ID MYL6B_HUMAN Reviewed; 208 AA. AC P14649; DT 01-APR-1990, integrated into UniProtKB/Swiss-Prot. DT 01-APR-1990, sequence version 1. DT 27-MAR-2024, entry version 202. DE RecName: Full=Myosin light chain 6B; DE AltName: Full=Myosin light chain 1 slow-twitch muscle A isoform; DE Short=MLC1sa; DE AltName: Full=Smooth muscle and nonmuscle myosin light chain alkali 6B; GN Name=MYL6B; Synonyms=MLC1SA; OS Homo sapiens (Human). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; OC Homo. OX NCBI_TaxID=9606; RN [1] RP NUCLEOTIDE SEQUENCE [MRNA]. RC TISSUE=Skeletal muscle; RX PubMed=2304459; DOI=10.1128/mcb.10.3.1095-1104.1990; RA Hailstones D.L., Gunning P.W.; RT "Characterization of human myosin light chains 1sa and 3nm: implications RT for isoform evolution and function."; RL Mol. Cell. Biol. 10:1095-1104(1990). RN [2] RP NUCLEOTIDE SEQUENCE [MRNA]. RC TISSUE=Skeletal muscle; RX PubMed=2602161; DOI=10.1093/nar/17.24.10496; RA Zimmermann K., Starzinski-Powitz A.; RT "A novel isoform of myosin alkali light chain isolated from human muscle RT cells."; RL Nucleic Acids Res. 17:10496-10496(1989). RN [3] RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. RC TISSUE=Brain, and Ovary; RX PubMed=15489334; DOI=10.1101/gr.2596504; RG The MGC Project Team; RT "The status, quality, and expansion of the NIH full-length cDNA project: RT the Mammalian Gene Collection (MGC)."; RL Genome Res. 14:2121-2127(2004). RN [4] RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]. RX PubMed=21269460; DOI=10.1186/1752-0509-5-17; RA Burkard T.R., Planyavsky M., Kaupe I., Breitwieser F.P., Buerckstuemmer T., RA Bennett K.L., Superti-Furga G., Colinge J.; RT "Initial characterization of the human central proteome."; RL BMC Syst. Biol. 5:17-17(2011). CC -!- FUNCTION: Regulatory light chain of myosin. Does not bind calcium. CC -!- SUBUNIT: Myosin is a hexamer of 2 heavy chains and 4 light chains. CC -!- INTERACTION: CC P14649; Q15506: SPA17; NbExp=12; IntAct=EBI-358570, EBI-1377865; CC P14649; Q02440: MYO5A; Xeno; NbExp=2; IntAct=EBI-358570, EBI-1040586; CC --------------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC --------------------------------------------------------------------------- DR EMBL; X16434; CAA34457.1; -; mRNA. DR EMBL; M31211; AAA36320.1; -; mRNA. DR EMBL; BC012425; AAH12425.1; -; mRNA. DR EMBL; BC014400; AAH14400.1; -; mRNA. DR CCDS; CCDS8905.1; -. DR PIR; A34757; MOHUSA. DR RefSeq; NP_001186558.1; NM_001199629.1. DR RefSeq; NP_002466.1; NM_002475.4. DR PDB; 1OE9; X-ray; 2.05 A; B=59-208. DR PDB; 1W7I; X-ray; 3.00 A; B=59-208. DR PDB; 1W7J; X-ray; 2.00 A; B=59-208. DR PDB; 7PLT; EM; 3.30 A; B=58-208. DR PDB; 7PLU; EM; 3.20 A; B/E=58-208. DR PDB; 7PLV; EM; 3.50 A; B=58-208. DR PDB; 7PLW; EM; 3.50 A; B=58-208. DR PDB; 7PLX; EM; 3.60 A; B=58-208. DR PDB; 7PLY; EM; 3.20 A; B=58-208. DR PDB; 7PLZ; EM; 3.20 A; B/E=58-208. DR PDB; 7PM0; EM; 3.60 A; B=58-208. DR PDB; 7PM1; EM; 3.50 A; B=58-208. DR PDB; 7PM2; EM; 3.60 A; B=58-208. DR PDB; 7PM5; EM; 3.10 A; B=58-208. DR PDB; 7PM6; EM; 3.00 A; B/E=58-208. DR PDB; 7PM7; EM; 3.50 A; B=58-208. DR PDB; 7PM8; EM; 3.50 A; B=58-208. DR PDB; 7PM9; EM; 3.70 A; B=58-208. DR PDB; 7PMA; EM; 3.60 A; B=58-208. DR PDB; 7PMB; EM; 3.60 A; B=58-208. DR PDB; 7PMC; EM; 3.70 A; B=58-208. DR PDB; 7PMD; EM; 2.90 A; B=58-208. DR PDB; 7PME; EM; 2.90 A; B/E=58-208. DR PDB; 7PMF; EM; 3.40 A; B=58-208. DR PDB; 7PMG; EM; 3.30 A; B=58-208. DR PDB; 7PMH; EM; 3.40 A; B=58-208. DR PDB; 7PMI; EM; 3.30 A; B=58-208. DR PDB; 7PMJ; EM; 3.40 A; B=58-208. DR PDB; 7PML; EM; 3.30 A; B=58-208. DR PDBsum; 1OE9; -. DR PDBsum; 1W7I; -. DR PDBsum; 1W7J; -. DR PDBsum; 7PLT; -. DR PDBsum; 7PLU; -. DR PDBsum; 7PLV; -. DR PDBsum; 7PLW; -. DR PDBsum; 7PLX; -. DR PDBsum; 7PLY; -. DR PDBsum; 7PLZ; -. DR PDBsum; 7PM0; -. DR PDBsum; 7PM1; -. DR PDBsum; 7PM2; -. DR PDBsum; 7PM5; -. DR PDBsum; 7PM6; -. DR PDBsum; 7PM7; -. DR PDBsum; 7PM8; -. DR PDBsum; 7PM9; -. DR PDBsum; 7PMA; -. DR PDBsum; 7PMB; -. DR PDBsum; 7PMC; -. DR PDBsum; 7PMD; -. DR PDBsum; 7PME; -. DR PDBsum; 7PMF; -. DR PDBsum; 7PMG; -. DR PDBsum; 7PMH; -. DR PDBsum; 7PMI; -. DR PDBsum; 7PMJ; -. DR PDBsum; 7PML; -. DR AlphaFoldDB; P14649; -. DR EMDB; EMD-13501; -. DR EMDB; EMD-13502; -. DR EMDB; EMD-13503; -. DR EMDB; EMD-13504; -. DR EMDB; EMD-13505; -. DR EMDB; EMD-13506; -. DR EMDB; EMD-13507; -. DR EMDB; EMD-13508; -. DR EMDB; EMD-13509; -. DR EMDB; EMD-13510; -. DR EMDB; EMD-13521; -. DR EMDB; EMD-13522; -. DR EMDB; EMD-13523; -. DR EMDB; EMD-13524; -. DR EMDB; EMD-13525; -. DR EMDB; EMD-13526; -. DR EMDB; EMD-13527; -. DR EMDB; EMD-13528; -. DR EMDB; EMD-13529; -. DR EMDB; EMD-13530; -. DR EMDB; EMD-13531; -. DR EMDB; EMD-13532; -. DR EMDB; EMD-13533; -. DR EMDB; EMD-13535; -. DR EMDB; EMD-13536; -. DR EMDB; EMD-13538; -. DR SMR; P14649; -. DR BioGRID; 126617; 114. DR IntAct; P14649; 38. DR MINT; P14649; -. DR STRING; 9606.ENSP00000450385; -. DR DrugBank; DB08378; 4-[4-(2,5-DIOXO-PYRROLIDIN-1-YL)-PHENYLAMINO]-4-HYDROXY-BUTYRIC ACID. DR GlyGen; P14649; 2 sites, 1 O-linked glycan (2 sites). DR iPTMnet; P14649; -. DR PhosphoSitePlus; P14649; -. DR SwissPalm; P14649; -. DR BioMuta; MYL6B; -. DR DMDM; 127153; -. DR EPD; P14649; -. DR jPOST; P14649; -. DR MassIVE; P14649; -. DR MaxQB; P14649; -. DR PaxDb; 9606-ENSP00000450385; -. DR PeptideAtlas; P14649; -. DR ProteomicsDB; 53069; -. DR Pumba; P14649; -. DR Antibodypedia; 27985; 227 antibodies from 26 providers. DR DNASU; 140465; -. DR Ensembl; ENST00000550443.5; ENSP00000446643.1; ENSG00000196465.11. DR Ensembl; ENST00000553066.5; ENSP00000450385.1; ENSG00000196465.11. DR Ensembl; ENST00000695999.1; ENSP00000512320.1; ENSG00000196465.11. DR GeneID; 140465; -. DR KEGG; hsa:140465; -. DR MANE-Select; ENST00000695999.1; ENSP00000512320.1; NM_002475.5; NP_002466.1. DR UCSC; uc001sjt.4; human. DR AGR; HGNC:29823; -. DR CTD; 140465; -. DR DisGeNET; 140465; -. DR GeneCards; MYL6B; -. DR HGNC; HGNC:29823; MYL6B. DR HPA; ENSG00000196465; Tissue enhanced (skeletal muscle, tongue). DR MIM; 609930; gene. DR neXtProt; NX_P14649; -. DR OpenTargets; ENSG00000196465; -. DR PharmGKB; PA144596407; -. DR VEuPathDB; HostDB:ENSG00000196465; -. DR eggNOG; KOG0030; Eukaryota. DR GeneTree; ENSGT01030000234570; -. DR HOGENOM; CLU_061288_13_0_1; -. DR InParanoid; P14649; -. DR OMA; NRDRGTY; -. DR OrthoDB; 3080916at2759; -. DR PhylomeDB; P14649; -. DR TreeFam; TF351553; -. DR PathwayCommons; P14649; -. DR Reactome; R-HSA-445355; Smooth Muscle Contraction. DR SignaLink; P14649; -. DR SIGNOR; P14649; -. DR BioGRID-ORCS; 140465; 9 hits in 1159 CRISPR screens. DR ChiTaRS; MYL6B; human. DR EvolutionaryTrace; P14649; -. DR GeneWiki; MYL6B; -. DR GenomeRNAi; 140465; -. DR Pharos; P14649; Tbio. DR PRO; PR:P14649; -. DR Proteomes; UP000005640; Chromosome 12. DR RNAct; P14649; Protein. DR Bgee; ENSG00000196465; Expressed in gluteal muscle and 202 other cell types or tissues. DR ExpressionAtlas; P14649; baseline and differential. DR GO; GO:0005829; C:cytosol; TAS:Reactome. DR GO; GO:0070062; C:extracellular exosome; HDA:UniProtKB. DR GO; GO:0005859; C:muscle myosin complex; TAS:ProtInc. DR GO; GO:0016459; C:myosin complex; TAS:HGNC-UCL. DR GO; GO:0016460; C:myosin II complex; IBA:GO_Central. DR GO; GO:0016461; C:unconventional myosin complex; TAS:BHF-UCL. DR GO; GO:0005509; F:calcium ion binding; IEA:InterPro. DR GO; GO:0003774; F:cytoskeletal motor activity; TAS:HGNC-UCL. DR GO; GO:0008307; F:structural constituent of muscle; IBA:GO_Central. DR GO; GO:0006936; P:muscle contraction; TAS:HGNC-UCL. DR GO; GO:0030049; P:muscle filament sliding; TAS:HGNC-UCL. DR GO; GO:0007519; P:skeletal muscle tissue development; TAS:HGNC-UCL. DR CDD; cd00051; EFh; 1. DR Gene3D; 1.10.238.10; EF-hand; 2. DR InterPro; IPR011992; EF-hand-dom_pair. DR InterPro; IPR002048; EF_hand_dom. DR PANTHER; PTHR23048; MYOSIN LIGHT CHAIN 1, 3; 1. DR PANTHER; PTHR23048:SF5; MYOSIN LIGHT CHAIN 6B; 1. DR SMART; SM00054; EFh; 2. DR SUPFAM; SSF47473; EF-hand; 1. DR PROSITE; PS50222; EF_HAND_2; 3. DR Genevisible; P14649; HS. PE 1: Evidence at protein level; KW 3D-structure; Motor protein; Muscle protein; Myosin; Reference proteome; KW Repeat. FT CHAIN 1..208 FT /note="Myosin light chain 6B" FT /id="PRO_0000198695" FT DOMAIN 64..99 FT /note="EF-hand 1" FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00448" FT DOMAIN 141..176 FT /note="EF-hand 2" FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00448" FT DOMAIN 176..208 FT /note="EF-hand 3" FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00448" FT REGION 1..51 FT /note="Disordered" FT /evidence="ECO:0000256|SAM:MobiDB-lite" FT HELIX 69..76 FT /evidence="ECO:0007829|PDB:1W7J" FT STRAND 79..86 FT /evidence="ECO:0007829|PDB:1W7J" FT HELIX 89..95 FT /evidence="ECO:0007829|PDB:1W7J" FT HELIX 102..108 FT /evidence="ECO:0007829|PDB:1W7J" FT HELIX 114..117 FT /evidence="ECO:0007829|PDB:1W7J" FT STRAND 121..123 FT /evidence="ECO:0007829|PDB:1W7J" FT HELIX 124..134 FT /evidence="ECO:0007829|PDB:1W7J" FT HELIX 147..151 FT /evidence="ECO:0007829|PDB:1W7J" FT STRAND 157..162 FT /evidence="ECO:0007829|PDB:1W7J" FT HELIX 163..172 FT /evidence="ECO:0007829|PDB:1W7J" FT STRAND 173..175 FT /evidence="ECO:0007829|PDB:1W7J" FT HELIX 179..186 FT /evidence="ECO:0007829|PDB:1W7J" FT TURN 187..189 FT /evidence="ECO:0007829|PDB:1OE9" FT STRAND 194..197 FT /evidence="ECO:0007829|PDB:1W7J" FT HELIX 198..204 FT /evidence="ECO:0007829|PDB:1W7J" SQ SEQUENCE 208 AA; 22764 MW; 6F3DFAC6CCA9877E CRC64; MPPKKDVPVK KPAGPSISKP AAKPAAAGAP PAKTKAEPAV PQAPQKTQEP PVDLSKVVIE FNKDQLEEFK EAFELFDRVG DGKILYSQCG DVMRALGQNP TNAEVLKVLG NPKSDELKSR RVDFETFLPM LQAVAKNRGQ GTYEDYLEGF RVFDKEGNGK VMGAELRHVL TTLGEKMTEE EVETVLAGHE DSNGCINYEA FLKHILSV //