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Protein

Myosin light chain 6B

Gene

MYL6B

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Regulatory light chain of myosin. Does not bind calcium.

GO - Molecular functioni

  • calcium ion binding Source: InterPro
  • motor activity Source: HGNC
  • structural constituent of muscle Source: HGNC

GO - Biological processi

  • muscle contraction Source: HGNC
  • muscle filament sliding Source: HGNC
  • skeletal muscle tissue development Source: HGNC
Complete GO annotation...

Keywords - Molecular functioni

Motor protein, Muscle protein, Myosin

Enzyme and pathway databases

ReactomeiR-HSA-445355. Smooth Muscle Contraction.
SIGNORiP14649.

Names & Taxonomyi

Protein namesi
Recommended name:
Myosin light chain 6B
Alternative name(s):
Myosin light chain 1 slow-twitch muscle A isoform
Short name:
MLC1sa
Smooth muscle and nonmuscle myosin light chain alkali 6B
Gene namesi
Name:MYL6B
Synonyms:MLC1SA
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 12

Organism-specific databases

HGNCiHGNC:29823. MYL6B.

Subcellular locationi

GO - Cellular componenti

  • cytosol Source: Reactome
  • extracellular exosome Source: UniProtKB
  • muscle myosin complex Source: ProtInc
  • myosin complex Source: HGNC
  • unconventional myosin complex Source: BHF-UCL
Complete GO annotation...

Pathology & Biotechi

Organism-specific databases

DisGeNETi140465.
OpenTargetsiENSG00000196465.
PharmGKBiPA144596407.

Polymorphism and mutation databases

BioMutaiMYL6B.
DMDMi127153.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Initiator methionineiRemovedBy similarity
ChainiPRO_00001986952 – 208Myosin light chain 6BAdd BLAST207

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei87PhosphoserineBy similarity1
Modified residuei101PhosphothreonineBy similarity1

Keywords - PTMi

Phosphoprotein

Proteomic databases

EPDiP14649.
MaxQBiP14649.
PaxDbiP14649.
PeptideAtlasiP14649.
PRIDEiP14649.

PTM databases

iPTMnetiP14649.
PhosphoSitePlusiP14649.
SwissPalmiP14649.

Expressioni

Gene expression databases

BgeeiENSG00000196465.
CleanExiHS_MYL6B.
ExpressionAtlasiP14649. baseline and differential.
GenevisibleiP14649. HS.

Organism-specific databases

HPAiHPA038887.
HPA046859.

Interactioni

Subunit structurei

Myosin is a hexamer of 2 heavy chains and 4 light chains.

Binary interactionsi

WithEntry#Exp.IntActNotes
MYO5AQ024402EBI-358570,EBI-1040586From a different organism.
SPA17Q155065EBI-358570,EBI-1377865

Protein-protein interaction databases

BioGridi126617. 25 interactors.
IntActiP14649. 20 interactors.
MINTiMINT-365219.
STRINGi9606.ENSP00000207437.

Structurei

Secondary structure

1208
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Helixi69 – 76Combined sources8
Beta strandi79 – 86Combined sources8
Helixi89 – 95Combined sources7
Helixi102 – 108Combined sources7
Helixi114 – 117Combined sources4
Beta strandi121 – 123Combined sources3
Helixi124 – 134Combined sources11
Helixi147 – 151Combined sources5
Beta strandi157 – 162Combined sources6
Helixi163 – 172Combined sources10
Beta strandi173 – 175Combined sources3
Helixi179 – 186Combined sources8
Turni187 – 189Combined sources3
Beta strandi194 – 197Combined sources4
Helixi198 – 204Combined sources7

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1OE9X-ray2.05B59-208[»]
1W7IX-ray3.00B59-208[»]
1W7JX-ray2.00B59-208[»]
ProteinModelPortaliP14649.
SMRiP14649.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP14649.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini64 – 99EF-hand 1PROSITE-ProRule annotationAdd BLAST36
Domaini141 – 176EF-hand 2PROSITE-ProRule annotationAdd BLAST36
Domaini176 – 208EF-hand 3PROSITE-ProRule annotationAdd BLAST33

Sequence similaritiesi

Contains 3 EF-hand domains.PROSITE-ProRule annotation

Keywords - Domaini

Repeat

Phylogenomic databases

eggNOGiKOG0030. Eukaryota.
COG5126. LUCA.
GeneTreeiENSGT00590000082921.
HOGENOMiHOG000233018.
HOVERGENiHBG012180.
InParanoidiP14649.
KOiK12751.
OMAiRVSFEVF.
OrthoDBiEOG091G0TQL.
PhylomeDBiP14649.
TreeFamiTF351553.

Family and domain databases

CDDicd00051. EFh. 1 hit.
Gene3Di1.10.238.10. 2 hits.
InterProiIPR011992. EF-hand-dom_pair.
IPR002048. EF_hand_dom.
[Graphical view]
SMARTiSM00054. EFh. 2 hits.
[Graphical view]
SUPFAMiSSF47473. SSF47473. 1 hit.
PROSITEiPS50222. EF_HAND_2. 3 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P14649-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MPPKKDVPVK KPAGPSISKP AAKPAAAGAP PAKTKAEPAV PQAPQKTQEP
60 70 80 90 100
PVDLSKVVIE FNKDQLEEFK EAFELFDRVG DGKILYSQCG DVMRALGQNP
110 120 130 140 150
TNAEVLKVLG NPKSDELKSR RVDFETFLPM LQAVAKNRGQ GTYEDYLEGF
160 170 180 190 200
RVFDKEGNGK VMGAELRHVL TTLGEKMTEE EVETVLAGHE DSNGCINYEA

FLKHILSV
Length:208
Mass (Da):22,764
Last modified:April 1, 1990 - v1
Checksum:i6F3DFAC6CCA9877E
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X16434 mRNA. Translation: CAA34457.1.
M31211 mRNA. Translation: AAA36320.1.
BC012425 mRNA. Translation: AAH12425.1.
BC014400 mRNA. Translation: AAH14400.1.
CCDSiCCDS8905.1.
PIRiA34757. MOHUSA.
RefSeqiNP_001186558.1. NM_001199629.1.
NP_002466.1. NM_002475.4.
UniGeneiHs.632731.

Genome annotation databases

EnsembliENST00000550443; ENSP00000446643; ENSG00000196465.
ENST00000553066; ENSP00000450385; ENSG00000196465.
GeneIDi140465.
KEGGihsa:140465.
UCSCiuc001sjt.4. human.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X16434 mRNA. Translation: CAA34457.1.
M31211 mRNA. Translation: AAA36320.1.
BC012425 mRNA. Translation: AAH12425.1.
BC014400 mRNA. Translation: AAH14400.1.
CCDSiCCDS8905.1.
PIRiA34757. MOHUSA.
RefSeqiNP_001186558.1. NM_001199629.1.
NP_002466.1. NM_002475.4.
UniGeneiHs.632731.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1OE9X-ray2.05B59-208[»]
1W7IX-ray3.00B59-208[»]
1W7JX-ray2.00B59-208[»]
ProteinModelPortaliP14649.
SMRiP14649.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi126617. 25 interactors.
IntActiP14649. 20 interactors.
MINTiMINT-365219.
STRINGi9606.ENSP00000207437.

PTM databases

iPTMnetiP14649.
PhosphoSitePlusiP14649.
SwissPalmiP14649.

Polymorphism and mutation databases

BioMutaiMYL6B.
DMDMi127153.

Proteomic databases

EPDiP14649.
MaxQBiP14649.
PaxDbiP14649.
PeptideAtlasiP14649.
PRIDEiP14649.

Protocols and materials databases

DNASUi140465.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000550443; ENSP00000446643; ENSG00000196465.
ENST00000553066; ENSP00000450385; ENSG00000196465.
GeneIDi140465.
KEGGihsa:140465.
UCSCiuc001sjt.4. human.

Organism-specific databases

CTDi140465.
DisGeNETi140465.
GeneCardsiMYL6B.
HGNCiHGNC:29823. MYL6B.
HPAiHPA038887.
HPA046859.
MIMi609930. gene.
neXtProtiNX_P14649.
OpenTargetsiENSG00000196465.
PharmGKBiPA144596407.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG0030. Eukaryota.
COG5126. LUCA.
GeneTreeiENSGT00590000082921.
HOGENOMiHOG000233018.
HOVERGENiHBG012180.
InParanoidiP14649.
KOiK12751.
OMAiRVSFEVF.
OrthoDBiEOG091G0TQL.
PhylomeDBiP14649.
TreeFamiTF351553.

Enzyme and pathway databases

ReactomeiR-HSA-445355. Smooth Muscle Contraction.
SIGNORiP14649.

Miscellaneous databases

EvolutionaryTraceiP14649.
GeneWikiiMYL6B.
GenomeRNAii140465.
PROiP14649.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000196465.
CleanExiHS_MYL6B.
ExpressionAtlasiP14649. baseline and differential.
GenevisibleiP14649. HS.

Family and domain databases

CDDicd00051. EFh. 1 hit.
Gene3Di1.10.238.10. 2 hits.
InterProiIPR011992. EF-hand-dom_pair.
IPR002048. EF_hand_dom.
[Graphical view]
SMARTiSM00054. EFh. 2 hits.
[Graphical view]
SUPFAMiSSF47473. SSF47473. 1 hit.
PROSITEiPS50222. EF_HAND_2. 3 hits.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiMYL6B_HUMAN
AccessioniPrimary (citable) accession number: P14649
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 1, 1990
Last sequence update: April 1, 1990
Last modified: November 30, 2016
This is version 154 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Human chromosome 12
    Human chromosome 12: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  4. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.