependent diabetes mellitus."
      Kusari J., Verma U.S., Buse J.B., Henry R.R., Olefsky J.M.
      J. Clin. Invest. 88:1323-1330(1991) [PubMed] [Europe PMC] [Abstract]
      Cited for: VARIANT NIDDM ILE-383.
    13. "Molecular scanning of insulin-responsive glucose transporter (GLUT4) gene in NIDDM subjects."
      Choi W.H., O'Rahilly S., Buse J.B., Rees A., Morgan R., Flier J.S., Moller D.E.
      Diabetes 40:1712-1718(1991) [PubMed] [Europe PMC] [Abstract]
      Cited for: VARIANT NIDDM ILE-383.
    14. "Insulin receptor and insulin-responsive glucose transporter (GLUT 4) mutations and polymorphisms in a Welsh type 2 (non-insulin-dependent) diabetic population."
      O'Rahilly S., Krook A., Morgan R., Rees A., Flier J.S., Moller D.E.
      Diabetologia 35:486-489(1992) [PubMed] [Europe PMC] [Abstract]
      Cited for: VARIANT NIDDM ILE-383.

    Entry informationi

    Entry nameiGTR4_HUMAN
    AccessioniPrimary (citable) accession number: P14672
    Secondary accession number(s): Q05BQ3, Q14CX2
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: April 1, 1990
    Last sequence update: April 1, 1990
    Last modified: October 1, 2014
    This is version 173 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Miscellaneous

    Insulin-stimulated phosphorylation of TBC1D4 is required for GLUT4 translocation.By similarity

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Human chromosome 17
      Human chromosome 17: entries, gene names and cross-references to MIM
    2. Human entries with polymorphisms or disease mutations
      List of human entries with polymorphisms or disease mutations
    3. Human polymorphisms and disease mutations
      Index of human polymorphisms and disease mutations
    4. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    5. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3