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Protein

Serum albumin

Gene

ALB

Organism
Ovis aries (Sheep)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

Serum albumin, the main protein of plasma, has a good binding capacity for water, Ca2+, Na+, K+, fatty acids, hormones, bilirubin and drugs. Its main function is the regulation of the colloidal osmotic pressure of blood. Major zinc transporter in plasma, typically binds about 80% of all plasma zinc.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi27CopperBy similarity1
Metal bindingi91ZincBy similarity1
Metal bindingi123ZincBy similarity1
Metal bindingi270ZincBy similarity1
Metal bindingi272ZincBy similarity1

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Ligandi

Copper, Lipid-binding, Metal-binding, Zinc

Names & Taxonomyi

Protein namesi
Recommended name:
Serum albumin
Gene namesi
Name:ALB
OrganismiOvis aries (Sheep)
Taxonomic identifieri9940 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaRuminantiaPecoraBovidaeCaprinaeOvis
Proteomesi
  • UP000002356 Componenti: Unplaced

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Secreted

Pathology & Biotechi

Protein family/group databases

Allergomei758. Ovi a 6.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 18Sequence analysisAdd BLAST18
PropeptideiPRO_000000108119 – 24By similarity6
ChainiPRO_000000108225 – 607Serum albuminAdd BLAST583

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei29PhosphoserineBy similarity1
Disulfide bondi77 ↔ 86PROSITE-ProRule annotation
Modified residuei82PhosphoserineBy similarity1
Modified residuei89PhosphoserineBy similarity1
Disulfide bondi99 ↔ 115PROSITE-ProRule annotation
Modified residuei107PhosphothreonineBy similarity1
Disulfide bondi114 ↔ 125PROSITE-ProRule annotation
Disulfide bondi147 ↔ 192PROSITE-ProRule annotation
Disulfide bondi191 ↔ 200PROSITE-ProRule annotation
Disulfide bondi223 ↔ 269PROSITE-ProRule annotation
Modified residuei228N6-succinyllysineBy similarity1
Disulfide bondi268 ↔ 276PROSITE-ProRule annotation
Disulfide bondi288 ↔ 302PROSITE-ProRule annotation
Modified residuei296PhosphoserineBy similarity1
Disulfide bondi301 ↔ 312PROSITE-ProRule annotation
Disulfide bondi339 ↔ 384PROSITE-ProRule annotation
Disulfide bondi383 ↔ 392PROSITE-ProRule annotation
Disulfide bondi415 ↔ 461PROSITE-ProRule annotation
Modified residuei442PhosphoserineBy similarity1
Modified residuei443PhosphothreonineBy similarity1
Modified residuei445PhosphothreonineBy similarity1
Modified residuei459N6-succinyllysineBy similarity1
Disulfide bondi460 ↔ 471PROSITE-ProRule annotation
Disulfide bondi484 ↔ 500PROSITE-ProRule annotation
Disulfide bondi499 ↔ 510PROSITE-ProRule annotation
Modified residuei512PhosphoserineBy similarity1
Disulfide bondi537 ↔ 582PROSITE-ProRule annotation
Modified residuei557N6-methyllysineBy similarity1
Modified residuei569PhosphothreonineBy similarity1
Disulfide bondi581 ↔ 590PROSITE-ProRule annotation
Modified residuei587N6-succinyllysineBy similarity1

Post-translational modificationi

Phosphorylated by FAM20C in the extracellular medium.By similarity

Keywords - PTMi

Cleavage on pair of basic residues, Disulfide bond, Methylation, Phosphoprotein

Proteomic databases

PRIDEiP14639.

Expressioni

Tissue specificityi

Plasma.

Structurei

Secondary structure

1607
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Helixi26 – 28Combined sources3
Helixi30 – 38Combined sources9
Helixi40 – 54Combined sources15
Helixi60 – 79Combined sources20
Turni84 – 87Combined sources4
Helixi90 – 99Combined sources10
Helixi104 – 108Combined sources5
Helixi109 – 116Combined sources8
Helixi121 – 128Combined sources8
Helixi143 – 152Combined sources10
Helixi154 – 168Combined sources15
Helixi174 – 183Combined sources10
Helixi185 – 191Combined sources7
Beta strandi194 – 196Combined sources3
Helixi197 – 229Combined sources33
Helixi231 – 245Combined sources15
Helixi251 – 269Combined sources19
Helixi273 – 289Combined sources17
Helixi291 – 293Combined sources3
Helixi296 – 300Combined sources5
Turni301 – 303Combined sources3
Helixi306 – 314Combined sources9
Helixi329 – 332Combined sources4
Helixi338 – 344Combined sources7
Helixi346 – 360Combined sources15
Helixi366 – 385Combined sources20
Beta strandi386 – 388Combined sources3
Helixi389 – 393Combined sources5
Helixi396 – 437Combined sources42
Helixi443 – 460Combined sources18
Helixi465 – 489Combined sources25
Helixi494 – 501Combined sources8
Helixi507 – 513Combined sources7
Helixi527 – 530Combined sources4
Helixi534 – 538Combined sources5
Helixi541 – 558Combined sources18
Helixi564 – 583Combined sources20
Beta strandi584 – 586Combined sources3
Helixi587 – 606Combined sources20

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
4LUFX-ray2.30A25-607[»]
4LUHX-ray2.20A25-607[»]
ProteinModelPortaliP14639.
SMRiP14639.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini19 – 209Albumin 1PROSITE-ProRule annotationAdd BLAST191
Domaini210 – 402Albumin 2PROSITE-ProRule annotationAdd BLAST193
Domaini403 – 600Albumin 3PROSITE-ProRule annotationAdd BLAST198

Sequence similaritiesi

Belongs to the ALB/AFP/VDB family.PROSITE-ProRule annotation
Contains 3 albumin domains.PROSITE-ProRule annotation

Keywords - Domaini

Repeat, Signal

Phylogenomic databases

HOVERGENiHBG004207.
KOiK16141.

Family and domain databases

CDDicd00015. ALBUMIN. 3 hits.
InterProiIPR000264. ALB/AFP/VDB.
IPR020858. Serum_albumin-like.
IPR021177. Serum_albumin/AFP/Afamin.
IPR020857. Serum_albumin_CS.
IPR014760. Serum_albumin_N.
[Graphical view]
PfamiPF00273. Serum_albumin. 3 hits.
[Graphical view]
PIRSFiPIRSF002520. Serum_albumin_subgroup. 1 hit.
PRINTSiPR00803. AFETOPROTEIN.
PR00802. SERUMALBUMIN.
SMARTiSM00103. ALBUMIN. 3 hits.
[Graphical view]
SUPFAMiSSF48552. SSF48552. 3 hits.
PROSITEiPS00212. ALBUMIN_1. 3 hits.
PS51438. ALBUMIN_2. 3 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P14639-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MKWVTFISLL LLFSSAYSRG VFRRDTHKSE IAHRFNDLGE ENFQGLVLIA
60 70 80 90 100
FSQYLQQCPF DEHVKLVKEL TEFAKTCVAD ESHAGCDKSL HTLFGDELCK
110 120 130 140 150
VATLRETYGD MADCCEKQEP ERNECFLNHK DDSPDLPKLK PEPDTLCAEF
160 170 180 190 200
KADEKKFWGK YLYEVARRHP YFYAPELLYY ANKYNGVFQE CCQAEDKGAC
210 220 230 240 250
LLPKIDAMRE KVLASSARQR LRCASIQKFG ERALKAWSVA RLSQKFPKAD
260 270 280 290 300
FTDVTKIVTD LTKVHKECCH GDLLECADDR ADLAKYICDH QDALSSKLKE
310 320 330 340 350
CCDKPVLEKS HCIAEVDKDA VPENLPPLTA DFAEDKEVCK NYQEAKDVFL
360 370 380 390 400
GSFLYEYSRR HPEYAVSVLL RLAKEYEATL EDCCAKEDPH ACYATVFDKL
410 420 430 440 450
KHLVDEPQNL IKKNCELFEK HGEYGFQNAL IVRYTRKAPQ VSTPTLVEIS
460 470 480 490 500
RSLGKVGTKC CAKPESERMP CTEDYLSLIL NRLCVLHEKT PVSEKVTKCC
510 520 530 540 550
TESLVNRRPC FSDLTLDETY VPKPFDEKFF TFHADICTLP DTEKQIKKQT
560 570 580 590 600
ALVELLKHKP KATDEQLKTV MENFVAFVDK CCAADDKEGC FVLEGPKLVA

STQAALA
Length:607
Mass (Da):69,188
Last modified:April 1, 1990 - v1
Checksum:i84979A87F8B86596
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X17055 mRNA. Translation: CAA34903.1.
PIRiS06936. ABSHS.
RefSeqiNP_001009376.1. NM_001009376.1.
UniGeneiOar.449.

Genome annotation databases

GeneIDi443393.
KEGGioas:443393.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X17055 mRNA. Translation: CAA34903.1.
PIRiS06936. ABSHS.
RefSeqiNP_001009376.1. NM_001009376.1.
UniGeneiOar.449.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
4LUFX-ray2.30A25-607[»]
4LUHX-ray2.20A25-607[»]
ProteinModelPortaliP14639.
SMRiP14639.
ModBaseiSearch...
MobiDBiSearch...

Protein family/group databases

Allergomei758. Ovi a 6.

Proteomic databases

PRIDEiP14639.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi443393.
KEGGioas:443393.

Organism-specific databases

CTDi213.

Phylogenomic databases

HOVERGENiHBG004207.
KOiK16141.

Family and domain databases

CDDicd00015. ALBUMIN. 3 hits.
InterProiIPR000264. ALB/AFP/VDB.
IPR020858. Serum_albumin-like.
IPR021177. Serum_albumin/AFP/Afamin.
IPR020857. Serum_albumin_CS.
IPR014760. Serum_albumin_N.
[Graphical view]
PfamiPF00273. Serum_albumin. 3 hits.
[Graphical view]
PIRSFiPIRSF002520. Serum_albumin_subgroup. 1 hit.
PRINTSiPR00803. AFETOPROTEIN.
PR00802. SERUMALBUMIN.
SMARTiSM00103. ALBUMIN. 3 hits.
[Graphical view]
SUPFAMiSSF48552. SSF48552. 3 hits.
PROSITEiPS00212. ALBUMIN_1. 3 hits.
PS51438. ALBUMIN_2. 3 hits.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiALBU_SHEEP
AccessioniPrimary (citable) accession number: P14639
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 1, 1990
Last sequence update: April 1, 1990
Last modified: November 30, 2016
This is version 95 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.