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P14621

- ACYP2_HUMAN

UniProt

P14621 - ACYP2_HUMAN

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Protein

Acylphosphatase-2

Gene

ACYP2

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at protein leveli

Functioni

Its physiological role is not yet clear.

Catalytic activityi

An acylphosphate + H2O = a carboxylate + phosphate.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei24 – 241PROSITE-ProRule annotation
Active sitei42 – 421PROSITE-ProRule annotation

GO - Molecular functioni

  1. acylphosphatase activity Source: RefGenome

GO - Biological processi

  1. phosphate-containing compound metabolic process Source: ProtInc
Complete GO annotation...

Keywords - Molecular functioni

Hydrolase

Enzyme and pathway databases

SABIO-RKP14621.

Names & Taxonomyi

Protein namesi
Recommended name:
Acylphosphatase-2 (EC:3.6.1.7)
Alternative name(s):
Acylphosphatase, muscle type isozyme
Acylphosphate phosphohydrolase 2
Gene namesi
Name:ACYP2
Synonyms:ACYP
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 2

Organism-specific databases

HGNCiHGNC:180. ACYP2.

Subcellular locationi

GO - Cellular componenti

  1. mitochondrion Source: Ensembl
Complete GO annotation...

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA24500.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Initiator methioninei1 – 11Removed2 Publications
Chaini2 – 9998Acylphosphatase-2PRO_0000158542Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei2 – 21N-acetylserine1 Publication

Keywords - PTMi

Acetylation

Proteomic databases

MaxQBiP14621.
PaxDbiP14621.
PRIDEiP14621.

Expressioni

Gene expression databases

BgeeiP14621.
CleanExiHS_ACYP2.
ExpressionAtlasiP14621. baseline and differential.
GenevestigatoriP14621.

Organism-specific databases

HPAiHPA035301.

Interactioni

Protein-protein interaction databases

BioGridi106613. 2 interactions.
DIPiDIP-48449N.
STRINGi9606.ENSP00000378161.

Structurei

3D structure databases

ProteinModelPortaliP14621.
SMRiP14621. Positions 2-99.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini9 – 9991Acylphosphatase-likePROSITE-ProRule annotationAdd
BLAST

Sequence similaritiesi

Belongs to the acylphosphatase family.Curated
Contains 1 acylphosphatase-like domain.PROSITE-ProRule annotation

Phylogenomic databases

eggNOGiCOG1254.
GeneTreeiENSGT00390000011103.
HOGENOMiHOG000292688.
HOVERGENiHBG050454.
InParanoidiP14621.
KOiK01512.
OMAiWLSKIGS.
PhylomeDBiP14621.
TreeFamiTF300288.

Family and domain databases

InterProiIPR020456. Acylphosphatase.
IPR027147. Acylphosphatase-2.
IPR001792. Acylphosphatase-like_dom.
IPR017968. Acylphosphatase_CS.
[Graphical view]
PANTHERiPTHR10029:SF5. PTHR10029:SF5. 1 hit.
PfamiPF00708. Acylphosphatase. 1 hit.
[Graphical view]
PRINTSiPR00112. ACYLPHPHTASE.
SUPFAMiSSF54975. SSF54975. 1 hit.
PROSITEiPS00150. ACYLPHOSPHATASE_1. 1 hit.
PS00151. ACYLPHOSPHATASE_2. 1 hit.
PS51160. ACYLPHOSPHATASE_3. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P14621-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MSTAQSLKSV DYEVFGRVQG VCFRMYTEDE ARKIGVVGWV KNTSKGTVTG
60 70 80 90
QVQGPEDKVN SMKSWLSKVG SPSSRIDRTN FSNEKTISKL EYSNFSIRY
Length:99
Mass (Da):11,140
Last modified:January 23, 2007 - v2
Checksum:iAEDE40E45B6207A0
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC012290 mRNA. Translation: AAH12290.1.
X84195 mRNA. Translation: CAA58988.1.
CCDSiCCDS1850.1.
PIRiS59138. S52327.
RefSeqiNP_612457.1. NM_138448.3.
UniGeneiHs.516173.
Hs.642983.

Genome annotation databases

EnsembliENST00000394666; ENSP00000378161; ENSG00000170634.
GeneIDi98.
KEGGihsa:98.
UCSCiuc002rxq.4. human.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC012290 mRNA. Translation: AAH12290.1 .
X84195 mRNA. Translation: CAA58988.1 .
CCDSi CCDS1850.1.
PIRi S59138. S52327.
RefSeqi NP_612457.1. NM_138448.3.
UniGenei Hs.516173.
Hs.642983.

3D structure databases

ProteinModelPortali P14621.
SMRi P14621. Positions 2-99.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 106613. 2 interactions.
DIPi DIP-48449N.
STRINGi 9606.ENSP00000378161.

Proteomic databases

MaxQBi P14621.
PaxDbi P14621.
PRIDEi P14621.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000394666 ; ENSP00000378161 ; ENSG00000170634 .
GeneIDi 98.
KEGGi hsa:98.
UCSCi uc002rxq.4. human.

Organism-specific databases

CTDi 98.
GeneCardsi GC02P054199.
HGNCi HGNC:180. ACYP2.
HPAi HPA035301.
MIMi 102595. gene.
neXtProti NX_P14621.
PharmGKBi PA24500.
GenAtlasi Search...

Phylogenomic databases

eggNOGi COG1254.
GeneTreei ENSGT00390000011103.
HOGENOMi HOG000292688.
HOVERGENi HBG050454.
InParanoidi P14621.
KOi K01512.
OMAi WLSKIGS.
PhylomeDBi P14621.
TreeFami TF300288.

Enzyme and pathway databases

SABIO-RK P14621.

Miscellaneous databases

ChiTaRSi ACYP2. human.
GeneWikii ACYP2.
GenomeRNAii 98.
NextBioi 373.
PROi P14621.
SOURCEi Search...

Gene expression databases

Bgeei P14621.
CleanExi HS_ACYP2.
ExpressionAtlasi P14621. baseline and differential.
Genevestigatori P14621.

Family and domain databases

InterProi IPR020456. Acylphosphatase.
IPR027147. Acylphosphatase-2.
IPR001792. Acylphosphatase-like_dom.
IPR017968. Acylphosphatase_CS.
[Graphical view ]
PANTHERi PTHR10029:SF5. PTHR10029:SF5. 1 hit.
Pfami PF00708. Acylphosphatase. 1 hit.
[Graphical view ]
PRINTSi PR00112. ACYLPHPHTASE.
SUPFAMi SSF54975. SSF54975. 1 hit.
PROSITEi PS00150. ACYLPHOSPHATASE_1. 1 hit.
PS00151. ACYLPHOSPHATASE_2. 1 hit.
PS51160. ACYLPHOSPHATASE_3. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Ovary.
  2. "Human skeletal muscle acylphosphatase: the primary structure."
    Manao G., Camici G., Modesti A., Liguri G., Berti A., Setfani M., Cappugi G., Ramponi G.
    Mol. Biol. Med. 2:369-378(1984) [PubMed] [Europe PMC] [Abstract]
    Cited for: PROTEIN SEQUENCE OF 2-99.
    Tissue: Muscle.
  3. "Cloning and expression of the cDNA coding for the erythrocyte isoenzyme of human acylphosphatase."
    Fiaschi T., Raugei G., Marzocchini R., Chiarugi P., Cirri P., Ramponi G.
    FEBS Lett. 367:145-148(1995) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 22-99.
    Tissue: Heart.
  4. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
  5. Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT SER-2, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS], CLEAVAGE OF INITIATOR METHIONINE [LARGE SCALE ANALYSIS].

Entry informationi

Entry nameiACYP2_HUMAN
AccessioniPrimary (citable) accession number: P14621
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 1, 1990
Last sequence update: January 23, 2007
Last modified: October 29, 2014
This is version 129 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. Human chromosome 2
    Human chromosome 2: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3