Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Apolipoprotein M

Gene

Apom

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

Probably involved in lipid transport. Can bind sphingosine-1-phosphate, myristic acid, palmitic acid and stearic acid, retinol, all-trans-retinoic acid and 9-cis-retinoic acid (By similarity).By similarity

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei138 – 1381Fatty acidBy similarity
Binding sitei145 – 1451Fatty acidBy similarity

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Lipid transport, Transport

Enzyme and pathway databases

ReactomeiR-RNO-975634. Retinoid metabolism and transport.

Names & Taxonomyi

Protein namesi
Recommended name:
Apolipoprotein M
Short name:
Apo-M
Short name:
ApoM
Alternative name(s):
Protein Px
Gene namesi
Name:Apom
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Chromosome 20

Organism-specific databases

RGDi620773. Apom.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

HDL, Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 17171 PublicationAdd
BLAST
Chaini18 – 190173Apolipoprotein MPRO_0000017877Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Disulfide bondi23 ↔ 169By similarity
Disulfide bondi95 ↔ 185By similarity
Disulfide bondi130 ↔ 159By similarity

Keywords - PTMi

Disulfide bond

Proteomic databases

PaxDbiP14630.
PRIDEiP14630.

Expressioni

Tissue specificityi

Expressed by the liver; secreted in plasma.

Gene expression databases

GenevisibleiP14630. RN.

Interactioni

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000001126.

Structurei

3D structure databases

ProteinModelPortaliP14630.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiENOG410IG6S. Eukaryota.
ENOG4111Z0U. LUCA.
GeneTreeiENSGT00390000001026.
HOGENOMiHOG000034009.
HOVERGENiHBG018735.
InParanoidiP14630.
OMAiWYFIAGA.
OrthoDBiEOG7GJ6F5.
PhylomeDBiP14630.
TreeFamiTF330771.

Family and domain databases

Gene3Di2.40.128.20. 1 hit.
InterProiIPR022734. ApoM.
IPR012674. Calycin.
IPR011038. Calycin-like.
[Graphical view]
PfamiPF11032. ApoM. 1 hit.
[Graphical view]
SUPFAMiSSF50814. SSF50814. 1 hit.

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P14630-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MFHQVWAALL YLYGLLFNSM NQCPEHSQLM TLGMDDKETP EPHLGLWYFI
60 70 80 90 100
AGAAPTMEEL ATFDQVDNIV FNMAAGSAPR QLQLRATIRT KNGVCVPRKW
110 120 130 140 150
TYHLTEGKGN TELRTEGRPD MKTDLFSISC PGGIMLKETG QGYQRFLLYN
160 170 180 190
RSPHPPEECV EEFQSLTSCL DFKAFLVTPR NQEACPLSSK
Length:190
Mass (Da):21,513
Last modified:September 26, 2001 - v2
Checksum:iE507BD6C202CBBAF
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti30 – 301M → T AA sequence (PubMed:2297521).Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF207821 mRNA. Translation: AAF23408.1.
BX883045 Genomic DNA. Translation: CAE83996.1.
BC089807 mRNA. Translation: AAH89807.1.
RefSeqiNP_062246.1. NM_019373.2.
UniGeneiRn.262.

Genome annotation databases

EnsembliENSRNOT00000001126; ENSRNOP00000001126; ENSRNOG00000000850.
GeneIDi55939.
KEGGirno:55939.
UCSCiRGD:620773. rat.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF207821 mRNA. Translation: AAF23408.1.
BX883045 Genomic DNA. Translation: CAE83996.1.
BC089807 mRNA. Translation: AAH89807.1.
RefSeqiNP_062246.1. NM_019373.2.
UniGeneiRn.262.

3D structure databases

ProteinModelPortaliP14630.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000001126.

Proteomic databases

PaxDbiP14630.
PRIDEiP14630.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSRNOT00000001126; ENSRNOP00000001126; ENSRNOG00000000850.
GeneIDi55939.
KEGGirno:55939.
UCSCiRGD:620773. rat.

Organism-specific databases

CTDi55937.
RGDi620773. Apom.

Phylogenomic databases

eggNOGiENOG410IG6S. Eukaryota.
ENOG4111Z0U. LUCA.
GeneTreeiENSGT00390000001026.
HOGENOMiHOG000034009.
HOVERGENiHBG018735.
InParanoidiP14630.
OMAiWYFIAGA.
OrthoDBiEOG7GJ6F5.
PhylomeDBiP14630.
TreeFamiTF330771.

Enzyme and pathway databases

ReactomeiR-RNO-975634. Retinoid metabolism and transport.

Miscellaneous databases

PROiP14630.

Gene expression databases

GenevisibleiP14630. RN.

Family and domain databases

Gene3Di2.40.128.20. 1 hit.
InterProiIPR022734. ApoM.
IPR012674. Calycin.
IPR011038. Calycin-like.
[Graphical view]
PfamiPF11032. ApoM. 1 hit.
[Graphical view]
SUPFAMiSSF50814. SSF50814. 1 hit.
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. Xu N., Dahlbaeck B.
    Submitted (NOV-1999) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Strain: Sprague-Dawley.
    Tissue: Liver.
  2. "The genomic sequence and comparative analysis of the rat major histocompatibility complex."
    Hurt P., Walter L., Sudbrak R., Klages S., Mueller I., Shiina T., Inoko H., Lehrach H., Guenther E., Reinhardt R., Himmelbauer H.
    Genome Res. 14:631-639(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: Brown Norway.
  3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Liver.
  4. "A novel high-density lipoprotein particle and associated protein in rat plasma."
    Blatter M.-C., James R.W., Borghini I., Martin B.M., Hochstrasser A.-C., Pometta D.
    Biochim. Biophys. Acta 1042:19-27(1990) [PubMed] [Europe PMC] [Abstract]
    Cited for: PROTEIN SEQUENCE OF 18-33.

Entry informationi

Entry nameiAPOM_RAT
AccessioniPrimary (citable) accession number: P14630
Secondary accession number(s): Q5EBB9, Q9QXI9
Entry historyi
Integrated into UniProtKB/Swiss-Prot: August 1, 1990
Last sequence update: September 26, 2001
Last modified: June 8, 2016
This is version 106 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.