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P14649

- MYL6B_HUMAN

UniProt

P14649 - MYL6B_HUMAN

Protein

Myosin light chain 6B

Gene

MYL6B

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 132 (01 Oct 2014)
      Sequence version 1 (01 Apr 1990)
      Previous versions | rss
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    Functioni

    Regulatory light chain of myosin. Does not bind calcium.

    GO - Molecular functioni

    1. calcium ion binding Source: InterPro
    2. motor activity Source: HGNC
    3. protein binding Source: IntAct
    4. structural constituent of muscle Source: HGNC

    GO - Biological processi

    1. metabolic process Source: GOC
    2. muscle contraction Source: HGNC
    3. muscle filament sliding Source: HGNC
    4. skeletal muscle tissue development Source: HGNC

    Keywords - Molecular functioni

    Motor protein, Muscle protein, Myosin

    Enzyme and pathway databases

    ReactomeiREACT_20558. Smooth Muscle Contraction.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Myosin light chain 6B
    Alternative name(s):
    Myosin light chain 1 slow-twitch muscle A isoform
    Short name:
    MLC1sa
    Smooth muscle and nonmuscle myosin light chain alkali 6B
    Gene namesi
    Name:MYL6B
    Synonyms:MLC1SA
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 12

    Organism-specific databases

    HGNCiHGNC:29823. MYL6B.

    Subcellular locationi

    GO - Cellular componenti

    1. cytosol Source: Reactome
    2. muscle myosin complex Source: ProtInc
    3. myosin complex Source: HGNC
    4. unconventional myosin complex Source: BHF-UCL

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA144596407.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 208208Myosin light chain 6BPRO_0000198695Add
    BLAST

    Proteomic databases

    MaxQBiP14649.
    PaxDbiP14649.
    PRIDEiP14649.

    PTM databases

    PhosphoSiteiP14649.

    Expressioni

    Gene expression databases

    ArrayExpressiP14649.
    BgeeiP14649.
    CleanExiHS_MYL6B.
    GenevestigatoriP14649.

    Organism-specific databases

    HPAiHPA038887.
    HPA046859.

    Interactioni

    Subunit structurei

    Myosin is a hexamer of 2 heavy chains and 4 light chains.

    Binary interactionsi

    WithEntry#Exp.IntActNotes
    MYO5AQ024402EBI-358570,EBI-1040586From a different organism.

    Protein-protein interaction databases

    BioGridi126617. 10 interactions.
    IntActiP14649. 4 interactions.
    MINTiMINT-365219.
    STRINGi9606.ENSP00000207437.

    Structurei

    Secondary structure

    1
    208
    Legend: HelixTurnBeta strand
    Show more details
    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Helixi69 – 768
    Beta strandi79 – 868
    Helixi89 – 957
    Helixi102 – 1087
    Helixi114 – 1174
    Beta strandi121 – 1233
    Helixi124 – 13411
    Helixi147 – 1515
    Beta strandi157 – 1626
    Helixi163 – 17210
    Beta strandi173 – 1753
    Helixi179 – 1868
    Turni187 – 1893
    Beta strandi194 – 1974
    Helixi198 – 2047

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    EntryMethodResolution (Å)ChainPositionsPDBsum
    1OE9X-ray2.05B59-208[»]
    1W7IX-ray3.00B59-208[»]
    1W7JX-ray2.00B59-208[»]
    ProteinModelPortaliP14649.
    SMRiP14649. Positions 60-207.
    ModBaseiSearch...
    MobiDBiSearch...

    Miscellaneous databases

    EvolutionaryTraceiP14649.

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini64 – 9936EF-hand 1PROSITE-ProRule annotationAdd
    BLAST
    Domaini141 – 17636EF-hand 2PROSITE-ProRule annotationAdd
    BLAST
    Domaini176 – 20833EF-hand 3PROSITE-ProRule annotationAdd
    BLAST

    Sequence similaritiesi

    Contains 3 EF-hand domains.PROSITE-ProRule annotation

    Keywords - Domaini

    Repeat

    Phylogenomic databases

    eggNOGiCOG5126.
    HOGENOMiHOG000233018.
    HOVERGENiHBG012180.
    InParanoidiP14649.
    KOiK12751.
    OMAiPIRRINY.
    OrthoDBiEOG7HQN9N.
    PhylomeDBiP14649.
    TreeFamiTF351553.

    Family and domain databases

    Gene3Di1.10.238.10. 2 hits.
    InterProiIPR011992. EF-hand-dom_pair.
    IPR002048. EF_hand_dom.
    [Graphical view]
    PfamiPF13405. EF-hand_6. 2 hits.
    [Graphical view]
    SMARTiSM00054. EFh. 2 hits.
    [Graphical view]
    PROSITEiPS50222. EF_HAND_2. 3 hits.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    P14649-1 [UniParc]FASTAAdd to Basket

    « Hide

    MPPKKDVPVK KPAGPSISKP AAKPAAAGAP PAKTKAEPAV PQAPQKTQEP    50
    PVDLSKVVIE FNKDQLEEFK EAFELFDRVG DGKILYSQCG DVMRALGQNP 100
    TNAEVLKVLG NPKSDELKSR RVDFETFLPM LQAVAKNRGQ GTYEDYLEGF 150
    RVFDKEGNGK VMGAELRHVL TTLGEKMTEE EVETVLAGHE DSNGCINYEA 200
    FLKHILSV 208
    Length:208
    Mass (Da):22,764
    Last modified:April 1, 1990 - v1
    Checksum:i6F3DFAC6CCA9877E
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    X16434 mRNA. Translation: CAA34457.1.
    M31211 mRNA. Translation: AAA36320.1.
    BC012425 mRNA. Translation: AAH12425.1.
    BC014400 mRNA. Translation: AAH14400.1.
    CCDSiCCDS8905.1.
    PIRiA34757. MOHUSA.
    RefSeqiNP_001186558.1. NM_001199629.1.
    NP_002466.1. NM_002475.4.
    UniGeneiHs.632731.

    Genome annotation databases

    EnsembliENST00000550443; ENSP00000446643; ENSG00000196465.
    ENST00000553066; ENSP00000450385; ENSG00000196465.
    GeneIDi140465.
    KEGGihsa:140465.
    UCSCiuc001sjs.3. human.

    Polymorphism databases

    DMDMi127153.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    X16434 mRNA. Translation: CAA34457.1 .
    M31211 mRNA. Translation: AAA36320.1 .
    BC012425 mRNA. Translation: AAH12425.1 .
    BC014400 mRNA. Translation: AAH14400.1 .
    CCDSi CCDS8905.1.
    PIRi A34757. MOHUSA.
    RefSeqi NP_001186558.1. NM_001199629.1.
    NP_002466.1. NM_002475.4.
    UniGenei Hs.632731.

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    Entry Method Resolution (Å) Chain Positions PDBsum
    1OE9 X-ray 2.05 B 59-208 [» ]
    1W7I X-ray 3.00 B 59-208 [» ]
    1W7J X-ray 2.00 B 59-208 [» ]
    ProteinModelPortali P14649.
    SMRi P14649. Positions 60-207.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 126617. 10 interactions.
    IntActi P14649. 4 interactions.
    MINTi MINT-365219.
    STRINGi 9606.ENSP00000207437.

    PTM databases

    PhosphoSitei P14649.

    Polymorphism databases

    DMDMi 127153.

    Proteomic databases

    MaxQBi P14649.
    PaxDbi P14649.
    PRIDEi P14649.

    Protocols and materials databases

    DNASUi 140465.
    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000550443 ; ENSP00000446643 ; ENSG00000196465 .
    ENST00000553066 ; ENSP00000450385 ; ENSG00000196465 .
    GeneIDi 140465.
    KEGGi hsa:140465.
    UCSCi uc001sjs.3. human.

    Organism-specific databases

    CTDi 140465.
    GeneCardsi GC12P056546.
    HGNCi HGNC:29823. MYL6B.
    HPAi HPA038887.
    HPA046859.
    MIMi 609930. gene.
    neXtProti NX_P14649.
    PharmGKBi PA144596407.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi COG5126.
    HOGENOMi HOG000233018.
    HOVERGENi HBG012180.
    InParanoidi P14649.
    KOi K12751.
    OMAi PIRRINY.
    OrthoDBi EOG7HQN9N.
    PhylomeDBi P14649.
    TreeFami TF351553.

    Enzyme and pathway databases

    Reactomei REACT_20558. Smooth Muscle Contraction.

    Miscellaneous databases

    EvolutionaryTracei P14649.
    GeneWikii MYL6B.
    GenomeRNAii 140465.
    NextBioi 84133.
    PROi P14649.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi P14649.
    Bgeei P14649.
    CleanExi HS_MYL6B.
    Genevestigatori P14649.

    Family and domain databases

    Gene3Di 1.10.238.10. 2 hits.
    InterProi IPR011992. EF-hand-dom_pair.
    IPR002048. EF_hand_dom.
    [Graphical view ]
    Pfami PF13405. EF-hand_6. 2 hits.
    [Graphical view ]
    SMARTi SM00054. EFh. 2 hits.
    [Graphical view ]
    PROSITEi PS50222. EF_HAND_2. 3 hits.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Characterization of human myosin light chains 1sa and 3nm: implications for isoform evolution and function."
      Hailstones D.L., Gunning P.W.
      Mol. Cell. Biol. 10:1095-1104(1990) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
      Tissue: Skeletal muscle.
    2. "A novel isoform of myosin alkali light chain isolated from human muscle cells."
      Zimmermann K., Starzinski-Powitz A.
      Nucleic Acids Res. 17:10496-10496(1989) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
      Tissue: Skeletal muscle.
    3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Tissue: Brain and Ovary.
    4. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].

    Entry informationi

    Entry nameiMYL6B_HUMAN
    AccessioniPrimary (citable) accession number: P14649
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: April 1, 1990
    Last sequence update: April 1, 1990
    Last modified: October 1, 2014
    This is version 132 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    3D-structure, Complete proteome, Reference proteome

    Documents

    1. Human chromosome 12
      Human chromosome 12: entries, gene names and cross-references to MIM
    2. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    3. PDB cross-references
      Index of Protein Data Bank (PDB) cross-references
    4. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3