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P14639 (ALBU_SHEEP) Reviewed, UniProtKB/Swiss-Prot

Last modified May 1, 2013. Version 80. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
Serum albumin
Gene names
Name:ALB
OrganismOvis aries (Sheep)
Taxonomic identifier9940 [NCBI]
Taxonomic lineageEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Laurasiatheria › Cetartiodactyla › Ruminantia › Pecora › Bovidae › Caprinae › Ovis

Protein attributes

Sequence length607 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

Serum albumin, the main protein of plasma, has a good binding capacity for water, Ca2+, Na+, K+, fatty acids, hormones, bilirubin and drugs. Its main function is the regulation of the colloidal osmotic pressure of blood. Major zinc transporter in plasma, typically binds about 80% of all plasma zinc.

Subcellular location

Secreted.

Tissue specificity

Plasma.

Post-translational modification

Phosphorylation sites are present in the extracellular medium By similarity.

Sequence similarities

Belongs to the ALB/AFP/VDB family.

Contains 3 albumin domains.

Ontologies

Keywords
   Cellular componentSecreted
   DomainRepeat
Signal
   LigandCopper
Lipid-binding
Metal-binding
Zinc
   PTMCleavage on pair of basic residues
Disulfide bond
Phosphoprotein
Gene Ontology (GO)
   Biological_processtransport

Inferred from electronic annotation. Source: InterPro

   Cellular_componentextracellular space

Inferred from electronic annotation. Source: InterPro

   Molecular_functionlipid binding

Inferred from electronic annotation. Source: UniProtKB-KW

metal ion binding

Inferred from electronic annotation. Source: UniProtKB-KW

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Signal peptide1 – 1818 By similarity
Propeptide19 – 224 By similarity
PRO_0000001081
Chain25 – 607583Serum albumin
PRO_0000001082

Regions

Domain19 – 209191Albumin 1
Domain210 – 402193Albumin 2
Domain403 – 600198Albumin 3

Sites

Metal binding271Copper By similarity
Metal binding911Zinc By similarity
Metal binding1231Zinc By similarity
Metal binding2701Zinc By similarity
Metal binding2721Zinc By similarity

Amino acid modifications

Modified residue821Phosphoserine By similarity
Modified residue4421Phosphoserine By similarity
Modified residue4431Phosphothreonine By similarity
Modified residue4451Phosphothreonine By similarity
Disulfide bond77 ↔ 86 By similarity
Disulfide bond99 ↔ 115 By similarity
Disulfide bond114 ↔ 125 By similarity
Disulfide bond147 ↔ 192 By similarity
Disulfide bond191 ↔ 200 By similarity
Disulfide bond223 ↔ 269 By similarity
Disulfide bond268 ↔ 276 By similarity
Disulfide bond288 ↔ 302 By similarity
Disulfide bond301 ↔ 312 By similarity
Disulfide bond339 ↔ 384 By similarity
Disulfide bond383 ↔ 392 By similarity
Disulfide bond415 ↔ 461 By similarity
Disulfide bond460 ↔ 471 By similarity
Disulfide bond484 ↔ 500 By similarity
Disulfide bond499 ↔ 510 By similarity
Disulfide bond537 ↔ 582 By similarity
Disulfide bond581 ↔ 590 By similarity

Sequences

Sequence LengthMass (Da)Tools
P14639 [UniParc].

Last modified April 1, 1990. Version 1.
Checksum: 84979A87F8B86596

FASTA60769,188
        10         20         30         40         50         60 
MKWVTFISLL LLFSSAYSRG VFRRDTHKSE IAHRFNDLGE ENFQGLVLIA FSQYLQQCPF 

        70         80         90        100        110        120 
DEHVKLVKEL TEFAKTCVAD ESHAGCDKSL HTLFGDELCK VATLRETYGD MADCCEKQEP 

       130        140        150        160        170        180 
ERNECFLNHK DDSPDLPKLK PEPDTLCAEF KADEKKFWGK YLYEVARRHP YFYAPELLYY 

       190        200        210        220        230        240 
ANKYNGVFQE CCQAEDKGAC LLPKIDAMRE KVLASSARQR LRCASIQKFG ERALKAWSVA 

       250        260        270        280        290        300 
RLSQKFPKAD FTDVTKIVTD LTKVHKECCH GDLLECADDR ADLAKYICDH QDALSSKLKE 

       310        320        330        340        350        360 
CCDKPVLEKS HCIAEVDKDA VPENLPPLTA DFAEDKEVCK NYQEAKDVFL GSFLYEYSRR 

       370        380        390        400        410        420 
HPEYAVSVLL RLAKEYEATL EDCCAKEDPH ACYATVFDKL KHLVDEPQNL IKKNCELFEK 

       430        440        450        460        470        480 
HGEYGFQNAL IVRYTRKAPQ VSTPTLVEIS RSLGKVGTKC CAKPESERMP CTEDYLSLIL 

       490        500        510        520        530        540 
NRLCVLHEKT PVSEKVTKCC TESLVNRRPC FSDLTLDETY VPKPFDEKFF TFHADICTLP 

       550        560        570        580        590        600 
DTEKQIKKQT ALVELLKHKP KATDEQLKTV MENFVAFVDK CCAADDKEGC FVLEGPKLVA 


STQAALA

« Hide

References

[1]"Nucleotide and deduced amino acid sequence of sheep serum albumin."
Brown W.M., Dziegielewska K.M., Foreman R.C., Saunders N.R.
Nucleic Acids Res. 17:10495-10495(1989) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
Tissue: Liver.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		X17055 mRNA. Translation: CAA34903.1.
PIRABSHS. S06936.
RefSeqNP_001009376.1. NM_001009376.1.
UniGeneOar.449.

3D structure databases

ProteinModelPortalP14639.
SMRP14639. Positions 29-584.
ModBaseSearch...

Protein family/group databases

Allergome758. Ovi a 6.

Proteomic databases

PRIDEP14639.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

GeneID443393.

Organism-specific databases

CTD213.

Phylogenomic databases

HOVERGENHBG004207.

Family and domain databases

InterProIPR000264. ALB/AFP/VDB.
IPR001703. Alpha-fetoprotein.
IPR020858. Serum_albumin-like.
IPR021177. Serum_albumin/AFP.
IPR020857. Serum_albumin_CS.
IPR014760. Serum_albumin_N.
[Graphical view]
PfamPF00273. Serum_albumin. 3 hits.
[Graphical view]
PIRSFPIRSF002520. Serum_albumin_subgroup. 1 hit.
PRINTSPR00803. AFETOPROTEIN.
PR00802. SERUMALBUMIN.
SMARTSM00103. ALBUMIN. 3 hits.
[Graphical view]
SUPFAMSSF48552. Serum_albumin. 3 hits.
PROSITEPS00212. ALBUMIN_1. 3 hits.
PS51438. ALBUMIN_2. 3 hits.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameALBU_SHEEP
AccessionPrimary (citable) accession number: P14639
Entry history
Integrated into UniProtKB/Swiss-Prot: April 1, 1990
Last sequence update: April 1, 1990
Last modified: May 1, 2013
This is version 80 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

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