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Protein

Acylphosphatase-2

Gene

ACYP2

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

Its physiological role is not yet clear.

Catalytic activityi

An acylphosphate + H2O = a carboxylate + phosphate.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei24 – 241PROSITE-ProRule annotation
Active sitei42 – 421PROSITE-ProRule annotation

GO - Molecular functioni

  1. acylphosphatase activity Source: GO_Central

GO - Biological processi

  1. phosphate-containing compound metabolic process Source: ProtInc
Complete GO annotation...

Keywords - Molecular functioni

Hydrolase

Enzyme and pathway databases

SABIO-RKP14621.

Names & Taxonomyi

Protein namesi
Recommended name:
Acylphosphatase-2 (EC:3.6.1.7)
Alternative name(s):
Acylphosphatase, muscle type isozyme
Acylphosphate phosphohydrolase 2
Gene namesi
Name:ACYP2
Synonyms:ACYP
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640 Componenti: Chromosome 2

Organism-specific databases

HGNCiHGNC:180. ACYP2.

Subcellular locationi

GO - Cellular componenti

  1. mitochondrion Source: Ensembl
Complete GO annotation...

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA24500.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Initiator methioninei1 – 11Removed2 Publications
Chaini2 – 9998Acylphosphatase-2PRO_0000158542Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei2 – 21N-acetylserine1 Publication

Keywords - PTMi

Acetylation

Proteomic databases

MaxQBiP14621.
PaxDbiP14621.
PRIDEiP14621.

Expressioni

Gene expression databases

BgeeiP14621.
CleanExiHS_ACYP2.
ExpressionAtlasiP14621. baseline and differential.
GenevestigatoriP14621.

Organism-specific databases

HPAiHPA035301.

Interactioni

Protein-protein interaction databases

BioGridi106613. 3 interactions.
DIPiDIP-48449N.
STRINGi9606.ENSP00000378161.

Structurei

3D structure databases

ProteinModelPortaliP14621.
SMRiP14621. Positions 2-99.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini9 – 9991Acylphosphatase-likePROSITE-ProRule annotationAdd
BLAST

Sequence similaritiesi

Belongs to the acylphosphatase family.Curated
Contains 1 acylphosphatase-like domain.PROSITE-ProRule annotation

Phylogenomic databases

eggNOGiCOG1254.
GeneTreeiENSGT00390000011103.
HOGENOMiHOG000292688.
HOVERGENiHBG050454.
InParanoidiP14621.
KOiK01512.
OMAiYANFHIK.
PhylomeDBiP14621.
TreeFamiTF300288.

Family and domain databases

InterProiIPR020456. Acylphosphatase.
IPR027147. Acylphosphatase-2.
IPR001792. Acylphosphatase-like_dom.
IPR017968. Acylphosphatase_CS.
[Graphical view]
PANTHERiPTHR10029:SF5. PTHR10029:SF5. 1 hit.
PfamiPF00708. Acylphosphatase. 1 hit.
[Graphical view]
PRINTSiPR00112. ACYLPHPHTASE.
SUPFAMiSSF54975. SSF54975. 1 hit.
PROSITEiPS00150. ACYLPHOSPHATASE_1. 1 hit.
PS00151. ACYLPHOSPHATASE_2. 1 hit.
PS51160. ACYLPHOSPHATASE_3. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P14621-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSTAQSLKSV DYEVFGRVQG VCFRMYTEDE ARKIGVVGWV KNTSKGTVTG
60 70 80 90
QVQGPEDKVN SMKSWLSKVG SPSSRIDRTN FSNEKTISKL EYSNFSIRY
Length:99
Mass (Da):11,140
Last modified:January 22, 2007 - v2
Checksum:iAEDE40E45B6207A0
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC012290 mRNA. Translation: AAH12290.1.
X84195 mRNA. Translation: CAA58988.1.
CCDSiCCDS1850.1.
PIRiS59138. S52327.
RefSeqiNP_612457.1. NM_138448.3.
UniGeneiHs.516173.
Hs.642983.

Genome annotation databases

EnsembliENST00000394666; ENSP00000378161; ENSG00000170634.
GeneIDi98.
KEGGihsa:98.
UCSCiuc002rxq.4. human.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC012290 mRNA. Translation: AAH12290.1.
X84195 mRNA. Translation: CAA58988.1.
CCDSiCCDS1850.1.
PIRiS59138. S52327.
RefSeqiNP_612457.1. NM_138448.3.
UniGeneiHs.516173.
Hs.642983.

3D structure databases

ProteinModelPortaliP14621.
SMRiP14621. Positions 2-99.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi106613. 3 interactions.
DIPiDIP-48449N.
STRINGi9606.ENSP00000378161.

Proteomic databases

MaxQBiP14621.
PaxDbiP14621.
PRIDEiP14621.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000394666; ENSP00000378161; ENSG00000170634.
GeneIDi98.
KEGGihsa:98.
UCSCiuc002rxq.4. human.

Organism-specific databases

CTDi98.
GeneCardsiGC02P054199.
HGNCiHGNC:180. ACYP2.
HPAiHPA035301.
MIMi102595. gene.
neXtProtiNX_P14621.
PharmGKBiPA24500.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiCOG1254.
GeneTreeiENSGT00390000011103.
HOGENOMiHOG000292688.
HOVERGENiHBG050454.
InParanoidiP14621.
KOiK01512.
OMAiYANFHIK.
PhylomeDBiP14621.
TreeFamiTF300288.

Enzyme and pathway databases

SABIO-RKP14621.

Miscellaneous databases

ChiTaRSiACYP2. human.
GeneWikiiACYP2.
GenomeRNAii98.
NextBioi373.
PROiP14621.
SOURCEiSearch...

Gene expression databases

BgeeiP14621.
CleanExiHS_ACYP2.
ExpressionAtlasiP14621. baseline and differential.
GenevestigatoriP14621.

Family and domain databases

InterProiIPR020456. Acylphosphatase.
IPR027147. Acylphosphatase-2.
IPR001792. Acylphosphatase-like_dom.
IPR017968. Acylphosphatase_CS.
[Graphical view]
PANTHERiPTHR10029:SF5. PTHR10029:SF5. 1 hit.
PfamiPF00708. Acylphosphatase. 1 hit.
[Graphical view]
PRINTSiPR00112. ACYLPHPHTASE.
SUPFAMiSSF54975. SSF54975. 1 hit.
PROSITEiPS00150. ACYLPHOSPHATASE_1. 1 hit.
PS00151. ACYLPHOSPHATASE_2. 1 hit.
PS51160. ACYLPHOSPHATASE_3. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Ovary.
  2. "Human skeletal muscle acylphosphatase: the primary structure."
    Manao G., Camici G., Modesti A., Liguri G., Berti A., Setfani M., Cappugi G., Ramponi G.
    Mol. Biol. Med. 2:369-378(1983) [PubMed] [Europe PMC] [Abstract]
    Cited for: PROTEIN SEQUENCE OF 2-99.
    Tissue: Muscle.
  3. "Cloning and expression of the cDNA coding for the erythrocyte isoenzyme of human acylphosphatase."
    Fiaschi T., Raugei G., Marzocchini R., Chiarugi P., Cirri P., Ramponi G.
    FEBS Lett. 367:145-148(1994) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 22-99.
    Tissue: Heart.
  4. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
  5. Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT SER-2, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS], CLEAVAGE OF INITIATOR METHIONINE [LARGE SCALE ANALYSIS].
  6. "An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome."
    Bian Y., Song C., Cheng K., Dong M., Wang F., Huang J., Sun D., Wang L., Ye M., Zou H.
    J. Proteomics 96:253-262(2013) [PubMed] [Europe PMC] [Abstract]
    Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Liver.

Entry informationi

Entry nameiACYP2_HUMAN
AccessioniPrimary (citable) accession number: P14621
Entry historyi
Integrated into UniProtKB/Swiss-Prot: March 31, 1990
Last sequence update: January 22, 2007
Last modified: March 3, 2015
This is version 132 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. Human chromosome 2
    Human chromosome 2: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.