ID   HXB3_HUMAN              Reviewed;         431 AA.
AC   P14651; A8K567; B7Z5N8; B7Z5P8; B7ZAD0; D3DTV3; O95615; P17484;
DT   01-APR-1990, integrated into UniProtKB/Swiss-Prot.
DT   25-NOV-2008, sequence version 2.
DT   24-JAN-2024, entry version 206.
DE   RecName: Full=Homeobox protein Hox-B3;
DE   AltName: Full=Homeobox protein Hox-2.7;
DE   AltName: Full=Homeobox protein Hox-2G;
GN   Name=HOXB3; Synonyms=HOX2G;
OS   Homo sapiens (Human).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC   Homo.
OX   NCBI_TaxID=9606;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), AND VARIANT THR-82.
RX   PubMed=2574852; DOI=10.1093/nar/17.24.10385;
RA   Acampora D., D'Esposito M., Faiella A., Pannese M., Migliaccio E.,
RA   Morelli F., Stornaiuolo A., Nigro V., Simeone A., Boncinelli E.;
RT   "The human HOX gene family.";
RL   Nucleic Acids Res. 17:10385-10402(1989).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), AND VARIANT THR-82.
RA   Sauvageau G., Thorsteinsdottir U., Hough M.R., Hugo P., Lawrence H.J.,
RA   Largman C., Humphries R.K.;
RT   "Deregulated expression of HoxB3 in hematopoietic cells causes defective
RT   development of alpha beta T Lymphocytes and progressive
RT   myeloproliferation.";
RL   Submitted (MAY-1996) to the EMBL/GenBank/DDBJ databases.
RN   [3]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA], AND VARIANT THR-82.
RA   Kidd K.K., Busygina V., DeMille M.M.C., Speed W.C., Ruggeri V., Kidd J.R.,
RA   Pakstis A.J.;
RT   "Overall linkage disequilibrium in 33 populations for highly informative
RT   multisite haplotypes spanning the HOXB gene cluster.";
RL   Am. J. Hum. Genet. 67:235-235(2000).
RN   [4]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1; 2 AND 3).
RX   PubMed=14702039; DOI=10.1038/ng1285;
RA   Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R.,
RA   Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H.,
RA   Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.,
RA   Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K.,
RA   Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H.,
RA   Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M.,
RA   Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K.,
RA   Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T.,
RA   Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M.,
RA   Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S.,
RA   Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H.,
RA   Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K.,
RA   Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N.,
RA   Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S.,
RA   Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O.,
RA   Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H.,
RA   Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B.,
RA   Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y.,
RA   Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K.,
RA   Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T.,
RA   Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T.,
RA   Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y.,
RA   Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H.,
RA   Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y.,
RA   Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H.,
RA   Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O.,
RA   Isogai T., Sugano S.;
RT   "Complete sequencing and characterization of 21,243 full-length human
RT   cDNAs.";
RL   Nat. Genet. 36:40-45(2004).
RN   [5]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=16625196; DOI=10.1038/nature04689;
RA   Zody M.C., Garber M., Adams D.J., Sharpe T., Harrow J., Lupski J.R.,
RA   Nicholson C., Searle S.M., Wilming L., Young S.K., Abouelleil A.,
RA   Allen N.R., Bi W., Bloom T., Borowsky M.L., Bugalter B.E., Butler J.,
RA   Chang J.L., Chen C.-K., Cook A., Corum B., Cuomo C.A., de Jong P.J.,
RA   DeCaprio D., Dewar K., FitzGerald M., Gilbert J., Gibson R., Gnerre S.,
RA   Goldstein S., Grafham D.V., Grocock R., Hafez N., Hagopian D.S., Hart E.,
RA   Norman C.H., Humphray S., Jaffe D.B., Jones M., Kamal M., Khodiyar V.K.,
RA   LaButti K., Laird G., Lehoczky J., Liu X., Lokyitsang T., Loveland J.,
RA   Lui A., Macdonald P., Major J.E., Matthews L., Mauceli E., McCarroll S.A.,
RA   Mihalev A.H., Mudge J., Nguyen C., Nicol R., O'Leary S.B., Osoegawa K.,
RA   Schwartz D.C., Shaw-Smith C., Stankiewicz P., Steward C., Swarbreck D.,
RA   Venkataraman V., Whittaker C.A., Yang X., Zimmer A.R., Bradley A.,
RA   Hubbard T., Birren B.W., Rogers J., Lander E.S., Nusbaum C.;
RT   "DNA sequence of human chromosome 17 and analysis of rearrangement in the
RT   human lineage.";
RL   Nature 440:1045-1049(2006).
RN   [6]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA], AND VARIANT THR-82.
RA   Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M.,
RA   Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J.,
RA   Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S.,
RA   Turner R., Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H.,
RA   Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K.,
RA   Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D.,
RA   Hunkapiller M.W., Myers E.W., Venter J.C.;
RL   Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases.
RN   [7]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 188-253.
RC   TISSUE=Placenta;
RX   PubMed=2570724; DOI=10.1111/j.1432-0436.1989.tb00598.x;
RA   Giampaolo A., Acampora D., Zappavigna V., Pannese M., D'Esposito M.,
RA   Care A., Faiella A., Stornaiuolo A., Russo G., Simeone A., Boncinelli E.,
RA   Peschle C.;
RT   "Differential expression of human HOX-2 genes along the anterior-posterior
RT   axis in embryonic central nervous system.";
RL   Differentiation 40:191-197(1989).
RN   [8]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 188-253.
RX   PubMed=2576652; DOI=10.1139/g89-133;
RA   Boncinelli E., Acampora D., Pannese M., D'Esposito M., Somma R.,
RA   Gaudino G., Stornaiuolo A., Cafiero M., Faiella A., Simeone A.;
RT   "Organization of human class I homeobox genes.";
RL   Genome 31:745-756(1989).
CC   -!- FUNCTION: Sequence-specific transcription factor which is part of a
CC       developmental regulatory system that provides cells with specific
CC       positional identities on the anterior-posterior axis.
CC   -!- SUBCELLULAR LOCATION: Nucleus.
CC   -!- ALTERNATIVE PRODUCTS:
CC       Event=Alternative splicing; Named isoforms=3;
CC       Name=1;
CC         IsoId=P14651-1; Sequence=Displayed;
CC       Name=2;
CC         IsoId=P14651-2; Sequence=VSP_056434;
CC       Name=3;
CC         IsoId=P14651-3; Sequence=VSP_056815;
CC   -!- DEVELOPMENTAL STAGE: Expressed in whole embryos and fetuses at 5-9
CC       weeks from conception.
CC   -!- SIMILARITY: Belongs to the Antp homeobox family. {ECO:0000305}.
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DR   EMBL; X16667; CAA34657.1; -; mRNA.
DR   EMBL; U59298; AAD10852.1; -; mRNA.
DR   EMBL; AF287967; AAG31555.1; -; Genomic_DNA.
DR   EMBL; AK291182; BAF83871.1; -; mRNA.
DR   EMBL; AK299226; BAH12974.1; -; mRNA.
DR   EMBL; AK299265; BAH12984.1; -; mRNA.
DR   EMBL; AK315102; BAG37563.1; -; mRNA.
DR   EMBL; AK316245; BAH14616.1; -; mRNA.
DR   EMBL; AC103702; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; CH471109; EAW94739.1; -; Genomic_DNA.
DR   EMBL; CH471109; EAW94740.1; -; Genomic_DNA.
DR   EMBL; CH471109; EAW94741.1; -; Genomic_DNA.
DR   EMBL; X16175; CAA34297.1; -; Genomic_DNA.
DR   CCDS; CCDS11528.1; -. [P14651-1]
DR   CCDS; CCDS82153.1; -. [P14651-3]
DR   CCDS; CCDS82154.1; -. [P14651-2]
DR   PIR; S07543; WJHU2G.
DR   RefSeq; NP_001317251.1; NM_001330322.1. [P14651-2]
DR   RefSeq; NP_001317252.1; NM_001330323.1. [P14651-3]
DR   RefSeq; NP_002137.4; NM_002146.4. [P14651-1]
DR   RefSeq; XP_005257334.1; XM_005257277.3.
DR   RefSeq; XP_006721917.1; XM_006721854.2.
DR   RefSeq; XP_011523010.1; XM_011524708.2. [P14651-3]
DR   RefSeq; XP_011523012.1; XM_011524710.1.
DR   RefSeq; XP_011523021.1; XM_011524719.1.
DR   RefSeq; XP_011523022.1; XM_011524720.2.
DR   RefSeq; XP_011523028.1; XM_011524726.2. [P14651-2]
DR   AlphaFoldDB; P14651; -.
DR   SMR; P14651; -.
DR   BioGRID; 109453; 32.
DR   ELM; P14651; -.
DR   IntAct; P14651; 1.
DR   STRING; 9606.ENSP00000417207; -.
DR   GlyConnect; 1942; 20 N-Linked glycans (3 sites).
DR   GlyCosmos; P14651; 3 sites, 20 glycans.
DR   GlyGen; P14651; 3 sites, 20 N-linked glycans (3 sites).
DR   iPTMnet; P14651; -.
DR   PhosphoSitePlus; P14651; -.
DR   BioMuta; HOXB3; -.
DR   DMDM; 215274007; -.
DR   MassIVE; P14651; -.
DR   PaxDb; 9606-ENSP00000417207; -.
DR   PeptideAtlas; P14651; -.
DR   ProteomicsDB; 53070; -. [P14651-1]
DR   ProteomicsDB; 6705; -.
DR   ProteomicsDB; 7060; -.
DR   Antibodypedia; 4079; 162 antibodies from 23 providers.
DR   DNASU; 3213; -.
DR   Ensembl; ENST00000311626.8; ENSP00000308252.4; ENSG00000120093.12. [P14651-1]
DR   Ensembl; ENST00000460160.5; ENSP00000418035.1; ENSG00000120093.12. [P14651-3]
DR   Ensembl; ENST00000470495.1; ENSP00000417207.1; ENSG00000120093.12. [P14651-1]
DR   Ensembl; ENST00000472863.5; ENSP00000419676.1; ENSG00000120093.12. [P14651-2]
DR   Ensembl; ENST00000476342.1; ENSP00000418892.1; ENSG00000120093.12. [P14651-1]
DR   Ensembl; ENST00000489475.5; ENSP00000418729.1; ENSG00000120093.12. [P14651-2]
DR   Ensembl; ENST00000498678.6; ENSP00000420595.1; ENSG00000120093.12. [P14651-1]
DR   GeneID; 3213; -.
DR   KEGG; hsa:3213; -.
DR   MANE-Select; ENST00000498678.6; ENSP00000420595.1; NM_001384749.1; NP_001371678.1.
DR   UCSC; uc002inn.4; human. [P14651-1]
DR   AGR; HGNC:5114; -.
DR   CTD; 3213; -.
DR   DisGeNET; 3213; -.
DR   GeneCards; HOXB3; -.
DR   HGNC; HGNC:5114; HOXB3.
DR   HPA; ENSG00000120093; Tissue enhanced (epididymis).
DR   MIM; 142966; gene.
DR   neXtProt; NX_P14651; -.
DR   OpenTargets; ENSG00000120093; -.
DR   PharmGKB; PA29390; -.
DR   VEuPathDB; HostDB:ENSG00000120093; -.
DR   eggNOG; KOG0489; Eukaryota.
DR   GeneTree; ENSGT00940000159774; -.
DR   HOGENOM; CLU_051508_1_0_1; -.
DR   InParanoid; P14651; -.
DR   OMA; GCAAPQK; -.
DR   OrthoDB; 728401at2759; -.
DR   PhylomeDB; P14651; -.
DR   TreeFam; TF315938; -.
DR   PathwayCommons; P14651; -.
DR   Reactome; R-HSA-5617472; Activation of anterior HOX genes in hindbrain development during early embryogenesis.
DR   SignaLink; P14651; -.
DR   SIGNOR; P14651; -.
DR   BioGRID-ORCS; 3213; 13 hits in 1185 CRISPR screens.
DR   ChiTaRS; HOXB3; human.
DR   GeneWiki; HOXB3; -.
DR   GenomeRNAi; 3213; -.
DR   Pharos; P14651; Tbio.
DR   PRO; PR:P14651; -.
DR   Proteomes; UP000005640; Chromosome 17.
DR   RNAct; P14651; Protein.
DR   Bgee; ENSG00000120093; Expressed in right uterine tube and 171 other cell types or tissues.
DR   ExpressionAtlas; P14651; baseline and differential.
DR   GO; GO:0000785; C:chromatin; ISA:NTNU_SB.
DR   GO; GO:0005654; C:nucleoplasm; IDA:HPA.
DR   GO; GO:0005634; C:nucleus; IBA:GO_Central.
DR   GO; GO:0001228; F:DNA-binding transcription activator activity, RNA polymerase II-specific; IDA:NTNU_SB.
DR   GO; GO:0000981; F:DNA-binding transcription factor activity, RNA polymerase II-specific; ISA:NTNU_SB.
DR   GO; GO:0000978; F:RNA polymerase II cis-regulatory region sequence-specific DNA binding; IDA:NTNU_SB.
DR   GO; GO:0001525; P:angiogenesis; IEP:UniProtKB.
DR   GO; GO:0009952; P:anterior/posterior pattern specification; IBA:GO_Central.
DR   GO; GO:0051216; P:cartilage development; IEA:Ensembl.
DR   GO; GO:0060216; P:definitive hemopoiesis; IEA:Ensembl.
DR   GO; GO:0048704; P:embryonic skeletal system morphogenesis; IBA:GO_Central.
DR   GO; GO:0060324; P:face development; IEA:Ensembl.
DR   GO; GO:0021615; P:glossopharyngeal nerve morphogenesis; IEA:Ensembl.
DR   GO; GO:0002244; P:hematopoietic progenitor cell differentiation; IEA:Ensembl.
DR   GO; GO:0000122; P:negative regulation of transcription by RNA polymerase II; IEA:Ensembl.
DR   GO; GO:0045944; P:positive regulation of transcription by RNA polymerase II; IDA:NTNU_SB.
DR   GO; GO:0050767; P:regulation of neurogenesis; IEA:Ensembl.
DR   GO; GO:0006357; P:regulation of transcription by RNA polymerase II; IBA:GO_Central.
DR   GO; GO:0021546; P:rhombomere development; IEA:Ensembl.
DR   GO; GO:0030878; P:thyroid gland development; IEA:Ensembl.
DR   CDD; cd00086; homeodomain; 1.
DR   Gene3D; 1.10.10.60; Homeodomain-like; 1.
DR   InterPro; IPR025281; DUF4074.
DR   InterPro; IPR009057; Homeobox-like_sf.
DR   InterPro; IPR001827; Homeobox_Antennapedia_CS.
DR   InterPro; IPR017970; Homeobox_CS.
DR   InterPro; IPR001356; Homeobox_dom.
DR   InterPro; IPR020479; Homeobox_metazoa.
DR   PANTHER; PTHR45664:SF11; HOMEOBOX PROTEIN HOX-B3; 1.
DR   PANTHER; PTHR45664; PROTEIN ZERKNUELLT 1-RELATED; 1.
DR   Pfam; PF13293; DUF4074; 1.
DR   Pfam; PF00046; Homeodomain; 1.
DR   PRINTS; PR00024; HOMEOBOX.
DR   SMART; SM00389; HOX; 1.
DR   SUPFAM; SSF46689; Homeodomain-like; 1.
DR   PROSITE; PS00032; ANTENNAPEDIA; 1.
DR   PROSITE; PS00027; HOMEOBOX_1; 1.
DR   PROSITE; PS50071; HOMEOBOX_2; 1.
DR   Genevisible; P14651; HS.
PE   2: Evidence at transcript level;
KW   Alternative splicing; Developmental protein; DNA-binding; Homeobox;
KW   Nucleus; Reference proteome; Transcription; Transcription regulation.
FT   CHAIN           1..431
FT                   /note="Homeobox protein Hox-B3"
FT                   /id="PRO_0000200117"
FT   DNA_BIND        188..247
FT                   /note="Homeobox"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00108"
FT   REGION          63..125
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          137..192
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          246..273
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          381..431
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   MOTIF           129..134
FT                   /note="Antp-type hexapeptide"
FT   COMPBIAS        80..94
FT                   /note="Pro residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        95..125
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   VAR_SEQ         1..132
FT                   /note="Missing (in isoform 3)"
FT                   /evidence="ECO:0000303|PubMed:14702039"
FT                   /id="VSP_056815"
FT   VAR_SEQ         1..73
FT                   /note="Missing (in isoform 2)"
FT                   /evidence="ECO:0000303|PubMed:14702039"
FT                   /id="VSP_056434"
FT   VARIANT         82
FT                   /note="P -> T (in dbSNP:rs2229304)"
FT                   /evidence="ECO:0000269|PubMed:2574852, ECO:0000269|Ref.2,
FT                   ECO:0000269|Ref.3, ECO:0000269|Ref.6"
FT                   /id="VAR_047729"
FT   CONFLICT        100
FT                   /note="T -> A (in Ref. 4; BAH12984)"
FT                   /evidence="ECO:0000305"
FT   CONFLICT        199..200
FT                   /note="QL -> HV (in Ref. 2; AAD10852)"
FT                   /evidence="ECO:0000305"
SQ   SEQUENCE   431 AA;  44340 MW;  56D39C0C9496E65A CRC64;
     MQKATYYDNA AAALFGGYSS YPGSNGFGFD VPPQPPFQAA THLEGDYQRS ACSLQSLGNA
     APHAKSKELN GSCMRPGLAP EPLSAPPGSP PPSAAPTSAT SNSSNGGGPS KSGPPKCGPG
     TNSTLTKQIF PWMKESRQTS KLKNNSPGTA EGCGGGGGGG GGGGSGGSGG GGGGGGGGDK
     SPPGSAASKR ARTAYTSAQL VELEKEFHFN RYLCRPRRVE MANLLNLSER QIKIWFQNRR
     MKYKKDQKAK GLASSSGGPS PAGSPPQPMQ STAGFMNALH SMTPSYESPS PPAFGKAHQN
     AYALPSNYQP PLKGCGAPQK YPPTPAPEYE PHVLQANGGA YGTPTMQGSP VYVGGGGYAD
     PLPPPAGPSL YGLNHLSHHP SGNLDYNGAP PMAPSQHHGP CEPHPTYTDL SSHHAPPPQG
     RIQEAPKLTH L
//