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P14644

- PDE4C_RAT

UniProt

P14644 - PDE4C_RAT

Protein

cAMP-specific 3',5'-cyclic phosphodiesterase 4C

Gene

Pde4c

Organism
Rattus norvegicus (Rat)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 101 (01 Oct 2014)
      Sequence version 2 (01 Oct 1996)
      Previous versions | rss
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    Functioni

    Hydrolyzes the second messenger cAMP, which is a key regulator of many important physiological processes.By similarity

    Catalytic activityi

    Adenosine 3',5'-cyclic phosphate + H2O = adenosine 5'-phosphate.

    Cofactori

    Binds 2 divalent metal cations per subunit. Site 1 may preferentially bind zinc ions, while site 2 has a preference for magnesium and/or manganese ions By similarity.By similarity

    Enzyme regulationi

    Inhibited by rolipram.

    Pathwayi

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Active sitei254 – 2541Proton donorBy similarity
    Metal bindingi258 – 2581Divalent metal cation 1By similarity
    Metal bindingi294 – 2941Divalent metal cation 1By similarity
    Metal bindingi295 – 2951Divalent metal cation 1By similarity
    Metal bindingi295 – 2951Divalent metal cation 2By similarity
    Binding sitei295 – 2951cAMPBy similarity
    Metal bindingi412 – 4121Divalent metal cation 1By similarity
    Binding sitei412 – 4121cAMPBy similarity
    Sitei415 – 4151Binds AMP, but not cAMPBy similarity
    Binding sitei463 – 4631cAMPBy similarity

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Nucleotide bindingi254 – 2585cAMPBy similarity

    GO - Molecular functioni

    1. 3',5'-cyclic-AMP phosphodiesterase activity Source: RGD
    2. drug binding Source: RGD
    3. metal ion binding Source: UniProtKB-KW

    GO - Biological processi

    1. cAMP catabolic process Source: UniProtKB
    2. negative regulation of insulin secretion Source: RGD
    3. signal transduction Source: InterPro

    Keywords - Molecular functioni

    Hydrolase

    Keywords - Ligandi

    cAMP, Metal-binding

    Enzyme and pathway databases

    UniPathwayiUPA00762; UER00747.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    cAMP-specific 3',5'-cyclic phosphodiesterase 4C (EC:3.1.4.53)
    Alternative name(s):
    DPDE1
    Gene namesi
    Name:Pde4c
    Synonyms:Dpde1
    OrganismiRattus norvegicus (Rat)
    Taxonomic identifieri10116 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
    ProteomesiUP000002494: Unplaced

    Organism-specific databases

    RGDi727918. Pde4c.

    Subcellular locationi

    Cell projectioncilium By similarity

    GO - Cellular componenti

    1. primary cilium Source: UniProtKB

    Keywords - Cellular componenti

    Cell projection, Cilium

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini‹1 – 536›536cAMP-specific 3',5'-cyclic phosphodiesterase 4CPRO_0000198813Add
    BLAST

    Proteomic databases

    PRIDEiP14644.

    Expressioni

    Gene expression databases

    GenevestigatoriP14644.

    Interactioni

    Subunit structurei

    Part of a complex containing AKAP5, ADCY5, ADCY6 and PKD2.By similarity

    Protein-protein interaction databases

    STRINGi10116.ENSRNOP00000026457.

    Structurei

    3D structure databases

    ProteinModelPortaliP14644.
    SMRiP14644. Positions 173-505.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Compositional bias

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Compositional biasi524 – 53411Poly-GluAdd
    BLAST

    Sequence similaritiesi

    Phylogenomic databases

    eggNOGiNOG122287.
    HOGENOMiHOG000236297.
    HOVERGENiHBG108239.
    InParanoidiP14644.
    PhylomeDBiP14644.

    Family and domain databases

    Gene3Di1.10.1300.10. 1 hit.
    InterProiIPR003607. HD/PDEase_dom.
    IPR023088. PDEase.
    IPR002073. PDEase_catalytic_dom.
    IPR023174. PDEase_CS.
    [Graphical view]
    PfamiPF00233. PDEase_I. 1 hit.
    [Graphical view]
    PRINTSiPR00387. PDIESTERASE1.
    SMARTiSM00471. HDc. 1 hit.
    [Graphical view]
    PROSITEiPS00126. PDEASE_I. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Fragment.

    P14644-1 [UniParc]FASTAAdd to Basket

    « Hide

    NSSRTSSAAS DLHGEDMIVT PFAQVLASLR TVRSNVAALA HGAGSATRQA    50
    LLGTPPQSSQ QAAPAEESGL QLAQETLEEL DWCLEQLETL QTRRSVGEMA 100
    SNKFKRMLNR ELTHLSETSR SGNQVSEYIS QTFLDQQAEV ELPAPPTEDH 150
    PWPMAQITGL RKSCHTSLPT AAIPRFGVQT DQEEQLAKEL EDTNKWGLDV 200
    FKVAELSGNR PLTAVIFRVL QERDLLKTFQ IPADTLLRYL LTLEGHYHSN 250
    VAYHNSIHAA DVVQSAHVLL GTPALEAVFT DLEVLAAIFA CAIHDVDHPG 300
    VSNQFLINTN SELALMYNDS SVLENHHLAV GFKLLQGENC DIFQNLSTKQ 350
    KLSLRRMVID MVLATDMSKH MSLLADLKTM VETKKVTSLG VLLLDNYSDR 400
    IQVLQSLVHC ADLSNPAKPL PLYRQWTERI MAEFFQQGDR ERESGLDISP 450
    MCDKHTASVE KSQVGFIDYI AHPLWETWAD LVHPDAQELL DTLEDNREWY 500
    QSRVPCSPPH AIGPDRFKFE LTLEETEEEE EEDERH 536
    Length:536
    Mass (Da):60,064
    Last modified:October 1, 1996 - v2
    Checksum:i87D12BE2C46642F3
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Non-terminal residuei1 – 11
    Sequence conflicti218 – 2181R → S in AAA41847. (PubMed:2546153)Curated
    Sequence conflicti507 – 5071S → N in AAA41847. (PubMed:2546153)Curated

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    L27061 mRNA. Translation: AAA56858.1.
    M25347 mRNA. Translation: AAA41847.1.
    PIRiI67945.
    UniGeneiRn.214181.
    Rn.92465.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    L27061 mRNA. Translation: AAA56858.1 .
    M25347 mRNA. Translation: AAA41847.1 .
    PIRi I67945.
    UniGenei Rn.214181.
    Rn.92465.

    3D structure databases

    ProteinModelPortali P14644.
    SMRi P14644. Positions 173-505.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 10116.ENSRNOP00000026457.

    Chemistry

    BindingDBi P14644.
    ChEMBLi CHEMBL2094267.

    Proteomic databases

    PRIDEi P14644.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Organism-specific databases

    RGDi 727918. Pde4c.

    Phylogenomic databases

    eggNOGi NOG122287.
    HOGENOMi HOG000236297.
    HOVERGENi HBG108239.
    InParanoidi P14644.
    PhylomeDBi P14644.

    Enzyme and pathway databases

    UniPathwayi UPA00762 ; UER00747 .

    Gene expression databases

    Genevestigatori P14644.

    Family and domain databases

    Gene3Di 1.10.1300.10. 1 hit.
    InterProi IPR003607. HD/PDEase_dom.
    IPR023088. PDEase.
    IPR002073. PDEase_catalytic_dom.
    IPR023174. PDEase_CS.
    [Graphical view ]
    Pfami PF00233. PDEase_I. 1 hit.
    [Graphical view ]
    PRINTSi PR00387. PDIESTERASE1.
    SMARTi SM00471. HDc. 1 hit.
    [Graphical view ]
    PROSITEi PS00126. PDEASE_I. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Differential CNS expression of alternative mRNA isoforms of the mammalian genes encoding cAMP-specific phosphodiesterases."
      Bolger G.B., Rodgers L., Riggs M.
      Gene 149:237-244(1994) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    2. "Molecular cloning of rat homologues of the Drosophila melanogaster dunce cAMP phosphodiesterase: evidence for a family of genes."
      Swinnen J.V., Joseph D.R., Conti M.
      Proc. Natl. Acad. Sci. U.S.A. 86:5325-5329(1989) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 153-511.
      Tissue: Testis.

    Entry informationi

    Entry nameiPDE4C_RAT
    AccessioniPrimary (citable) accession number: P14644
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: April 1, 1990
    Last sequence update: October 1, 1996
    Last modified: October 1, 2014
    This is version 101 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3