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P14657

- DHE4_UNKP

UniProt

P14657 - DHE4_UNKP

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Protein
NADP-specific glutamate dehydrogenase
Gene
gdhA
Organism
Unknown prokaryotic organism
Status
Reviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

Catalyzes the reversible oxidative deamination of glutamate to a-ketoglutarate and ammonia By similarity.

Catalytic activityi

L-glutamate + H2O + NADP+ = 2-oxoglutarate + NH3 + NADPH.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei92 – 921Substrate By similarity
Binding sitei113 – 1131Substrate By similarity
Binding sitei116 – 1161Substrate By similarity
Active sitei128 – 1281Proton donor By similarity
Binding sitei167 – 1671Substrate; via carbonyl oxygen By similarity
Sitei168 – 1681Important for catalysis By similarity
Binding sitei211 – 2111NADP By similarity
Binding sitei242 – 2421NADP By similarity
Binding sitei379 – 3791Substrate By similarity

GO - Molecular functioni

  1. glutamate dehydrogenase (NADP+) activity Source: UniProtKB

GO - Biological processi

  1. glutamate biosynthetic process Source: UniProtKB
Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Keywords - Ligandi

NADP

Names & Taxonomyi

Protein namesi
Recommended name:
NADP-specific glutamate dehydrogenase (EC:1.4.1.4)
Short name:
NADP-GDH
Gene namesi
Name:gdhA
OrganismiUnknown prokaryotic organism
Taxonomic identifieri2725 [NCBI]
Taxonomic lineageiBacteriaenvironmental samples

Subcellular locationi

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB
Complete GO annotation...

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 446446NADP-specific glutamate dehydrogenase
PRO_0000182778Add
BLAST

Proteomic databases

PRIDEiP14657.

Interactioni

Subunit structurei

Homohexamer By similarity.

Structurei

3D structure databases

ProteinModelPortaliP14657.
SMRiP14657. Positions 6-446.

Family & Domainsi

Sequence similaritiesi

Family and domain databases

Gene3Di3.40.50.720. 1 hit.
InterProiIPR006095. Glu/Leu/Phe/Val_DH.
IPR006096. Glu/Leu/Phe/Val_DH_C.
IPR006097. Glu/Leu/Phe/Val_DH_dimer_dom.
IPR014362. Glu_DH.
IPR016040. NAD(P)-bd_dom.
[Graphical view]
PfamiPF00208. ELFV_dehydrog. 1 hit.
PF02812. ELFV_dehydrog_N. 1 hit.
[Graphical view]
PIRSFiPIRSF000185. Glu_DH. 1 hit.
PRINTSiPR00082. GLFDHDRGNASE.
SMARTiSM00839. ELFV_dehydrog. 1 hit.
[Graphical view]
PROSITEiPS00074. GLFV_DEHYDROGENASE. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P14657-1 [UniParc]FASTAAdd to Basket

« Hide

MEYAVSVESF LSSLQRHNPH QPEYLQAVRE VFTSLWPFIE RNPAYREQAL    50
LERLVEPERI IQFRVSWVDD RGQVQVNRAF RVQFNSAIGP YKGGMRFHPS 100
VNLSILKFLG FEQTFKNALT TLPMGGGKGG SDFDPKGKSQ GRIMRFCQAL 150
MTELYRHLGP DTDVPAGDIG DGGREVGFMA GMMKKLSNNT ACVFTGKGLS 200
FGGSLIRPEA TGYGLVYFTD AMLQRHGLGF EGMRVAVSGS GNVAQYTIEK 250
ALELDARVIT VSDSGGTLVD EDGFTTEKLA HLAEIKNQRY GRVADYAAER 300
GLTYLAGQQP WNVPVDIALP CATQNELDLE AARVIRNGVK AVAEGANMPT 350
TIQATDAFLD AGVLFAPGKA ANAAGLATSG LEMAQNAARI GWRAEKVDVR 400
LQHIMADIHH ACVEYGGEGK QTHYVHGANI AGFVKVAEAM LAQGVL 446
Length:446
Mass (Da):48,490
Last modified:April 1, 1990 - v1
Checksum:iEDCD53EF87F1A090
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
X16399 Genomic DNA. Translation: CAA34434.1.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
X16399 Genomic DNA. Translation: CAA34434.1 .

3D structure databases

ProteinModelPortali P14657.
SMRi P14657. Positions 6-446.
ModBasei Search...
MobiDBi Search...

Proteomic databases

PRIDEi P14657.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Family and domain databases

Gene3Di 3.40.50.720. 1 hit.
InterProi IPR006095. Glu/Leu/Phe/Val_DH.
IPR006096. Glu/Leu/Phe/Val_DH_C.
IPR006097. Glu/Leu/Phe/Val_DH_dimer_dom.
IPR014362. Glu_DH.
IPR016040. NAD(P)-bd_dom.
[Graphical view ]
Pfami PF00208. ELFV_dehydrog. 1 hit.
PF02812. ELFV_dehydrog_N. 1 hit.
[Graphical view ]
PIRSFi PIRSF000185. Glu_DH. 1 hit.
PRINTSi PR00082. GLFDHDRGNASE.
SMARTi SM00839. ELFV_dehydrog. 1 hit.
[Graphical view ]
PROSITEi PS00074. GLFV_DEHYDROGENASE. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].

Entry informationi

Entry nameiDHE4_UNKP
AccessioniPrimary (citable) accession number: P14657
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 1, 1990
Last sequence update: April 1, 1990
Last modified: May 29, 2013
This is version 65 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Caution

This sequence originates from an organism contaminating a Chlorella sorokiniana culture, probably a bacterium.

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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