P14651 (HXB3_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Homeobox protein Hox-B3

Alternative name(s):
Homeobox protein Hox-2.7
Homeobox protein Hox-2G

Gene names

Name:	HOXB3
Synonyms:	HOX2G

Organism

Homo sapiens (Human) [Reference proteome]

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo

Protein attributes

Sequence length	431 AA.
Sequence status	Complete.
Protein existence	Evidence at protein level

General annotation (Comments)

Function	Sequence-specific transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis.
Subcellular location	Nucleus.
Developmental stage	Expressed in whole embryos and fetuses at 5-9 weeks from conception.
Sequence similarities	Belongs to the Antp homeobox family. Contains 1 homeobox DNA-binding domain.

Ontologies

Keywords
Biological process	Transcription Transcription regulation
Cellular component	Nucleus
Coding sequence diversity	Polymorphism
Domain	Homeobox
Ligand	DNA-binding
Molecular function	Developmental protein
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	angiogenesis Inferred from expression pattern PubMed 17972163. Source: UniProtKB anterior/posterior pattern specification Inferred from electronic annotation. Source: Compara cartilage development Inferred from electronic annotation. Source: Compara definitive hemopoiesis Inferred from electronic annotation. Source: Compara embryonic skeletal system morphogenesis Inferred from electronic annotation. Source: Compara face development Inferred from electronic annotation. Source: Compara glossopharyngeal nerve morphogenesis Inferred from electronic annotation. Source: Compara negative regulation of transcription from RNA polymerase II promoter Inferred from electronic annotation. Source: Compara regulation of neurogenesis Inferred from electronic annotation. Source: Compara rhombomere development Inferred from electronic annotation. Source: Compara thyroid gland development Inferred from electronic annotation. Source: Compara transcription, DNA-dependent Inferred from electronic annotation. Source: UniProtKB-KW
Cellular_component	nucleus Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular_function	RNA polymerase II core promoter sequence-specific DNA binding Inferred from electronic annotation. Source: Compara sequence-specific DNA binding transcription factor activity Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 431	431	Homeobox protein Hox-B3		PRO_0000200117
Regions
	DNA binding	188 – 247	60	Homeobox
	Motif	129 – 134	6	Antp-type hexapeptide
	Compositional bias	154 – 178	25	Gly-rich
Natural variations
	Natural variant	82	1	P → T. Ref.1 Ref.2 Ref.3 Ref.5 Corresponds to variant rs2229304 [ dbSNP | Ensembl ].		VAR_047729
Experimental info
	Sequence conflict	199 – 200	2	QL → HV in AAD10852. Ref.2

Sequences

	Sequence		Length	Mass (Da)
	P14651 [UniParc]. Last modified November 25, 2008. Version 2. Checksum: 56D39C0C9496E65A	FASTA	431	44,340
	10 20 30 40 50 60 MQKATYYDNA AAALFGGYSS YPGSNGFGFD VPPQPPFQAA THLEGDYQRS ACSLQSLGNA 70 80 90 100 110 120 APHAKSKELN GSCMRPGLAP EPLSAPPGSP PPSAAPTSAT SNSSNGGGPS KSGPPKCGPG 130 140 150 160 170 180 TNSTLTKQIF PWMKESRQTS KLKNNSPGTA EGCGGGGGGG GGGGSGGSGG GGGGGGGGDK 190 200 210 220 230 240 SPPGSAASKR ARTAYTSAQL VELEKEFHFN RYLCRPRRVE MANLLNLSER QIKIWFQNRR 250 260 270 280 290 300 MKYKKDQKAK GLASSSGGPS PAGSPPQPMQ STAGFMNALH SMTPSYESPS PPAFGKAHQN 310 320 330 340 350 360 AYALPSNYQP PLKGCGAPQK YPPTPAPEYE PHVLQANGGA YGTPTMQGSP VYVGGGGYAD 370 380 390 400 410 420 PLPPPAGPSL YGLNHLSHHP SGNLDYNGAP PMAPSQHHGP CEPHPTYTDL SSHHAPPPQG 430 RIQEAPKLTH L

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"The human HOX gene family." Acampora D., D'Esposito M., Faiella A., Pannese M., Migliaccio E., Morelli F., Stornaiuolo A., Nigro V., Simeone A., Boncinelli E. Nucleic Acids Res. 17:10385-10402(1989) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA], VARIANT THR-82.
[2]	"Deregulated expression of HoxB3 in hematopoietic cells causes defective development of alpha beta T Lymphocytes and progressive myeloproliferation." Sauvageau G., Thorsteinsdottir U., Hough M.R., Hugo P., Lawrence H.J., Largman C., Humphries R.K. Submitted (MAY-1996) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [MRNA], VARIANT THR-82.
[3]	"Overall linkage disequilibrium in 33 populations for highly informative multisite haplotypes spanning the HOXB gene cluster." Kidd K.K., Busygina V., DeMille M.M.C., Speed W.C., Ruggeri V., Kidd J.R., Pakstis A.J. Am. J. Hum. Genet. 67:235-235(2000) Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], VARIANT THR-82.
[4]	"Complete sequencing and characterization of 21,243 full-length human cDNAs." Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S. , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S. Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
[5]	Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M., Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J., Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S., Turner R. , Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H., Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K., Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D., Hunkapiller M.W., Myers E.W., Venter J.C. Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA], VARIANT THR-82.
[6]	"Differential expression of human HOX-2 genes along the anterior-posterior axis in embryonic central nervous system." Giampaolo A., Acampora D., Zappavigna V., Pannese M., D'Esposito M., Care A., Faiella A., Stornaiuolo A., Russo G., Simeone A., Boncinelli E., Peschle C. Differentiation 40:191-197(1989) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 188-253. Tissue: Placenta.
[7]	"Organization of human class I homeobox genes." Boncinelli E., Acampora D., Pannese M., D'Esposito M., Somma R., Gaudino G., Stornaiuolo A., Cafiero M., Faiella A., Simeone A. Genome 31:745-756(1989) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 188-253.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	X16667 mRNA. Translation: CAA34657.1. U59298 mRNA. Translation: AAD10852.1. AF287967 Genomic DNA. Translation: AAG31555.1. AK291182 mRNA. Translation: BAF83871.1. AK315102 mRNA. Translation: BAG37563.1. CH471109 Genomic DNA. Translation: EAW94739.1. CH471109 Genomic DNA. Translation: EAW94740.1. CH471109 Genomic DNA. Translation: EAW94741.1. X16175 Genomic DNA. Translation: CAA34297.1.
IPI	IPI00027259.
PIR	WJHU2G. S07543.
RefSeq	NP_002137.4. NM_002146.4.
UniGene	Hs.654560.
3D structure databases
ProteinModelPortal	P14651.
ModBase	Search...
Protein-protein interaction databases
STRING	9606.ENSP00000308252.
Polymorphism databases
DMDM	215274007.
Proteomic databases
PaxDb	P14651.
PRIDE	P14651.
Protocols and materials databases
DNASU	3213.
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENST00000311626; ENSP00000308252; ENSG00000120093. ENST00000470495; ENSP00000417207; ENSG00000120093. ENST00000476342; ENSP00000418892; ENSG00000120093. ENST00000498678; ENSP00000420595; ENSG00000120093.
GeneID	3213.
KEGG	hsa:3213.
UCSC	uc002inn.3. human.
Organism-specific databases
CTD	3213.
GeneCards	GC17M046626.
HGNC	HGNC:5114. HOXB3.
HPA	CAB009860.
MIM	142966. gene.
neXtProt	NX_P14651.
PharmGKB	PA29390.
GenAtlas	Search...
Phylogenomic databases
eggNOG	NOG284589.
HOGENOM	HOG000252944.
HOVERGEN	HBG107984.
InParanoid	P14651.
KO	K09303.
OMA	ATYYDNT.
OrthoDB	EOG4S4PH1.
PhylomeDB	P14651.
Gene expression databases
ArrayExpress	P14651.
Bgee	P14651.
CleanEx	HS_HOXB3.
Genevestigator	P14651.
GermOnline	ENSG00000120093. Homo sapiens.
Family and domain databases
Gene3D	1.10.10.60. 1 hit.
InterPro	IPR025281. DUF4074. IPR001827. Homeobox_Antennapedia_CS. IPR017970. Homeobox_CS. IPR020479. Homeobox_metazoa. IPR001356. Homeodomain. IPR009057. Homeodomain-like. [Graphical view]
Pfam	PF13293. DUF4074. 1 hit. PF00046. Homeobox. 1 hit. [Graphical view]
PRINTS	PR00024. HOMEOBOX.
SMART	SM00389. HOX. 1 hit. [Graphical view]
SUPFAM	SSF46689. Homeodomain_like. 1 hit.
PROSITE	PS00032. ANTENNAPEDIA. 1 hit. PS00027. HOMEOBOX_1. 1 hit. PS50071. HOMEOBOX_2. 1 hit. [Graphical view]
ProtoNet	Search...
Other
ChiTaRS	HOXB3. human.
GenomeRNAi	3213.
NextBio	12784.
SOURCE	Search...

Entry information

Entry name

HXB3_HUMAN

Accession

Primary (citable) accession number: P14651
Secondary accession number(s): A8K567 , D3DTV3, O95615, P17484

Entry history

Integrated into UniProtKB/Swiss-Prot:	April 1, 1990
Last sequence update:	November 25, 2008
Last modified:	May 1, 2013
This is version 131 of the entry and version 2 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.