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P14649 (MYL6B_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 127. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (4) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Interactions·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Myosin light chain 6B
Alternative name(s):
Myosin light chain 1 slow-twitch muscle A isoform
Short name=MLC1sa
Smooth muscle and nonmuscle myosin light chain alkali 6B
Gene names
Name:MYL6B
Synonyms:MLC1SA
OrganismHomo sapiens (Human) [Reference proteome]
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Protein attributes

Sequence length208 AA.
Sequence statusComplete.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

Regulatory light chain of myosin. Does not bind calcium.

Subunit structure

Myosin is a hexamer of 2 heavy chains and 4 light chains.

Sequence similarities

Contains 3 EF-hand domains.

Binary interactions

With

Entry

#Exp.

IntAct

Notes

MYO5AQ024402EBI-358570,EBI-1040586From a different organism.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 208208Myosin light chain 6B
PRO_0000198695

Regions

Domain64 – 9936EF-hand 1
Domain141 – 17636EF-hand 2
Domain176 – 20833EF-hand 3

Secondary structure

.......................... 208
Helix Strand Turn

Details...

Sequences

Sequence LengthMass (Da)Tools
P14649 [UniParc].

Last modified April 1, 1990. Version 1.
Checksum: 6F3DFAC6CCA9877E

FASTA20822,764
        10         20         30         40         50         60 
MPPKKDVPVK KPAGPSISKP AAKPAAAGAP PAKTKAEPAV PQAPQKTQEP PVDLSKVVIE 

        70         80         90        100        110        120 
FNKDQLEEFK EAFELFDRVG DGKILYSQCG DVMRALGQNP TNAEVLKVLG NPKSDELKSR 

       130        140        150        160        170        180 
RVDFETFLPM LQAVAKNRGQ GTYEDYLEGF RVFDKEGNGK VMGAELRHVL TTLGEKMTEE 

       190        200 
EVETVLAGHE DSNGCINYEA FLKHILSV 

« Hide

References

« Hide 'large scale' references
[1]"Characterization of human myosin light chains 1sa and 3nm: implications for isoform evolution and function."
Hailstones D.L., Gunning P.W.
Mol. Cell. Biol. 10:1095-1104(1990) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
Tissue: Skeletal muscle.
[2]"A novel isoform of myosin alkali light chain isolated from human muscle cells."
Zimmermann K., Starzinski-Powitz A.
Nucleic Acids Res. 17:10496-10496(1989) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
Tissue: Skeletal muscle.
[3]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Tissue: Brain and Ovary.
[4]"Initial characterization of the human central proteome."
Burkard T.R., Planyavsky M., Kaupe I., Breitwieser F.P., Buerckstuemmer T., Bennett K.L., Superti-Furga G., Colinge J.
BMC Syst. Biol. 5:17-17(2011) [PubMed] [Europe PMC] [Abstract]
Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
X16434 mRNA. Translation: CAA34457.1.
M31211 mRNA. Translation: AAA36320.1.
BC012425 mRNA. Translation: AAH12425.1.
BC014400 mRNA. Translation: AAH14400.1.
PIRMOHUSA. A34757.
RefSeqNP_001186558.1. NM_001199629.1.
NP_002466.1. NM_002475.4.
UniGeneHs.632731.

3D structure databases

PDBe
RCSB PDB
PDBj
EntryMethodResolution (Å)ChainPositionsPDBsum
1OE9X-ray2.05B59-208[»]
1W7IX-ray3.00B59-208[»]
1W7JX-ray2.00B59-208[»]
ProteinModelPortalP14649.
SMRP14649. Positions 60-207.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

BioGrid126617. 9 interactions.
IntActP14649. 4 interactions.
MINTMINT-365219.
STRING9606.ENSP00000207437.

PTM databases

PhosphoSiteP14649.

Polymorphism databases

DMDM127153.

Proteomic databases

PaxDbP14649.
PRIDEP14649.

Protocols and materials databases

DNASU140465.
StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENST00000207437; ENSP00000207437; ENSG00000196465.
ENST00000550443; ENSP00000446643; ENSG00000196465.
ENST00000553066; ENSP00000450385; ENSG00000196465.
GeneID140465.
KEGGhsa:140465.
UCSCuc001sjs.3. human.

Organism-specific databases

CTD140465.
GeneCardsGC12P056546.
HGNCHGNC:29823. MYL6B.
HPAHPA038887.
HPA046859.
MIM609930. gene.
neXtProtNX_P14649.
PharmGKBPA144596407.
GenAtlasSearch...

Phylogenomic databases

eggNOGCOG5126.
HOGENOMHOG000233018.
HOVERGENHBG012180.
InParanoidP14649.
KOK12751.
OMAQNTKTYK.
OrthoDBEOG7HQN9N.
PhylomeDBP14649.
TreeFamTF351553.

Enzyme and pathway databases

ReactomeREACT_17044. Muscle contraction.

Gene expression databases

ArrayExpressP14649.
BgeeP14649.
CleanExHS_MYL6B.
GenevestigatorP14649.

Family and domain databases

Gene3D1.10.238.10. 2 hits.
InterProIPR011992. EF-hand-dom_pair.
IPR002048. EF_hand_dom.
[Graphical view]
PfamPF13405. EF-hand_6. 2 hits.
[Graphical view]
SMARTSM00054. EFh. 2 hits.
[Graphical view]
PROSITEPS50222. EF_HAND_2. 3 hits.
[Graphical view]
ProtoNetSearch...

Other

EvolutionaryTraceP14649.
GeneWikiMYL6B.
GenomeRNAi140465.
NextBio84133.
PROP14649.
SOURCESearch...

Entry information

Entry nameMYL6B_HUMAN
AccessionPrimary (citable) accession number: P14649
Entry history
Integrated into UniProtKB/Swiss-Prot: April 1, 1990
Last sequence update: April 1, 1990
Last modified: April 16, 2014
This is version 127 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Relevant documents

SIMILARITY comments

Index of protein domains and families

PDB cross-references

Index of Protein Data Bank (PDB) cross-references

MIM cross-references

Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

Human chromosome 12

Human chromosome 12: entries, gene names and cross-references to MIM