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P14652 (HXB2_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Last modified July 9, 2014. Version 138. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (4) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Homeobox protein Hox-B2
Alternative name(s):
Homeobox protein Hox-2.8
Homeobox protein Hox-2H
K8
Gene names
Name:HOXB2
Synonyms:HOX2H
OrganismHomo sapiens (Human) [Reference proteome]
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Protein attributes

Sequence length356 AA.
Sequence statusComplete.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

Sequence-specific transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis. Ref.7

Subunit structure

Part of the nuclear protein complex gamma-globin promoter and enhancer binding factor (gamma-PE) composed at least by SATB1 and HOXB2.

Subcellular location

Nucleus.

Developmental stage

Expressed in whole embryos and fetuses at 5-9 weeks from conception.

Sequence similarities

Belongs to the Antp homeobox family. Proboscipedia subfamily.

Contains 1 homeobox DNA-binding domain.

Ontologies

Keywords
   Biological processTranscription
Transcription regulation
   Cellular componentNucleus
   DomainHomeobox
   LigandDNA-binding
   Molecular functionDevelopmental protein
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Biological_processanterior/posterior pattern specification

Inferred from electronic annotation. Source: Ensembl

blood circulation

Traceable author statement Ref.6. Source: ProtInc

dorsal/ventral pattern formation

Inferred from electronic annotation. Source: Ensembl

embryonic skeletal system morphogenesis

Inferred from electronic annotation. Source: Ensembl

facial nerve structural organization

Inferred from electronic annotation. Source: Ensembl

morphogenesis of an epithelial sheet

Inferred from electronic annotation. Source: Ensembl

multicellular organismal development

Traceable author statement Ref.6. Source: ProtInc

neural nucleus development

Inferred from electronic annotation. Source: Ensembl

rhombomere 3 development

Inferred from electronic annotation. Source: Ensembl

rhombomere 4 development

Inferred from electronic annotation. Source: Ensembl

transcription, DNA-templated

Inferred from electronic annotation. Source: UniProtKB-KW

   Cellular_componentnucleus

Inferred from electronic annotation. Source: UniProtKB-SubCell

   Molecular_functionsequence-specific DNA binding

Inferred from electronic annotation. Source: InterPro

sequence-specific DNA binding transcription factor activity

Inferred from electronic annotation. Source: InterPro

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 356356Homeobox protein Hox-B2
PRO_0000200114

Regions

DNA binding143 – 20260Homeobox
Motif94 – 996Antp-type hexapeptide

Experimental info

Sequence conflict136 – 1383PEA → RRL in CAA34298. Ref.3

Sequences

Sequence LengthMass (Da)Tools
P14652 [UniParc].

Last modified April 1, 1990. Version 1.
Checksum: D7ACA0E3D5BEBFB9

FASTA35637,914
        10         20         30         40         50         60 
MNFEFEREIG FINSQPSLAE CLTSFPAVLE TFQTSSIKES TLIPPPPPFE QTFPSLQPGA 

        70         80         90        100        110        120 
STLQRPRSQK RAEDGPALPP PPPPPLPAAP PAPEFPWMKE KKSAKKPSQS ATSPSPAASA 

       130        140        150        160        170        180 
VPASGVGSPA DGLGLPEAGG GGARRLRTAY TNTQLLELEK EFHFNKYLCR PRRVEIAALL 

       190        200        210        220        230        240 
DLTERQVKVW FQNRRMKHKR QTQHREPPDG EPACPGALED ICDPAEEPAA SPGGPSASRA 

       250        260        270        280        290        300 
AWEACCHPPE VVPGALSADP RPLAVRLEGA GASSPGCALR GAGGLEPGPL PEDVFSGRQD 

       310        320        330        340        350 
SPFLPDLNFF AADSCLQLSG GLSPSLQGSL DSPVPFSEEE LDFFTSTLCA IDLQFP 

« Hide

References

« Hide 'large scale' references
[1]"The human HOX gene family."
Acampora D., D'Esposito M., Faiella A., Pannese M., Migliaccio E., Morelli F., Stornaiuolo A., Nigro V., Simeone A., Boncinelli E.
Nucleic Acids Res. 17:10385-10402(1989) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
[2]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
[3]"Differential expression of human HOX-2 genes along the anterior-posterior axis in embryonic central nervous system."
Giampaolo A., Acampora D., Zappavigna V., Pannese M., D'Esposito M., Care A., Faiella A., Stornaiuolo A., Russo G., Simeone A., Boncinelli E., Peschle C.
Differentiation 40:191-197(1989) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 132-208.
Tissue: Placenta.
[4]"Organization of human class I homeobox genes."
Boncinelli E., Acampora D., Pannese M., D'Esposito M., Somma R., Gaudino G., Stornaiuolo A., Cafiero M., Faiella A., Simeone A.
Genome 31:745-756(1989) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 143-208.
[5]"Expression of multiple homeobox genes within diverse mammalian haemopoietic lineages."
Kongsuwan K., Webb E., Housiaux P., Adams J.M.
EMBO J. 7:2131-2138(1988) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE OF 143-202.
[6]"Transcription factor GATA-1 regulates human HOXB2 gene expression in erythroid cells."
Vieille-Grosjean I., Huber P.
J. Biol. Chem. 270:4544-4550(1995) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 1-42.
[7]"The gammaPE complex contains both SATB1 and HOXB2 and has positive and negative roles in human gamma-globin gene regulation."
Case S.S., Huber P., Lloyd J.A.
DNA Cell Biol. 18:805-817(1999) [PubMed] [Europe PMC] [Abstract]
Cited for: FUNCTION, GAMMA-GLOBIN PROMOTER AND ENHANCER BINDING FACTOR COMPLEX.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
X16665 mRNA. Translation: CAA34655.1.
BC074805 mRNA. Translation: AAH74805.1.
BC074806 mRNA. Translation: AAH74806.1.
X16176 Genomic DNA. Translation: CAA34298.1.
X14571 mRNA. Translation: CAA32709.1.
X78978 Genomic DNA. Translation: CAA55581.1.
CCDSCCDS11527.1.
PIRWJHU2H. S07542.
RefSeqNP_002136.1. NM_002145.3.
UniGeneHs.514289.

3D structure databases

ProteinModelPortalP14652.
SMRP14652. Positions 145-201.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

BioGrid109452. 1 interaction.
IntActP14652. 1 interaction.
STRING9606.ENSP00000331741.

PTM databases

PhosphoSiteP14652.

Polymorphism databases

DMDM123270.

Proteomic databases

PaxDbP14652.
PRIDEP14652.

Protocols and materials databases

DNASU3212.
StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENST00000330070; ENSP00000331741; ENSG00000173917.
GeneID3212.
KEGGhsa:3212.
UCSCuc002inm.3. human.

Organism-specific databases

CTD3212.
GeneCardsGC17M046620.
HGNCHGNC:5113. HOXB2.
MIM142967. gene.
neXtProtNX_P14652.
PharmGKBPA29389.
GenAtlasSearch...

Phylogenomic databases

eggNOGNOG295272.
HOGENOMHOG000063664.
HOVERGENHBG006088.
InParanoidP14652.
KOK09302.
OMALEDICDP.
OrthoDBEOG73RBBF.
PhylomeDBP14652.
TreeFamTF317730.

Gene expression databases

ArrayExpressP14652.
BgeeP14652.
CleanExHS_HOXB2.
GenevestigatorP14652.

Family and domain databases

Gene3D1.10.10.60. 1 hit.
InterProIPR001827. Homeobox_Antennapedia_CS.
IPR017970. Homeobox_CS.
IPR001356. Homeobox_dom.
IPR020479. Homeobox_metazoa.
IPR009057. Homeodomain-like.
[Graphical view]
PfamPF00046. Homeobox. 1 hit.
[Graphical view]
PRINTSPR00024. HOMEOBOX.
SMARTSM00389. HOX. 1 hit.
[Graphical view]
SUPFAMSSF46689. SSF46689. 1 hit.
PROSITEPS00032. ANTENNAPEDIA. 1 hit.
PS00027. HOMEOBOX_1. 1 hit.
PS50071. HOMEOBOX_2. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

GeneWikiHOXB2.
GenomeRNAi3212.
NextBio12780.
PROP14652.
SOURCESearch...

Entry information

Entry nameHXB2_HUMAN
AccessionPrimary (citable) accession number: P14652
Secondary accession number(s): P10913, P17485
Entry history
Integrated into UniProtKB/Swiss-Prot: April 1, 1990
Last sequence update: April 1, 1990
Last modified: July 9, 2014
This is version 138 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Relevant documents

SIMILARITY comments

Index of protein domains and families

MIM cross-references

Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

Human chromosome 17

Human chromosome 17: entries, gene names and cross-references to MIM

Vertebrate homeotic Hox proteins

Nomenclature of vertebrate homeotic Hox proteins and list of entries