SubmitCancel

Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.

P14649

- MYL6B_HUMAN

UniProt

P14649 - MYL6B_HUMAN

(max 400 entries)x

Your basket is currently empty.

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

Protein
Myosin light chain 6B
Gene
MYL6B, MLC1SA
Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5 - Experimental evidence at protein leveli

Functioni

Regulatory light chain of myosin. Does not bind calcium.

GO - Molecular functioni

  1. calcium ion binding Source: InterPro
  2. motor activity Source: HGNC
  3. protein binding Source: IntAct
  4. structural constituent of muscle Source: HGNC
Complete GO annotation...

GO - Biological processi

  1. metabolic process Source: GOC
  2. muscle contraction Source: HGNC
  3. muscle filament sliding Source: HGNC
  4. skeletal muscle tissue development Source: HGNC
Complete GO annotation...

Keywords - Molecular functioni

Motor protein, Muscle protein, Myosin

Enzyme and pathway databases

ReactomeiREACT_20558. Smooth Muscle Contraction.

Names & Taxonomyi

Protein namesi
Recommended name:
Myosin light chain 6B
Alternative name(s):
Myosin light chain 1 slow-twitch muscle A isoform
Short name:
MLC1sa
Smooth muscle and nonmuscle myosin light chain alkali 6B
Gene namesi
Name:MYL6B
Synonyms:MLC1SA
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 12

Organism-specific databases

HGNCiHGNC:29823. MYL6B.

Subcellular locationi

GO - Cellular componenti

  1. cytosol Source: Reactome
  2. muscle myosin complex Source: ProtInc
  3. myosin complex Source: HGNC
  4. unconventional myosin complex Source: BHF-UCL
Complete GO annotation...

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA144596407.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 208208Myosin light chain 6B
PRO_0000198695Add
BLAST

Proteomic databases

MaxQBiP14649.
PaxDbiP14649.
PRIDEiP14649.

PTM databases

PhosphoSiteiP14649.

Expressioni

Gene expression databases

ArrayExpressiP14649.
BgeeiP14649.
CleanExiHS_MYL6B.
GenevestigatoriP14649.

Organism-specific databases

HPAiHPA038887.
HPA046859.

Interactioni

Subunit structurei

Myosin is a hexamer of 2 heavy chains and 4 light chains.

Binary interactionsi

WithEntry#Exp.IntActNotes
MYO5AQ024402EBI-358570,EBI-1040586From a different organism.

Protein-protein interaction databases

BioGridi126617. 10 interactions.
IntActiP14649. 4 interactions.
MINTiMINT-365219.
STRINGi9606.ENSP00000207437.

Structurei

Secondary structure

Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Helixi69 – 768
Beta strandi79 – 868
Helixi89 – 957
Helixi102 – 1087
Helixi114 – 1174
Beta strandi121 – 1233
Helixi124 – 13411
Helixi147 – 1515
Beta strandi157 – 1626
Helixi163 – 17210
Beta strandi173 – 1753
Helixi179 – 1868
Turni187 – 1893
Beta strandi194 – 1974
Helixi198 – 2047

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
1OE9X-ray2.05B59-208[»]
1W7IX-ray3.00B59-208[»]
1W7JX-ray2.00B59-208[»]
ProteinModelPortaliP14649.
SMRiP14649. Positions 60-207.

Miscellaneous databases

EvolutionaryTraceiP14649.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini64 – 9936EF-hand 1
Add
BLAST
Domaini141 – 17636EF-hand 2
Add
BLAST
Domaini176 – 20833EF-hand 3
Add
BLAST

Sequence similaritiesi

Contains 3 EF-hand domains.

Keywords - Domaini

Repeat

Phylogenomic databases

eggNOGiCOG5126.
HOGENOMiHOG000233018.
HOVERGENiHBG012180.
InParanoidiP14649.
KOiK12751.
OMAiPIRRINY.
OrthoDBiEOG7HQN9N.
PhylomeDBiP14649.
TreeFamiTF351553.

Family and domain databases

Gene3Di1.10.238.10. 2 hits.
InterProiIPR011992. EF-hand-dom_pair.
IPR002048. EF_hand_dom.
[Graphical view]
PfamiPF13405. EF-hand_6. 2 hits.
[Graphical view]
SMARTiSM00054. EFh. 2 hits.
[Graphical view]
PROSITEiPS50222. EF_HAND_2. 3 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P14649-1 [UniParc]FASTAAdd to Basket

« Hide

MPPKKDVPVK KPAGPSISKP AAKPAAAGAP PAKTKAEPAV PQAPQKTQEP    50
PVDLSKVVIE FNKDQLEEFK EAFELFDRVG DGKILYSQCG DVMRALGQNP 100
TNAEVLKVLG NPKSDELKSR RVDFETFLPM LQAVAKNRGQ GTYEDYLEGF 150
RVFDKEGNGK VMGAELRHVL TTLGEKMTEE EVETVLAGHE DSNGCINYEA 200
FLKHILSV 208
Length:208
Mass (Da):22,764
Last modified:April 1, 1990 - v1
Checksum:i6F3DFAC6CCA9877E
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
X16434 mRNA. Translation: CAA34457.1.
M31211 mRNA. Translation: AAA36320.1.
BC012425 mRNA. Translation: AAH12425.1.
BC014400 mRNA. Translation: AAH14400.1.
CCDSiCCDS8905.1.
PIRiA34757. MOHUSA.
RefSeqiNP_001186558.1. NM_001199629.1.
NP_002466.1. NM_002475.4.
UniGeneiHs.632731.

Genome annotation databases

EnsembliENST00000207437; ENSP00000207437; ENSG00000196465.
ENST00000550443; ENSP00000446643; ENSG00000196465.
ENST00000553066; ENSP00000450385; ENSG00000196465.
GeneIDi140465.
KEGGihsa:140465.
UCSCiuc001sjs.3. human.

Polymorphism databases

DMDMi127153.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
X16434 mRNA. Translation: CAA34457.1 .
M31211 mRNA. Translation: AAA36320.1 .
BC012425 mRNA. Translation: AAH12425.1 .
BC014400 mRNA. Translation: AAH14400.1 .
CCDSi CCDS8905.1.
PIRi A34757. MOHUSA.
RefSeqi NP_001186558.1. NM_001199629.1.
NP_002466.1. NM_002475.4.
UniGenei Hs.632731.

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
Entry Method Resolution (Å) Chain Positions PDBsum
1OE9 X-ray 2.05 B 59-208 [» ]
1W7I X-ray 3.00 B 59-208 [» ]
1W7J X-ray 2.00 B 59-208 [» ]
ProteinModelPortali P14649.
SMRi P14649. Positions 60-207.
ModBasei Search...

Protein-protein interaction databases

BioGridi 126617. 10 interactions.
IntActi P14649. 4 interactions.
MINTi MINT-365219.
STRINGi 9606.ENSP00000207437.

PTM databases

PhosphoSitei P14649.

Polymorphism databases

DMDMi 127153.

Proteomic databases

MaxQBi P14649.
PaxDbi P14649.
PRIDEi P14649.

Protocols and materials databases

DNASUi 140465.
Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000207437 ; ENSP00000207437 ; ENSG00000196465 .
ENST00000550443 ; ENSP00000446643 ; ENSG00000196465 .
ENST00000553066 ; ENSP00000450385 ; ENSG00000196465 .
GeneIDi 140465.
KEGGi hsa:140465.
UCSCi uc001sjs.3. human.

Organism-specific databases

CTDi 140465.
GeneCardsi GC12P056546.
HGNCi HGNC:29823. MYL6B.
HPAi HPA038887.
HPA046859.
MIMi 609930. gene.
neXtProti NX_P14649.
PharmGKBi PA144596407.
GenAtlasi Search...

Phylogenomic databases

eggNOGi COG5126.
HOGENOMi HOG000233018.
HOVERGENi HBG012180.
InParanoidi P14649.
KOi K12751.
OMAi PIRRINY.
OrthoDBi EOG7HQN9N.
PhylomeDBi P14649.
TreeFami TF351553.

Enzyme and pathway databases

Reactomei REACT_20558. Smooth Muscle Contraction.

Miscellaneous databases

EvolutionaryTracei P14649.
GeneWikii MYL6B.
GenomeRNAii 140465.
NextBioi 84133.
PROi P14649.
SOURCEi Search...

Gene expression databases

ArrayExpressi P14649.
Bgeei P14649.
CleanExi HS_MYL6B.
Genevestigatori P14649.

Family and domain databases

Gene3Di 1.10.238.10. 2 hits.
InterProi IPR011992. EF-hand-dom_pair.
IPR002048. EF_hand_dom.
[Graphical view ]
Pfami PF13405. EF-hand_6. 2 hits.
[Graphical view ]
SMARTi SM00054. EFh. 2 hits.
[Graphical view ]
PROSITEi PS50222. EF_HAND_2. 3 hits.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Characterization of human myosin light chains 1sa and 3nm: implications for isoform evolution and function."
    Hailstones D.L., Gunning P.W.
    Mol. Cell. Biol. 10:1095-1104(1990) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Tissue: Skeletal muscle.
  2. "A novel isoform of myosin alkali light chain isolated from human muscle cells."
    Zimmermann K., Starzinski-Powitz A.
    Nucleic Acids Res. 17:10496-10496(1989) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Tissue: Skeletal muscle.
  3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Brain and Ovary.
  4. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].

Entry informationi

Entry nameiMYL6B_HUMAN
AccessioniPrimary (citable) accession number: P14649
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 1, 1990
Last sequence update: April 1, 1990
Last modified: September 3, 2014
This is version 131 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Human chromosome 12
    Human chromosome 12: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  4. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi