P14621 (ACYP2_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Acylphosphatase-2
EC=3.6.1.7

Alternative name(s):
Acylphosphatase, muscle type isozyme
Acylphosphate phosphohydrolase 2

Gene names

Name:	ACYP2
Synonyms:	ACYP

Organism

Homo sapiens (Human) [Reference proteome]

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo

Protein attributes

Sequence length	99 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is further processed into a mature form.
Protein existence	Evidence at protein level

General annotation (Comments)

Function	Its physiological role is not yet clear.
Catalytic activity	An acylphosphate + H2O = a carboxylate + phosphate.
Sequence similarities	Belongs to the acylphosphatase family. Contains 1 acylphosphatase-like domain.

Ontologies

Keywords
Molecular function	Hydrolase
PTM	Acetylation
Technical term	Complete proteome Direct protein sequencing Reference proteome
Gene Ontology (GO)
Biological_process	phosphate-containing compound metabolic process Traceable author statement PubMed 8268218. Source: ProtInc
Cellular_component	mitochondrion Inferred from electronic annotation. Source: Compara
Molecular_function	acylphosphatase activity Traceable author statement PubMed 8268218. Source: ProtInc
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Initiator methionine	1	1	Removed Ref.2
	Chain	2 – 99	98	Acylphosphatase-2		PRO_0000158542
Regions
	Domain	9 – 99	91	Acylphosphatase-like
Sites
	Active site	24	1	Potential
	Active site	42	1	Potential
Amino acid modifications
	Modified residue	2	1	N-acetylserine

Sequences

	Sequence		Length	Mass (Da)
	P14621 [UniParc]. Last modified January 23, 2007. Version 2. Checksum: AEDE40E45B6207A0	FASTA	99	11,140
	10 20 30 40 50 60 MSTAQSLKSV DYEVFGRVQG VCFRMYTEDE ARKIGVVGWV KNTSKGTVTG QVQGPEDKVN 70 80 90 SMKSWLSKVG SPSSRIDRTN FSNEKTISKL EYSNFSIRY

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Tissue: Ovary.
[2]	"Human skeletal muscle acylphosphatase: the primary structure." Manao G., Camici G., Modesti A., Liguri G., Berti A., Setfani M., Cappugi G., Ramponi G. Mol. Biol. Med. 2:369-378(1984) [PubMed] [Europe PMC] [Abstract] Cited for: PROTEIN SEQUENCE OF 2-99. Tissue: Muscle.
[3]	"Cloning and expression of the cDNA coding for the erythrocyte isoenzyme of human acylphosphatase." Fiaschi T., Raugei G., Marzocchini R., Chiarugi P., Cirri P., Ramponi G. FEBS Lett. 367:145-148(1995) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 22-99. Tissue: Heart.
[4]	"Initial characterization of the human central proteome." Burkard T.R., Planyavsky M., Kaupe I., Breitwieser F.P., Buerckstuemmer T., Bennett K.L., Superti-Furga G., Colinge J. BMC Syst. Biol. 5:17-17(2011) [PubMed] [Europe PMC] [Abstract] Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	BC012290 mRNA. Translation: AAH12290.1. X84195 mRNA. Translation: CAA58988.1.
IPI	IPI00216461.
PIR	S52327. S59138.
RefSeq	NP_612457.1. NM_138448.3.
UniGene	Hs.516173. Hs.642983.
3D structure databases
ProteinModelPortal	P14621.
ModBase	Search...
Protein-protein interaction databases
DIP	DIP-48449N.
STRING	9606.ENSP00000378161.
Polymorphism databases
DMDM	2822108.
Proteomic databases
PaxDb	P14621.
PRIDE	P14621.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENST00000394666; ENSP00000378161; ENSG00000170634.
GeneID	98.
KEGG	hsa:98.
UCSC	uc002rxq.4. human.
Organism-specific databases
CTD	98.
GeneCards	GC02P054342.
HGNC	HGNC:180. ACYP2.
HPA	HPA035301.
MIM	102595. gene.
neXtProt	NX_P14621.
PharmGKB	PA24500.
GenAtlas	Search...
Phylogenomic databases
eggNOG	COG1254.
HOGENOM	HOG000292688.
HOVERGEN	HBG050454.
InParanoid	P14621.
KO	K01512.
OMA	KSWLSNV.
PhylomeDB	P14621.
Enzyme and pathway databases
SABIO-RK	P14621.
Gene expression databases
ArrayExpress	P14621.
Bgee	P14621.
CleanEx	HS_ACYP2.
Genevestigator	P14621.
Family and domain databases
InterPro	IPR020456. Acylphosphatase. IPR027147. Acylphosphatase-2. IPR001792. Acylphosphatase-like. IPR017968. Acylphosphatase_CS. [Graphical view]
PANTHER	PTHR10029:SF1. PTHR10029:SF1. 1 hit.
Pfam	PF00708. Acylphosphatase. 1 hit. [Graphical view]
PRINTS	PR00112. ACYLPHPHTASE.
SUPFAM	SSF54975. Acylphosphatase. 1 hit.
PROSITE	PS00150. ACYLPHOSPHATASE_1. 1 hit. PS00151. ACYLPHOSPHATASE_2. 1 hit. PS51160. ACYLPHOSPHATASE_3. 1 hit. [Graphical view]
ProtoNet	Search...
Other
ChiTaRS	ACYP2. human.
GenomeRNAi	98.
NextBio	373.
SOURCE	Search...

Entry information

Entry name

ACYP2_HUMAN

Accession

Primary (citable) accession number: P14621

Entry history

Integrated into UniProtKB/Swiss-Prot:	April 1, 1990
Last sequence update:	January 23, 2007
Last modified:	May 1, 2013
This is version 117 of the entry and version 2 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.