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Protein

Homeobox protein Hox-B3

Gene

HOXB3

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Sequence-specific transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis.

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
DNA bindingi188 – 24760HomeoboxPROSITE-ProRule annotationAdd
BLAST

GO - Molecular functioni

  1. RNA polymerase II core promoter sequence-specific DNA binding Source: Ensembl
  2. sequence-specific DNA binding transcription factor activity Source: InterPro

GO - Biological processi

  1. angiogenesis Source: UniProtKB
  2. anterior/posterior pattern specification Source: Ensembl
  3. cartilage development Source: Ensembl
  4. definitive hemopoiesis Source: Ensembl
  5. embryonic skeletal system morphogenesis Source: Ensembl
  6. face development Source: Ensembl
  7. glossopharyngeal nerve morphogenesis Source: Ensembl
  8. hematopoietic progenitor cell differentiation Source: Ensembl
  9. negative regulation of transcription from RNA polymerase II promoter Source: Ensembl
  10. regulation of neurogenesis Source: Ensembl
  11. rhombomere development Source: Ensembl
  12. thyroid gland development Source: Ensembl
  13. transcription, DNA-templated Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Developmental protein

Keywords - Biological processi

Transcription, Transcription regulation

Keywords - Ligandi

DNA-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Homeobox protein Hox-B3
Alternative name(s):
Homeobox protein Hox-2.7
Homeobox protein Hox-2G
Gene namesi
Name:HOXB3
Synonyms:HOX2G
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640 Componenti: Chromosome 17

Organism-specific databases

HGNCiHGNC:5114. HOXB3.

Subcellular locationi

GO - Cellular componenti

  1. nucleus Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA29390.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 431431Homeobox protein Hox-B3PRO_0000200117Add
BLAST

Proteomic databases

PaxDbiP14651.
PRIDEiP14651.

Expressioni

Developmental stagei

Expressed in whole embryos and fetuses at 5-9 weeks from conception.

Gene expression databases

BgeeiP14651.
CleanExiHS_HOXB3.
ExpressionAtlasiP14651. baseline and differential.
GenevestigatoriP14651.

Organism-specific databases

HPAiCAB009860.

Interactioni

Protein-protein interaction databases

BioGridi109453. 2 interactions.
STRINGi9606.ENSP00000308252.

Structurei

3D structure databases

ProteinModelPortaliP14651.
SMRiP14651. Positions 190-247.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Motif

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Motifi129 – 1346Antp-type hexapeptide

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi154 – 17825Gly-richAdd
BLAST

Sequence similaritiesi

Belongs to the Antp homeobox family.Curated
Contains 1 homeobox DNA-binding domain.PROSITE-ProRule annotation

Keywords - Domaini

Homeobox

Phylogenomic databases

eggNOGiNOG284589.
GeneTreeiENSGT00760000118940.
HOGENOMiHOG000252944.
HOVERGENiHBG107984.
InParanoidiP14651.
KOiK09303.
OMAiEYEPHVL.
OrthoDBiEOG754HPS.
PhylomeDBiP14651.
TreeFamiTF315938.

Family and domain databases

Gene3Di1.10.10.60. 1 hit.
InterProiIPR025281. DUF4074.
IPR001827. Homeobox_Antennapedia_CS.
IPR017970. Homeobox_CS.
IPR001356. Homeobox_dom.
IPR020479. Homeobox_metazoa.
IPR009057. Homeodomain-like.
[Graphical view]
PfamiPF13293. DUF4074. 1 hit.
PF00046. Homeobox. 1 hit.
[Graphical view]
PRINTSiPR00024. HOMEOBOX.
SMARTiSM00389. HOX. 1 hit.
[Graphical view]
SUPFAMiSSF46689. SSF46689. 1 hit.
PROSITEiPS00032. ANTENNAPEDIA. 1 hit.
PS00027. HOMEOBOX_1. 1 hit.
PS50071. HOMEOBOX_2. 1 hit.
[Graphical view]

Sequences (3)i

Sequence statusi: Complete.

This entry describes 3 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: P14651-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MQKATYYDNA AAALFGGYSS YPGSNGFGFD VPPQPPFQAA THLEGDYQRS
60 70 80 90 100
ACSLQSLGNA APHAKSKELN GSCMRPGLAP EPLSAPPGSP PPSAAPTSAT
110 120 130 140 150
SNSSNGGGPS KSGPPKCGPG TNSTLTKQIF PWMKESRQTS KLKNNSPGTA
160 170 180 190 200
EGCGGGGGGG GGGGSGGSGG GGGGGGGGDK SPPGSAASKR ARTAYTSAQL
210 220 230 240 250
VELEKEFHFN RYLCRPRRVE MANLLNLSER QIKIWFQNRR MKYKKDQKAK
260 270 280 290 300
GLASSSGGPS PAGSPPQPMQ STAGFMNALH SMTPSYESPS PPAFGKAHQN
310 320 330 340 350
AYALPSNYQP PLKGCGAPQK YPPTPAPEYE PHVLQANGGA YGTPTMQGSP
360 370 380 390 400
VYVGGGGYAD PLPPPAGPSL YGLNHLSHHP SGNLDYNGAP PMAPSQHHGP
410 420 430
CEPHPTYTDL SSHHAPPPQG RIQEAPKLTH L
Length:431
Mass (Da):44,340
Last modified:November 24, 2008 - v2
Checksum:i56D39C0C9496E65A
GO
Isoform 2 (identifier: P14651-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-73: Missing.

Note: No experimental confirmation available.

Show »
Length:358
Mass (Da):36,698
Checksum:i8E6B18948B2AD02E
GO
Isoform 3 (identifier: P14651-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-132: Missing.

Note: No experimental confirmation available.

Show »
Length:299
Mass (Da):30,989
Checksum:i6C0A22D64D10D5FD
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti100 – 1001T → A in BAH12984 (PubMed:14702039).Curated
Sequence conflicti199 – 2002QL → HV in AAD10852 (Ref. 2) Curated

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti82 – 821P → T.4 Publications
Corresponds to variant rs2229304 [ dbSNP | Ensembl ].
VAR_047729

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei1 – 132132Missing in isoform 3. 1 PublicationVSP_056815Add
BLAST
Alternative sequencei1 – 7373Missing in isoform 2. 1 PublicationVSP_056434Add
BLAST

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X16667 mRNA. Translation: CAA34657.1.
U59298 mRNA. Translation: AAD10852.1.
AF287967 Genomic DNA. Translation: AAG31555.1.
AK291182 mRNA. Translation: BAF83871.1.
AK299226 mRNA. Translation: BAH12974.1.
AK299265 mRNA. Translation: BAH12984.1.
AK315102 mRNA. Translation: BAG37563.1.
AK316245 mRNA. Translation: BAH14616.1.
AC103702 Genomic DNA. No translation available.
CH471109 Genomic DNA. Translation: EAW94739.1.
CH471109 Genomic DNA. Translation: EAW94740.1.
CH471109 Genomic DNA. Translation: EAW94741.1.
X16175 Genomic DNA. Translation: CAA34297.1.
CCDSiCCDS11528.1. [P14651-1]
PIRiS07543. WJHU2G.
RefSeqiNP_002137.4. NM_002146.4. [P14651-1]
XP_005257334.1. XM_005257277.2. [P14651-1]
XP_005257337.1. XM_005257280.2. [P14651-2]
XP_005257339.1. XM_005257282.2. [P14651-3]
XP_006721917.1. XM_006721854.1. [P14651-1]
XP_006721918.1. XM_006721855.1. [P14651-1]
UniGeneiHs.654560.

Genome annotation databases

EnsembliENST00000311626; ENSP00000308252; ENSG00000120093. [P14651-1]
ENST00000460160; ENSP00000418035; ENSG00000120093. [P14651-3]
ENST00000470495; ENSP00000417207; ENSG00000120093. [P14651-1]
ENST00000472863; ENSP00000419676; ENSG00000120093. [P14651-2]
ENST00000476342; ENSP00000418892; ENSG00000120093. [P14651-1]
ENST00000489475; ENSP00000418729; ENSG00000120093. [P14651-2]
ENST00000498678; ENSP00000420595; ENSG00000120093. [P14651-1]
GeneIDi3213.
KEGGihsa:3213.
UCSCiuc002inn.3. human. [P14651-1]

Polymorphism databases

DMDMi215274007.

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X16667 mRNA. Translation: CAA34657.1.
U59298 mRNA. Translation: AAD10852.1.
AF287967 Genomic DNA. Translation: AAG31555.1.
AK291182 mRNA. Translation: BAF83871.1.
AK299226 mRNA. Translation: BAH12974.1.
AK299265 mRNA. Translation: BAH12984.1.
AK315102 mRNA. Translation: BAG37563.1.
AK316245 mRNA. Translation: BAH14616.1.
AC103702 Genomic DNA. No translation available.
CH471109 Genomic DNA. Translation: EAW94739.1.
CH471109 Genomic DNA. Translation: EAW94740.1.
CH471109 Genomic DNA. Translation: EAW94741.1.
X16175 Genomic DNA. Translation: CAA34297.1.
CCDSiCCDS11528.1. [P14651-1]
PIRiS07543. WJHU2G.
RefSeqiNP_002137.4. NM_002146.4. [P14651-1]
XP_005257334.1. XM_005257277.2. [P14651-1]
XP_005257337.1. XM_005257280.2. [P14651-2]
XP_005257339.1. XM_005257282.2. [P14651-3]
XP_006721917.1. XM_006721854.1. [P14651-1]
XP_006721918.1. XM_006721855.1. [P14651-1]
UniGeneiHs.654560.

3D structure databases

ProteinModelPortaliP14651.
SMRiP14651. Positions 190-247.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi109453. 2 interactions.
STRINGi9606.ENSP00000308252.

Polymorphism databases

DMDMi215274007.

Proteomic databases

PaxDbiP14651.
PRIDEiP14651.

Protocols and materials databases

DNASUi3213.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000311626; ENSP00000308252; ENSG00000120093. [P14651-1]
ENST00000460160; ENSP00000418035; ENSG00000120093. [P14651-3]
ENST00000470495; ENSP00000417207; ENSG00000120093. [P14651-1]
ENST00000472863; ENSP00000419676; ENSG00000120093. [P14651-2]
ENST00000476342; ENSP00000418892; ENSG00000120093. [P14651-1]
ENST00000489475; ENSP00000418729; ENSG00000120093. [P14651-2]
ENST00000498678; ENSP00000420595; ENSG00000120093. [P14651-1]
GeneIDi3213.
KEGGihsa:3213.
UCSCiuc002inn.3. human. [P14651-1]

Organism-specific databases

CTDi3213.
GeneCardsiGC17M046626.
HGNCiHGNC:5114. HOXB3.
HPAiCAB009860.
MIMi142966. gene.
neXtProtiNX_P14651.
PharmGKBiPA29390.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiNOG284589.
GeneTreeiENSGT00760000118940.
HOGENOMiHOG000252944.
HOVERGENiHBG107984.
InParanoidiP14651.
KOiK09303.
OMAiEYEPHVL.
OrthoDBiEOG754HPS.
PhylomeDBiP14651.
TreeFamiTF315938.

Miscellaneous databases

ChiTaRSiHOXB3. human.
GeneWikiiHOXB3.
GenomeRNAii3213.
NextBioi12784.
PROiP14651.
SOURCEiSearch...

Gene expression databases

BgeeiP14651.
CleanExiHS_HOXB3.
ExpressionAtlasiP14651. baseline and differential.
GenevestigatoriP14651.

Family and domain databases

Gene3Di1.10.10.60. 1 hit.
InterProiIPR025281. DUF4074.
IPR001827. Homeobox_Antennapedia_CS.
IPR017970. Homeobox_CS.
IPR001356. Homeobox_dom.
IPR020479. Homeobox_metazoa.
IPR009057. Homeodomain-like.
[Graphical view]
PfamiPF13293. DUF4074. 1 hit.
PF00046. Homeobox. 1 hit.
[Graphical view]
PRINTSiPR00024. HOMEOBOX.
SMARTiSM00389. HOX. 1 hit.
[Graphical view]
SUPFAMiSSF46689. SSF46689. 1 hit.
PROSITEiPS00032. ANTENNAPEDIA. 1 hit.
PS00027. HOMEOBOX_1. 1 hit.
PS50071. HOMEOBOX_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), VARIANT THR-82.
  2. "Deregulated expression of HoxB3 in hematopoietic cells causes defective development of alpha beta T Lymphocytes and progressive myeloproliferation."
    Sauvageau G., Thorsteinsdottir U., Hough M.R., Hugo P., Lawrence H.J., Largman C., Humphries R.K.
    Submitted (APR-1996) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), VARIANT THR-82.
  3. "Overall linkage disequilibrium in 33 populations for highly informative multisite haplotypes spanning the HOXB gene cluster."
    Kidd K.K., Busygina V., DeMille M.M.C., Speed W.C., Ruggeri V., Kidd J.R., Pakstis A.J.
    Am. J. Hum. Genet. 67:235-235(1999)
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], VARIANT THR-82.
  4. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1; 2 AND 3).
  5. "DNA sequence of human chromosome 17 and analysis of rearrangement in the human lineage."
    Zody M.C., Garber M., Adams D.J., Sharpe T., Harrow J., Lupski J.R., Nicholson C., Searle S.M., Wilming L., Young S.K., Abouelleil A., Allen N.R., Bi W., Bloom T., Borowsky M.L., Bugalter B.E., Butler J., Chang J.L.
    , Chen C.-K., Cook A., Corum B., Cuomo C.A., de Jong P.J., DeCaprio D., Dewar K., FitzGerald M., Gilbert J., Gibson R., Gnerre S., Goldstein S., Grafham D.V., Grocock R., Hafez N., Hagopian D.S., Hart E., Norman C.H., Humphray S., Jaffe D.B., Jones M., Kamal M., Khodiyar V.K., LaButti K., Laird G., Lehoczky J., Liu X., Lokyitsang T., Loveland J., Lui A., Macdonald P., Major J.E., Matthews L., Mauceli E., McCarroll S.A., Mihalev A.H., Mudge J., Nguyen C., Nicol R., O'Leary S.B., Osoegawa K., Schwartz D.C., Shaw-Smith C., Stankiewicz P., Steward C., Swarbreck D., Venkataraman V., Whittaker C.A., Yang X., Zimmer A.R., Bradley A., Hubbard T., Birren B.W., Rogers J., Lander E.S., Nusbaum C.
    Nature 440:1045-1049(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  6. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA], VARIANT THR-82.
  7. "Differential expression of human HOX-2 genes along the anterior-posterior axis in embryonic central nervous system."
    Giampaolo A., Acampora D., Zappavigna V., Pannese M., D'Esposito M., Care A., Faiella A., Stornaiuolo A., Russo G., Simeone A., Boncinelli E., Peschle C.
    Differentiation 40:191-197(1988) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 188-253.
    Tissue: Placenta.
  8. "Organization of human class I homeobox genes."
    Boncinelli E., Acampora D., Pannese M., D'Esposito M., Somma R., Gaudino G., Stornaiuolo A., Cafiero M., Faiella A., Simeone A.
    Genome 31:745-756(1988) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 188-253.

Entry informationi

Entry nameiHXB3_HUMAN
AccessioniPrimary (citable) accession number: P14651
Secondary accession number(s): A8K567
, B7Z5N8, B7Z5P8, B7ZAD0, D3DTV3, O95615, P17484
Entry historyi
Integrated into UniProtKB/Swiss-Prot: March 31, 1990
Last sequence update: November 24, 2008
Last modified: February 3, 2015
This is version 145 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Vertebrate homeotic Hox proteins
    Nomenclature of vertebrate homeotic Hox proteins and list of entries
  2. Human chromosome 17
    Human chromosome 17: entries, gene names and cross-references to MIM
  3. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  4. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  5. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  6. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.