Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Annexin A3

Gene

Anxa3

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Inhibitor of phospholipase A2, also possesses anti-coagulant properties.

GO - Molecular functioni

  • calcium-dependent phospholipid binding Source: RGD
  • calcium-dependent protein binding Source: Ensembl
  • calcium ion binding Source: InterPro
  • phospholipase A2 inhibitor activity Source: RGD

GO - Biological processi

  • animal organ regeneration Source: RGD
  • defense response to bacterium Source: Ensembl
  • hippocampus development Source: RGD
  • neutrophil degranulation Source: Ensembl
  • phagocytosis Source: Ensembl
  • positive regulation of angiogenesis Source: Ensembl
  • positive regulation of DNA binding transcription factor activity Source: Ensembl
  • positive regulation of DNA metabolic process Source: RGD
  • positive regulation of endothelial cell migration Source: Ensembl
  • response to glucocorticoid Source: RGD
  • response to growth factor Source: RGD

Keywordsi

Molecular functionPhospholipase A2 inhibitor
LigandCalcium, Calcium/phospholipid-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Annexin A3
Alternative name(s):
35-alpha calcimedin
Annexin III
Annexin-3
Lipocortin III
Placental anticoagulant protein III
Short name:
PAP-III
Gene namesi
Name:Anxa3
Synonyms:Anx3
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeRattus
Proteomesi

Organism-specific databases

RGDi2119 Anxa3

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000674791 – 324Annexin A3Add BLAST324

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei178N6-acetyllysineBy similarity1
Modified residuei268PhosphothreonineCombined sources1

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

PaxDbiP14669
PRIDEiP14669

2D gel databases

World-2DPAGEi0004:P14669

PTM databases

iPTMnetiP14669
PhosphoSitePlusiP14669

Expressioni

Gene expression databases

BgeeiENSRNOG00000002045
ExpressionAtlasiP14669 baseline and differential
GenevisibleiP14669 RN

Interactioni

GO - Molecular functioni

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000063496

Structurei

3D structure databases

ProteinModelPortaliP14669
SMRiP14669
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Repeati28 – 88Annexin 1Add BLAST61
Repeati100 – 160Annexin 2Add BLAST61
Repeati184 – 244Annexin 3Add BLAST61
Repeati259 – 319Annexin 4Add BLAST61

Domaini

A pair of annexin repeats may form one binding site for calcium and phospholipid.

Sequence similaritiesi

Belongs to the annexin family.Curated

Keywords - Domaini

Annexin, Repeat

Phylogenomic databases

eggNOGiKOG0819 Eukaryota
ENOG410XPUN LUCA
GeneTreeiENSGT00760000118972
HOGENOMiHOG000158803
HOVERGENiHBG061815
InParanoidiP14669
KOiK17089
OMAiCLRSFPQ
OrthoDBiEOG091G0H6H
PhylomeDBiP14669

Family and domain databases

Gene3Di1.10.220.10, 4 hits
InterProiView protein in InterPro
IPR001464 Annexin
IPR018502 Annexin_repeat
IPR018252 Annexin_repeat_CS
IPR037104 Annexin_sf
IPR002390 ANX3
PANTHERiPTHR10502:SF25 PTHR10502:SF25, 1 hit
PfamiView protein in Pfam
PF00191 Annexin, 4 hits
PRINTSiPR00196 ANNEXIN
PR00199 ANNEXINIII
SMARTiView protein in SMART
SM00335 ANX, 4 hits
PROSITEiView protein in PROSITE
PS00223 ANNEXIN, 4 hits

Sequencei

Sequence statusi: Complete.

P14669-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAASLWVGPR GTINNYPGFN PSVDAEAIRK AIKGIGTDEK TLINILTERS
60 70 80 90 100
NAQRQLIVKQ YQEAYEQALK ADLKGDLSGH FEHVMVALIT APAVFDAKQL
110 120 130 140 150
KKSMRGMGTD EDTLIEILTT RTSRQMKEIS QAYYTAYKKN LRDDISSETS
160 170 180 190 200
GDFRKALLTL ADGGRDESLK VDEHLAKKDA QTLYDAGEKK WGTDEDKFTE
210 220 230 240 250
ILCLRSFPQL KLTFDEYRNI SQKDIEDSIK GELSGHFEDL LLAVVRCTRN
260 270 280 290 300
TPAFLAGRLH QALKGAGTDE FTLNRIMVSR SEIDLLDIRR EFKKHYGCSL
310 320
YSAIQSDTSG DYRTVLLKIC GGDD
Length:324
Mass (Da):36,363
Last modified:January 23, 2007 - v4
Checksum:iAD10CBB301A01E41
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti60 – 61QY → HI in AAA41511 (PubMed:2968983).Curated2

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M20559 mRNA Translation: AAA41511.1
BC081856 mRNA Translation: AAH81856.1
PIRiA29250 LURT3
RefSeqiNP_036955.2, NM_012823.2
XP_006250756.1, XM_006250694.3
XP_006250758.1, XM_006250696.3
UniGeneiRn.6589

Genome annotation databases

EnsembliENSRNOT00000068134; ENSRNOP00000063496; ENSRNOG00000002045
GeneIDi25291
KEGGirno:25291
UCSCiRGD:2119 rat

Similar proteinsi

Entry informationi

Entry nameiANXA3_RAT
AccessioniPrimary (citable) accession number: P14669
Secondary accession number(s): Q642C2
Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 1, 1990
Last sequence update: January 23, 2007
Last modified: May 23, 2018
This is version 141 of the entry and version 4 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Cookie policy

We would like to use anonymized google analytics cookies to gather statistics on how uniprot.org is used in aggregate. Learn more

UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health