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Protein

Homeobox protein Hox-B3

Gene

HOXB3

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at transcript leveli

Functioni

Sequence-specific transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis.

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
DNA bindingi188 – 247HomeoboxPROSITE-ProRule annotationAdd BLAST60

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionDevelopmental protein, DNA-binding
Biological processTranscription, Transcription regulation

Enzyme and pathway databases

ReactomeiR-HSA-5617472. Activation of anterior HOX genes in hindbrain development during early embryogenesis.
SIGNORiP14651.

Names & Taxonomyi

Protein namesi
Recommended name:
Homeobox protein Hox-B3
Alternative name(s):
Homeobox protein Hox-2.7
Homeobox protein Hox-2G
Gene namesi
Name:HOXB3
Synonyms:HOX2G
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 17

Organism-specific databases

HGNCiHGNC:5114. HOXB3.

Subcellular locationi

GO - Cellular componenti

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Organism-specific databases

DisGeNETi3213.
OpenTargetsiENSG00000120093.
PharmGKBiPA29390.

Polymorphism and mutation databases

BioMutaiHOXB3.
DMDMi215274007.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002001171 – 431Homeobox protein Hox-B3Add BLAST431

Proteomic databases

PaxDbiP14651.
PeptideAtlasiP14651.
PRIDEiP14651.

PTM databases

iPTMnetiP14651.
PhosphoSitePlusiP14651.

Expressioni

Developmental stagei

Expressed in whole embryos and fetuses at 5-9 weeks from conception.

Gene expression databases

BgeeiENSG00000120093.
CleanExiHS_HOXB3.
ExpressionAtlasiP14651. baseline and differential.
GenevisibleiP14651. HS.

Organism-specific databases

HPAiCAB009860.
HPA064990.

Interactioni

Protein-protein interaction databases

BioGridi109453. 2 interactors.
ELMiP14651.
STRINGi9606.ENSP00000308252.

Structurei

3D structure databases

ProteinModelPortaliP14651.
SMRiP14651.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi129 – 134Antp-type hexapeptide6

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi154 – 178Gly-richAdd BLAST25

Sequence similaritiesi

Belongs to the Antp homeobox family.Curated

Keywords - Domaini

Homeobox

Phylogenomic databases

eggNOGiKOG0489. Eukaryota.
ENOG410ZTBY. LUCA.
GeneTreeiENSGT00760000118940.
HOGENOMiHOG000252944.
HOVERGENiHBG107984.
InParanoidiP14651.
KOiK09303.
OMAiEYEPHVL.
OrthoDBiEOG091G09XD.
PhylomeDBiP14651.
TreeFamiTF315938.

Family and domain databases

InterProiView protein in InterPro
IPR025281. DUF4074.
IPR009057. Homeobox-like.
IPR001827. Homeobox_Antennapedia_CS.
IPR017970. Homeobox_CS.
IPR001356. Homeobox_dom.
IPR020479. Homeobox_metazoa.
PfamiView protein in Pfam
PF13293. DUF4074. 1 hit.
PF00046. Homeobox. 1 hit.
PRINTSiPR00024. HOMEOBOX.
SMARTiView protein in SMART
SM00389. HOX. 1 hit.
SUPFAMiSSF46689. SSF46689. 1 hit.
PROSITEiView protein in PROSITE
PS00032. ANTENNAPEDIA. 1 hit.
PS00027. HOMEOBOX_1. 1 hit.
PS50071. HOMEOBOX_2. 1 hit.

Sequences (3)i

Sequence statusi: Complete.

This entry describes 3 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: P14651-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MQKATYYDNA AAALFGGYSS YPGSNGFGFD VPPQPPFQAA THLEGDYQRS
60 70 80 90 100
ACSLQSLGNA APHAKSKELN GSCMRPGLAP EPLSAPPGSP PPSAAPTSAT
110 120 130 140 150
SNSSNGGGPS KSGPPKCGPG TNSTLTKQIF PWMKESRQTS KLKNNSPGTA
160 170 180 190 200
EGCGGGGGGG GGGGSGGSGG GGGGGGGGDK SPPGSAASKR ARTAYTSAQL
210 220 230 240 250
VELEKEFHFN RYLCRPRRVE MANLLNLSER QIKIWFQNRR MKYKKDQKAK
260 270 280 290 300
GLASSSGGPS PAGSPPQPMQ STAGFMNALH SMTPSYESPS PPAFGKAHQN
310 320 330 340 350
AYALPSNYQP PLKGCGAPQK YPPTPAPEYE PHVLQANGGA YGTPTMQGSP
360 370 380 390 400
VYVGGGGYAD PLPPPAGPSL YGLNHLSHHP SGNLDYNGAP PMAPSQHHGP
410 420 430
CEPHPTYTDL SSHHAPPPQG RIQEAPKLTH L
Length:431
Mass (Da):44,340
Last modified:November 25, 2008 - v2
Checksum:i56D39C0C9496E65A
GO
Isoform 2 (identifier: P14651-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-73: Missing.

Note: No experimental confirmation available.
Show »
Length:358
Mass (Da):36,698
Checksum:i8E6B18948B2AD02E
GO
Isoform 3 (identifier: P14651-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-132: Missing.

Note: No experimental confirmation available.
Show »
Length:299
Mass (Da):30,989
Checksum:i6C0A22D64D10D5FD
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti100T → A in BAH12984 (PubMed:14702039).Curated1
Sequence conflicti199 – 200QL → HV in AAD10852 (Ref. 2) Curated2

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_04772982P → T4 PublicationsCorresponds to variant dbSNP:rs2229304Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_0568151 – 132Missing in isoform 3. 1 PublicationAdd BLAST132
Alternative sequenceiVSP_0564341 – 73Missing in isoform 2. 1 PublicationAdd BLAST73

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X16667 mRNA. Translation: CAA34657.1.
U59298 mRNA. Translation: AAD10852.1.
AF287967 Genomic DNA. Translation: AAG31555.1.
AK291182 mRNA. Translation: BAF83871.1.
AK299226 mRNA. Translation: BAH12974.1.
AK299265 mRNA. Translation: BAH12984.1.
AK315102 mRNA. Translation: BAG37563.1.
AK316245 mRNA. Translation: BAH14616.1.
AC103702 Genomic DNA. No translation available.
CH471109 Genomic DNA. Translation: EAW94739.1.
CH471109 Genomic DNA. Translation: EAW94740.1.
CH471109 Genomic DNA. Translation: EAW94741.1.
X16175 Genomic DNA. Translation: CAA34297.1.
CCDSiCCDS11528.1. [P14651-1]
CCDS82153.1. [P14651-3]
CCDS82154.1. [P14651-2]
PIRiS07543. WJHU2G.
RefSeqiNP_001317251.1. NM_001330322.1. [P14651-2]
NP_001317252.1. NM_001330323.1. [P14651-3]
NP_002137.4. NM_002146.4. [P14651-1]
XP_005257334.1. XM_005257277.3. [P14651-1]
XP_006721917.1. XM_006721854.2. [P14651-1]
XP_011523012.1. XM_011524710.1. [P14651-1]
XP_011523021.1. XM_011524719.1. [P14651-1]
XP_011523022.1. XM_011524720.2. [P14651-1]
XP_011523028.1. XM_011524726.2. [P14651-2]
UniGeneiHs.654560.
Hs.675434.
Hs.687723.

Genome annotation databases

EnsembliENST00000311626; ENSP00000308252; ENSG00000120093. [P14651-1]
ENST00000460160; ENSP00000418035; ENSG00000120093. [P14651-3]
ENST00000470495; ENSP00000417207; ENSG00000120093. [P14651-1]
ENST00000472863; ENSP00000419676; ENSG00000120093. [P14651-2]
ENST00000476342; ENSP00000418892; ENSG00000120093. [P14651-1]
ENST00000489475; ENSP00000418729; ENSG00000120093. [P14651-2]
ENST00000498678; ENSP00000420595; ENSG00000120093. [P14651-1]
GeneIDi3213.
KEGGihsa:3213.
UCSCiuc002inn.4. human. [P14651-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Similar proteinsi

Entry informationi

Entry nameiHXB3_HUMAN
AccessioniPrimary (citable) accession number: P14651
Secondary accession number(s): A8K567
, B7Z5N8, B7Z5P8, B7ZAD0, D3DTV3, O95615, P17484
Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 1, 1990
Last sequence update: November 25, 2008
Last modified: August 30, 2017
This is version 165 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Vertebrate homeotic Hox proteins
    Nomenclature of vertebrate homeotic Hox proteins and list of entries
  2. Human chromosome 17
    Human chromosome 17: entries, gene names and cross-references to MIM
  3. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  4. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  5. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  6. SIMILARITY comments
    Index of protein domains and families