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Protein

Interleukin-1 beta

Gene

IL1B

Organism
Oryctolagus cuniculus (Rabbit)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

Potent proinflammatory cytokine. Initially discovered as the major endogenous pyrogen, induces prostaglandin synthesis, neutrophil influx and activation, T-cell activation and cytokine production, B-cell activation and antibody production, and fibroblast proliferation and collagen production.By similarity

Miscellaneous

IL1B production occurs in 2 steps, each being controlled by different stimuli. First, inflammatory signals, such as LPS, stimulate the synthesis and promote the accumulation of cytosolic stores of pro-IL1B (priming). Then additional signals are required for inflammasome assembly, leading to CASP1 activation, pro-IL1B processing and eventually secretion of the active cytokine. IL1B processing and secretion are temporarily associated.By similarity

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionCytokine, Mitogen, Pyrogen
Biological processInflammatory response

Names & Taxonomyi

Protein namesi
Recommended name:
Interleukin-1 beta
Short name:
IL-1 beta
Alternative name(s):
Lymphocyte proliferation-potentiating factor
Gene namesi
Name:IL1B
OrganismiOryctolagus cuniculus (Rabbit)
Taxonomic identifieri9986 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresLagomorphaLeporidaeOryctolagus
Proteomesi
  • UP000001811 Componenti: Unplaced

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm, Cytoplasmic vesicle, Lysosome, Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
PropeptideiPRO_00000153151 – 116Add BLAST116
ChainiPRO_0000015316117 – 268Interleukin-1 betaAdd BLAST152

Interactioni

Subunit structurei

Monomer. Interacts with MEFV (By similarity).By similarity

GO - Molecular functioni

Protein-protein interaction databases

STRINGi9986.ENSOCUP00000021869.

Structurei

3D structure databases

ProteinModelPortaliP14628.
SMRiP14628.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the IL-1 family.Curated

Phylogenomic databases

eggNOGiENOG410IGSZ. Eukaryota.
ENOG410XU2E. LUCA.
HOVERGENiHBG007328.
InParanoidiP14628.
KOiK04519.

Family and domain databases

InterProiView protein in InterPro
IPR003296. IL-1_beta.
IPR020877. IL-1_CS.
IPR000975. IL-1_fam.
IPR003502. IL-1_propep.
IPR008996. IL1/FGF.
PANTHERiPTHR10078:SF42. PTHR10078:SF42. 1 hit.
PfamiView protein in Pfam
PF00340. IL1. 1 hit.
PF02394. IL1_propep. 1 hit.
PRINTSiPR00264. INTERLEUKIN1.
SUPFAMiSSF50353. SSF50353. 1 hit.
PROSITEiView protein in PROSITE
PS00253. INTERLEUKIN_1. 1 hit.

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P14628-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MATVPELTSE MMAYHSGNEN DLFFEADGPN YMKSCFQDLD LCCPDEGIQL
60 70 80 90 100
RISCQPYNKS FRQVLSVVVA LEKLRQKAVP CPQAFQDDGL RTFFSLIFEE
110 120 130 140 150
EPVLCNTWDD YSLECDAVRS LHCRLQDAQQ KSLVLSGTYE LKALHLNAEN
160 170 180 190 200
LNQQVVFSMS FVQGEESNDK IPVALGLRGK NLYLSCVMKD DKPTLQLESV
210 220 230 240 250
DPNRYPKKKM EKRFVFNKIE IKDKLEFESA QFPNWYISTS QTEYMPVFLG
260
NNSGGQDLID FSMEFVSS
Length:268
Mass (Da):30,665
Last modified:April 1, 1990 - v1
Checksum:i55BF44DD78D1B297
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
D21835 mRNA. Translation: BAA04863.1.
M26295 mRNA. Translation: AAA31373.1.
PIRiA27714. A30584.
RefSeqiNP_001075670.1. NM_001082201.1.
UniGeneiOcu.1993.

Genome annotation databases

GeneIDi100008990.
KEGGiocu:100008990.

Similar proteinsi

Entry informationi

Entry nameiIL1B_RABIT
AccessioniPrimary (citable) accession number: P14628
Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 1, 1990
Last sequence update: April 1, 1990
Last modified: August 30, 2017
This is version 95 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families