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Protein

Myosin light chain 6B

Gene

MYL6B

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Regulatory light chain of myosin. Does not bind calcium.

GO - Molecular functioni

  • calcium ion binding Source: InterPro
  • motor activity Source: HGNC
  • structural constituent of muscle Source: HGNC

GO - Biological processi

  • metabolic process Source: GOC
  • muscle contraction Source: HGNC
  • muscle filament sliding Source: HGNC
  • skeletal muscle tissue development Source: HGNC
Complete GO annotation...

Keywords - Molecular functioni

Motor protein, Muscle protein, Myosin

Enzyme and pathway databases

ReactomeiREACT_20558. Smooth Muscle Contraction.

Names & Taxonomyi

Protein namesi
Recommended name:
Myosin light chain 6B
Alternative name(s):
Myosin light chain 1 slow-twitch muscle A isoform
Short name:
MLC1sa
Smooth muscle and nonmuscle myosin light chain alkali 6B
Gene namesi
Name:MYL6B
Synonyms:MLC1SA
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640 Componenti: Chromosome 12

Organism-specific databases

HGNCiHGNC:29823. MYL6B.

Subcellular locationi

GO - Cellular componenti

  • cytosol Source: Reactome
  • extracellular exosome Source: UniProtKB
  • muscle myosin complex Source: ProtInc
  • myosin complex Source: HGNC
  • unconventional myosin complex Source: BHF-UCL
Complete GO annotation...

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA144596407.

Polymorphism and mutation databases

BioMutaiMYL6B.
DMDMi127153.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Initiator methioninei1 – 11RemovedBy similarity
Chaini2 – 208207Myosin light chain 6BPRO_0000198695Add
BLAST

Proteomic databases

MaxQBiP14649.
PaxDbiP14649.
PRIDEiP14649.

PTM databases

PhosphoSiteiP14649.

Expressioni

Gene expression databases

BgeeiP14649.
CleanExiHS_MYL6B.
ExpressionAtlasiP14649. baseline and differential.
GenevisibleiP14649. HS.

Organism-specific databases

HPAiHPA038887.
HPA046859.

Interactioni

Subunit structurei

Myosin is a hexamer of 2 heavy chains and 4 light chains.

Binary interactionsi

WithEntry#Exp.IntActNotes
MYO5AQ024402EBI-358570,EBI-1040586From a different organism.
SPA17Q155063EBI-358570,EBI-1377865

Protein-protein interaction databases

BioGridi126617. 15 interactions.
IntActiP14649. 5 interactions.
MINTiMINT-365219.
STRINGi9606.ENSP00000207437.

Structurei

Secondary structure

1
208
Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Helixi69 – 768Combined sources
Beta strandi79 – 868Combined sources
Helixi89 – 957Combined sources
Helixi102 – 1087Combined sources
Helixi114 – 1174Combined sources
Beta strandi121 – 1233Combined sources
Helixi124 – 13411Combined sources
Helixi147 – 1515Combined sources
Beta strandi157 – 1626Combined sources
Helixi163 – 17210Combined sources
Beta strandi173 – 1753Combined sources
Helixi179 – 1868Combined sources
Turni187 – 1893Combined sources
Beta strandi194 – 1974Combined sources
Helixi198 – 2047Combined sources

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
1OE9X-ray2.05B59-208[»]
1W7IX-ray3.00B59-208[»]
1W7JX-ray2.00B59-208[»]
ProteinModelPortaliP14649.
SMRiP14649. Positions 60-207.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP14649.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini64 – 9936EF-hand 1PROSITE-ProRule annotationAdd
BLAST
Domaini141 – 17636EF-hand 2PROSITE-ProRule annotationAdd
BLAST
Domaini176 – 20833EF-hand 3PROSITE-ProRule annotationAdd
BLAST

Sequence similaritiesi

Contains 3 EF-hand domains.PROSITE-ProRule annotation

Keywords - Domaini

Repeat

Phylogenomic databases

eggNOGiCOG5126.
GeneTreeiENSGT00590000082921.
HOGENOMiHOG000233018.
HOVERGENiHBG012180.
InParanoidiP14649.
KOiK12751.
OMAiLFDSRGD.
OrthoDBiEOG7HQN9N.
PhylomeDBiP14649.
TreeFamiTF351553.

Family and domain databases

Gene3Di1.10.238.10. 2 hits.
InterProiIPR011992. EF-hand-dom_pair.
IPR002048. EF_hand_dom.
[Graphical view]
PfamiPF13405. EF-hand_6. 2 hits.
[Graphical view]
SMARTiSM00054. EFh. 2 hits.
[Graphical view]
PROSITEiPS50222. EF_HAND_2. 3 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P14649-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MPPKKDVPVK KPAGPSISKP AAKPAAAGAP PAKTKAEPAV PQAPQKTQEP
60 70 80 90 100
PVDLSKVVIE FNKDQLEEFK EAFELFDRVG DGKILYSQCG DVMRALGQNP
110 120 130 140 150
TNAEVLKVLG NPKSDELKSR RVDFETFLPM LQAVAKNRGQ GTYEDYLEGF
160 170 180 190 200
RVFDKEGNGK VMGAELRHVL TTLGEKMTEE EVETVLAGHE DSNGCINYEA

FLKHILSV
Length:208
Mass (Da):22,764
Last modified:April 1, 1990 - v1
Checksum:i6F3DFAC6CCA9877E
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X16434 mRNA. Translation: CAA34457.1.
M31211 mRNA. Translation: AAA36320.1.
BC012425 mRNA. Translation: AAH12425.1.
BC014400 mRNA. Translation: AAH14400.1.
CCDSiCCDS8905.1.
PIRiA34757. MOHUSA.
RefSeqiNP_001186558.1. NM_001199629.1.
NP_002466.1. NM_002475.4.
UniGeneiHs.632731.

Genome annotation databases

EnsembliENST00000550443; ENSP00000446643; ENSG00000196465.
ENST00000553066; ENSP00000450385; ENSG00000196465.
GeneIDi140465.
KEGGihsa:140465.
UCSCiuc001sjs.3. human.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X16434 mRNA. Translation: CAA34457.1.
M31211 mRNA. Translation: AAA36320.1.
BC012425 mRNA. Translation: AAH12425.1.
BC014400 mRNA. Translation: AAH14400.1.
CCDSiCCDS8905.1.
PIRiA34757. MOHUSA.
RefSeqiNP_001186558.1. NM_001199629.1.
NP_002466.1. NM_002475.4.
UniGeneiHs.632731.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
1OE9X-ray2.05B59-208[»]
1W7IX-ray3.00B59-208[»]
1W7JX-ray2.00B59-208[»]
ProteinModelPortaliP14649.
SMRiP14649. Positions 60-207.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi126617. 15 interactions.
IntActiP14649. 5 interactions.
MINTiMINT-365219.
STRINGi9606.ENSP00000207437.

PTM databases

PhosphoSiteiP14649.

Polymorphism and mutation databases

BioMutaiMYL6B.
DMDMi127153.

Proteomic databases

MaxQBiP14649.
PaxDbiP14649.
PRIDEiP14649.

Protocols and materials databases

DNASUi140465.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000550443; ENSP00000446643; ENSG00000196465.
ENST00000553066; ENSP00000450385; ENSG00000196465.
GeneIDi140465.
KEGGihsa:140465.
UCSCiuc001sjs.3. human.

Organism-specific databases

CTDi140465.
GeneCardsiGC12P056546.
HGNCiHGNC:29823. MYL6B.
HPAiHPA038887.
HPA046859.
MIMi609930. gene.
neXtProtiNX_P14649.
PharmGKBiPA144596407.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiCOG5126.
GeneTreeiENSGT00590000082921.
HOGENOMiHOG000233018.
HOVERGENiHBG012180.
InParanoidiP14649.
KOiK12751.
OMAiLFDSRGD.
OrthoDBiEOG7HQN9N.
PhylomeDBiP14649.
TreeFamiTF351553.

Enzyme and pathway databases

ReactomeiREACT_20558. Smooth Muscle Contraction.

Miscellaneous databases

EvolutionaryTraceiP14649.
GeneWikiiMYL6B.
GenomeRNAii140465.
NextBioi84133.
PROiP14649.
SOURCEiSearch...

Gene expression databases

BgeeiP14649.
CleanExiHS_MYL6B.
ExpressionAtlasiP14649. baseline and differential.
GenevisibleiP14649. HS.

Family and domain databases

Gene3Di1.10.238.10. 2 hits.
InterProiIPR011992. EF-hand-dom_pair.
IPR002048. EF_hand_dom.
[Graphical view]
PfamiPF13405. EF-hand_6. 2 hits.
[Graphical view]
SMARTiSM00054. EFh. 2 hits.
[Graphical view]
PROSITEiPS50222. EF_HAND_2. 3 hits.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Characterization of human myosin light chains 1sa and 3nm: implications for isoform evolution and function."
    Hailstones D.L., Gunning P.W.
    Mol. Cell. Biol. 10:1095-1104(1990) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Tissue: Skeletal muscle.
  2. "A novel isoform of myosin alkali light chain isolated from human muscle cells."
    Zimmermann K., Starzinski-Powitz A.
    Nucleic Acids Res. 17:10496-10496(1989) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Tissue: Skeletal muscle.
  3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Brain and Ovary.
  4. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].

Entry informationi

Entry nameiMYL6B_HUMAN
AccessioniPrimary (citable) accession number: P14649
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 1, 1990
Last sequence update: April 1, 1990
Last modified: June 24, 2015
This is version 139 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Human chromosome 12
    Human chromosome 12: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  4. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.