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P14651 (HXB3_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Last modified July 9, 2014. Version 140. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (6) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Homeobox protein Hox-B3
Alternative name(s):
Homeobox protein Hox-2.7
Homeobox protein Hox-2G
Gene names
Name:HOXB3
Synonyms:HOX2G
OrganismHomo sapiens (Human) [Reference proteome]
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Protein attributes

Sequence length431 AA.
Sequence statusComplete.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

Sequence-specific transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis.

Subcellular location

Nucleus.

Developmental stage

Expressed in whole embryos and fetuses at 5-9 weeks from conception.

Sequence similarities

Belongs to the Antp homeobox family.

Contains 1 homeobox DNA-binding domain.

Ontologies

Keywords
   Biological processTranscription
Transcription regulation
   Cellular componentNucleus
   Coding sequence diversityPolymorphism
   DomainHomeobox
   LigandDNA-binding
   Molecular functionDevelopmental protein
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Biological_processangiogenesis

Inferred from expression pattern PubMed 17972163. Source: UniProtKB

anterior/posterior pattern specification

Inferred from electronic annotation. Source: Ensembl

cartilage development

Inferred from electronic annotation. Source: Ensembl

definitive hemopoiesis

Inferred from electronic annotation. Source: Ensembl

embryonic skeletal system morphogenesis

Inferred from electronic annotation. Source: Ensembl

face development

Inferred from electronic annotation. Source: Ensembl

glossopharyngeal nerve morphogenesis

Inferred from electronic annotation. Source: Ensembl

negative regulation of transcription from RNA polymerase II promoter

Inferred from electronic annotation. Source: Ensembl

regulation of neurogenesis

Inferred from electronic annotation. Source: Ensembl

rhombomere development

Inferred from electronic annotation. Source: Ensembl

thyroid gland development

Inferred from electronic annotation. Source: Ensembl

transcription, DNA-templated

Inferred from electronic annotation. Source: UniProtKB-KW

   Cellular_componentnucleus

Inferred from electronic annotation. Source: UniProtKB-SubCell

   Molecular_functionRNA polymerase II core promoter sequence-specific DNA binding

Inferred from electronic annotation. Source: Ensembl

sequence-specific DNA binding transcription factor activity

Inferred from electronic annotation. Source: InterPro

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 431431Homeobox protein Hox-B3
PRO_0000200117

Regions

DNA binding188 – 24760Homeobox
Motif129 – 1346Antp-type hexapeptide
Compositional bias154 – 17825Gly-rich

Natural variations

Natural variant821P → T. Ref.1 Ref.2 Ref.3 Ref.5
Corresponds to variant rs2229304 [ dbSNP | Ensembl ].
VAR_047729

Experimental info

Sequence conflict199 – 2002QL → HV in AAD10852. Ref.2

Sequences

Sequence LengthMass (Da)Tools
P14651 [UniParc].

Last modified November 25, 2008. Version 2.
Checksum: 56D39C0C9496E65A

FASTA43144,340
        10         20         30         40         50         60 
MQKATYYDNA AAALFGGYSS YPGSNGFGFD VPPQPPFQAA THLEGDYQRS ACSLQSLGNA 

        70         80         90        100        110        120 
APHAKSKELN GSCMRPGLAP EPLSAPPGSP PPSAAPTSAT SNSSNGGGPS KSGPPKCGPG 

       130        140        150        160        170        180 
TNSTLTKQIF PWMKESRQTS KLKNNSPGTA EGCGGGGGGG GGGGSGGSGG GGGGGGGGDK 

       190        200        210        220        230        240 
SPPGSAASKR ARTAYTSAQL VELEKEFHFN RYLCRPRRVE MANLLNLSER QIKIWFQNRR 

       250        260        270        280        290        300 
MKYKKDQKAK GLASSSGGPS PAGSPPQPMQ STAGFMNALH SMTPSYESPS PPAFGKAHQN 

       310        320        330        340        350        360 
AYALPSNYQP PLKGCGAPQK YPPTPAPEYE PHVLQANGGA YGTPTMQGSP VYVGGGGYAD 

       370        380        390        400        410        420 
PLPPPAGPSL YGLNHLSHHP SGNLDYNGAP PMAPSQHHGP CEPHPTYTDL SSHHAPPPQG 

       430 
RIQEAPKLTH L 

« Hide

References

« Hide 'large scale' references
[1]"The human HOX gene family."
Acampora D., D'Esposito M., Faiella A., Pannese M., Migliaccio E., Morelli F., Stornaiuolo A., Nigro V., Simeone A., Boncinelli E.
Nucleic Acids Res. 17:10385-10402(1989) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA], VARIANT THR-82.
[2]"Deregulated expression of HoxB3 in hematopoietic cells causes defective development of alpha beta T Lymphocytes and progressive myeloproliferation."
Sauvageau G., Thorsteinsdottir U., Hough M.R., Hugo P., Lawrence H.J., Largman C., Humphries R.K.
Submitted (MAY-1996) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [MRNA], VARIANT THR-82.
[3]"Overall linkage disequilibrium in 33 populations for highly informative multisite haplotypes spanning the HOXB gene cluster."
Kidd K.K., Busygina V., DeMille M.M.C., Speed W.C., Ruggeri V., Kidd J.R., Pakstis A.J.
Am. J. Hum. Genet. 67:235-235(2000)
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], VARIANT THR-82.
[4]"Complete sequencing and characterization of 21,243 full-length human cDNAs."
Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S. expand/collapse author list , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
[5]Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M., Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J., Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S., Turner R. expand/collapse author list , Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H., Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K., Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D., Hunkapiller M.W., Myers E.W., Venter J.C.
Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA], VARIANT THR-82.
[6]"Differential expression of human HOX-2 genes along the anterior-posterior axis in embryonic central nervous system."
Giampaolo A., Acampora D., Zappavigna V., Pannese M., D'Esposito M., Care A., Faiella A., Stornaiuolo A., Russo G., Simeone A., Boncinelli E., Peschle C.
Differentiation 40:191-197(1989) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 188-253.
Tissue: Placenta.
[7]"Organization of human class I homeobox genes."
Boncinelli E., Acampora D., Pannese M., D'Esposito M., Somma R., Gaudino G., Stornaiuolo A., Cafiero M., Faiella A., Simeone A.
Genome 31:745-756(1989) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 188-253.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
X16667 mRNA. Translation: CAA34657.1.
U59298 mRNA. Translation: AAD10852.1.
AF287967 Genomic DNA. Translation: AAG31555.1.
AK291182 mRNA. Translation: BAF83871.1.
AK315102 mRNA. Translation: BAG37563.1.
CH471109 Genomic DNA. Translation: EAW94739.1.
CH471109 Genomic DNA. Translation: EAW94740.1.
CH471109 Genomic DNA. Translation: EAW94741.1.
X16175 Genomic DNA. Translation: CAA34297.1.
CCDSCCDS11528.1.
PIRWJHU2G. S07543.
RefSeqNP_002137.4. NM_002146.4.
XP_005257334.1. XM_005257277.2.
XP_006721917.1. XM_006721854.1.
XP_006721918.1. XM_006721855.1.
UniGeneHs.654560.

3D structure databases

ProteinModelPortalP14651.
SMRP14651. Positions 190-247.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

BioGrid109453. 2 interactions.
STRING9606.ENSP00000308252.

Polymorphism databases

DMDM215274007.

Proteomic databases

PaxDbP14651.
PRIDEP14651.

Protocols and materials databases

DNASU3213.
StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENST00000311626; ENSP00000308252; ENSG00000120093.
ENST00000470495; ENSP00000417207; ENSG00000120093.
ENST00000476342; ENSP00000418892; ENSG00000120093.
ENST00000498678; ENSP00000420595; ENSG00000120093.
GeneID3213.
KEGGhsa:3213.
UCSCuc002inn.3. human.

Organism-specific databases

CTD3213.
GeneCardsGC17M046626.
HGNCHGNC:5114. HOXB3.
HPACAB009860.
MIM142966. gene.
neXtProtNX_P14651.
PharmGKBPA29390.
GenAtlasSearch...

Phylogenomic databases

eggNOGNOG284589.
HOGENOMHOG000252944.
HOVERGENHBG107984.
InParanoidP14651.
KOK09303.
OMAATYYDNT.
OrthoDBEOG754HPS.
PhylomeDBP14651.
TreeFamTF315938.

Gene expression databases

ArrayExpressP14651.
BgeeP14651.
CleanExHS_HOXB3.
GenevestigatorP14651.

Family and domain databases

Gene3D1.10.10.60. 1 hit.
InterProIPR025281. DUF4074.
IPR001827. Homeobox_Antennapedia_CS.
IPR017970. Homeobox_CS.
IPR001356. Homeobox_dom.
IPR020479. Homeobox_metazoa.
IPR009057. Homeodomain-like.
[Graphical view]
PfamPF13293. DUF4074. 1 hit.
PF00046. Homeobox. 1 hit.
[Graphical view]
PRINTSPR00024. HOMEOBOX.
SMARTSM00389. HOX. 1 hit.
[Graphical view]
SUPFAMSSF46689. SSF46689. 1 hit.
PROSITEPS00032. ANTENNAPEDIA. 1 hit.
PS00027. HOMEOBOX_1. 1 hit.
PS50071. HOMEOBOX_2. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

ChiTaRSHOXB3. human.
GeneWikiHOXB3.
GenomeRNAi3213.
NextBio12784.
PROP14651.
SOURCESearch...

Entry information

Entry nameHXB3_HUMAN
AccessionPrimary (citable) accession number: P14651
Secondary accession number(s): A8K567 expand/collapse secondary AC list , D3DTV3, O95615, P17484
Entry history
Integrated into UniProtKB/Swiss-Prot: April 1, 1990
Last sequence update: November 25, 2008
Last modified: July 9, 2014
This is version 140 of the entry and version 2 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Relevant documents

SIMILARITY comments

Index of protein domains and families

MIM cross-references

Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

Human polymorphisms and disease mutations

Index of human polymorphisms and disease mutations

Human entries with polymorphisms or disease mutations

List of human entries with polymorphisms or disease mutations

Human chromosome 17

Human chromosome 17: entries, gene names and cross-references to MIM

Vertebrate homeotic Hox proteins

Nomenclature of vertebrate homeotic Hox proteins and list of entries