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P14652

- HXB2_HUMAN

UniProt

P14652 - HXB2_HUMAN

Protein

Homeobox protein Hox-B2

Gene

HOXB2

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 139 (01 Oct 2014)
      Sequence version 1 (01 Apr 1990)
      Previous versions | rss
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    Functioni

    Sequence-specific transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis.1 Publication

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    DNA bindingi143 – 20260HomeoboxPROSITE-ProRule annotationAdd
    BLAST

    GO - Molecular functioni

    1. sequence-specific DNA binding Source: InterPro
    2. sequence-specific DNA binding transcription factor activity Source: InterPro

    GO - Biological processi

    1. anterior/posterior pattern specification Source: Ensembl
    2. blood circulation Source: ProtInc
    3. dorsal/ventral pattern formation Source: Ensembl
    4. embryonic skeletal system morphogenesis Source: Ensembl
    5. facial nerve structural organization Source: Ensembl
    6. morphogenesis of an epithelial sheet Source: Ensembl
    7. multicellular organismal development Source: ProtInc
    8. neural nucleus development Source: Ensembl
    9. rhombomere 3 development Source: Ensembl
    10. rhombomere 4 development Source: Ensembl
    11. transcription, DNA-templated Source: UniProtKB-KW

    Keywords - Molecular functioni

    Developmental protein

    Keywords - Biological processi

    Transcription, Transcription regulation

    Keywords - Ligandi

    DNA-binding

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Homeobox protein Hox-B2
    Alternative name(s):
    Homeobox protein Hox-2.8
    Homeobox protein Hox-2H
    K8
    Gene namesi
    Name:HOXB2
    Synonyms:HOX2H
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 17

    Organism-specific databases

    HGNCiHGNC:5113. HOXB2.

    Subcellular locationi

    GO - Cellular componenti

    1. nucleus Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Nucleus

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA29389.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 356356Homeobox protein Hox-B2PRO_0000200114Add
    BLAST

    Proteomic databases

    PaxDbiP14652.
    PRIDEiP14652.

    PTM databases

    PhosphoSiteiP14652.

    Expressioni

    Developmental stagei

    Expressed in whole embryos and fetuses at 5-9 weeks from conception.

    Gene expression databases

    ArrayExpressiP14652.
    BgeeiP14652.
    CleanExiHS_HOXB2.
    GenevestigatoriP14652.

    Interactioni

    Subunit structurei

    Part of the nuclear protein complex gamma-globin promoter and enhancer binding factor (gamma-PE) composed at least by SATB1 and HOXB2.

    Protein-protein interaction databases

    BioGridi109452. 1 interaction.
    IntActiP14652. 1 interaction.
    STRINGi9606.ENSP00000331741.

    Structurei

    3D structure databases

    ProteinModelPortaliP14652.
    SMRiP14652. Positions 145-201.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Motif

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Motifi94 – 996Antp-type hexapeptide

    Sequence similaritiesi

    Contains 1 homeobox DNA-binding domain.PROSITE-ProRule annotation

    Keywords - Domaini

    Homeobox

    Phylogenomic databases

    eggNOGiNOG295272.
    HOGENOMiHOG000063664.
    HOVERGENiHBG006088.
    InParanoidiP14652.
    KOiK09302.
    OMAiLEDICDP.
    OrthoDBiEOG73RBBF.
    PhylomeDBiP14652.
    TreeFamiTF317730.

    Family and domain databases

    Gene3Di1.10.10.60. 1 hit.
    InterProiIPR001827. Homeobox_Antennapedia_CS.
    IPR017970. Homeobox_CS.
    IPR001356. Homeobox_dom.
    IPR020479. Homeobox_metazoa.
    IPR009057. Homeodomain-like.
    [Graphical view]
    PfamiPF00046. Homeobox. 1 hit.
    [Graphical view]
    PRINTSiPR00024. HOMEOBOX.
    SMARTiSM00389. HOX. 1 hit.
    [Graphical view]
    SUPFAMiSSF46689. SSF46689. 1 hit.
    PROSITEiPS00032. ANTENNAPEDIA. 1 hit.
    PS00027. HOMEOBOX_1. 1 hit.
    PS50071. HOMEOBOX_2. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    P14652-1 [UniParc]FASTAAdd to Basket

    « Hide

    MNFEFEREIG FINSQPSLAE CLTSFPAVLE TFQTSSIKES TLIPPPPPFE    50
    QTFPSLQPGA STLQRPRSQK RAEDGPALPP PPPPPLPAAP PAPEFPWMKE 100
    KKSAKKPSQS ATSPSPAASA VPASGVGSPA DGLGLPEAGG GGARRLRTAY 150
    TNTQLLELEK EFHFNKYLCR PRRVEIAALL DLTERQVKVW FQNRRMKHKR 200
    QTQHREPPDG EPACPGALED ICDPAEEPAA SPGGPSASRA AWEACCHPPE 250
    VVPGALSADP RPLAVRLEGA GASSPGCALR GAGGLEPGPL PEDVFSGRQD 300
    SPFLPDLNFF AADSCLQLSG GLSPSLQGSL DSPVPFSEEE LDFFTSTLCA 350
    IDLQFP 356
    Length:356
    Mass (Da):37,914
    Last modified:April 1, 1990 - v1
    Checksum:iD7ACA0E3D5BEBFB9
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti136 – 1383PEA → RRL in CAA34298. (PubMed:2570724)Curated

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    X16665 mRNA. Translation: CAA34655.1.
    BC074805 mRNA. Translation: AAH74805.1.
    BC074806 mRNA. Translation: AAH74806.1.
    X16176 Genomic DNA. Translation: CAA34298.1.
    X14571 mRNA. Translation: CAA32709.1.
    X78978 Genomic DNA. Translation: CAA55581.1.
    CCDSiCCDS11527.1.
    PIRiS07542. WJHU2H.
    RefSeqiNP_002136.1. NM_002145.3.
    UniGeneiHs.514289.

    Genome annotation databases

    EnsembliENST00000330070; ENSP00000331741; ENSG00000173917.
    GeneIDi3212.
    KEGGihsa:3212.
    UCSCiuc002inm.3. human.

    Polymorphism databases

    DMDMi123270.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    X16665 mRNA. Translation: CAA34655.1 .
    BC074805 mRNA. Translation: AAH74805.1 .
    BC074806 mRNA. Translation: AAH74806.1 .
    X16176 Genomic DNA. Translation: CAA34298.1 .
    X14571 mRNA. Translation: CAA32709.1 .
    X78978 Genomic DNA. Translation: CAA55581.1 .
    CCDSi CCDS11527.1.
    PIRi S07542. WJHU2H.
    RefSeqi NP_002136.1. NM_002145.3.
    UniGenei Hs.514289.

    3D structure databases

    ProteinModelPortali P14652.
    SMRi P14652. Positions 145-201.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 109452. 1 interaction.
    IntActi P14652. 1 interaction.
    STRINGi 9606.ENSP00000331741.

    PTM databases

    PhosphoSitei P14652.

    Polymorphism databases

    DMDMi 123270.

    Proteomic databases

    PaxDbi P14652.
    PRIDEi P14652.

    Protocols and materials databases

    DNASUi 3212.
    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000330070 ; ENSP00000331741 ; ENSG00000173917 .
    GeneIDi 3212.
    KEGGi hsa:3212.
    UCSCi uc002inm.3. human.

    Organism-specific databases

    CTDi 3212.
    GeneCardsi GC17M046620.
    HGNCi HGNC:5113. HOXB2.
    MIMi 142967. gene.
    neXtProti NX_P14652.
    PharmGKBi PA29389.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi NOG295272.
    HOGENOMi HOG000063664.
    HOVERGENi HBG006088.
    InParanoidi P14652.
    KOi K09302.
    OMAi LEDICDP.
    OrthoDBi EOG73RBBF.
    PhylomeDBi P14652.
    TreeFami TF317730.

    Miscellaneous databases

    GeneWikii HOXB2.
    GenomeRNAii 3212.
    NextBioi 12780.
    PROi P14652.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi P14652.
    Bgeei P14652.
    CleanExi HS_HOXB2.
    Genevestigatori P14652.

    Family and domain databases

    Gene3Di 1.10.10.60. 1 hit.
    InterProi IPR001827. Homeobox_Antennapedia_CS.
    IPR017970. Homeobox_CS.
    IPR001356. Homeobox_dom.
    IPR020479. Homeobox_metazoa.
    IPR009057. Homeodomain-like.
    [Graphical view ]
    Pfami PF00046. Homeobox. 1 hit.
    [Graphical view ]
    PRINTSi PR00024. HOMEOBOX.
    SMARTi SM00389. HOX. 1 hit.
    [Graphical view ]
    SUPFAMi SSF46689. SSF46689. 1 hit.
    PROSITEi PS00032. ANTENNAPEDIA. 1 hit.
    PS00027. HOMEOBOX_1. 1 hit.
    PS50071. HOMEOBOX_2. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    3. "Differential expression of human HOX-2 genes along the anterior-posterior axis in embryonic central nervous system."
      Giampaolo A., Acampora D., Zappavigna V., Pannese M., D'Esposito M., Care A., Faiella A., Stornaiuolo A., Russo G., Simeone A., Boncinelli E., Peschle C.
      Differentiation 40:191-197(1989) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 132-208.
      Tissue: Placenta.
    4. "Organization of human class I homeobox genes."
      Boncinelli E., Acampora D., Pannese M., D'Esposito M., Somma R., Gaudino G., Stornaiuolo A., Cafiero M., Faiella A., Simeone A.
      Genome 31:745-756(1989) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 143-208.
    5. "Expression of multiple homeobox genes within diverse mammalian haemopoietic lineages."
      Kongsuwan K., Webb E., Housiaux P., Adams J.M.
      EMBO J. 7:2131-2138(1988) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE OF 143-202.
    6. "Transcription factor GATA-1 regulates human HOXB2 gene expression in erythroid cells."
      Vieille-Grosjean I., Huber P.
      J. Biol. Chem. 270:4544-4550(1995) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 1-42.
    7. "The gammaPE complex contains both SATB1 and HOXB2 and has positive and negative roles in human gamma-globin gene regulation."
      Case S.S., Huber P., Lloyd J.A.
      DNA Cell Biol. 18:805-817(1999) [PubMed] [Europe PMC] [Abstract]
      Cited for: FUNCTION, GAMMA-GLOBIN PROMOTER AND ENHANCER BINDING FACTOR COMPLEX.

    Entry informationi

    Entry nameiHXB2_HUMAN
    AccessioniPrimary (citable) accession number: P14652
    Secondary accession number(s): P10913, P17485
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: April 1, 1990
    Last sequence update: April 1, 1990
    Last modified: October 1, 2014
    This is version 139 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Vertebrate homeotic Hox proteins
      Nomenclature of vertebrate homeotic Hox proteins and list of entries
    2. Human chromosome 17
      Human chromosome 17: entries, gene names and cross-references to MIM
    3. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    4. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3