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P14657

- DHE4_UNKP

UniProt

P14657 - DHE4_UNKP

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Protein

NADP-specific glutamate dehydrogenase

Gene

gdhA

Organism
Unknown prokaryotic organism
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi

Functioni

Catalyzes the reversible oxidative deamination of glutamate to a-ketoglutarate and ammonia.By similarity

Catalytic activityi

L-glutamate + H2O + NADP+ = 2-oxoglutarate + NH3 + NADPH.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei92 – 921SubstrateBy similarity
Binding sitei113 – 1131SubstrateBy similarity
Binding sitei116 – 1161SubstrateBy similarity
Active sitei128 – 1281Proton donorPROSITE-ProRule annotation
Binding sitei167 – 1671Substrate; via carbonyl oxygenBy similarity
Sitei168 – 1681Important for catalysisBy similarity
Binding sitei211 – 2111NADPBy similarity
Binding sitei242 – 2421NADPBy similarity
Binding sitei379 – 3791SubstrateBy similarity

GO - Molecular functioni

  1. glutamate dehydrogenase (NADP+) activity Source: UniProtKB

GO - Biological processi

  1. glutamate biosynthetic process Source: UniProtKB
Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Keywords - Ligandi

NADP

Names & Taxonomyi

Protein namesi
Recommended name:
NADP-specific glutamate dehydrogenase (EC:1.4.1.4)
Short name:
NADP-GDH
Gene namesi
Name:gdhA
OrganismiUnknown prokaryotic organism
Taxonomic identifieri2725 [NCBI]
Taxonomic lineageiBacteriaenvironmental samples

Subcellular locationi

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB
Complete GO annotation...

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 446446NADP-specific glutamate dehydrogenasePRO_0000182778Add
BLAST

Proteomic databases

PRIDEiP14657.

Interactioni

Subunit structurei

Homohexamer.By similarity

Structurei

3D structure databases

ProteinModelPortaliP14657.
SMRiP14657. Positions 6-446.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Family and domain databases

Gene3Di3.40.50.720. 1 hit.
InterProiIPR006095. Glu/Leu/Phe/Val_DH.
IPR006096. Glu/Leu/Phe/Val_DH_C.
IPR006097. Glu/Leu/Phe/Val_DH_dimer_dom.
IPR014362. Glu_DH.
IPR016040. NAD(P)-bd_dom.
[Graphical view]
PfamiPF00208. ELFV_dehydrog. 1 hit.
PF02812. ELFV_dehydrog_N. 1 hit.
[Graphical view]
PIRSFiPIRSF000185. Glu_DH. 1 hit.
PRINTSiPR00082. GLFDHDRGNASE.
SMARTiSM00839. ELFV_dehydrog. 1 hit.
[Graphical view]
PROSITEiPS00074. GLFV_DEHYDROGENASE. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P14657-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MEYAVSVESF LSSLQRHNPH QPEYLQAVRE VFTSLWPFIE RNPAYREQAL
60 70 80 90 100
LERLVEPERI IQFRVSWVDD RGQVQVNRAF RVQFNSAIGP YKGGMRFHPS
110 120 130 140 150
VNLSILKFLG FEQTFKNALT TLPMGGGKGG SDFDPKGKSQ GRIMRFCQAL
160 170 180 190 200
MTELYRHLGP DTDVPAGDIG DGGREVGFMA GMMKKLSNNT ACVFTGKGLS
210 220 230 240 250
FGGSLIRPEA TGYGLVYFTD AMLQRHGLGF EGMRVAVSGS GNVAQYTIEK
260 270 280 290 300
ALELDARVIT VSDSGGTLVD EDGFTTEKLA HLAEIKNQRY GRVADYAAER
310 320 330 340 350
GLTYLAGQQP WNVPVDIALP CATQNELDLE AARVIRNGVK AVAEGANMPT
360 370 380 390 400
TIQATDAFLD AGVLFAPGKA ANAAGLATSG LEMAQNAARI GWRAEKVDVR
410 420 430 440
LQHIMADIHH ACVEYGGEGK QTHYVHGANI AGFVKVAEAM LAQGVL
Length:446
Mass (Da):48,490
Last modified:April 1, 1990 - v1
Checksum:iEDCD53EF87F1A090
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X16399 Genomic DNA. Translation: CAA34434.1.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X16399 Genomic DNA. Translation: CAA34434.1 .

3D structure databases

ProteinModelPortali P14657.
SMRi P14657. Positions 6-446.
ModBasei Search...
MobiDBi Search...

Proteomic databases

PRIDEi P14657.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Family and domain databases

Gene3Di 3.40.50.720. 1 hit.
InterProi IPR006095. Glu/Leu/Phe/Val_DH.
IPR006096. Glu/Leu/Phe/Val_DH_C.
IPR006097. Glu/Leu/Phe/Val_DH_dimer_dom.
IPR014362. Glu_DH.
IPR016040. NAD(P)-bd_dom.
[Graphical view ]
Pfami PF00208. ELFV_dehydrog. 1 hit.
PF02812. ELFV_dehydrog_N. 1 hit.
[Graphical view ]
PIRSFi PIRSF000185. Glu_DH. 1 hit.
PRINTSi PR00082. GLFDHDRGNASE.
SMARTi SM00839. ELFV_dehydrog. 1 hit.
[Graphical view ]
PROSITEi PS00074. GLFV_DEHYDROGENASE. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].

Entry informationi

Entry nameiDHE4_UNKP
AccessioniPrimary (citable) accession number: P14657
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 1, 1990
Last sequence update: April 1, 1990
Last modified: October 1, 2014
This is version 66 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Caution

This sequence originates from an organism contaminating a Chlorella sorokiniana culture, probably a bacterium.Curated

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3