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P14617 (INSRR_CAVPO) Reviewed, UniProtKB/Swiss-Prot

Last modified April 3, 2013. Version 118. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
Insulin receptor-related protein
Short name=IRR
EC=2.7.10.1
Alternative name(s):
IR-related receptor

Cleaved into the following 2 chains:

  1. Insulin receptor-related protein alpha chain
  2. Insulin receptor-related protein beta chain
Gene names
Name:INSRR
OrganismCavia porcellus (Guinea pig) [Reference proteome]
Taxonomic identifier10141 [NCBI]
Taxonomic lineageEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Hystricognathi › Caviidae › Cavia

Protein attributes

Sequence length1300 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceInferred from homology

General annotation (Comments)

Function

Receptor with tyrosine-protein kinase activity. Functions as a pH sensing receptor which is activated by increased extracellular pH. Activates an intracellular signaling pathway that involves IRS1 and AKT1/PKB By similarity.

Catalytic activity

ATP + a [protein]-L-tyrosine = ADP + a [protein]-L-tyrosine phosphate.

Subunit structure

Probable tetramer of 2 alpha and 2 beta chains linked by disulfide bonds. The alpha chains contribute to the formation of the ligand-binding domain, while the beta chains carry the kinase domain.

Subcellular location

Membrane; Single-pass type I membrane protein By similarity.

Domain

The extracellular domain is required for sensing alterations in external pH By similarity.

Post-translational modification

Autophosphorylated on tyrosine residues between pH 7.9 and pH 10.5 By similarity.

Sequence similarities

Belongs to the protein kinase superfamily. Tyr protein kinase family. Insulin receptor subfamily.

Contains 3 fibronectin type-III domains.

Contains 1 protein kinase domain.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Signal peptide1 – 2626
Chain27 – 746720Insulin receptor-related protein alpha chain Probable
PRO_0000016699
Chain747 – 1300554Insulin receptor-related protein beta chain Probable
PRO_0000016700

Regions

Topological domain747 – 921175Extracellular Potential
Transmembrane922 – 94322Helical; Potential
Topological domain944 – 1300357Cytoplasmic Potential
Domain484 – 594111Fibronectin type-III 1
Domain605 – 707103Fibronectin type-III 2
Domain815 – 90995Fibronectin type-III 3
Domain979 – 1254276Protein kinase
Nucleotide binding985 – 9939ATP By similarity

Sites

Active site11151Proton acceptor By similarity
Binding site10131ATP

Amino acid modifications

Modified residue11451Phosphotyrosine; by autocatalysis By similarity
Modified residue11461Phosphotyrosine; by autocatalysis By similarity
Glycosylation471N-linked (GlcNAc...) Potential
Glycosylation3111N-linked (GlcNAc...) Potential
Glycosylation4111N-linked (GlcNAc...) Potential
Glycosylation4921N-linked (GlcNAc...) Potential
Glycosylation5281N-linked (GlcNAc...) Potential
Glycosylation6161N-linked (GlcNAc...) Potential
Glycosylation6341N-linked (GlcNAc...) Potential
Glycosylation7561N-linked (GlcNAc...) Potential
Glycosylation8851N-linked (GlcNAc...) Potential
Glycosylation8981N-linked (GlcNAc...) Potential
Disulfide bond214 ↔ 222 By similarity
Disulfide bond216 ↔ 228 By similarity
Disulfide bond229 ↔ 237 By similarity
Disulfide bond233 ↔ 246 By similarity
Disulfide bond249 ↔ 258 By similarity
Disulfide bond262 ↔ 274 By similarity
Disulfide bond280 ↔ 300 By similarity
Disulfide bond304 ↔ 317 By similarity
Disulfide bond320 ↔ 324 By similarity
Disulfide bond657 ↔ 864Interchain (between alpha and beta chains) Potential

Sequences

Sequence LengthMass (Da)Tools
P14617 [UniParc].

Last modified April 1, 1990. Version 1.
Checksum: 3344DF4B6A57B24F

FASTA1,300144,518
        10         20         30         40         50         60 
MARPKLWPWG ILLLVSLLSA GFNLDTMNVC PSLDIRSEVA ELRRLENCSV VEGHLQILLM 

        70         80         90        100        110        120 
FTATGEDFRS LSFPHLTQVT DYLLLFRVYG LESLRDLFPN LAVIRGAHLF LGYALVIFEM 

       130        140        150        160        170        180 
PHLRDVGLPA LGAVLHGSVR VEKNQELCHL STIDWGLLQP TPSTNYIVGN KLGEECADVC 

       190        200        210        220        230        240 
PGTLGAAGEP CARTTFNGHT DYRCWTSSHC QRVCPCPQGL ACTISGECCH TECLGGCSQP 

       250        260        270        280        290        300 
EDPRACVACR HFYYQSACHR ACPLGTYEHE SWRCVTAESC ANLRSVPGRA STFGIHQGKC 

       310        320        330        340        350        360 
LAQCPPGFTR NGSSIFCHKC EGLCPKECKV GTKTIDSVQA AQDLVGCTHV EGSLILNLRR 

       370        380        390        400        410        420 
GYNLEPELQR SLGLVETITG FLKIKHSFAL VSLSFFKNLK LIRGDTMVDG NYTLYVLDNQ 

       430        440        450        460        470        480 
NLQQLGPWVS AGLTIPVGKI YFAFNPRLCL EHIYRLEEVT GTRGRQNKAE INPRTNGDRA 

       490        500        510        520        530        540 
ACQTRTLRFV SNVTEADRIL LRWERYEPLE ARDLLSFIVY YKESPFQNAT EHVGPDACGS 

       550        560        570        580        590        600 
QSWNLLDVEL PLSRTQEPGV ILAPLKPWTQ YAVFVRAITL TTAEDSPHQG AQSPIVYLWT 

       610        620        630        640        650        660 
LPAAPTVPQD VISSSNSSSH LLVRWKPPTQ RNGNITYYLV LWQRLAEDGD LYLNDYCHRG 

       670        680        690        700        710        720 
LRLPTSNHDP RFDREDGDLE AELELGCCPC QHAPPGQVLP ALEAQEASFQ KKFENFLHNA 

       730        740        750        760        770        780 
ITIPKPPWKV TSIHRNLQRD AGRHRRAIGS PRPGGNSSDF EIQEDKVPRE RAVLGGLRHF 

       790        800        810        820        830        840 
TEYRIDIHAC NHAAHIVGCS AATFVFARTM PRREADDIPG KLSWEAASKS SVLLRWFEPP 

       850        860        870        880        890        900 
DPNGLILKYE IKYRRLGEEA TVLCVSRLRY AKVGGVQLAL LPPGNYSARV RATSLAGNGS 

       910        920        930        940        950        960 
WTDSVAFYIP GPEEEDSGGL HILLTVTPAG LMLLIILAAL GFFYSRKRNG TLYTSVNPEY 

       970        980        990       1000       1010       1020 
LSASDMYIPD EWEVPREQIS IIRELGQGSF GMVYEGVAKG LEAGEESTPV ALKTVNELAS 

      1030       1040       1050       1060       1070       1080 
PRERIEFLKE ASVMKAFQCH HVVRLLGVVS QGQPTLVIME LMTRGDLKSH LRSLRPEAEN 

      1090       1100       1110       1120       1130       1140 
NPGIPRPALG DMIQMAGEIA DGMAYLAANK FVHRDLAARN CMVSQDFTVK IGDFGMTRDV 

      1150       1160       1170       1180       1190       1200 
YETDYYRKGG KGLLPVRWMA PESLKDGIFT THSDVWSFGV VLWEIVTLAE QPYQGLSNEQ 

      1210       1220       1230       1240       1250       1260 
VLKFVMDGGV LEELEDCPHQ LQELMSSCWQ QNPRLRPTFT QILNSIQKEL RPSFRLLSFY 

      1270       1280       1290       1300 
HSPECQGGCG LQPTTDAESS SPPTSKGASD CSLQNGGPEH

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References

[1]"Primary structure of a putative receptor for a ligand of the insulin family."
Shier P., Watt V.M.
J. Biol. Chem. 264:14605-14608(1989) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		J05047 Genomic DNA. Translation: AAA37044.1.
PIRA36502.
RefSeqXP_003475448.1. XM_003475400.1.

3D structure databases

ProteinModelPortalP14617.
SMRP14617. Positions 29-487, 957-1264.
ModBaseSearch...

Protein-protein interaction databases

STRING10141.ENSCPOP00000017876.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENSCPOT00000003232; ENSCPOP00000002888; ENSCPOG00000003189.
GeneID100716566.

Phylogenomic databases

eggNOGCOG0515.
GeneTreeENSGT00690000101688.
HOGENOMHOG000038045.
HOVERGENHBG006134.

Enzyme and pathway databases

BRENDA2.7.10.1. 1225.

Family and domain databases

Gene3D2.60.40.10. 4 hits.
InterProIPR000494. EGF_rcpt_L.
IPR003961. Fibronectin_type3.
IPR006211. Furin-like_Cys-rich_dom.
IPR006212. Furin_repeat.
IPR009030. Growth_fac_rcpt.
IPR013783. Ig-like_fold.
IPR011009. Kinase-like_dom.
IPR000719. Prot_kinase_cat_dom.
IPR017441. Protein_kinase_ATP_BS.
IPR001245. Ser-Thr/Tyr_kinase_cat_dom.
IPR008266. Tyr_kinase_AS.
IPR020635. Tyr_kinase_cat_dom.
IPR016246. Tyr_kinase_insulin-like_rcpt.
IPR002011. Tyr_kinase_rcpt_2_CS.
[Graphical view]
PfamPF00041. fn3. 1 hit.
PF00757. Furin-like. 1 hit.
PF07714. Pkinase_Tyr. 1 hit.
PF01030. Recep_L_domain. 2 hits.
[Graphical view]
PIRSFPIRSF000620. Insulin_receptor. 1 hit.
PRINTSPR00109. TYRKINASE.
SMARTSM00060. FN3. 3 hits.
SM00261. FU. 1 hit.
SM00219. TyrKc. 1 hit.
[Graphical view]
SUPFAMSSF49265. FN_III-like. 3 hits.
SSF57184. Grow_fac_recept. 1 hit.
SSF56112. Kinase_like. 1 hit.
PROSITEPS50853. FN3. 3 hits.
PS00107. PROTEIN_KINASE_ATP. 1 hit.
PS50011. PROTEIN_KINASE_DOM. 1 hit.
PS00109. PROTEIN_KINASE_TYR. 1 hit.
PS00239. RECEPTOR_TYR_KIN_II. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameINSRR_CAVPO
AccessionPrimary (citable) accession number: P14617
Entry history
Integrated into UniProtKB/Swiss-Prot: April 1, 1990
Last sequence update: April 1, 1990
Last modified: April 3, 2013
This is version 118 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

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