P14652 (HXB2_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Homeobox protein Hox-B2

Alternative name(s):
Homeobox protein Hox-2.8
Homeobox protein Hox-2H
K8

Gene names

Name:	HOXB2
Synonyms:	HOX2H

Organism

Homo sapiens (Human) [Reference proteome]

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo

Protein attributes

Sequence length	356 AA.
Sequence status	Complete.
Protein existence	Evidence at protein level

General annotation (Comments)

Function	Sequence-specific transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis. Ref.7
Subunit structure	Part of the nuclear protein complex gamma-globin promoter and enhancer binding factor (gamma-PE) composed at least by SATB1 and HOXB2.
Subcellular location	Nucleus.
Developmental stage	Expressed in whole embryos and fetuses at 5-9 weeks from conception.
Sequence similarities	Belongs to the Antp homeobox family. Proboscipedia subfamily. Contains 1 homeobox DNA-binding domain.

Ontologies

Keywords
Biological process	Transcription Transcription regulation
Cellular component	Nucleus
Domain	Homeobox
Ligand	DNA-binding
Molecular function	Developmental protein
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	anterior/posterior pattern specification Inferred from electronic annotation. Source: Compara blood circulation Traceable author statement Ref.6. Source: ProtInc dorsal/ventral pattern formation Inferred from electronic annotation. Source: Compara embryonic skeletal system morphogenesis Inferred from electronic annotation. Source: Compara facial nerve structural organization Inferred from electronic annotation. Source: Compara morphogenesis of an epithelial sheet Inferred from electronic annotation. Source: Compara multicellular organismal development Traceable author statement Ref.6. Source: ProtInc neural nucleus development Inferred from electronic annotation. Source: Compara rhombomere 3 development Inferred from electronic annotation. Source: Compara rhombomere 4 development Inferred from electronic annotation. Source: Compara transcription, DNA-dependent Inferred from electronic annotation. Source: UniProtKB-KW
Cellular_component	nucleus Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular_function	sequence-specific DNA binding Inferred from electronic annotation. Source: InterPro sequence-specific DNA binding transcription factor activity Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 356	356	Homeobox protein Hox-B2		PRO_0000200114
Regions
	DNA binding	143 – 202	60	Homeobox
	Motif	94 – 99	6	Antp-type hexapeptide
Experimental info
	Sequence conflict	136 – 138	3	PEA → RRL in CAA34298. Ref.3

Sequences

	Sequence		Length	Mass (Da)
	P14652 [UniParc]. Last modified April 1, 1990. Version 1. Checksum: D7ACA0E3D5BEBFB9	FASTA	356	37,914
	10 20 30 40 50 60 MNFEFEREIG FINSQPSLAE CLTSFPAVLE TFQTSSIKES TLIPPPPPFE QTFPSLQPGA 70 80 90 100 110 120 STLQRPRSQK RAEDGPALPP PPPPPLPAAP PAPEFPWMKE KKSAKKPSQS ATSPSPAASA 130 140 150 160 170 180 VPASGVGSPA DGLGLPEAGG GGARRLRTAY TNTQLLELEK EFHFNKYLCR PRRVEIAALL 190 200 210 220 230 240 DLTERQVKVW FQNRRMKHKR QTQHREPPDG EPACPGALED ICDPAEEPAA SPGGPSASRA 250 260 270 280 290 300 AWEACCHPPE VVPGALSADP RPLAVRLEGA GASSPGCALR GAGGLEPGPL PEDVFSGRQD 310 320 330 340 350 SPFLPDLNFF AADSCLQLSG GLSPSLQGSL DSPVPFSEEE LDFFTSTLCA IDLQFP

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"The human HOX gene family." Acampora D., D'Esposito M., Faiella A., Pannese M., Migliaccio E., Morelli F., Stornaiuolo A., Nigro V., Simeone A., Boncinelli E. Nucleic Acids Res. 17:10385-10402(1989) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA].
[2]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
[3]	"Differential expression of human HOX-2 genes along the anterior-posterior axis in embryonic central nervous system." Giampaolo A., Acampora D., Zappavigna V., Pannese M., D'Esposito M., Care A., Faiella A., Stornaiuolo A., Russo G., Simeone A., Boncinelli E., Peschle C. Differentiation 40:191-197(1989) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 132-208. Tissue: Placenta.
[4]	"Organization of human class I homeobox genes." Boncinelli E., Acampora D., Pannese M., D'Esposito M., Somma R., Gaudino G., Stornaiuolo A., Cafiero M., Faiella A., Simeone A. Genome 31:745-756(1989) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 143-208.
[5]	"Expression of multiple homeobox genes within diverse mammalian haemopoietic lineages." Kongsuwan K., Webb E., Housiaux P., Adams J.M. EMBO J. 7:2131-2138(1988) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE OF 143-202.
[6]	"Transcription factor GATA-1 regulates human HOXB2 gene expression in erythroid cells." Vieille-Grosjean I., Huber P. J. Biol. Chem. 270:4544-4550(1995) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 1-42.
[7]	"The gammaPE complex contains both SATB1 and HOXB2 and has positive and negative roles in human gamma-globin gene regulation." Case S.S., Huber P., Lloyd J.A. DNA Cell Biol. 18:805-817(1999) [PubMed] [Europe PMC] [Abstract] Cited for: FUNCTION, GAMMA-GLOBIN PROMOTER AND ENHANCER BINDING FACTOR COMPLEX.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	X16665 mRNA. Translation: CAA34655.1. BC074805 mRNA. Translation: AAH74805.1. BC074806 mRNA. Translation: AAH74806.1. X16176 Genomic DNA. Translation: CAA34298.1. X14571 mRNA. Translation: CAA32709.1. X78978 Genomic DNA. Translation: CAA55581.1.
IPI	IPI00027261.
PIR	WJHU2H. S07542.
RefSeq	NP_002136.1. NM_002145.3.
UniGene	Hs.514289.
3D structure databases
ProteinModelPortal	P14652.
ModBase	Search...
Protein-protein interaction databases
IntAct	P14652. 1 interaction.
STRING	9606.ENSP00000331741.
PTM databases
PhosphoSite	P14652.
Polymorphism databases
DMDM	123270.
Proteomic databases
PaxDb	P14652.
PRIDE	P14652.
Protocols and materials databases
DNASU	3212.
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENST00000330070; ENSP00000331741; ENSG00000173917.
GeneID	3212.
KEGG	hsa:3212.
UCSC	uc002inm.3. human.
Organism-specific databases
CTD	3212.
GeneCards	GC17M046620.
HGNC	HGNC:5113. HOXB2.
MIM	142967. gene.
neXtProt	NX_P14652.
PharmGKB	PA29389.
GenAtlas	Search...
Phylogenomic databases
eggNOG	NOG295272.
HOGENOM	HOG000063664.
HOVERGEN	HBG006088.
InParanoid	P14652.
KO	K09302.
OMA	RAAWEAC.
OrthoDB	EOG4QC167.
PhylomeDB	P14652.
Gene expression databases
ArrayExpress	P14652.
Bgee	P14652.
CleanEx	HS_HOXB2.
Genevestigator	P14652.
GermOnline	ENSG00000173917. Homo sapiens.
Family and domain databases
Gene3D	1.10.10.60. 1 hit.
InterPro	IPR001827. Homeobox_Antennapedia_CS. IPR017970. Homeobox_CS. IPR020479. Homeobox_metazoa. IPR001356. Homeodomain. IPR009057. Homeodomain-like. [Graphical view]
Pfam	PF00046. Homeobox. 1 hit. [Graphical view]
PRINTS	PR00024. HOMEOBOX.
SMART	SM00389. HOX. 1 hit. [Graphical view]
SUPFAM	SSF46689. Homeodomain_like. 1 hit.
PROSITE	PS00032. ANTENNAPEDIA. 1 hit. PS00027. HOMEOBOX_1. 1 hit. PS50071. HOMEOBOX_2. 1 hit. [Graphical view]
ProtoNet	Search...
Other
GenomeRNAi	3212.
NextBio	12780.
SOURCE	Search...

Entry information

Entry name

HXB2_HUMAN

Accession

Primary (citable) accession number: P14652
Secondary accession number(s): P10913, P17485

Entry history

Integrated into UniProtKB/Swiss-Prot:	April 1, 1990
Last sequence update:	April 1, 1990
Last modified:	May 1, 2013
This is version 131 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.