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Protein

Homeobox protein Hox-B2

Gene

HOXB2

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Sequence-specific transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis.1 Publication

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
DNA bindingi143 – 20260HomeoboxPROSITE-ProRule annotationAdd
BLAST

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Developmental protein

Keywords - Biological processi

Transcription, Transcription regulation

Keywords - Ligandi

DNA-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Homeobox protein Hox-B2
Alternative name(s):
Homeobox protein Hox-2.8
Homeobox protein Hox-2H
K8
Gene namesi
Name:HOXB2
Synonyms:HOX2H
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640 Componenti: Chromosome 17

Organism-specific databases

HGNCiHGNC:5113. HOXB2.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA29389.

Polymorphism and mutation databases

BioMutaiHOXB2.
DMDMi123270.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 356356Homeobox protein Hox-B2PRO_0000200114Add
BLAST

Proteomic databases

PaxDbiP14652.
PRIDEiP14652.

PTM databases

PhosphoSiteiP14652.

Expressioni

Developmental stagei

Expressed in whole embryos and fetuses at 5-9 weeks from conception.

Gene expression databases

BgeeiP14652.
CleanExiHS_HOXB2.
GenevisibleiP14652. HS.

Interactioni

Subunit structurei

Part of the nuclear protein complex gamma-globin promoter and enhancer binding factor (gamma-PE) composed at least by SATB1 and HOXB2.

Protein-protein interaction databases

BioGridi109452. 1 interaction.
IntActiP14652. 1 interaction.
STRINGi9606.ENSP00000331741.

Structurei

3D structure databases

ProteinModelPortaliP14652.
SMRiP14652. Positions 145-201.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Motif

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Motifi94 – 996Antp-type hexapeptide

Sequence similaritiesi

Contains 1 homeobox DNA-binding domain.PROSITE-ProRule annotation

Keywords - Domaini

Homeobox

Phylogenomic databases

eggNOGiNOG295272.
GeneTreeiENSGT00760000118940.
HOGENOMiHOG000063664.
HOVERGENiHBG006088.
InParanoidiP14652.
KOiK09302.
OMAiTTHHRDG.
OrthoDBiEOG73RBBF.
PhylomeDBiP14652.
TreeFamiTF317730.

Family and domain databases

Gene3Di1.10.10.60. 1 hit.
InterProiIPR001827. Homeobox_Antennapedia_CS.
IPR017970. Homeobox_CS.
IPR001356. Homeobox_dom.
IPR020479. Homeobox_metazoa.
IPR009057. Homeodomain-like.
[Graphical view]
PfamiPF00046. Homeobox. 1 hit.
[Graphical view]
PRINTSiPR00024. HOMEOBOX.
SMARTiSM00389. HOX. 1 hit.
[Graphical view]
SUPFAMiSSF46689. SSF46689. 1 hit.
PROSITEiPS00032. ANTENNAPEDIA. 1 hit.
PS00027. HOMEOBOX_1. 1 hit.
PS50071. HOMEOBOX_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P14652-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MNFEFEREIG FINSQPSLAE CLTSFPAVLE TFQTSSIKES TLIPPPPPFE
60 70 80 90 100
QTFPSLQPGA STLQRPRSQK RAEDGPALPP PPPPPLPAAP PAPEFPWMKE
110 120 130 140 150
KKSAKKPSQS ATSPSPAASA VPASGVGSPA DGLGLPEAGG GGARRLRTAY
160 170 180 190 200
TNTQLLELEK EFHFNKYLCR PRRVEIAALL DLTERQVKVW FQNRRMKHKR
210 220 230 240 250
QTQHREPPDG EPACPGALED ICDPAEEPAA SPGGPSASRA AWEACCHPPE
260 270 280 290 300
VVPGALSADP RPLAVRLEGA GASSPGCALR GAGGLEPGPL PEDVFSGRQD
310 320 330 340 350
SPFLPDLNFF AADSCLQLSG GLSPSLQGSL DSPVPFSEEE LDFFTSTLCA

IDLQFP
Length:356
Mass (Da):37,914
Last modified:April 1, 1990 - v1
Checksum:iD7ACA0E3D5BEBFB9
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti136 – 1383PEA → RRL in CAA34298 (PubMed:2570724).Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X16665 mRNA. Translation: CAA34655.1.
BC074805 mRNA. Translation: AAH74805.1.
BC074806 mRNA. Translation: AAH74806.1.
X16176 Genomic DNA. Translation: CAA34298.1.
X14571 mRNA. Translation: CAA32709.1.
X78978 Genomic DNA. Translation: CAA55581.1.
CCDSiCCDS11527.1.
PIRiS07542. WJHU2H.
RefSeqiNP_002136.1. NM_002145.3.
UniGeneiHs.514289.

Genome annotation databases

EnsembliENST00000330070; ENSP00000331741; ENSG00000173917.
GeneIDi3212.
KEGGihsa:3212.
UCSCiuc002inm.3. human.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X16665 mRNA. Translation: CAA34655.1.
BC074805 mRNA. Translation: AAH74805.1.
BC074806 mRNA. Translation: AAH74806.1.
X16176 Genomic DNA. Translation: CAA34298.1.
X14571 mRNA. Translation: CAA32709.1.
X78978 Genomic DNA. Translation: CAA55581.1.
CCDSiCCDS11527.1.
PIRiS07542. WJHU2H.
RefSeqiNP_002136.1. NM_002145.3.
UniGeneiHs.514289.

3D structure databases

ProteinModelPortaliP14652.
SMRiP14652. Positions 145-201.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi109452. 1 interaction.
IntActiP14652. 1 interaction.
STRINGi9606.ENSP00000331741.

PTM databases

PhosphoSiteiP14652.

Polymorphism and mutation databases

BioMutaiHOXB2.
DMDMi123270.

Proteomic databases

PaxDbiP14652.
PRIDEiP14652.

Protocols and materials databases

DNASUi3212.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000330070; ENSP00000331741; ENSG00000173917.
GeneIDi3212.
KEGGihsa:3212.
UCSCiuc002inm.3. human.

Organism-specific databases

CTDi3212.
GeneCardsiGC17M046620.
HGNCiHGNC:5113. HOXB2.
MIMi142967. gene.
neXtProtiNX_P14652.
PharmGKBiPA29389.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiNOG295272.
GeneTreeiENSGT00760000118940.
HOGENOMiHOG000063664.
HOVERGENiHBG006088.
InParanoidiP14652.
KOiK09302.
OMAiTTHHRDG.
OrthoDBiEOG73RBBF.
PhylomeDBiP14652.
TreeFamiTF317730.

Miscellaneous databases

GeneWikiiHOXB2.
GenomeRNAii3212.
NextBioi12780.
PROiP14652.
SOURCEiSearch...

Gene expression databases

BgeeiP14652.
CleanExiHS_HOXB2.
GenevisibleiP14652. HS.

Family and domain databases

Gene3Di1.10.10.60. 1 hit.
InterProiIPR001827. Homeobox_Antennapedia_CS.
IPR017970. Homeobox_CS.
IPR001356. Homeobox_dom.
IPR020479. Homeobox_metazoa.
IPR009057. Homeodomain-like.
[Graphical view]
PfamiPF00046. Homeobox. 1 hit.
[Graphical view]
PRINTSiPR00024. HOMEOBOX.
SMARTiSM00389. HOX. 1 hit.
[Graphical view]
SUPFAMiSSF46689. SSF46689. 1 hit.
PROSITEiPS00032. ANTENNAPEDIA. 1 hit.
PS00027. HOMEOBOX_1. 1 hit.
PS50071. HOMEOBOX_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. Cited for: NUCLEOTIDE SEQUENCE [MRNA].
  2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
  3. "Differential expression of human HOX-2 genes along the anterior-posterior axis in embryonic central nervous system."
    Giampaolo A., Acampora D., Zappavigna V., Pannese M., D'Esposito M., Care A., Faiella A., Stornaiuolo A., Russo G., Simeone A., Boncinelli E., Peschle C.
    Differentiation 40:191-197(1989) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 132-208.
    Tissue: Placenta.
  4. "Organization of human class I homeobox genes."
    Boncinelli E., Acampora D., Pannese M., D'Esposito M., Somma R., Gaudino G., Stornaiuolo A., Cafiero M., Faiella A., Simeone A.
    Genome 31:745-756(1989) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 143-208.
  5. "Expression of multiple homeobox genes within diverse mammalian haemopoietic lineages."
    Kongsuwan K., Webb E., Housiaux P., Adams J.M.
    EMBO J. 7:2131-2138(1988) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE OF 143-202.
  6. "Transcription factor GATA-1 regulates human HOXB2 gene expression in erythroid cells."
    Vieille-Grosjean I., Huber P.
    J. Biol. Chem. 270:4544-4550(1995) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 1-42.
  7. "The gammaPE complex contains both SATB1 and HOXB2 and has positive and negative roles in human gamma-globin gene regulation."
    Case S.S., Huber P., Lloyd J.A.
    DNA Cell Biol. 18:805-817(1999) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION, GAMMA-GLOBIN PROMOTER AND ENHANCER BINDING FACTOR COMPLEX.

Entry informationi

Entry nameiHXB2_HUMAN
AccessioniPrimary (citable) accession number: P14652
Secondary accession number(s): P10913, P17485
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 1, 1990
Last sequence update: April 1, 1990
Last modified: June 24, 2015
This is version 145 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Vertebrate homeotic Hox proteins
    Nomenclature of vertebrate homeotic Hox proteins and list of entries
  2. Human chromosome 17
    Human chromosome 17: entries, gene names and cross-references to MIM
  3. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  4. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.