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P14652

- HXB2_HUMAN

UniProt

P14652 - HXB2_HUMAN

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Protein

Homeobox protein Hox-B2

Gene

HOXB2

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli

Functioni

Sequence-specific transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis.1 Publication

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
DNA bindingi143 – 20260HomeoboxPROSITE-ProRule annotationAdd
BLAST

GO - Molecular functioni

  1. sequence-specific DNA binding Source: InterPro
  2. sequence-specific DNA binding transcription factor activity Source: InterPro

GO - Biological processi

  1. anterior/posterior pattern specification Source: Ensembl
  2. blood circulation Source: ProtInc
  3. dorsal/ventral pattern formation Source: Ensembl
  4. embryonic skeletal system morphogenesis Source: Ensembl
  5. facial nerve structural organization Source: Ensembl
  6. morphogenesis of an epithelial sheet Source: Ensembl
  7. multicellular organismal development Source: ProtInc
  8. neural nucleus development Source: Ensembl
  9. rhombomere 3 development Source: Ensembl
  10. rhombomere 4 development Source: Ensembl
  11. transcription, DNA-templated Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Developmental protein

Keywords - Biological processi

Transcription, Transcription regulation

Keywords - Ligandi

DNA-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Homeobox protein Hox-B2
Alternative name(s):
Homeobox protein Hox-2.8
Homeobox protein Hox-2H
K8
Gene namesi
Name:HOXB2
Synonyms:HOX2H
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 17

Organism-specific databases

HGNCiHGNC:5113. HOXB2.

Subcellular locationi

GO - Cellular componenti

  1. nucleus Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA29389.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 356356Homeobox protein Hox-B2PRO_0000200114Add
BLAST

Proteomic databases

PaxDbiP14652.
PRIDEiP14652.

PTM databases

PhosphoSiteiP14652.

Expressioni

Developmental stagei

Expressed in whole embryos and fetuses at 5-9 weeks from conception.

Gene expression databases

BgeeiP14652.
CleanExiHS_HOXB2.
ExpressionAtlasiP14652. baseline and differential.
GenevestigatoriP14652.

Interactioni

Subunit structurei

Part of the nuclear protein complex gamma-globin promoter and enhancer binding factor (gamma-PE) composed at least by SATB1 and HOXB2.

Protein-protein interaction databases

BioGridi109452. 1 interaction.
IntActiP14652. 1 interaction.
STRINGi9606.ENSP00000331741.

Structurei

3D structure databases

ProteinModelPortaliP14652.
SMRiP14652. Positions 145-201.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Motif

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Motifi94 – 996Antp-type hexapeptide

Sequence similaritiesi

Contains 1 homeobox DNA-binding domain.PROSITE-ProRule annotation

Keywords - Domaini

Homeobox

Phylogenomic databases

eggNOGiNOG295272.
GeneTreeiENSGT00760000118940.
HOGENOMiHOG000063664.
HOVERGENiHBG006088.
InParanoidiP14652.
KOiK09302.
OMAiLEDICDP.
OrthoDBiEOG73RBBF.
PhylomeDBiP14652.
TreeFamiTF317730.

Family and domain databases

Gene3Di1.10.10.60. 1 hit.
InterProiIPR001827. Homeobox_Antennapedia_CS.
IPR017970. Homeobox_CS.
IPR001356. Homeobox_dom.
IPR020479. Homeobox_metazoa.
IPR009057. Homeodomain-like.
[Graphical view]
PfamiPF00046. Homeobox. 1 hit.
[Graphical view]
PRINTSiPR00024. HOMEOBOX.
SMARTiSM00389. HOX. 1 hit.
[Graphical view]
SUPFAMiSSF46689. SSF46689. 1 hit.
PROSITEiPS00032. ANTENNAPEDIA. 1 hit.
PS00027. HOMEOBOX_1. 1 hit.
PS50071. HOMEOBOX_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P14652-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MNFEFEREIG FINSQPSLAE CLTSFPAVLE TFQTSSIKES TLIPPPPPFE
60 70 80 90 100
QTFPSLQPGA STLQRPRSQK RAEDGPALPP PPPPPLPAAP PAPEFPWMKE
110 120 130 140 150
KKSAKKPSQS ATSPSPAASA VPASGVGSPA DGLGLPEAGG GGARRLRTAY
160 170 180 190 200
TNTQLLELEK EFHFNKYLCR PRRVEIAALL DLTERQVKVW FQNRRMKHKR
210 220 230 240 250
QTQHREPPDG EPACPGALED ICDPAEEPAA SPGGPSASRA AWEACCHPPE
260 270 280 290 300
VVPGALSADP RPLAVRLEGA GASSPGCALR GAGGLEPGPL PEDVFSGRQD
310 320 330 340 350
SPFLPDLNFF AADSCLQLSG GLSPSLQGSL DSPVPFSEEE LDFFTSTLCA

IDLQFP
Length:356
Mass (Da):37,914
Last modified:April 1, 1990 - v1
Checksum:iD7ACA0E3D5BEBFB9
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti136 – 1383PEA → RRL in CAA34298. (PubMed:2570724)Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X16665 mRNA. Translation: CAA34655.1.
BC074805 mRNA. Translation: AAH74805.1.
BC074806 mRNA. Translation: AAH74806.1.
X16176 Genomic DNA. Translation: CAA34298.1.
X14571 mRNA. Translation: CAA32709.1.
X78978 Genomic DNA. Translation: CAA55581.1.
CCDSiCCDS11527.1.
PIRiS07542. WJHU2H.
RefSeqiNP_002136.1. NM_002145.3.
UniGeneiHs.514289.

Genome annotation databases

EnsembliENST00000330070; ENSP00000331741; ENSG00000173917.
GeneIDi3212.
KEGGihsa:3212.
UCSCiuc002inm.3. human.

Polymorphism databases

DMDMi123270.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X16665 mRNA. Translation: CAA34655.1 .
BC074805 mRNA. Translation: AAH74805.1 .
BC074806 mRNA. Translation: AAH74806.1 .
X16176 Genomic DNA. Translation: CAA34298.1 .
X14571 mRNA. Translation: CAA32709.1 .
X78978 Genomic DNA. Translation: CAA55581.1 .
CCDSi CCDS11527.1.
PIRi S07542. WJHU2H.
RefSeqi NP_002136.1. NM_002145.3.
UniGenei Hs.514289.

3D structure databases

ProteinModelPortali P14652.
SMRi P14652. Positions 145-201.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 109452. 1 interaction.
IntActi P14652. 1 interaction.
STRINGi 9606.ENSP00000331741.

PTM databases

PhosphoSitei P14652.

Polymorphism databases

DMDMi 123270.

Proteomic databases

PaxDbi P14652.
PRIDEi P14652.

Protocols and materials databases

DNASUi 3212.
Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000330070 ; ENSP00000331741 ; ENSG00000173917 .
GeneIDi 3212.
KEGGi hsa:3212.
UCSCi uc002inm.3. human.

Organism-specific databases

CTDi 3212.
GeneCardsi GC17M046620.
HGNCi HGNC:5113. HOXB2.
MIMi 142967. gene.
neXtProti NX_P14652.
PharmGKBi PA29389.
GenAtlasi Search...

Phylogenomic databases

eggNOGi NOG295272.
GeneTreei ENSGT00760000118940.
HOGENOMi HOG000063664.
HOVERGENi HBG006088.
InParanoidi P14652.
KOi K09302.
OMAi LEDICDP.
OrthoDBi EOG73RBBF.
PhylomeDBi P14652.
TreeFami TF317730.

Miscellaneous databases

GeneWikii HOXB2.
GenomeRNAii 3212.
NextBioi 12780.
PROi P14652.
SOURCEi Search...

Gene expression databases

Bgeei P14652.
CleanExi HS_HOXB2.
ExpressionAtlasi P14652. baseline and differential.
Genevestigatori P14652.

Family and domain databases

Gene3Di 1.10.10.60. 1 hit.
InterProi IPR001827. Homeobox_Antennapedia_CS.
IPR017970. Homeobox_CS.
IPR001356. Homeobox_dom.
IPR020479. Homeobox_metazoa.
IPR009057. Homeodomain-like.
[Graphical view ]
Pfami PF00046. Homeobox. 1 hit.
[Graphical view ]
PRINTSi PR00024. HOMEOBOX.
SMARTi SM00389. HOX. 1 hit.
[Graphical view ]
SUPFAMi SSF46689. SSF46689. 1 hit.
PROSITEi PS00032. ANTENNAPEDIA. 1 hit.
PS00027. HOMEOBOX_1. 1 hit.
PS50071. HOMEOBOX_2. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. Cited for: NUCLEOTIDE SEQUENCE [MRNA].
  2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
  3. "Differential expression of human HOX-2 genes along the anterior-posterior axis in embryonic central nervous system."
    Giampaolo A., Acampora D., Zappavigna V., Pannese M., D'Esposito M., Care A., Faiella A., Stornaiuolo A., Russo G., Simeone A., Boncinelli E., Peschle C.
    Differentiation 40:191-197(1989) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 132-208.
    Tissue: Placenta.
  4. "Organization of human class I homeobox genes."
    Boncinelli E., Acampora D., Pannese M., D'Esposito M., Somma R., Gaudino G., Stornaiuolo A., Cafiero M., Faiella A., Simeone A.
    Genome 31:745-756(1989) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 143-208.
  5. "Expression of multiple homeobox genes within diverse mammalian haemopoietic lineages."
    Kongsuwan K., Webb E., Housiaux P., Adams J.M.
    EMBO J. 7:2131-2138(1988) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE OF 143-202.
  6. "Transcription factor GATA-1 regulates human HOXB2 gene expression in erythroid cells."
    Vieille-Grosjean I., Huber P.
    J. Biol. Chem. 270:4544-4550(1995) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 1-42.
  7. "The gammaPE complex contains both SATB1 and HOXB2 and has positive and negative roles in human gamma-globin gene regulation."
    Case S.S., Huber P., Lloyd J.A.
    DNA Cell Biol. 18:805-817(1999) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION, GAMMA-GLOBIN PROMOTER AND ENHANCER BINDING FACTOR COMPLEX.

Entry informationi

Entry nameiHXB2_HUMAN
AccessioniPrimary (citable) accession number: P14652
Secondary accession number(s): P10913, P17485
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 1, 1990
Last sequence update: April 1, 1990
Last modified: October 29, 2014
This is version 140 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Vertebrate homeotic Hox proteins
    Nomenclature of vertebrate homeotic Hox proteins and list of entries
  2. Human chromosome 17
    Human chromosome 17: entries, gene names and cross-references to MIM
  3. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  4. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3