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Protein

Annexin A3

Gene

Anxa3

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Inhibitor of phospholipase A2, also possesses anti-coagulant properties.

GO - Molecular functioni

  • calcium-dependent phospholipid binding Source: RGD
  • calcium ion binding Source: InterPro
  • phospholipase A2 inhibitor activity Source: RGD

GO - Biological processi

  • defense response to bacterium Source: Ensembl
  • hippocampus development Source: RGD
  • negative regulation of catalytic activity Source: GOC
  • neutrophil degranulation Source: Ensembl
  • organ regeneration Source: RGD
  • phagocytosis Source: Ensembl
  • positive regulation of angiogenesis Source: Ensembl
  • positive regulation of DNA metabolic process Source: RGD
  • positive regulation of endothelial cell migration Source: Ensembl
  • positive regulation of sequence-specific DNA binding transcription factor activity Source: Ensembl
  • response to glucocorticoid Source: RGD
  • response to growth factor Source: RGD
Complete GO annotation...

Keywords - Molecular functioni

Phospholipase A2 inhibitor

Keywords - Ligandi

Calcium, Calcium/phospholipid-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Annexin A3
Alternative name(s):
35-alpha calcimedin
Annexin III
Annexin-3
Lipocortin III
Placental anticoagulant protein III
Short name:
PAP-III
Gene namesi
Name:Anxa3
Synonyms:Anx3
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Chromosome 14

Organism-specific databases

RGDi2119. Anxa3.

Subcellular locationi

GO - Cellular componenti

  • axon Source: RGD
  • dendrite Source: RGD
  • extracellular exosome Source: Ensembl
  • neuronal cell body Source: RGD
  • phagocytic vesicle membrane Source: Ensembl
  • plasma membrane Source: Ensembl
  • specific granule Source: Ensembl
Complete GO annotation...

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 324324Annexin A3PRO_0000067479Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei178 – 1781N6-acetyllysineBy similarity
Modified residuei268 – 2681PhosphothreonineCombined sources

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

PaxDbiP14669.
PRIDEiP14669.

2D gel databases

World-2DPAGE0004:P14669.

PTM databases

iPTMnetiP14669.
PhosphoSiteiP14669.

Expressioni

Gene expression databases

ExpressionAtlasiP14669. baseline and differential.
GenevisibleiP14669. RN.

Interactioni

Protein-protein interaction databases

MINTiMINT-4542642.
STRINGi10116.ENSRNOP00000063496.

Structurei

3D structure databases

ProteinModelPortaliP14669.
SMRiP14669. Positions 2-324.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Repeati28 – 8861Annexin 1Add
BLAST
Repeati100 – 16061Annexin 2Add
BLAST
Repeati184 – 24461Annexin 3Add
BLAST
Repeati259 – 31961Annexin 4Add
BLAST

Domaini

A pair of annexin repeats may form one binding site for calcium and phospholipid.

Sequence similaritiesi

Belongs to the annexin family.Curated
Contains 4 annexin repeats.Curated

Keywords - Domaini

Annexin, Repeat

Phylogenomic databases

eggNOGiKOG0819. Eukaryota.
ENOG410XPUN. LUCA.
GeneTreeiENSGT00760000118972.
HOGENOMiHOG000158803.
HOVERGENiHBG061815.
InParanoidiP14669.
KOiK17089.
PhylomeDBiP14669.

Family and domain databases

Gene3Di1.10.220.10. 4 hits.
InterProiIPR001464. Annexin.
IPR018502. Annexin_repeat.
IPR018252. Annexin_repeat_CS.
IPR002390. AnnexinIII.
[Graphical view]
PANTHERiPTHR10502:SF25. PTHR10502:SF25. 1 hit.
PfamiPF00191. Annexin. 4 hits.
[Graphical view]
PRINTSiPR00196. ANNEXIN.
PR00199. ANNEXINIII.
SMARTiSM00335. ANX. 4 hits.
[Graphical view]
PROSITEiPS00223. ANNEXIN. 4 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P14669-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAASLWVGPR GTINNYPGFN PSVDAEAIRK AIKGIGTDEK TLINILTERS
60 70 80 90 100
NAQRQLIVKQ YQEAYEQALK ADLKGDLSGH FEHVMVALIT APAVFDAKQL
110 120 130 140 150
KKSMRGMGTD EDTLIEILTT RTSRQMKEIS QAYYTAYKKN LRDDISSETS
160 170 180 190 200
GDFRKALLTL ADGGRDESLK VDEHLAKKDA QTLYDAGEKK WGTDEDKFTE
210 220 230 240 250
ILCLRSFPQL KLTFDEYRNI SQKDIEDSIK GELSGHFEDL LLAVVRCTRN
260 270 280 290 300
TPAFLAGRLH QALKGAGTDE FTLNRIMVSR SEIDLLDIRR EFKKHYGCSL
310 320
YSAIQSDTSG DYRTVLLKIC GGDD
Length:324
Mass (Da):36,363
Last modified:January 23, 2007 - v4
Checksum:iAD10CBB301A01E41
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti60 – 612QY → HI in AAA41511 (PubMed:2968983).Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M20559 mRNA. Translation: AAA41511.1.
BC081856 mRNA. Translation: AAH81856.1.
PIRiA29250. LURT3.
RefSeqiNP_036955.2. NM_012823.2.
XP_006250756.1. XM_006250694.2.
XP_006250758.1. XM_006250696.2.
UniGeneiRn.6589.

Genome annotation databases

EnsembliENSRNOT00000068134; ENSRNOP00000063496; ENSRNOG00000002045.
GeneIDi25291.
KEGGirno:25291.
UCSCiRGD:2119. rat.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M20559 mRNA. Translation: AAA41511.1.
BC081856 mRNA. Translation: AAH81856.1.
PIRiA29250. LURT3.
RefSeqiNP_036955.2. NM_012823.2.
XP_006250756.1. XM_006250694.2.
XP_006250758.1. XM_006250696.2.
UniGeneiRn.6589.

3D structure databases

ProteinModelPortaliP14669.
SMRiP14669. Positions 2-324.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

MINTiMINT-4542642.
STRINGi10116.ENSRNOP00000063496.

PTM databases

iPTMnetiP14669.
PhosphoSiteiP14669.

2D gel databases

World-2DPAGE0004:P14669.

Proteomic databases

PaxDbiP14669.
PRIDEiP14669.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSRNOT00000068134; ENSRNOP00000063496; ENSRNOG00000002045.
GeneIDi25291.
KEGGirno:25291.
UCSCiRGD:2119. rat.

Organism-specific databases

CTDi306.
RGDi2119. Anxa3.

Phylogenomic databases

eggNOGiKOG0819. Eukaryota.
ENOG410XPUN. LUCA.
GeneTreeiENSGT00760000118972.
HOGENOMiHOG000158803.
HOVERGENiHBG061815.
InParanoidiP14669.
KOiK17089.
PhylomeDBiP14669.

Miscellaneous databases

PROiP14669.

Gene expression databases

ExpressionAtlasiP14669. baseline and differential.
GenevisibleiP14669. RN.

Family and domain databases

Gene3Di1.10.220.10. 4 hits.
InterProiIPR001464. Annexin.
IPR018502. Annexin_repeat.
IPR018252. Annexin_repeat_CS.
IPR002390. AnnexinIII.
[Graphical view]
PANTHERiPTHR10502:SF25. PTHR10502:SF25. 1 hit.
PfamiPF00191. Annexin. 4 hits.
[Graphical view]
PRINTSiPR00196. ANNEXIN.
PR00199. ANNEXINIII.
SMARTiSM00335. ANX. 4 hits.
[Graphical view]
PROSITEiPS00223. ANNEXIN. 4 hits.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Five distinct calcium and phospholipid binding proteins share homology with lipocortin I."
    Pepinsky R.B., Tizard R., Mattaliano R.J., Sinclair L.K., Miller G.T., Browning J.L., Chow E.P., Burne C., Huang K.-S., Pratt D., Wachter L., Hession C., Frey A.Z., Wallner B.P.
    J. Biol. Chem. 263:10799-10811(1988) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
  2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Heart.
  3. Lubec G., Afjehi-Sadat L., Chen W.-Q.
    Submitted (APR-2007) to UniProtKB
    Cited for: PROTEIN SEQUENCE OF 41-49; 191-205; 231-246 AND 295-313, IDENTIFICATION BY MASS SPECTROMETRY.
    Strain: Sprague-Dawley.
    Tissue: Hippocampus and Spinal cord.
  4. "Quantitative maps of protein phosphorylation sites across 14 different rat organs and tissues."
    Lundby A., Secher A., Lage K., Nordsborg N.B., Dmytriyev A., Lundby C., Olsen J.V.
    Nat. Commun. 3:876-876(2012) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT THR-268, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].

Entry informationi

Entry nameiANXA3_RAT
AccessioniPrimary (citable) accession number: P14669
Secondary accession number(s): Q642C2
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 1, 1990
Last sequence update: January 23, 2007
Last modified: June 8, 2016
This is version 127 of the entry and version 4 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.