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P14621

- ACYP2_HUMAN

UniProt

P14621 - ACYP2_HUMAN

Protein

Acylphosphatase-2

Gene

ACYP2

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at protein leveli
  1. Functioni

    Its physiological role is not yet clear.

    Catalytic activityi

    An acylphosphate + H2O = a carboxylate + phosphate.

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Active sitei24 – 241PROSITE-ProRule annotation
    Active sitei42 – 421PROSITE-ProRule annotation

    GO - Molecular functioni

    1. acylphosphatase activity Source: RefGenome

    GO - Biological processi

    1. phosphate-containing compound metabolic process Source: ProtInc

    Keywords - Molecular functioni

    Hydrolase

    Enzyme and pathway databases

    SABIO-RKP14621.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Acylphosphatase-2 (EC:3.6.1.7)
    Alternative name(s):
    Acylphosphatase, muscle type isozyme
    Acylphosphate phosphohydrolase 2
    Gene namesi
    Name:ACYP2
    Synonyms:ACYP
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 2

    Organism-specific databases

    HGNCiHGNC:180. ACYP2.

    Subcellular locationi

    GO - Cellular componenti

    1. mitochondrion Source: Ensembl

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA24500.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Initiator methioninei1 – 11Removed2 Publications
    Chaini2 – 9998Acylphosphatase-2PRO_0000158542Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei2 – 21N-acetylserine1 Publication

    Keywords - PTMi

    Acetylation

    Proteomic databases

    MaxQBiP14621.
    PaxDbiP14621.
    PRIDEiP14621.

    Expressioni

    Gene expression databases

    ArrayExpressiP14621.
    BgeeiP14621.
    CleanExiHS_ACYP2.
    GenevestigatoriP14621.

    Organism-specific databases

    HPAiHPA035301.

    Interactioni

    Protein-protein interaction databases

    BioGridi106613. 2 interactions.
    DIPiDIP-48449N.
    STRINGi9606.ENSP00000378161.

    Structurei

    3D structure databases

    ProteinModelPortaliP14621.
    SMRiP14621. Positions 2-99.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini9 – 9991Acylphosphatase-likePROSITE-ProRule annotationAdd
    BLAST

    Sequence similaritiesi

    Belongs to the acylphosphatase family.Curated
    Contains 1 acylphosphatase-like domain.PROSITE-ProRule annotation

    Phylogenomic databases

    eggNOGiCOG1254.
    HOGENOMiHOG000292688.
    HOVERGENiHBG050454.
    InParanoidiP14621.
    KOiK01512.
    OMAiWLSKIGS.
    PhylomeDBiP14621.
    TreeFamiTF300288.

    Family and domain databases

    InterProiIPR020456. Acylphosphatase.
    IPR027147. Acylphosphatase-2.
    IPR001792. Acylphosphatase-like_dom.
    IPR017968. Acylphosphatase_CS.
    [Graphical view]
    PANTHERiPTHR10029:SF5. PTHR10029:SF5. 1 hit.
    PfamiPF00708. Acylphosphatase. 1 hit.
    [Graphical view]
    PRINTSiPR00112. ACYLPHPHTASE.
    SUPFAMiSSF54975. SSF54975. 1 hit.
    PROSITEiPS00150. ACYLPHOSPHATASE_1. 1 hit.
    PS00151. ACYLPHOSPHATASE_2. 1 hit.
    PS51160. ACYLPHOSPHATASE_3. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    P14621-1 [UniParc]FASTAAdd to Basket

    « Hide

    MSTAQSLKSV DYEVFGRVQG VCFRMYTEDE ARKIGVVGWV KNTSKGTVTG   50
    QVQGPEDKVN SMKSWLSKVG SPSSRIDRTN FSNEKTISKL EYSNFSIRY 99
    Length:99
    Mass (Da):11,140
    Last modified:January 23, 2007 - v2
    Checksum:iAEDE40E45B6207A0
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    BC012290 mRNA. Translation: AAH12290.1.
    X84195 mRNA. Translation: CAA58988.1.
    CCDSiCCDS1850.1.
    PIRiS59138. S52327.
    RefSeqiNP_612457.1. NM_138448.3.
    UniGeneiHs.516173.
    Hs.642983.

    Genome annotation databases

    EnsembliENST00000394666; ENSP00000378161; ENSG00000170634.
    GeneIDi98.
    KEGGihsa:98.
    UCSCiuc002rxq.4. human.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    BC012290 mRNA. Translation: AAH12290.1 .
    X84195 mRNA. Translation: CAA58988.1 .
    CCDSi CCDS1850.1.
    PIRi S59138. S52327.
    RefSeqi NP_612457.1. NM_138448.3.
    UniGenei Hs.516173.
    Hs.642983.

    3D structure databases

    ProteinModelPortali P14621.
    SMRi P14621. Positions 2-99.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 106613. 2 interactions.
    DIPi DIP-48449N.
    STRINGi 9606.ENSP00000378161.

    Proteomic databases

    MaxQBi P14621.
    PaxDbi P14621.
    PRIDEi P14621.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000394666 ; ENSP00000378161 ; ENSG00000170634 .
    GeneIDi 98.
    KEGGi hsa:98.
    UCSCi uc002rxq.4. human.

    Organism-specific databases

    CTDi 98.
    GeneCardsi GC02P054199.
    HGNCi HGNC:180. ACYP2.
    HPAi HPA035301.
    MIMi 102595. gene.
    neXtProti NX_P14621.
    PharmGKBi PA24500.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi COG1254.
    HOGENOMi HOG000292688.
    HOVERGENi HBG050454.
    InParanoidi P14621.
    KOi K01512.
    OMAi WLSKIGS.
    PhylomeDBi P14621.
    TreeFami TF300288.

    Enzyme and pathway databases

    SABIO-RK P14621.

    Miscellaneous databases

    ChiTaRSi ACYP2. human.
    GeneWikii ACYP2.
    GenomeRNAii 98.
    NextBioi 373.
    PROi P14621.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi P14621.
    Bgeei P14621.
    CleanExi HS_ACYP2.
    Genevestigatori P14621.

    Family and domain databases

    InterProi IPR020456. Acylphosphatase.
    IPR027147. Acylphosphatase-2.
    IPR001792. Acylphosphatase-like_dom.
    IPR017968. Acylphosphatase_CS.
    [Graphical view ]
    PANTHERi PTHR10029:SF5. PTHR10029:SF5. 1 hit.
    Pfami PF00708. Acylphosphatase. 1 hit.
    [Graphical view ]
    PRINTSi PR00112. ACYLPHPHTASE.
    SUPFAMi SSF54975. SSF54975. 1 hit.
    PROSITEi PS00150. ACYLPHOSPHATASE_1. 1 hit.
    PS00151. ACYLPHOSPHATASE_2. 1 hit.
    PS51160. ACYLPHOSPHATASE_3. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Tissue: Ovary.
    2. "Human skeletal muscle acylphosphatase: the primary structure."
      Manao G., Camici G., Modesti A., Liguri G., Berti A., Setfani M., Cappugi G., Ramponi G.
      Mol. Biol. Med. 2:369-378(1984) [PubMed] [Europe PMC] [Abstract]
      Cited for: PROTEIN SEQUENCE OF 2-99.
      Tissue: Muscle.
    3. "Cloning and expression of the cDNA coding for the erythrocyte isoenzyme of human acylphosphatase."
      Fiaschi T., Raugei G., Marzocchini R., Chiarugi P., Cirri P., Ramponi G.
      FEBS Lett. 367:145-148(1995) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 22-99.
      Tissue: Heart.
    4. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    5. Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT SER-2, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS], CLEAVAGE OF INITIATOR METHIONINE [LARGE SCALE ANALYSIS].

    Entry informationi

    Entry nameiACYP2_HUMAN
    AccessioniPrimary (citable) accession number: P14621
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: April 1, 1990
    Last sequence update: January 23, 2007
    Last modified: October 1, 2014
    This is version 128 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Direct protein sequencing, Reference proteome

    Documents

    1. Human chromosome 2
      Human chromosome 2: entries, gene names and cross-references to MIM
    2. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    3. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3