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Protein

Solute carrier family 2, facilitated glucose transporter member 4

Gene

SLC2A4

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Insulin-regulated facilitative glucose transporter.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei333 – 3331MonosaccharideBy similarity
Binding sitei404 – 4041MonosaccharideBy similarity

GO - Molecular functioni

  1. D-glucose transmembrane transporter activity Source: Ensembl
  2. glucose transmembrane transporter activity Source: ProtInc

GO - Biological processi

  1. amylopectin biosynthetic process Source: Ensembl
  2. brown fat cell differentiation Source: Ensembl
  3. carbohydrate metabolic process Source: Reactome
  4. cellular response to hypoxia Source: Ensembl
  5. cellular response to insulin stimulus Source: UniProtKB
  6. cellular response to osmotic stress Source: Ensembl
  7. glucose homeostasis Source: BHF-UCL
  8. glucose import Source: BHF-UCL
  9. glucose transport Source: UniProtKB
  10. hexose transport Source: Reactome
  11. membrane organization Source: Reactome
  12. pathogenesis Source: Reactome
  13. response to ethanol Source: Ensembl
  14. small molecule metabolic process Source: Reactome
  15. transmembrane transport Source: Reactome
Complete GO annotation...

Keywords - Biological processi

Sugar transport, Transport

Enzyme and pathway databases

ReactomeiREACT_147867. Translocation of GLUT4 to the plasma membrane.
REACT_19343. Facilitative Na+-independent glucose transporters.
REACT_212. Glucose transport.
REACT_27161. Transcriptional regulation of white adipocyte differentiation.

Protein family/group databases

TCDBi2.A.1.1.80. the major facilitator superfamily (mfs).

Names & Taxonomyi

Protein namesi
Recommended name:
Solute carrier family 2, facilitated glucose transporter member 4
Alternative name(s):
Glucose transporter type 4, insulin-responsive
Short name:
GLUT-4
Gene namesi
Name:SLC2A4
Synonyms:GLUT4
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640 Componenti: Chromosome 17

Organism-specific databases

HGNCiHGNC:11009. SLC2A4.

Subcellular locationi

  1. Cell membrane By similarity; Multi-pass membrane protein By similarity
  2. Endomembrane system 1 Publication; Multi-pass membrane protein 1 Publication
  3. Cytoplasmperinuclear region 1 Publication

  4. Note: Localizes primarily to the perinuclear region, undergoing continued recycling to the plasma membrane where it is rapidly reinternalized. The dileucine internalization motif is critical for intracellular sequestration.

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 2424CytoplasmicSequence AnalysisAdd
BLAST
Transmembranei25 – 4521Helical; Name=1Sequence AnalysisAdd
BLAST
Topological domaini46 – 8136ExtracellularSequence AnalysisAdd
BLAST
Transmembranei82 – 10221Helical; Name=2Sequence AnalysisAdd
BLAST
Topological domaini103 – 1119CytoplasmicSequence Analysis
Transmembranei112 – 13221Helical; Name=3Sequence AnalysisAdd
BLAST
Topological domaini133 – 14210ExtracellularSequence Analysis
Transmembranei143 – 16321Helical; Name=4Sequence AnalysisAdd
BLAST
Topological domaini164 – 1718CytoplasmicSequence Analysis
Transmembranei172 – 19221Helical; Name=5Sequence AnalysisAdd
BLAST
Topological domaini193 – 2019ExtracellularSequence Analysis
Transmembranei202 – 22221Helical; Name=6Sequence AnalysisAdd
BLAST
Topological domaini223 – 28765CytoplasmicSequence AnalysisAdd
BLAST
Transmembranei288 – 30821Helical; Name=7Sequence AnalysisAdd
BLAST
Topological domaini309 – 32315ExtracellularSequence AnalysisAdd
BLAST
Transmembranei324 – 34421Helical; Name=8Sequence AnalysisAdd
BLAST
Topological domaini345 – 3539CytoplasmicSequence Analysis
Transmembranei354 – 37421Helical; Name=9Sequence AnalysisAdd
BLAST
Topological domaini375 – 38410ExtracellularSequence Analysis
Transmembranei385 – 40521Helical; Name=10Sequence AnalysisAdd
BLAST
Topological domaini406 – 41712CytoplasmicSequence AnalysisAdd
BLAST
Transmembranei418 – 43821Helical; Name=11Sequence AnalysisAdd
BLAST
Topological domaini439 – 4457ExtracellularSequence Analysis
Transmembranei446 – 46621Helical; Name=12Sequence AnalysisAdd
BLAST
Topological domaini467 – 50943CytoplasmicSequence AnalysisAdd
BLAST

GO - Cellular componenti

  1. clathrin-coated vesicle Source: UniProtKB
  2. coated pit Source: Ensembl
  3. cytosol Source: Ensembl
  4. endomembrane system Source: UniProtKB
  5. external side of plasma membrane Source: MGI
  6. extracellular vesicular exosome Source: Ensembl
  7. insulin-responsive compartment Source: UniProtKB
  8. integral component of plasma membrane Source: ProtInc
  9. membrane Source: ProtInc
  10. membrane raft Source: Ensembl
  11. multivesicular body Source: Ensembl
  12. perinuclear region of cytoplasm Source: UniProtKB
  13. plasma membrane Source: UniProtKB
  14. trans-Golgi network transport vesicle Source: Ensembl
  15. T-tubule Source: Ensembl
  16. vesicle membrane Source: MGI
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Cytoplasm, Membrane

Pathology & Biotechi

Involvement in diseasei

Diabetes mellitus, non-insulin-dependent (NIDDM)3 Publications

The disease may be caused by mutations affecting the gene represented in this entry.

Disease descriptionA multifactorial disorder of glucose homeostasis caused by a lack of sensitivity to the body's own insulin. Affected individuals usually have an obese body habitus and manifestations of a metabolic syndrome characterized by diabetes, insulin resistance, hypertension and hypertriglyceridemia. The disease results in long-term complications that affect the eyes, kidneys, nerves, and blood vessels.

See also OMIM:125853
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti383 – 3831V → I in NIDDM. 3 Publications
Corresponds to variant rs121434581 [ dbSNP | Ensembl ].
VAR_007170

Mutagenesis

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Mutagenesisi489 – 4902LL → AA: Changes subcellular location mainly to the plasma membrane. 1 Publication

Keywords - Diseasei

Diabetes mellitus, Disease mutation

Organism-specific databases

MIMi125853. phenotype.
PharmGKBiPA35879.

Polymorphism and mutation databases

BioMutaiSLC2A4.
DMDMi121761.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 509509Solute carrier family 2, facilitated glucose transporter member 4PRO_0000050363Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi57 – 571N-linked (GlcNAc...)1 Publication
Modified residuei274 – 2741Phosphoserine; by SGK11 Publication

Post-translational modificationi

Sumoylated.1 Publication

Keywords - PTMi

Glycoprotein, Phosphoprotein, Ubl conjugation

Proteomic databases

PaxDbiP14672.
PRIDEiP14672.

PTM databases

PhosphoSiteiP14672.

Expressioni

Tissue specificityi

Skeletal and cardiac muscles; brown and white fat.

Gene expression databases

BgeeiP14672.
CleanExiHS_SLC2A4.
ExpressionAtlasiP14672. baseline and differential.
GenevestigatoriP14672.

Organism-specific databases

HPAiCAB016544.

Interactioni

Subunit structurei

Interacts with NDUFA9 (By similarity). Binds to DAXX. Interacts via its N-terminus with SRFBP1.By similarity2 Publications

Protein-protein interaction databases

BioGridi112408. 40 interactions.
IntActiP14672. 2 interactions.
MINTiMINT-232088.
STRINGi9606.ENSP00000320935.

Structurei

3D structure databases

ProteinModelPortaliP14672.
SMRiP14672. Positions 21-471.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni7 – 137SRFBP1-binding
Regioni298 – 3047Monosaccharide bindingBy similarity

Motif

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Motifi489 – 4902Dileucine internalization motif

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiCOG0477.
GeneTreeiENSGT00760000119022.
HOGENOMiHOG000202871.
HOVERGENiHBG014816.
InParanoidiP14672.
KOiK07191.
OMAiAMLVNNI.
PhylomeDBiP14672.
TreeFamiTF313762.

Family and domain databases

InterProiIPR002441. Glc_transpt_4.
IPR020846. MFS_dom.
IPR005828. Sub_transporter.
IPR003663. Sugar/inositol_transpt.
IPR005829. Sugar_transporter_CS.
[Graphical view]
PfamiPF00083. Sugar_tr. 1 hit.
[Graphical view]
PRINTSiPR01193. GLUCTRSPORT4.
PR00171. SUGRTRNSPORT.
SUPFAMiSSF103473. SSF103473. 1 hit.
TIGRFAMsiTIGR00879. SP. 1 hit.
PROSITEiPS50850. MFS. 1 hit.
PS00216. SUGAR_TRANSPORT_1. 1 hit.
PS00217. SUGAR_TRANSPORT_2. 1 hit.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: P14672-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MPSGFQQIGS EDGEPPQQRV TGTLVLAVFS AVLGSLQFGY NIGVINAPQK
60 70 80 90 100
VIEQSYNETW LGRQGPEGPS SIPPGTLTTL WALSVAIFSV GGMISSFLIG
110 120 130 140 150
IISQWLGRKR AMLVNNVLAV LGGSLMGLAN AAASYEMLIL GRFLIGAYSG
160 170 180 190 200
LTSGLVPMYV GEIAPTHLRG ALGTLNQLAI VIGILIAQVL GLESLLGTAS
210 220 230 240 250
LWPLLLGLTV LPALLQLVLL PFCPESPRYL YIIQNLEGPA RKSLKRLTGW
260 270 280 290 300
ADVSGVLAEL KDEKRKLERE RPLSLLQLLG SRTHRQPLII AVVLQLSQQL
310 320 330 340 350
SGINAVFYYS TSIFETAGVG QPAYATIGAG VVNTVFTLVS VLLVERAGRR
360 370 380 390 400
TLHLLGLAGM CGCAILMTVA LLLLERVPAM SYVSIVAIFG FVAFFEIGPG
410 420 430 440 450
PIPWFIVAEL FSQGPRPAAM AVAGFSNWTS NFIIGMGFQY VAEAMGPYVF
460 470 480 490 500
LLFAVLLLGF FIFTFLRVPE TRGRTFDQIS AAFHRTPSLL EQEVKPSTEL

EYLGPDEND
Length:509
Mass (Da):54,787
Last modified:April 1, 1990 - v1
Checksum:i8E20CD97562C1EBF
GO
Isoform 2 (identifier: P14672-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     342-415: LLVERAGRRT...IVAELFSQGP → TAHLWNGPSH...CGHLWLRGIF
     416-509: Missing.

Note: No experimental confirmation available.

Show »
Length:415
Mass (Da):43,760
Checksum:iA46E00FD028AA5BE
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti151 – 1544Missing in AAA52569 (PubMed:1397719).Curated

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti55 – 551S → R.
Corresponds to variant rs35198331 [ dbSNP | Ensembl ].
VAR_052503
Natural varianti78 – 781T → S.
Corresponds to variant rs5434 [ dbSNP | Ensembl ].
VAR_012060
Natural varianti358 – 3581A → V.
Corresponds to variant rs8192702 [ dbSNP | Ensembl ].
VAR_020336
Natural varianti383 – 3831V → I in NIDDM. 3 Publications
Corresponds to variant rs121434581 [ dbSNP | Ensembl ].
VAR_007170
Natural varianti385 – 3851I → T.1 Publication
VAR_007171

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei342 – 41574LLVER…FSQGP → TAHLWNGPSHWLHLPGCPGG VVGGAGGAPDAPSPGPGGHV WLCHPDDCGSAPAGASSSHE LRLHCGHLWLRGIF in isoform 2. 1 PublicationVSP_056331Add
BLAST
Alternative sequencei416 – 50994Missing in isoform 2. 1 PublicationVSP_056332Add
BLAST

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M20747 mRNA. Translation: AAA59189.1.
M91463 Genomic DNA. Translation: AAA52569.1.
AC003688 Genomic DNA. No translation available.
BC034387 mRNA. Translation: AAH34387.1.
BC069615 mRNA. Translation: AAH69615.1.
BC069621 mRNA. Translation: AAH69621.1.
BC113592 mRNA. Translation: AAI13593.1.
BC126164 mRNA. Translation: AAI26165.1.
X58489 Genomic DNA. Translation: CAA41399.1.
CCDSiCCDS11097.1. [P14672-1]
PIRiA49158. A33801.
RefSeqiNP_001033.1. NM_001042.2. [P14672-1]
UniGeneiHs.380691.

Genome annotation databases

EnsembliENST00000317370; ENSP00000320935; ENSG00000181856. [P14672-1]
ENST00000572485; ENSP00000461086; ENSG00000181856. [P14672-2]
GeneIDi6517.
KEGGihsa:6517.
UCSCiuc002gfp.3. human. [P14672-1]

Polymorphism and mutation databases

BioMutaiSLC2A4.

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Web resourcesi

Wikipedia

GLUT4 entry

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M20747 mRNA. Translation: AAA59189.1.
M91463 Genomic DNA. Translation: AAA52569.1.
AC003688 Genomic DNA. No translation available.
BC034387 mRNA. Translation: AAH34387.1.
BC069615 mRNA. Translation: AAH69615.1.
BC069621 mRNA. Translation: AAH69621.1.
BC113592 mRNA. Translation: AAI13593.1.
BC126164 mRNA. Translation: AAI26165.1.
X58489 Genomic DNA. Translation: CAA41399.1.
CCDSiCCDS11097.1. [P14672-1]
PIRiA49158. A33801.
RefSeqiNP_001033.1. NM_001042.2. [P14672-1]
UniGeneiHs.380691.

3D structure databases

ProteinModelPortaliP14672.
SMRiP14672. Positions 21-471.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi112408. 40 interactions.
IntActiP14672. 2 interactions.
MINTiMINT-232088.
STRINGi9606.ENSP00000320935.

Chemistry

ChEMBLiCHEMBL5874.
GuidetoPHARMACOLOGYi878.

Protein family/group databases

TCDBi2.A.1.1.80. the major facilitator superfamily (mfs).

PTM databases

PhosphoSiteiP14672.

Polymorphism and mutation databases

BioMutaiSLC2A4.
DMDMi121761.

Proteomic databases

PaxDbiP14672.
PRIDEiP14672.

Protocols and materials databases

DNASUi6517.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000317370; ENSP00000320935; ENSG00000181856. [P14672-1]
ENST00000572485; ENSP00000461086; ENSG00000181856. [P14672-2]
GeneIDi6517.
KEGGihsa:6517.
UCSCiuc002gfp.3. human. [P14672-1]

Organism-specific databases

CTDi6517.
GeneCardsiGC17P007186.
HGNCiHGNC:11009. SLC2A4.
HPAiCAB016544.
MIMi125853. phenotype.
138190. gene.
neXtProtiNX_P14672.
PharmGKBiPA35879.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiCOG0477.
GeneTreeiENSGT00760000119022.
HOGENOMiHOG000202871.
HOVERGENiHBG014816.
InParanoidiP14672.
KOiK07191.
OMAiAMLVNNI.
PhylomeDBiP14672.
TreeFamiTF313762.

Enzyme and pathway databases

ReactomeiREACT_147867. Translocation of GLUT4 to the plasma membrane.
REACT_19343. Facilitative Na+-independent glucose transporters.
REACT_212. Glucose transport.
REACT_27161. Transcriptional regulation of white adipocyte differentiation.

Miscellaneous databases

GeneWikiiGLUT4.
GenomeRNAii6517.
NextBioi25341.
PROiP14672.
SOURCEiSearch...

Gene expression databases

BgeeiP14672.
CleanExiHS_SLC2A4.
ExpressionAtlasiP14672. baseline and differential.
GenevestigatoriP14672.

Family and domain databases

InterProiIPR002441. Glc_transpt_4.
IPR020846. MFS_dom.
IPR005828. Sub_transporter.
IPR003663. Sugar/inositol_transpt.
IPR005829. Sugar_transporter_CS.
[Graphical view]
PfamiPF00083. Sugar_tr. 1 hit.
[Graphical view]
PRINTSiPR01193. GLUCTRSPORT4.
PR00171. SUGRTRNSPORT.
SUPFAMiSSF103473. SSF103473. 1 hit.
TIGRFAMsiTIGR00879. SP. 1 hit.
PROSITEiPS50850. MFS. 1 hit.
PS00216. SUGAR_TRANSPORT_1. 1 hit.
PS00217. SUGAR_TRANSPORT_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Cloning and characterization of the major insulin-responsive glucose transporter expressed in human skeletal muscle and other insulin-responsive tissues."
    Fukumoto H., Kayano T., Buse J.B., Edwards Y., Pilch P.F., Bell G.I., Seino S.
    J. Biol. Chem. 264:7776-7779(1989) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
  2. "Human GLUT4/muscle-fat glucose-transporter gene. Characterization and genetic variation."
    Buse J.B., Yasuda K., Lay T.P., Seo T.S., Olson A.L., Pessin J.E., Karam J.H., Seino S., Bell G.I.
    Diabetes 41:1436-1445(1992) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], VARIANT THR-385.
  3. "DNA sequence of human chromosome 17 and analysis of rearrangement in the human lineage."
    Zody M.C., Garber M., Adams D.J., Sharpe T., Harrow J., Lupski J.R., Nicholson C., Searle S.M., Wilming L., Young S.K., Abouelleil A., Allen N.R., Bi W., Bloom T., Borowsky M.L., Bugalter B.E., Butler J., Chang J.L.
    , Chen C.-K., Cook A., Corum B., Cuomo C.A., de Jong P.J., DeCaprio D., Dewar K., FitzGerald M., Gilbert J., Gibson R., Gnerre S., Goldstein S., Grafham D.V., Grocock R., Hafez N., Hagopian D.S., Hart E., Norman C.H., Humphray S., Jaffe D.B., Jones M., Kamal M., Khodiyar V.K., LaButti K., Laird G., Lehoczky J., Liu X., Lokyitsang T., Loveland J., Lui A., Macdonald P., Major J.E., Matthews L., Mauceli E., McCarroll S.A., Mihalev A.H., Mudge J., Nguyen C., Nicol R., O'Leary S.B., Osoegawa K., Schwartz D.C., Shaw-Smith C., Stankiewicz P., Steward C., Swarbreck D., Venkataraman V., Whittaker C.A., Yang X., Zimmer A.R., Bradley A., Hubbard T., Birren B.W., Rogers J., Lander E.S., Nusbaum C.
    Nature 440:1045-1049(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2).
    Tissue: Colon.
  5. "Identification of the 5' end of the gene encoding a human insulin-responsive glucose transporter."
    Chiaramonte R., Martini R., Taramelli R., Comi P.
    Gene 130:307-308(1993) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 1-11.
  6. "A Leu-Leu sequence is essential for COOH-terminal targeting signal of GLUT4 glucose transporter in fibroblasts."
    Verhey K.J., Birnbaum M.J.
    J. Biol. Chem. 269:2353-2356(1994) [PubMed] [Europe PMC] [Abstract]
    Cited for: SUBCELLULAR LOCATION, MUTAGENESIS OF 489-LEU-LEU-490.
  7. "The insulin-sensitive glucose transporter, GLUT4, interacts physically with Daxx. Two proteins with capacity to bind Ubc9 and conjugated to SUMO1."
    Lalioti V.S., Vergarajauregui S., Pulido D., Sandoval I.V.
    J. Biol. Chem. 277:19783-19791(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: INTERACTION WITH DAXX, SUMOYLATION.
  8. "Identification and characterization of p49/STRAP as a novel GLUT4-binding protein."
    Lisinski I., Matsumoto H., Yver D.R., Schuermann A., Cushman S.W., Al-Hasani H.
    Biochem. Biophys. Res. Commun. 344:1179-1185(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: INTERACTION WITH SRFBP1.
  9. "Role of SGK1 kinase in regulating glucose transport via glucose transporter GLUT4."
    Jeyaraj S., Boehmer C., Lang F., Palmada M.
    Biochem. Biophys. Res. Commun. 356:629-635(2007) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION AT SER-274 BY SGK1.
  10. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Cervix carcinoma.
  11. "Mass-spectrometric identification and relative quantification of N-linked cell surface glycoproteins."
    Wollscheid B., Bausch-Fluck D., Henderson C., O'Brien R., Bibel M., Schiess R., Aebersold R., Watts J.D.
    Nat. Biotechnol. 27:378-386(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: GLYCOSYLATION [LARGE SCALE ANALYSIS] AT ASN-57.
    Tissue: Leukemic T-cell.
  12. "Analysis of the gene sequences of the insulin receptor and the insulin-sensitive glucose transporter (GLUT-4) in patients with common-type non-insulin-dependent diabetes mellitus."
    Kusari J., Verma U.S., Buse J.B., Henry R.R., Olefsky J.M.
    J. Clin. Invest. 88:1323-1330(1991) [PubMed] [Europe PMC] [Abstract]
    Cited for: VARIANT NIDDM ILE-383.
  13. "Molecular scanning of insulin-responsive glucose transporter (GLUT4) gene in NIDDM subjects."
    Choi W.H., O'Rahilly S., Buse J.B., Rees A., Morgan R., Flier J.S., Moller D.E.
    Diabetes 40:1712-1718(1991) [PubMed] [Europe PMC] [Abstract]
    Cited for: VARIANT NIDDM ILE-383.
  14. "Insulin receptor and insulin-responsive glucose transporter (GLUT 4) mutations and polymorphisms in a Welsh type 2 (non-insulin-dependent) diabetic population."
    O'Rahilly S., Krook A., Morgan R., Rees A., Flier J.S., Moller D.E.
    Diabetologia 35:486-489(1992) [PubMed] [Europe PMC] [Abstract]
    Cited for: VARIANT NIDDM ILE-383.

Entry informationi

Entry nameiGTR4_HUMAN
AccessioniPrimary (citable) accession number: P14672
Secondary accession number(s): Q05BQ3, Q14CX2
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 1, 1990
Last sequence update: April 1, 1990
Last modified: April 29, 2015
This is version 179 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Miscellaneous

Insulin-stimulated phosphorylation of TBC1D4 is required for GLUT4 translocation.By similarity

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 17
    Human chromosome 17: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.