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P14651

- HXB3_HUMAN

UniProt

P14651 - HXB3_HUMAN

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Protein
Homeobox protein Hox-B3
Gene
HOXB3, HOX2G
Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5 - Experimental evidence at protein leveli

Functioni

Sequence-specific transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis.

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
DNA bindingi188 – 24760Homeobox
Add
BLAST

GO - Molecular functioni

  1. RNA polymerase II core promoter sequence-specific DNA binding Source: Ensembl
  2. sequence-specific DNA binding transcription factor activity Source: InterPro

GO - Biological processi

  1. angiogenesis Source: UniProtKB
  2. anterior/posterior pattern specification Source: Ensembl
  3. cartilage development Source: Ensembl
  4. definitive hemopoiesis Source: Ensembl
  5. embryonic skeletal system morphogenesis Source: Ensembl
  6. face development Source: Ensembl
  7. glossopharyngeal nerve morphogenesis Source: Ensembl
  8. negative regulation of transcription from RNA polymerase II promoter Source: Ensembl
  9. regulation of neurogenesis Source: Ensembl
  10. rhombomere development Source: Ensembl
  11. thyroid gland development Source: Ensembl
  12. transcription, DNA-templated Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Developmental protein

Keywords - Biological processi

Transcription, Transcription regulation

Keywords - Ligandi

DNA-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Homeobox protein Hox-B3
Alternative name(s):
Homeobox protein Hox-2.7
Homeobox protein Hox-2G
Gene namesi
Name:HOXB3
Synonyms:HOX2G
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 17

Organism-specific databases

HGNCiHGNC:5114. HOXB3.

Subcellular locationi

GO - Cellular componenti

  1. nucleus Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA29390.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 431431Homeobox protein Hox-B3
PRO_0000200117Add
BLAST

Proteomic databases

PaxDbiP14651.
PRIDEiP14651.

Expressioni

Developmental stagei

Expressed in whole embryos and fetuses at 5-9 weeks from conception.

Gene expression databases

ArrayExpressiP14651.
BgeeiP14651.
CleanExiHS_HOXB3.
GenevestigatoriP14651.

Organism-specific databases

HPAiCAB009860.

Interactioni

Protein-protein interaction databases

BioGridi109453. 2 interactions.
STRINGi9606.ENSP00000308252.

Structurei

3D structure databases

ProteinModelPortaliP14651.
SMRiP14651. Positions 190-247.

Family & Domainsi

Motif

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Motifi129 – 1346Antp-type hexapeptide

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi154 – 17825Gly-rich
Add
BLAST

Sequence similaritiesi

Belongs to the Antp homeobox family.

Keywords - Domaini

Homeobox

Phylogenomic databases

eggNOGiNOG284589.
HOGENOMiHOG000252944.
HOVERGENiHBG107984.
InParanoidiP14651.
KOiK09303.
OMAiATYYDNT.
OrthoDBiEOG754HPS.
PhylomeDBiP14651.
TreeFamiTF315938.

Family and domain databases

Gene3Di1.10.10.60. 1 hit.
InterProiIPR025281. DUF4074.
IPR001827. Homeobox_Antennapedia_CS.
IPR017970. Homeobox_CS.
IPR001356. Homeobox_dom.
IPR020479. Homeobox_metazoa.
IPR009057. Homeodomain-like.
[Graphical view]
PfamiPF13293. DUF4074. 1 hit.
PF00046. Homeobox. 1 hit.
[Graphical view]
PRINTSiPR00024. HOMEOBOX.
SMARTiSM00389. HOX. 1 hit.
[Graphical view]
SUPFAMiSSF46689. SSF46689. 1 hit.
PROSITEiPS00032. ANTENNAPEDIA. 1 hit.
PS00027. HOMEOBOX_1. 1 hit.
PS50071. HOMEOBOX_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P14651-1 [UniParc]FASTAAdd to Basket

« Hide

MQKATYYDNA AAALFGGYSS YPGSNGFGFD VPPQPPFQAA THLEGDYQRS    50
ACSLQSLGNA APHAKSKELN GSCMRPGLAP EPLSAPPGSP PPSAAPTSAT 100
SNSSNGGGPS KSGPPKCGPG TNSTLTKQIF PWMKESRQTS KLKNNSPGTA 150
EGCGGGGGGG GGGGSGGSGG GGGGGGGGDK SPPGSAASKR ARTAYTSAQL 200
VELEKEFHFN RYLCRPRRVE MANLLNLSER QIKIWFQNRR MKYKKDQKAK 250
GLASSSGGPS PAGSPPQPMQ STAGFMNALH SMTPSYESPS PPAFGKAHQN 300
AYALPSNYQP PLKGCGAPQK YPPTPAPEYE PHVLQANGGA YGTPTMQGSP 350
VYVGGGGYAD PLPPPAGPSL YGLNHLSHHP SGNLDYNGAP PMAPSQHHGP 400
CEPHPTYTDL SSHHAPPPQG RIQEAPKLTH L 431
Length:431
Mass (Da):44,340
Last modified:November 25, 2008 - v2
Checksum:i56D39C0C9496E65A
GO

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti82 – 821P → T.4 Publications
Corresponds to variant rs2229304 [ dbSNP | Ensembl ].
VAR_047729

Sequence conflict

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti199 – 2002QL → HV in AAD10852. 1 Publication

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
X16667 mRNA. Translation: CAA34657.1.
U59298 mRNA. Translation: AAD10852.1.
AF287967 Genomic DNA. Translation: AAG31555.1.
AK291182 mRNA. Translation: BAF83871.1.
AK315102 mRNA. Translation: BAG37563.1.
CH471109 Genomic DNA. Translation: EAW94739.1.
CH471109 Genomic DNA. Translation: EAW94740.1.
CH471109 Genomic DNA. Translation: EAW94741.1.
X16175 Genomic DNA. Translation: CAA34297.1.
CCDSiCCDS11528.1.
PIRiS07543. WJHU2G.
RefSeqiNP_002137.4. NM_002146.4.
XP_005257334.1. XM_005257277.2.
XP_006721917.1. XM_006721854.1.
XP_006721918.1. XM_006721855.1.
UniGeneiHs.654560.

Genome annotation databases

EnsembliENST00000311626; ENSP00000308252; ENSG00000120093.
ENST00000470495; ENSP00000417207; ENSG00000120093.
ENST00000476342; ENSP00000418892; ENSG00000120093.
ENST00000498678; ENSP00000420595; ENSG00000120093.
GeneIDi3213.
KEGGihsa:3213.
UCSCiuc002inn.3. human.

Polymorphism databases

DMDMi215274007.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
X16667 mRNA. Translation: CAA34657.1 .
U59298 mRNA. Translation: AAD10852.1 .
AF287967 Genomic DNA. Translation: AAG31555.1 .
AK291182 mRNA. Translation: BAF83871.1 .
AK315102 mRNA. Translation: BAG37563.1 .
CH471109 Genomic DNA. Translation: EAW94739.1 .
CH471109 Genomic DNA. Translation: EAW94740.1 .
CH471109 Genomic DNA. Translation: EAW94741.1 .
X16175 Genomic DNA. Translation: CAA34297.1 .
CCDSi CCDS11528.1.
PIRi S07543. WJHU2G.
RefSeqi NP_002137.4. NM_002146.4.
XP_005257334.1. XM_005257277.2.
XP_006721917.1. XM_006721854.1.
XP_006721918.1. XM_006721855.1.
UniGenei Hs.654560.

3D structure databases

ProteinModelPortali P14651.
SMRi P14651. Positions 190-247.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 109453. 2 interactions.
STRINGi 9606.ENSP00000308252.

Polymorphism databases

DMDMi 215274007.

Proteomic databases

PaxDbi P14651.
PRIDEi P14651.

Protocols and materials databases

DNASUi 3213.
Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000311626 ; ENSP00000308252 ; ENSG00000120093 .
ENST00000470495 ; ENSP00000417207 ; ENSG00000120093 .
ENST00000476342 ; ENSP00000418892 ; ENSG00000120093 .
ENST00000498678 ; ENSP00000420595 ; ENSG00000120093 .
GeneIDi 3213.
KEGGi hsa:3213.
UCSCi uc002inn.3. human.

Organism-specific databases

CTDi 3213.
GeneCardsi GC17M046626.
HGNCi HGNC:5114. HOXB3.
HPAi CAB009860.
MIMi 142966. gene.
neXtProti NX_P14651.
PharmGKBi PA29390.
GenAtlasi Search...

Phylogenomic databases

eggNOGi NOG284589.
HOGENOMi HOG000252944.
HOVERGENi HBG107984.
InParanoidi P14651.
KOi K09303.
OMAi ATYYDNT.
OrthoDBi EOG754HPS.
PhylomeDBi P14651.
TreeFami TF315938.

Miscellaneous databases

ChiTaRSi HOXB3. human.
GeneWikii HOXB3.
GenomeRNAii 3213.
NextBioi 12784.
PROi P14651.
SOURCEi Search...

Gene expression databases

ArrayExpressi P14651.
Bgeei P14651.
CleanExi HS_HOXB3.
Genevestigatori P14651.

Family and domain databases

Gene3Di 1.10.10.60. 1 hit.
InterProi IPR025281. DUF4074.
IPR001827. Homeobox_Antennapedia_CS.
IPR017970. Homeobox_CS.
IPR001356. Homeobox_dom.
IPR020479. Homeobox_metazoa.
IPR009057. Homeodomain-like.
[Graphical view ]
Pfami PF13293. DUF4074. 1 hit.
PF00046. Homeobox. 1 hit.
[Graphical view ]
PRINTSi PR00024. HOMEOBOX.
SMARTi SM00389. HOX. 1 hit.
[Graphical view ]
SUPFAMi SSF46689. SSF46689. 1 hit.
PROSITEi PS00032. ANTENNAPEDIA. 1 hit.
PS00027. HOMEOBOX_1. 1 hit.
PS50071. HOMEOBOX_2. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. Cited for: NUCLEOTIDE SEQUENCE [MRNA], VARIANT THR-82.
  2. "Deregulated expression of HoxB3 in hematopoietic cells causes defective development of alpha beta T Lymphocytes and progressive myeloproliferation."
    Sauvageau G., Thorsteinsdottir U., Hough M.R., Hugo P., Lawrence H.J., Largman C., Humphries R.K.
    Submitted (MAY-1996) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA], VARIANT THR-82.
  3. "Overall linkage disequilibrium in 33 populations for highly informative multisite haplotypes spanning the HOXB gene cluster."
    Kidd K.K., Busygina V., DeMille M.M.C., Speed W.C., Ruggeri V., Kidd J.R., Pakstis A.J.
    Am. J. Hum. Genet. 67:235-235(2000)
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], VARIANT THR-82.
  4. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
  5. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA], VARIANT THR-82.
  6. "Differential expression of human HOX-2 genes along the anterior-posterior axis in embryonic central nervous system."
    Giampaolo A., Acampora D., Zappavigna V., Pannese M., D'Esposito M., Care A., Faiella A., Stornaiuolo A., Russo G., Simeone A., Boncinelli E., Peschle C.
    Differentiation 40:191-197(1989) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 188-253.
    Tissue: Placenta.
  7. "Organization of human class I homeobox genes."
    Boncinelli E., Acampora D., Pannese M., D'Esposito M., Somma R., Gaudino G., Stornaiuolo A., Cafiero M., Faiella A., Simeone A.
    Genome 31:745-756(1989) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 188-253.

Entry informationi

Entry nameiHXB3_HUMAN
AccessioniPrimary (citable) accession number: P14651
Secondary accession number(s): A8K567
, D3DTV3, O95615, P17484
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 1, 1990
Last sequence update: November 25, 2008
Last modified: July 9, 2014
This is version 140 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Vertebrate homeotic Hox proteins
    Nomenclature of vertebrate homeotic Hox proteins and list of entries
  2. Human chromosome 17
    Human chromosome 17: entries, gene names and cross-references to MIM
  3. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  4. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  5. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  6. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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