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Protein

Serum albumin

Gene

ALB

Organism
Ovis aries (Sheep)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

Serum albumin, the main protein of plasma, has a good binding capacity for water, Ca2+, Na+, K+, fatty acids, hormones, bilirubin and drugs. Its main function is the regulation of the colloidal osmotic pressure of blood. Major zinc transporter in plasma, typically binds about 80% of all plasma zinc.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi27 – 271CopperBy similarity
Metal bindingi91 – 911ZincBy similarity
Metal bindingi123 – 1231ZincBy similarity
Metal bindingi270 – 2701ZincBy similarity
Metal bindingi272 – 2721ZincBy similarity

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Ligandi

Copper, Lipid-binding, Metal-binding, Zinc

Names & Taxonomyi

Protein namesi
Recommended name:
Serum albumin
Gene namesi
Name:ALB
OrganismiOvis aries (Sheep)
Taxonomic identifieri9940 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaRuminantiaPecoraBovidaeCaprinaeOvis
Proteomesi
  • UP000002356 Componenti: Unplaced

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Secreted

Pathology & Biotechi

Protein family/group databases

Allergomei758. Ovi a 6.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 1818Sequence analysisAdd
BLAST
Propeptidei19 – 246By similarityPRO_0000001081
Chaini25 – 607583Serum albuminPRO_0000001082Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei29 – 291PhosphoserineBy similarity
Disulfide bondi77 ↔ 86PROSITE-ProRule annotation
Modified residuei82 – 821PhosphoserineBy similarity
Modified residuei89 – 891PhosphoserineBy similarity
Disulfide bondi99 ↔ 115PROSITE-ProRule annotation
Modified residuei107 – 1071PhosphothreonineBy similarity
Disulfide bondi114 ↔ 125PROSITE-ProRule annotation
Disulfide bondi147 ↔ 192PROSITE-ProRule annotation
Disulfide bondi191 ↔ 200PROSITE-ProRule annotation
Disulfide bondi223 ↔ 269PROSITE-ProRule annotation
Modified residuei228 – 2281N6-succinyllysineBy similarity
Disulfide bondi268 ↔ 276PROSITE-ProRule annotation
Disulfide bondi288 ↔ 302PROSITE-ProRule annotation
Modified residuei296 – 2961PhosphoserineBy similarity
Disulfide bondi301 ↔ 312PROSITE-ProRule annotation
Disulfide bondi339 ↔ 384PROSITE-ProRule annotation
Disulfide bondi383 ↔ 392PROSITE-ProRule annotation
Disulfide bondi415 ↔ 461PROSITE-ProRule annotation
Modified residuei442 – 4421PhosphoserineBy similarity
Modified residuei443 – 4431PhosphothreonineBy similarity
Modified residuei445 – 4451PhosphothreonineBy similarity
Modified residuei459 – 4591N6-succinyllysineBy similarity
Disulfide bondi460 ↔ 471PROSITE-ProRule annotation
Disulfide bondi484 ↔ 500PROSITE-ProRule annotation
Disulfide bondi499 ↔ 510PROSITE-ProRule annotation
Modified residuei512 – 5121PhosphoserineBy similarity
Disulfide bondi537 ↔ 582PROSITE-ProRule annotation
Modified residuei569 – 5691PhosphothreonineBy similarity
Disulfide bondi581 ↔ 590PROSITE-ProRule annotation
Modified residuei587 – 5871N6-succinyllysineBy similarity

Post-translational modificationi

Phosphorylated by FAM20C in the extracellular medium.By similarity

Keywords - PTMi

Cleavage on pair of basic residues, Disulfide bond, Phosphoprotein

Proteomic databases

PRIDEiP14639.

Expressioni

Tissue specificityi

Plasma.

Structurei

Secondary structure

1
607
Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Helixi26 – 283Combined sources
Helixi30 – 389Combined sources
Helixi40 – 5415Combined sources
Helixi60 – 7920Combined sources
Turni84 – 874Combined sources
Helixi90 – 9910Combined sources
Helixi104 – 1085Combined sources
Helixi109 – 1168Combined sources
Helixi121 – 1288Combined sources
Helixi143 – 15210Combined sources
Helixi154 – 16815Combined sources
Helixi174 – 18310Combined sources
Helixi185 – 1917Combined sources
Beta strandi194 – 1963Combined sources
Helixi197 – 22933Combined sources
Helixi231 – 24515Combined sources
Helixi251 – 26919Combined sources
Helixi273 – 28917Combined sources
Helixi291 – 2933Combined sources
Helixi296 – 3005Combined sources
Turni301 – 3033Combined sources
Helixi306 – 3149Combined sources
Helixi329 – 3324Combined sources
Helixi338 – 3447Combined sources
Helixi346 – 36015Combined sources
Helixi366 – 38520Combined sources
Beta strandi386 – 3883Combined sources
Helixi389 – 3935Combined sources
Helixi396 – 43742Combined sources
Helixi443 – 46018Combined sources
Helixi465 – 48925Combined sources
Helixi494 – 5018Combined sources
Helixi507 – 5137Combined sources
Helixi527 – 5304Combined sources
Helixi534 – 5385Combined sources
Helixi541 – 55818Combined sources
Helixi564 – 58320Combined sources
Beta strandi584 – 5863Combined sources
Helixi587 – 60620Combined sources

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
4LUFX-ray2.30A25-607[»]
4LUHX-ray2.20A25-607[»]
ProteinModelPortaliP14639.
SMRiP14639. Positions 29-584.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini19 – 209191Albumin 1PROSITE-ProRule annotationAdd
BLAST
Domaini210 – 402193Albumin 2PROSITE-ProRule annotationAdd
BLAST
Domaini403 – 600198Albumin 3PROSITE-ProRule annotationAdd
BLAST

Sequence similaritiesi

Belongs to the ALB/AFP/VDB family.PROSITE-ProRule annotation
Contains 3 albumin domains.PROSITE-ProRule annotation

Keywords - Domaini

Repeat, Signal

Phylogenomic databases

HOVERGENiHBG004207.
KOiK16141.

Family and domain databases

InterProiIPR000264. ALB/AFP/VDB.
IPR020858. Serum_albumin-like.
IPR021177. Serum_albumin/AFP/Afamin.
IPR020857. Serum_albumin_CS.
IPR014760. Serum_albumin_N.
[Graphical view]
PfamiPF00273. Serum_albumin. 3 hits.
[Graphical view]
PIRSFiPIRSF002520. Serum_albumin_subgroup. 1 hit.
PRINTSiPR00803. AFETOPROTEIN.
PR00802. SERUMALBUMIN.
SMARTiSM00103. ALBUMIN. 3 hits.
[Graphical view]
SUPFAMiSSF48552. SSF48552. 3 hits.
PROSITEiPS00212. ALBUMIN_1. 3 hits.
PS51438. ALBUMIN_2. 3 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P14639-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MKWVTFISLL LLFSSAYSRG VFRRDTHKSE IAHRFNDLGE ENFQGLVLIA
60 70 80 90 100
FSQYLQQCPF DEHVKLVKEL TEFAKTCVAD ESHAGCDKSL HTLFGDELCK
110 120 130 140 150
VATLRETYGD MADCCEKQEP ERNECFLNHK DDSPDLPKLK PEPDTLCAEF
160 170 180 190 200
KADEKKFWGK YLYEVARRHP YFYAPELLYY ANKYNGVFQE CCQAEDKGAC
210 220 230 240 250
LLPKIDAMRE KVLASSARQR LRCASIQKFG ERALKAWSVA RLSQKFPKAD
260 270 280 290 300
FTDVTKIVTD LTKVHKECCH GDLLECADDR ADLAKYICDH QDALSSKLKE
310 320 330 340 350
CCDKPVLEKS HCIAEVDKDA VPENLPPLTA DFAEDKEVCK NYQEAKDVFL
360 370 380 390 400
GSFLYEYSRR HPEYAVSVLL RLAKEYEATL EDCCAKEDPH ACYATVFDKL
410 420 430 440 450
KHLVDEPQNL IKKNCELFEK HGEYGFQNAL IVRYTRKAPQ VSTPTLVEIS
460 470 480 490 500
RSLGKVGTKC CAKPESERMP CTEDYLSLIL NRLCVLHEKT PVSEKVTKCC
510 520 530 540 550
TESLVNRRPC FSDLTLDETY VPKPFDEKFF TFHADICTLP DTEKQIKKQT
560 570 580 590 600
ALVELLKHKP KATDEQLKTV MENFVAFVDK CCAADDKEGC FVLEGPKLVA

STQAALA
Length:607
Mass (Da):69,188
Last modified:April 1, 1990 - v1
Checksum:i84979A87F8B86596
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X17055 mRNA. Translation: CAA34903.1.
PIRiS06936. ABSHS.
RefSeqiNP_001009376.1. NM_001009376.1.
UniGeneiOar.449.

Genome annotation databases

GeneIDi443393.
KEGGioas:443393.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X17055 mRNA. Translation: CAA34903.1.
PIRiS06936. ABSHS.
RefSeqiNP_001009376.1. NM_001009376.1.
UniGeneiOar.449.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
4LUFX-ray2.30A25-607[»]
4LUHX-ray2.20A25-607[»]
ProteinModelPortaliP14639.
SMRiP14639. Positions 29-584.
ModBaseiSearch...
MobiDBiSearch...

Protein family/group databases

Allergomei758. Ovi a 6.

Proteomic databases

PRIDEiP14639.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi443393.
KEGGioas:443393.

Organism-specific databases

CTDi213.

Phylogenomic databases

HOVERGENiHBG004207.
KOiK16141.

Family and domain databases

InterProiIPR000264. ALB/AFP/VDB.
IPR020858. Serum_albumin-like.
IPR021177. Serum_albumin/AFP/Afamin.
IPR020857. Serum_albumin_CS.
IPR014760. Serum_albumin_N.
[Graphical view]
PfamiPF00273. Serum_albumin. 3 hits.
[Graphical view]
PIRSFiPIRSF002520. Serum_albumin_subgroup. 1 hit.
PRINTSiPR00803. AFETOPROTEIN.
PR00802. SERUMALBUMIN.
SMARTiSM00103. ALBUMIN. 3 hits.
[Graphical view]
SUPFAMiSSF48552. SSF48552. 3 hits.
PROSITEiPS00212. ALBUMIN_1. 3 hits.
PS51438. ALBUMIN_2. 3 hits.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "Nucleotide and deduced amino acid sequence of sheep serum albumin."
    Brown W.M., Dziegielewska K.M., Foreman R.C., Saunders N.R.
    Nucleic Acids Res. 17:10495-10495(1989) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Tissue: Liver.

Entry informationi

Entry nameiALBU_SHEEP
AccessioniPrimary (citable) accession number: P14639
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 1, 1990
Last sequence update: April 1, 1990
Last modified: October 14, 2015
This is version 92 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.